Organophosphorus Compounds - Diseases

These diseases are associated with Organophosphorus Compounds or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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1–50 of 42,411 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Diazinon	Lung Neoplasms	M	65 genes: ACSM1 \| AKT1 \| ALX4 \| APOE \| AZGP1 \| BCL2L1 \| BIRC5 \| CASP8 \| CCND1 \| CCNG1 \| CDKN1A \| CDKN1C \| CHRNA3 \| CHRNA5 \| CHRNA7 \| CYP1A2 \| DDR1 \| DOK1 \| EGFR \| EPHX1 \| ERBB3 \| ESR1 \| FAS \| FASLG \| FGF9 \| FGFR1 \| FOXM1 \| GATA6 \| GPX1 \| GPX3 \| GSTM1 \| GSTP2 \| GSTT1 \| HMOX1 \| IFNG \| IL10 \| IL2 \| IL6 \| JUN \| JUNB \| MAP2K7 \| MAPK1 \| MAPK3 \| MCL1 \| MET \| MYC \| NFYA \| NOS2 \| PCNA \| PON1 \| PRKN \| PTEN \| PTMA \| PYCARD \| RASSF1 \| RUNX3 \| SERPINA1 \| SLC22A18 \| TGFB1 \| TLR4 \| TNF \| TP53 \| VHL \| WNT5A \| WT1	61.04	78
2.	Malathion	Prostatic Neoplasms	M	27 genes: ACHE \| AHR \| AR \| BAX \| BCL2 \| CALCA \| CASP9 \| CTSB \| CTSD \| CYP19A1 \| CYP1A1 \| CYP2A6 \| CYP2E1 \| CYP3A4 \| CYP3A5 \| EHBP1 \| EPHX1 \| ESR1 \| GSK3B \| IL6 \| KEAP1 \| MPO \| NQO1 \| PPARA \| SOD2 \| TP53 \| TYMS	51.33	62
3.	Cyclophosphamide	Myocardial Ischemia	M	41 genes: ACTB \| CALR \| CANX \| CCL2 \| CCND2 \| CD38 \| CDH2 \| CX3CL1 \| CXCL10 \| DCN \| EDN1 \| EGR2 \| F2RL1 \| F3 \| GCLC \| GSTA1 \| GSTM2 \| GSTP1 \| HMOX1 \| HSPA1A \| HSPA2 \| HSPA9 \| ICAM1 \| IFNGR1 \| IGFBP3 \| IL1A \| IL1B \| IL6 \| KDR \| KLF4 \| MAPK14 \| NOS3 \| NPPA \| POMC \| SOD2 \| SPARC \| TAP1 \| TNF \| TXNRD1 \| VCAM1 \| VEGFA	49.97	14
4.	Malathion	Breast Neoplasms	M	28 genes: ACHE \| AHR \| AR \| BAX \| BCHE \| BCL2 \| CASP8 \| CAT \| CENPF \| CYP19A1 \| CYP1A1 \| CYP3A4 \| ESR1 \| HES1 \| HRAS \| HSP90AA1 \| IFNB1 \| IFNG \| IL1B \| IL6 \| JUN \| NOS2 \| NQO1 \| OCLN \| SOD2 \| TP53 \| TRP53 \| TYMS	49.50	59
5.	Cyclophosphamide	Inflammation	M	53 genes: AKT1 \| ANGPT1 \| BDKRB1 \| BDKRB2 \| BDNF \| CASP1 \| CCL2 \| CD3E \| CRHR2 \| CSF2 \| CYP2B1 \| CYP2B2 \| CYP3A2 \| CYP3A23/3A1 \| DUSP10 \| EDN1 \| EGR1 \| EIF4EBP1 \| EPO \| F2RL1 \| GAL \| GATA3 \| HMOX1 \| ICAM1 \| IFNG \| IL10 \| IL1A \| IL1B \| IL1RN \| IL6 \| LCN2 \| LTF \| MIF \| MPO \| NGF \| NOS2 \| NPPB \| PARP1 \| PPARG \| PROCR \| PTGER4 \| PTGS2 \| SLC22A5 \| SOD1 \| STAT3 \| TAC1 \| TGFB1 \| TIMP1 \| TNF \| TNFAIP3 \| TRPA1 \| TRPV1 \| VEGFA	45.18	104
6.	Chlorpyrifos	Lung Neoplasms	M	47 genes: BCL2L1 \| CCND1 \| CDH13 \| CDKN1B \| CES1 \| CHRNA5 \| CHRNA7 \| CHRNB4 \| CTGF \| CTNNB1 \| CYP1A2 \| CYP1B1 \| CYP2A6 \| CYP2E1 \| EGFR \| ESR1 \| FAS \| FGF9 \| FGFR2 \| FOS \| GPX1 \| GSTM1 \| GSTP2 \| GSTT1 \| HMOX1 \| IL10 \| IL1B \| IL6 \| JUN \| JUNB \| KRAS \| MAPK1 \| MAPK3 \| MPO \| MYC \| PON1 \| PRDX6 \| PRKN \| PYCARD \| SELENOP \| SERPINA1 \| TGFB1 \| TLR4 \| TNF \| TP53 \| TP63 \| WNT5A	41.89	91
7.	Parathion	Prostatic Neoplasms	M	46 genes: ACHE \| ADRB2 \| AHR \| AR \| ASZ1 \| CDKN1A \| CTNNB1 \| CYP1A1 \| CYP2A6 \| CYP2C19 \| CYP2E1 \| CYP3A4 \| CYP3A5 \| EGFR \| ESR1 \| EZR \| FOXA1 \| GSTP1 \| HSD17B3 \| IGFBP3 \| IGFBP6 \| IL10 \| IL17RC \| IL6 \| LEP \| LPAR1 \| MDM2 \| MT2A \| NGFR \| NPR3 \| NR3C1 \| PENK \| PIK3CD \| PON1 \| PTPRK \| RFX6 \| SLC22A3 \| ST14 \| SULT1A1 \| SULT2A1 \| TERT \| TIMP4 \| TMEFF2 \| TP53 \| ZFHX3 \| ZMYM3	38.82	81
8.	Parathion	Breast Neoplasms	M	50 genes: ABCB1 \| ABL1 \| ACHE \| ADAMTS1 \| AHR \| AR \| BCHE \| CCNE1 \| CDKN2A \| CLDN1 \| CLIC1 \| CTNNB1 \| CYP1A1 \| CYP2B1 \| CYP2D6 \| CYP3A4 \| DKK1 \| DSC3 \| EGFR \| ESR1 \| FABP7 \| FAM19A4 \| FOXA1 \| GSTP1 \| GUCY1A2 \| HRAS \| IFNG \| IL1B \| IL6 \| KIT \| KLK10 \| LEP \| LPAR1 \| MDM2 \| MT3 \| NMBR \| NOTCH4 \| NRG1 \| PAK1 \| RARA \| RPL31 \| RXRB \| SFRP2 \| TBX3 \| TERT \| TFPI2 \| TNF \| TP53 \| VEGFC \| ZNF365	38.28	72
9.	Malathion	Neurotoxicity Syndromes	M	15 genes: ADD3 \| BCHE \| CASP3 \| CCK \| CRISPLD2 \| CYP3A5 \| LAT \| MTOR \| NQO1 \| P2RX1 \| PLAT \| RNASE6 \| SRSF5 \| ST8SIA1 \| TIMP3	36.05	8
10.	Cyclophosphamide	Esophageal Neoplasms	M	21 genes: ABCB1 \| ACTB \| ALDH2 \| BAX \| BCL2 \| CASP8 \| EGFR \| ERBB2 \| KDR \| NOS2 \| NOS3 \| NR1I2 \| PTGS1 \| PTGS2 \| RUNX3 \| SFN \| SOD2 \| TGFBR2 \| TP53 \| TPM1 \| TRP53	32.82	22
11.	Cyclophosphamide	Brain Injuries	M	25 genes: APEX1 \| BDNF \| CCL2 \| CD14 \| CEBPB \| CFB \| CXCL10 \| EPO \| FOS \| HSPA1A \| IL10 \| IL1A \| IL1B \| IL1RN \| IL2 \| IL6 \| LSG1 \| MPO \| NPPB \| PARP1 \| PTGS2 \| SOD2 \| TNF \| TNFRSF14 \| VEGFA	31.73	18
12.	Cyclophosphamide	Status Epilepticus	M	26 genes: BDNF \| BECN1 \| CASP1 \| CASP3 \| CASP8 \| CAT \| CCL2 \| CCR8 \| CCR9 \| CD40 \| CDH2 \| CRH \| EPO \| FOS \| GAP43 \| GDNF \| HMOX1 \| HSPB1 \| IL1RN \| NGF \| NOS2 \| NTF3 \| NTRK2 \| PTGS2 \| TNF \| VEGFA	30.97	28
13.	Methyl Parathion	Neurotoxicity Syndromes	M	11 genes: ABCB1 \| ADD3 \| BCHE \| CCK \| FOS \| GABRR2 \| P2RX1 \| PON1 \| SRSF5 \| TGM1 \| TIMP3	29.86	5
14.	Cyclophosphamide	Cardiomyopathies	M	28 genes: ADCYAP1 \| AKT1 \| BDKRB2 \| CAT \| CYP2C9 \| EDN1 \| EPO \| FAS \| FASLG \| HSPD1 \| HSPE1 \| IL1A \| IL1B \| IL4 \| IL6 \| MAPK1 \| MAPK14 \| MAPK3 \| NDUFS2 \| NPPB \| PARP1 \| POMC \| PTGS2 \| SOD2 \| STAT3 \| TNF \| TNNI3 \| TRP53	29.60	41
15.	Cyclophosphamide	Hypersensitivity	M	21 genes: CASP1 \| CCL2 \| CCL7 \| CCL8 \| CCL9 \| CCR9 \| CX3CL1 \| CXCL1 \| CXCL5 \| CXCL9 \| CYP1A1 \| IFNG \| IL16 \| IL18 \| IL1B \| IL4 \| IL6 \| SPP1 \| TAC1 \| TGFB1 \| TNF	27.15	9
16.	Chlorpyrifos	Parkinson Disease	M	26 genes: ABCB1 \| AIF1 \| BDNF \| BST1 \| CYP2D6 \| CYP2E1 \| DRD1 \| DRD2 \| GFAP \| GPX1 \| GSTA4 \| GSTM1 \| HMOX1 \| IGF2R \| IL6 \| MAG \| NGF \| NQO1 \| PINK1 \| PRKN \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TNF	26.95	56
17.	Cyclophosphamide	Hyperalgesia	M	34 genes: ADM \| BDKRB1 \| BDKRB2 \| CCL2 \| CSK \| EDN1 \| FOS \| GAL \| GDNF \| IL10 \| IL1A \| IL1B \| IL1RN \| IL6 \| MAPK1 \| MAPK3 \| MAPK7 \| MAPK8 \| MAPK9 \| MMP3 \| NGF \| NOS2 \| NTF3 \| P2RX3 \| PTGER1 \| PTGS1 \| PTGS2 \| SPARC \| TAC1 \| TACR1 \| TNF \| TRPA1 \| TRPV1 \| VIP	26.17	52
18.	Dichlorvos	Prostatic Neoplasms	M	19 genes: ACHE \| AR \| ATM \| BAX \| CASP9 \| CDKN1A \| CHEK2 \| ESR1 \| HMOX1 \| IL2 \| IL6 \| LPL \| NFE2L2 \| NQO1 \| PARP1 \| PON1 \| PRKDC \| SOD2 \| TP53	25.35	60
19.	Cyclophosphamide	Pneumonia	M	22 genes: CASP1 \| CCL2 \| CCL7 \| CCL8 \| CCL9 \| CCR9 \| CSF2 \| CX3CL1 \| CXCL1 \| CXCL5 \| CXCL9 \| HMOX1 \| IFNG \| IL18 \| IL1B \| IL4 \| IL6 \| PARP1 \| POMC \| SPP1 \| TGFB1 \| TNF	25.31	6
20.	Diazinon	Parkinson Disease	M	28 genes: ABCB1 \| BDNF \| BST1 \| CYP2D6 \| DDIT4 \| DRD2 \| GAK \| GFAP \| GPX1 \| GSTA4 \| GSTM1 \| HMOX1 \| HSPA1A \| IGF2 \| IL6 \| INS \| MAOB \| NGF \| NQO1 \| PARK7 \| PINK1 \| PRKN \| SLC18A2 \| SLC6A3 \| SOD1 \| SOD2 \| TNF \| VPS35	24.50	42
21.	Monocrotophos	Diabetes Mellitus, Experimental	M	8 genes: BAX \| BCL2 \| CASP3 \| CAT \| CYP1A1 \| GSR \| TP53 \| TRP53	24.28	11
22.	Malathion	Colonic Neoplasms	M	12 genes: BAX \| BCL2 \| HES1 \| IFNG \| IL1B \| JUN \| MCM2 \| NOS2 \| PCNA \| SOD2 \| TP53 \| TYMS	23.46	24
23.	Cyclophosphamide	Heart Failure	M	29 genes: CAT \| CSF2 \| EDN1 \| GPX4 \| HIF1A \| HMOX1 \| HSPB1 \| IFNG \| IL1B \| IL6 \| NFE2L2 \| NOS2 \| NOS3 \| NPPA \| NPPB \| NRG1 \| POMC \| PON1 \| PPARG \| PTGS1 \| PTGS2 \| SERPINE1 \| SOD1 \| SOD2 \| TNF \| TRP53 \| UCP1 \| VEGFA \| XDH	23.41	66
24.	Fonofos	Colorectal Neoplasms	M	22 genes: ABCA1 \| ABCA5 \| CABYR \| CD226 \| CYP1A2 \| DCC \| EYA4 \| GATA4 \| GATA5 \| GUCY1A2 \| IGF2 \| IGFBP3 \| LGR5 \| NXN \| PGM1 \| PYCARD \| RET \| SFRP2 \| SFRP4 \| TCERG1L \| TFPI2 \| TLR2	22.89	19
25.	Cyclophosphamide	Disease Models, Animal	M	21 genes: AKT1 \| BSCL2 \| CAR2 \| ERBB2 \| ESR1 \| FAS \| FOS \| IFNG \| IL1B \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| MAPT \| SERPINE1 \| SOD1 \| STAT3 \| TIMP1 \| TNF \| TRP53 \| VIM	22.66	30
26.	cyclohexyl methylphosphonofluoridate	Organophosphate Poisoning	M	4 genes: ACHE \| BCHE \| PEPD \| PON1	22.30	16
27.	Cyclophosphamide	Myocardial Infarction	M	29 genes: APOE \| BAX \| BCL2 \| BCL2L1 \| BECN1 \| CASP3 \| CAT \| CREB1 \| CREM \| DDIT3 \| EPO \| ESR1 \| GCLC \| HSPA5 \| ICAM1 \| IL10 \| IL1B \| IL1RN \| IL6 \| NOS2 \| NOS3 \| NPPA \| PLAU \| SOD1 \| SOD2 \| TGFB1 \| TNF \| TNNI3 \| TRP53	21.79	32
28.	Cyclophosphamide	Hypertension	M	44 genes: ABCC1 \| ALAD \| APOE \| BCL2 \| BDKRB2 \| CAT \| CCL2 \| CRHR2 \| CYP1A1 \| DRD2 \| EDN1 \| EPO \| FOS \| GAL \| GCLC \| GJA1 \| GPX1 \| HIF1A \| HMOX1 \| ICAM1 \| IER3 \| IL1B \| IL6 \| LHB \| LTF \| NOS2 \| NOS3 \| NPPA \| NPPB \| POMC \| PPARG \| PTGS2 \| RELA \| SERPINE1 \| SOD1 \| SOD2 \| STK39 \| TACR1 \| TGFB1 \| TIMP1 \| TNF \| TP53 \| TPM1 \| VCAM1	20.73	134
29.	Malathion	Diabetes Mellitus, Type 2	M	10 genes: BCL2 \| CASP3 \| CASP8 \| CAT \| CYP1A2 \| INS1 \| NOS2 \| PPARA \| SOD1 \| SOD2	20.57	7
30.	tabun	Organophosphate Poisoning	M	4 genes: ACHE \| BCHE \| PEPD \| PON1	20.48	18
31.	Cyclophosphamide	Precancerous Conditions	M	21 genes: AKT1 \| ALDH2 \| ARG1 \| CAT \| CDH1 \| EIF4EBP1 \| GJB1 \| GSTP1 \| IL6 \| IRS1 \| KRT8 \| MAPK8 \| MAPK9 \| MGMT \| MPO \| NR1I3 \| PTGS2 \| SOD2 \| STAT3 \| TRP53 \| VEGFA	20.23	20
32.	VX	Organophosphate Poisoning	M	4 genes: ACHE \| BCHE \| PEPD \| PON1	20.20	17
33.	Dichlorvos	Nerve Degeneration	M	13 genes: APP \| BAX \| CASP3 \| CHRNB2 \| CNR1 \| GST-1 \| IFNG \| SKN-1 \| SNCA \| SOD1 \| SOD2 \| TH \| TNF	20.14	35
34.	Malathion	Drug-Induced Liver Injury	M	19 genes: AHR \| BAX \| CAT \| CYP2A6 \| CYP2C9 \| CYP2E1 \| EPHX1 \| GPT \| GSR \| IFNG \| IL1B \| IL1R2 \| IL6 \| NR1I3 \| PLAT \| PPARA \| SOD1 \| SOD2 \| TTR	19.82	27
35.	Ifosfamide	Brain Ischemia	M	12 genes: CASP3 \| CASP9 \| CAT \| GPX1 \| HIF1A \| IL1B \| IL6 \| MMP9 \| NOS2 \| PTGS2 \| TNF \| TP53	19.77	15
36.	Cyclophosphamide	Mammary Neoplasms, Animal	M	18 genes: ACTB \| ALCAM \| CDH1 \| COMT \| EGFR \| EPHX1 \| ERBB2 \| ESR1 \| ESR2 \| GATA3 \| LGALS7 \| MIF \| PRLR \| PTGER1 \| SGK1 \| STAT3 \| TUBB2B \| XDH	19.46	8
37.	Paraoxon	Status Epilepticus	M	9 genes: CASP3 \| CASP8 \| CNR1 \| FOS \| GAP43 \| JUN \| PTK2B \| TNF \| VEGFA	19.45	12
38.	Dichlorvos	Necrosis	M	17 genes: AIFM1 \| APP \| CAT \| FAS \| FASL \| IFNG \| IL1B \| IL6 \| INS1 \| LPL \| MGMT \| NFE2L2 \| NOS2 \| POMC \| SOD1 \| SOD2 \| TNF	19.09	19
39.	Dichlorvos	Drug-Induced Liver Injury	M	21 genes: AIFM1 \| ALB \| ANXA2 \| BAX \| CAT \| CHRM3 \| GCLC \| GOT1 \| GPT \| GSR \| HMOX1 \| IFNG \| IL1B \| IL6 \| NFE2L2 \| PON1 \| PRKDC \| SOD1 \| SOD2 \| TF \| TNF	18.85	34
40.	Diazinon	Ovarian Neoplasms	M	23 genes: AKT1 \| BIRC5 \| CCNE1 \| DOK1 \| EGFR \| FASN \| FGF1 \| GADD45A \| IL6 \| MAPK1 \| MAPK3 \| MET \| MKI67 \| MSH2 \| MYC \| NR5A1 \| PLEKHF1 \| PRKN \| PTEN \| RBL2 \| SOD1 \| SOD2 \| TLR4	18.32	23
41.	Cyclophosphamide	Liver Cirrhosis	M	19 genes: ALAD \| CCL2 \| CD14 \| CYP1A2 \| F3 \| IL6 \| KRT8 \| LAMC2 \| LGALS1 \| NFE2L2 \| NPPA \| PLAU \| SPARC \| SPP1 \| STAT1 \| TGFB1 \| THBS1 \| VEGFA \| VIM	17.42	18
42.	Cyclophosphamide	Cerebral Hemorrhage	M	14 genes: BAX \| BCL2 \| BCL2L1 \| CASP3 \| CASP8 \| HMOX1 \| HMOX2 \| KDR \| MMP3 \| NPPB \| PLAU \| POMC \| SPP1 \| VEGFA	17.39	14
43.	terbufos	Prostatic Neoplasms	M	28 genes: ADRB2 \| ALOXE3 \| ASZ1 \| FOXA1 \| GADD45A \| HSD17B3 \| IGFBP3 \| IGFBP6 \| IL10 \| IL17RC \| LEP \| LPAR1 \| MPO \| MYC \| NGFR \| NPR3 \| PENK \| PIK3CD \| PTPRK \| RFX6 \| SLC22A3 \| ST14 \| TERT \| TIMP4 \| TMEFF2 \| VDR \| ZFHX3 \| ZMYM3	17.03	35
44.	Dichlorvos	Hypertension	M	17 genes: ALB \| AR \| CAT \| CYBB \| DRD2 \| GCLC \| HMOX1 \| IL1B \| IL6 \| LPL \| NOS2 \| POMC \| SOD1 \| SOD2 \| TH \| TNF \| TP53	16.78	86
45.	Methyl Parathion	Infertility, Male	M	6 genes: AR \| CYP1A1 \| ESR1 \| MDM2 \| PON1 \| TP53	16.46	10
46.	Cyclophosphamide	Diabetes Mellitus, Type 1	M	10 genes: CAT \| CD69 \| CTSH \| DDIT3 \| FOXP3 \| IFNG \| IL10 \| NOS3 \| STAT3 \| TNF	15.85	10
47.	Isoflurophate	Organophosphate Poisoning	M	4 genes: ACHE \| BCHE \| PEPD \| PON1	15.59	21
48.	Cyclophosphamide	Cardiomegaly	M	18 genes: AKT1 \| CCND2 \| CYP1A1 \| CYP1B1 \| CYP2C11 \| CYP2E1 \| EDN1 \| HIF1A \| HMOX1 \| IL18 \| IL1B \| NOS3 \| NPPA \| NPPB \| POMC \| SOD2 \| STAT3 \| TNF	15.58	29
49.	Dichlorvos	Stomach Neoplasms	M	11 genes: ALB \| ATM \| CA2 \| CDKN1A \| CHEK2 \| HMOX1 \| IL1B \| IL6 \| SOD2 \| TNF \| TP53	15.05	19
50.	diazoxon	Organophosphate Poisoning	M	3 genes: ACHE \| BCHE \| PON1	15.01	15

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