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Chemical N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride

These diseases are associated with N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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1–50 of 143 results.
  Disease Direct Evidence Enrichment Analysis Inference Network Inference Score References
1. Precancerous Conditions M
2 genes: MDM2 | MGMT 		4.61 3
2. Liver Neoplasms M   1 gene: NFE2L2 2.54 2
3. Liver Cirrhosis, Experimental  
17 genes: AEN | CASP12 | CCNG1 | CDKN1A | CDKN3 | CYP1A2 | FABP2 | GSTA3 | HSD17B2 | MGMT | MKI67 | NFE2L2 | NRG1 | PTRH1 | RT1-CE5 | SLC20A1 | TUBB6 		35.73 3
4. Polycystic Ovary Syndrome  
5 genes: BAX | CCNB1 | NRG1 | RACGAP1 | RRM2 		13.57 2
5. Prostatic Neoplasms  
8 genes: AURKA | BAX | CDKN1A | CRYL1 | CYP1A1 | EPHX1 | MDM2 | NFE2L2 		13.57 12
Has associated exposure references.
6. Micronuclei, Chromosome-Defective  
5 genes: CYP1A1 | EPHX1 | MGMT | NFE2L2 | RAD51 		13.24 5
7. Breast Neoplasms  
7 genes: AURKA | BAX | CYP1A1 | MDM2 | MKI67 | NRG1 | RAD51 		10.08 9
8. Pulmonary Disease, Chronic Obstructive  
3 genes: CYP1A1 | CYP1A2 | EPHX1 		9.24 3
9. Esophageal Squamous Cell Carcinoma  
3 genes: CDKN1A | MGMT | NFE2L2 		9.05 3
10. Mammary Neoplasms, Experimental  
4 genes: AURKA | EPHX1 | PIK3R1 | THRSP 		8.40 4
11. Infertility, Male  
3 genes: BAX | CYP1A1 | MDM2 		7.84 3
12. Colorectal Neoplasms  
4 genes: AURKA | CYP1A2 | MKI67 | RRM2 		7.82 4
13. HIV Infections  
3 genes: BAX | CDKN1A | MDM2 		7.36 1
14. Mammary Neoplasms, Animal  
3 genes: EPHX1 | PIK3R1 | THRSP 		7.19 3
15. Severe Combined Immunodeficiency with Microcephaly, Growth Retardation, and Sensitivity to Ionizing Radiation     1 gene: NHEJ1 6.97 1
16. Carcinoma, Hepatocellular  
4 genes: CYP1A1 | EPHX1 | NFE2L2 | RRM2 		6.66 4
17. Lung Neoplasms  
4 genes: CCNG1 | CDKN1A | CYP1A2 | EPHX1 		6.47 6
18. Intestinal Neoplasms  
2 genes: BAX | CDKN1A 		6.40 3
19. Carcinoma  
3 genes: EPHX1 | PIK3R1 | THRSP 		6.20 3
20. Advanced Sleep-Phase Syndrome, Familial     1 gene: PER2 6.10 1
21. Endometrial Neoplasms  
2 genes: HSD17B2 | NFE2L2 		5.86 2
22. Colonic Neoplasms  
3 genes: BAX | CDKN1A | MKI67 		5.77 3
23. Acute Lung Injury  
2 genes: EPHX1 | NFE2L2 		5.71 2
24. Amphetamine-Related Disorders  
2 genes: EPHX1 | NRG1 		5.57 2
25. Mesothelioma, Malignant  
2 genes: CDKN1A | EPHX1 		5.55 2
Has associated exposure references.
26. Non-alcoholic Fatty Liver Disease  
2 genes: CYP1A2 | NFE2L2 		5.52 2
27. Hepatomegaly  
3 genes: AKR7A3 | CYP1A1 | CYP1A2 		5.49 2
28. Aortic Valve, Calcification of     1 gene: SLC20A1 5.45 1
29. Cholestasis  
3 genes: CYP1A2 | CYP7A1 | NFE2L2 		5.43 4
30. Endometriosis  
2 genes: HSD17B2 | SLC20A1 		5.40 3
31. Precursor Cell Lymphoblastic Leukemia-Lymphoma  
2 genes: CYP1A2 | EPHX1 		5.32 2
Has associated exposure references.
32. Kidney Neoplasms  
2 genes: AURKA | CYP1A1 		5.28 2
33. Hypercholanemia, Familial     1 gene: EPHX1 5.17 1
34. Dermatitis, Contact  
2 genes: CYP1A1 | NRG1 		5.07 1
35. Myocardial Reperfusion Injury  
2 genes: BAX | CASP12 		5.07 2
36. Chondrosarcoma, Mesenchymal     1 gene: MKI67 4.99 1
37. Lung Injury  
2 genes: CYP1A1 | CYP1A2 		4.99 2
38. Alcoholic Intoxication     1 gene: PER2 4.96 1
39. Carcinoma, Non-Small-Cell Lung  
2 genes: MDM2 | NFE2L2 		4.88 4
40. Diabetes Mellitus, Type 2  
2 genes: CYP1A2 | MOK 		4.82 2
41. Hirschsprung Disease     1 gene: NRG1 4.78 1
42. Enterocolitis, Necrotizing     1 gene: CRYL1 4.72 1
43. Skin Neoplasms  
2 genes: EPHX1 | NFE2L2 		4.71 2
44. Cholangitis     1 gene: CAR2 4.63 1
45. Copper-Overload Cirrhosis     1 gene: MKI67 4.55 1
46. Carcinoma, Squamous Cell  
2 genes: CYP1A2 | NFE2L2 		4.53 2
47. Chromosomal Instability     1 gene: AURKA 4.53 1
48. Peripheral Nervous System Diseases  
2 genes: AURKA | MKI67 		4.53 1
49. Cell Transformation, Neoplastic  
2 genes: MDM2 | NRG1 		4.52 2
50. Hyperoxia     1 gene: CYP1A1 4.36 1
1–50 of 143 results.
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