Polybrominated Biphenyls - Diseases

These diseases are associated with Polybrominated Biphenyls or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

Disease categories [Show chart]

1–50 of 2,417 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	tetrabromobisphenol A	Carcinoma	M	27 genes: ABCB1 \| ALCAM \| ANGPTL4 \| BCL2 \| CCND1 \| CDK4 \| EGFR \| ESR1 \| ESR2 \| FABP4 \| GSTP1 \| GSTT1 \| MYC \| PGAM1 \| PGR \| PLAUR \| PLK2 \| PPARA \| PRDX2 \| PTGS2 \| RBP4 \| SOX9 \| TGFB1 \| TKT \| TLR4 \| TP53 \| URI1	28.76	20
2.	tetrabromobisphenol A	Drug-Induced Liver Injury	M	43 genes: ABCB1 \| ABCB1A \| ABCB1B \| ABCC1 \| AHR \| ATOH8 \| BAX \| CAT \| CTSE \| CXCL1 \| FASN \| GADD45A \| GPT \| GSR \| GSTP1 \| GSTT1 \| HMOX1 \| IFNG \| IGF1 \| IL18 \| IL1B \| IL1R2 \| IL4 \| IL6 \| LBP \| LTF \| MIR103-1 \| MIR107 \| MMP2 \| NR1I2 \| NR1I3 \| NREP \| OAS1A \| PPARA \| PTF1A \| PTGS2 \| SLC22A8 \| SLPI \| SOD1 \| SPP1 \| SULT1E1 \| TNF \| TTR	11.84	41
3.	tetrabromobisphenol A	Uterine Cervical Neoplasms	M	6 genes: BIRC5 \| CCND1 \| EGFR \| ERCC1 \| FGFR3 \| MYC	7.20	7
4.	Firemaster 550	Obesity	M	3 genes: AHR \| PLIN1 \| PPARG	7.10	5
5.	tetrabromobisphenol A	Weight Gain	M	12 genes: AHR \| APP \| CAV1 \| FBXO21 \| FGF1 \| IGFBP5 \| LBP \| LPGAT1 \| MMP2 \| SCD1 \| SCD2 \| TNF	6.73	6
6.	tetrabromobisphenol A	Neoplasms, Experimental	M	12 genes: AHR \| CCND1 \| CDK4 \| ENO2 \| ERBB2 \| IFNG \| NQO1 \| PCNA \| RELA \| SPP1 \| TNF \| URI1	6.09	12
7.	hexabromodiphenyl ether 154	Cryptorchidism	M	1 gene: CASP3	3.99	2
8.	tetrabromobisphenol A	Movement Disorders	M	2 genes: MT1 \| NRG1	3.62	3
9.	2,4,5,2',4',5'-hexabromobiphenyl	Neoplasms	M	1 gene: AHR	3.60	2
10.	tetrabromobisphenol A	Uterine Neoplasms	M	1 gene: HMGA1	3.37	2
11.	tetrabromobisphenol A	Kidney Diseases	M	17 genes: ABCB1A \| CDKN1A \| EGF \| GSTP1 \| IGF1 \| IL1RN \| LRP2 \| MT4 \| NQO1 \| PPARA \| PTGS2 \| RBP4 \| REN \| SLC22A2 \| SLC47A1 \| SPP1 \| TGFB1	3.31	22
12.	Firemaster 550	Heart Defects, Congenital	M	1 gene: AHR	3.12	2
13.	tetrabromobisphenol A	Hyperemia	M	4 genes: BDKRB2 \| CAT \| IL1B \| PTGS2	3.09	5
14.	2,4,5,2',4',5'-hexabromobiphenyl	Drug-Induced Liver Injury	M	1 gene: AHR	3.07	2
15.	Firemaster BP-6	Drug-Induced Liver Injury	M	1 gene: AHR	2.92	2
16.	tetrabromobisphenol A	Hepatomegaly	M	9 genes: ABCC3 \| ACOT1 \| ADAMTS5 \| CYP1A1 \| CYP2B1 \| DAPK2 \| NR1I2 \| NR1I3 \| PPARA	2.80	6
17.	tetrabromobisphenol A	Hemorrhage	M	3 genes: BDKRB2 \| NQO1 \| REN	2.58	4
18.	tetrabromobisphenol A	Hearing Loss	M	3 genes: SOD1 \| STAT1 \| TLR4	2.55	4
19.	tetrabromobisphenol A	Necrosis	M	13 genes: AHR \| APP \| BCL2 \| CAT \| CYP2B1 \| GSTP1 \| IFNG \| IL1B \| IL1RN \| IL6 \| RBP4 \| SOD1 \| TNF	2.20	18
20.	tetrabromobisphenol A	Edema	M	10 genes: CASP3 \| CASP9 \| CAT \| CXCL8 \| CYP1A \| GSR \| IL6 \| PTGS2 \| PTHLH \| TNF	2.12	6
21.	Firemaster BP-6	Anorexia	M			2
22.	tribromodiphenyl ether 28	Cryptorchidism	M			1
23.	Firemaster BP-6	Dehydration	M			1
24.	Firemaster BP-6	Diarrhea	M			1
25.	octabromobiphenyl	Drug-Induced Liver Injury	M			1
26.	tetrabromobisphenol A dimethyl ether	Edema	M			1
27.	tetrabromobisphenol A	Edema, Cardiac	M			1
28.	Firemaster BP-6	Fetal Death	M			1
29.	tetrabromobisphenol A dimethyl ether	Hemorrhage	M			1
30.	tetrabromobisphenol A	Immune System Diseases	M			1
31.	3,3',4,4',5,5'-hexabromobiphenyl	Keratosis	M			1
32.	3,3',4,4'-tetrabromobiphenyl	Keratosis	M			1
33.	Firemaster BP-6	Kidney Diseases	M			1
34.	2,2',4,4',5,5'-hexabrominated diphenyl ether	Learning Disorders	M			1
35.	Polybrominated Biphenyls	Male Urogenital Diseases	M			1
36.	2,2',4,4',5,5'-hexabrominated diphenyl ether	Memory Disorders	M			1
37.	Polybrominated Biphenyls	Motor Skills Disorders	M			1
38.	tetrabromobisphenol A	Nervous System Malformations	M			1
39.	Polybrominated Biphenyls	Neutrophil Chemotactic Response, Abnormal	M			1
40.	Firemaster 550	Pericardial Effusion	M			1
41.	Polybrominated Biphenyls	Prenatal Exposure Delayed Effects	M			2
42.	Firemaster 550	Puberty, Precocious	M			1
43.	tetrabromobisphenol A	Teratogenesis	M			2
44.	tetrabromobisphenol A	Liver Cirrhosis, Experimental		112 genes: ABCB1 \| ABCB1A \| ADGRE1 \| AGFG1 \| AIF1 \| APOA4 \| APP \| ASPN \| ATF3 \| BMF \| C1QA \| C8G \| CASP12 \| CASP4 \| CASP7 \| CAV1 \| CCL6 \| CCNB2 \| CD53 \| CD68 \| CD86 \| CDK1 \| CDKN1A \| CEBPD \| CLEC4A3 \| CNP \| CPQ \| CRY1 \| CSGALNACT1 \| CTSE \| CTSZ \| CXCL1 \| CXCL12 \| CYP17A1 \| DEPDC7 \| DHRS3 \| EGF \| FABP7 \| FCER1G \| FCGR1A \| FHL2 \| FMO1 \| FRY \| FTCD \| GLS2 \| GPT \| GSTA3 \| HAGH \| HAL \| HIP1 \| HMOX1 \| HSD17B2 \| ID2 \| IFNG \| IGF1 \| IGFBP3 \| IL10 \| IL18 \| IL1B \| LBH \| LBP \| LGMN \| LOX \| MAGEE1 \| MME \| MMP13 \| MMP2 \| MMP9 \| MYC \| NAT8 \| NDRG2 \| NLRC5 \| NPAS2 \| NREP \| NRG1 \| OLFML2B \| OSGIN1 \| OTUB2 \| PCK1 \| PLEK \| PLEKHB1 \| PQLC3 \| PROCR \| PTGS2 \| RARRES1 \| RBL2 \| RELA \| RELL1 \| RT1-DA \| RT1-DMB \| S100A9 \| SCD2 \| SERPINA7 \| SGK2 \| SLC10A1 \| SLC20A1 \| SLC22A8 \| SLC46A1 \| SOAT1 \| SOX4 \| SRD5A1 \| SULT1E1 \| SULT2A1 \| TGFB1 \| TGFB3 \| TIMP1 \| TLR4 \| TMEM65 \| TNF \| TNFRSF12A \| TPM1 \| VSIR	140.14	34
45.	tetrabromobisphenol A	Prostatic Neoplasms		72 genes: ABCC4 \| AGR2 \| AHR \| AKT1 \| ALDH1A2 \| AR \| ATF3 \| BAX \| BCL2 \| CASP9 \| CAV1 \| CCND1 \| CCND2 \| CDKN1A \| COMT \| CXCL12 \| CXCL8 \| CYP17A1 \| CYP19A1 \| CYP1A1 \| CYP1B1 \| CYP3A4 \| CYP7B1 \| EGF \| EGFR \| EGR1 \| ERBB2 \| ESR1 \| ESR2 \| ETV4 \| GADD45A \| GSK3B \| GSTP1 \| GSTT1 \| HERPUD1 \| HIP1 \| HMOX1 \| HSD3B1 \| ICAM1 \| IGF1 \| IGFBP3 \| IL10 \| IL16 \| IL17RD \| IL18 \| IL1RN \| IL6 \| LRP2 \| MAPK3 \| MME \| MMP13 \| MMP9 \| MYC \| NQO1 \| NR3C1 \| P4HB \| PLAUR \| PPARA \| PRDX2 \| PRSS8 \| PTGS2 \| PTHLH \| RALBP1 \| SLC22A3 \| SRD5A1 \| SULT1A1 \| SULT1E1 \| SULT2A1 \| TGFB1 \| TLR4 \| TP53 \| TRAF1	78.73	109
46.	tetrabromobisphenol A	Breast Neoplasms		69 genes: ABCB1 \| ABCB1B \| ABCC1 \| ABCG2 \| AGR2 \| AHR \| AKT1 \| ANGPTL4 \| AR \| AREG \| BAX \| BCL2 \| BIRC5 \| BMP4 \| CASP7 \| CAT \| CAV1 \| CCND1 \| CDA \| COMT \| CXCL12 \| CXCL8 \| CXCR4 \| CYP17A1 \| CYP19A1 \| CYP1A1 \| CYP1B1 \| CYP2B1 \| CYP3A4 \| DDIT3 \| EGF \| EGFR \| ERBB2 \| ESR1 \| ESR2 \| ETV4 \| FABP7 \| FASN \| FBL \| FHL2 \| GPER1 \| GPX2 \| GSTP1 \| HMOX1 \| IFNG \| IGF1 \| IGFBP5 \| IL1B \| IL6 \| JAG1 \| MME \| MMP2 \| MMP9 \| NQO1 \| NR2F1 \| NRCAM \| NRG1 \| PGR \| PTGS2 \| PTHLH \| RELA \| REPS2 \| RSPO3 \| SLCO1B1 \| SPP1 \| TFRC \| TNF \| TP53 \| TUBB3	62.24	144
47.	tetrabromobisphenol A	Diabetes Mellitus, Experimental		37 genes: ACOT1 \| ATF3 \| ATP2A2 \| ATP2A3 \| BAX \| BCL2 \| CASP3 \| CAT \| CAV1 \| CD68 \| CYP1A1 \| FGF21 \| GSR \| HMOX1 \| IAPP \| ICAM1 \| IFNG \| IGF1 \| IL1B \| IL6 \| MMP2 \| MMP9 \| NQO1 \| PCK1 \| PFKM \| PPARA \| PPARG \| PTGS2 \| RELA \| REN \| SNAP25 \| SOD1 \| TGFB1 \| TIMP1 \| TNF \| TP53 \| YWHAH	58.20	34
48.	tetrabromobisphenol A	Reperfusion Injury		31 genes: ABCB1A \| BCL2 \| CASP3 \| CAT \| CDKN1A \| CXCL1 \| CXCL8 \| EGF \| EGR1 \| GPT \| HBEGF \| HMOX1 \| ICAM1 \| IL10 \| IL1B \| IL6 \| MAPK8 \| MAPK9 \| MMP9 \| PPARA \| PPARG \| PTGS2 \| RELA \| SLPI \| SOD1 \| SULT1E1 \| THY1 \| TLR2 \| TLR4 \| TNF \| VEGFD	45.12	43
49.	tetrabromobisphenol A	Arthritis, Rheumatoid		32 genes: ABCB1 \| ABCC3 \| ABCC4 \| ABCG2 \| AHR \| B3GNT2 \| BDKRB2 \| BMP4 \| CAT \| CXCL8 \| CXCR4 \| GPRC5A \| IFNG \| IGFBP3 \| IL10 \| IL18 \| IL1B \| IL1RN \| IL6 \| IRAK1 \| IRF5 \| MMP2 \| NCF2 \| PLEK \| PTGS2 \| RUNX2 \| STAT1 \| TLR2 \| TMPO \| TNF \| TRAF1 \| TXNIP	40.86	21
50.	tetrabromobisphenol A	Stomach Neoplasms		39 genes: AHR \| AREG \| BIRC5 \| CAV1 \| CCND1 \| CDK4 \| CDKN1A \| CST7 \| CXCL8 \| EGFR \| ERBB2 \| ERCC1 \| FAT4 \| GADD45A \| GREM1 \| GSTP1 \| HBEGF \| HMOX1 \| HSPD1 \| IGFBP3 \| IL1B \| IL1RN \| IL6 \| IRF1 \| MAPK1 \| MAPK3 \| MAPK8 \| MMP7 \| MUC1 \| MYC \| PGAM1 \| PLAGL1 \| PLPP1 \| PPARG \| PTGS2 \| RARRES1 \| RBP4 \| TNF \| TP53	40.25	37

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