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Data Status: April 2018

These statistics reflect our latest monthly data release.

Chemical–gene interactions (curated) 1,747,232
Unique chemicals 12,716
Unique genes 45,211
Unique organisms 579
Phenotype–based interactions (curated) 170,090
Unique chemicals 6,601
Unique genes 1,704
Unique GO terms 4,009
Unique anatomical terms 774
Unique organisms 225
Gene–disease associations 23,781,866
Curated[1] 37,119
Unique genes 8,224
Unique diseases 5,743
Inferred[2] 23,744,747
Unique genes 44,253
Unique diseases 3,133
Chemical–disease associations 2,440,001
Curated[1] 210,352
Unique chemicals 9,465
Unique diseases 3,179
Inferred[2] 2,229,649
Unique chemicals 12,466
Unique diseases 5,730
Chemical–GO associations (enriched) 5,085,881
Chemical–pathway associations (enriched) 1,152,540
Disease–pathway associations (inferred) 280,721
Gene–gene interactions 489,052
Gene–GO annotations 1,159,699
Gene–pathway annotations 135,804
GO–disease associations (inferred) 931,623
Chemicals with curated data 15,520
Diseases with curated data 7,159
Via OMIM curation 4,114
Genes with curated data 45,281
Via OMIM curation 3,682
Curated references 128,340
[1]
Curated associations are established by CTD (chemical–disease and gene–disease) and OMIM (gene–disease) curation.
[2]
Inferred associations are established via CTD-curated chemical–gene interactions (e.g., Chemical A is associated by inference with Disease B because Chemical A has a curated interaction with Gene C, and Gene C has a curated association with Disease B).

Curated Exposure Statements 113,658
Unique Chemicals 1,072
Unique Genes 353
Unique Diseases 393
Unique GO Terms 307
Curated Exposure References 1,982

Integrated Data

In the current release, CTD data is integrated with data from these resources:

  1. BioGRID (3.4.158 release)
  2. ChemIDplus® (as of March 30, 2018)
  3. DrugBank (as of March 31, 2018)
  4. GO (as of March 29, 2018)
  5. KEGG (as of March 30, 2018)
  6. MeSH® (2018 MeSH release)
  7. NCBI Gene (as of March 30, 2018)
  8. NCBI Taxonomy (as of March 29, 2018)
  9. PubMed® (as of March 30, 2018)
  10. Reactome (as of March 30, 2018)