Bicyclo Compounds - Diseases

These diseases are associated with Bicyclo Compounds or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

Disease categories [Show chart]

1–50 of 15,906 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Cocaine	Schizophrenia	M	48 genes: AKT1 \| APOL2 \| BDNF \| CAMK2B \| CASP4 \| CCL2 \| CNR1 \| COL3A1 \| CPLX1 \| DRD1 \| DRD2 \| DRD3 \| DRD4 \| FGFR1 \| GABRB2 \| GAD1 \| GAD2 \| GRIK2 \| GRIK5 \| GRIN2B \| GRIN2D \| GRM2 \| GRM3 \| GSK3A \| GSK3B \| HTR2A \| HTR6 \| IL1B \| IL2RA \| IL6 \| MAOB \| MET \| MIR137 \| ND4 \| NDUFV2 \| NOS1 \| NR3C1 \| OXTR \| PLCB1 \| PVALB \| RGS9 \| SBNO1 \| SLC6A3 \| SLC6A4 \| SYN2 \| SYP \| TAC1 \| TNF	51.81	44
2.	Cocaine	Myocardial Ischemia	M	49 genes: ADRB1 \| AGT \| AK1 \| ARNTL \| ATP1A1 \| BHLHE40 \| CALR \| CCL2 \| CCL3 \| CCND1 \| CRP \| CX3CL1 \| CXCL10 \| DUSP1 \| EDN1 \| EGR2 \| EIF2AK3 \| FEV \| FGF2 \| GSTP1 \| GYG1 \| HSPA1A \| HSPA9 \| ICAM1 \| IL1A \| IL1B \| IL6 \| JUNB \| KCNJ8 \| KLF4 \| MAPK14 \| NFKBIA \| NOS3 \| NPPA \| NR4A1 \| PEBP1 \| POMC \| PPP2CA \| PRKCE \| PTPRA \| RAB12 \| RYR2 \| SELP \| TFRC \| TMPO \| TNF \| UGCG \| VCAM1 \| VEGFA	41.10	55
3.	beta-Lactams	Hypersensitivity, Immediate	M	5 genes: IL10 \| IL13 \| IL4 \| IL4RA \| MS4A2	33.97	3
4.	Cocaine	Brain Ischemia	M	30 genes: ACE \| BDNF \| CASP3 \| CASP9 \| CAT \| CCL2 \| CCL3 \| CXCL10 \| CYCS \| DYNLL1 \| EGR1 \| HIF1A \| ICAM1 \| IL1A \| IL1B \| IL6 \| JUN \| MAP2K1 \| MAPK1 \| MAPK3 \| MMP9 \| MPO \| NFKB1 \| NFKBIA \| PARP1 \| RELA \| SOD1 \| TNF \| TNFRSF1A \| TNFRSF1B	31.16	26
5.	Cocaine	Reperfusion Injury	M	32 genes: AGT \| BCL2 \| CASP3 \| CASP8 \| CAT \| CCL2 \| CCL3 \| CXCL8 \| CYBB \| EDN1 \| EFNA5 \| EFNB2 \| EGR1 \| FGF2 \| FOS \| GJB1 \| HSPA1A \| ICAM1 \| IL10 \| IL1A \| IL1B \| IL6 \| JUN \| MAPK8 \| MMP9 \| MPO \| NOS3 \| PTEN \| RELA \| SOD1 \| TNF \| XDH	29.99	38
6.	Cocaine	Status Epilepticus	M	30 genes: BDNF \| CASP3 \| CASP8 \| CAT \| CCL2 \| CCL3 \| CCR2 \| CNR1 \| CRH \| EIF2AK3 \| EIF2S1 \| FOS \| GAP43 \| GDNF \| GRIA2 \| GRM1 \| GRM5 \| JUN \| JUNB \| JUND \| LAMP2 \| NGF \| NOS1 \| NTRK2 \| PTK2B \| SRC \| SSTR1 \| SSTR2 \| TNF \| VEGFA	23.61	44
7.	Cocaine	Myocardial Reperfusion Injury	M	24 genes: ADRB1 \| AGT \| BAX \| CASP3 \| CASP8 \| CASP9 \| CAT \| CCL2 \| CYBB \| EDN1 \| HIF1A \| ICAM1 \| MIR137 \| MIR186 \| MIR301B \| MIR337 \| MIR369 \| MIR376A \| MIR500 \| NOS3 \| PTEN \| SELP \| TFRC \| VEGFA	22.32	15
8.	Scopolamine Hydrobromide	Amnesia	M	11 genes: APP \| AVP \| CSF2 \| HRH3 \| IL1A \| IL6 \| NGF \| PDYN \| PREP \| SIGMAR1 \| TAC1	21.43	177
9.	beta-Lactams	Drug Hypersensitivity	M	5 genes: IL10 \| IL13 \| IL4 \| IL4RA \| MS4A2	20.81	5
10.	Atropine	Myocardial Ischemia	M	12 genes: EDN1 \| EGR2 \| ICAM1 \| IL1B \| IL6 \| JUNB \| MAPK14 \| NPPA \| POMC \| SOCS3 \| TNF \| VCAM1	20.02	11
11.	Cocaine	Heat Stroke	M	11 genes: FOS \| IL10 \| IL1A \| IL1B \| IL6 \| JUN \| NFKB1 \| NFKB2 \| REL \| RELA \| TNF	19.94	3
12.	Cocaine	Brain Injuries	M	25 genes: BDNF \| CCL2 \| CES1 \| CXCL10 \| FGF2 \| FOS \| GABRB3 \| GSK3B \| HSPA1A \| IL10 \| IL1A \| IL1B \| IL2 \| IL6 \| JUN \| MIR132 \| MMP9 \| MPO \| PARP1 \| PPP3CA \| S100B \| TNF \| TNFRSF14 \| TNFRSF1A \| VEGFA	18.77	21
13.	Cocaine	Cardiomyopathies	M	30 genes: ADORA2A \| AGT \| AKT1 \| ATF3 \| CAT \| COX1 \| CYP2C9 \| EDN1 \| FAS \| GRK2 \| HSPD1 \| IL1A \| IL1B \| IL4 \| IL6 \| ITGB1 \| MAPK1 \| MAPK11 \| MAPK14 \| MAPK3 \| NDUFS2 \| NDUFV2 \| PARP1 \| POMC \| PRKCE \| SGCB \| TNF \| TNNI3 \| TRP53 \| YWHAH	18.45	39
14.	Cocaine	Acute Coronary Syndrome	M	14 genes: CAPZB \| CKB \| CKM \| CRP \| GSN \| GSTP1 \| HSPD1 \| IL6 \| ITGB3 \| LDHB \| MMP9 \| PDIA3 \| TNF \| TNNI3	17.75	19
15.	Cocaine	Nerve Degeneration	M	34 genes: ADORA1 \| ADRA1B \| APP \| ATXN3 \| BAX \| BCL2 \| BDNF \| CASP3 \| CD4 \| CD44 \| CDH1 \| CDK5R1 \| CHRNB2 \| CNR1 \| CTNNB1 \| EIF2S1 \| FGF2 \| GRIN2D \| IFNG \| IGF2 \| KCNJ4 \| KCNJ6 \| MAPK1 \| MAPK3 \| NGF \| NOS1 \| SLC18A2 \| SLC1A2 \| SLC6A3 \| SNCA \| SOD1 \| TH \| TNF \| XDH	16.74	53
16.	Atropine	Substance Withdrawal Syndrome	M	11 genes: CHRM5 \| CHRNB2 \| CREB1 \| CRH \| FOS \| MAPK1 \| MAPK3 \| NOS2 \| OPRL1 \| PNOC \| POMC	16.20	16
17.	Cocaine	Substance Withdrawal Syndrome	M	34 genes: ADCY8 \| ADORA1 \| ADORA2A \| BDNF \| CCKBR \| CHRM5 \| CHRNA5 \| CHRNB2 \| CNR1 \| CREB1 \| CRH \| CRP \| DRD2 \| FOS \| GNAO1 \| GRIA1 \| GRIA2 \| GRIN2A \| HCRT \| HTR2C \| MAPK1 \| MAPK3 \| MMP9 \| NPTX2 \| NPY \| OPRD1 \| OPRK1 \| PER1 \| PER2 \| PER3 \| POMC \| PRL \| SLC6A4 \| TACR1	15.98	117
18.	Cocaine	Heart Failure	M	34 genes: ACE \| ADRB1 \| AGT \| APCS \| ATP1A3 \| CAT \| CIDEA \| CRP \| CTGF \| CYBB \| EDN1 \| GRK2 \| GSK3B \| HIF1A \| IFNG \| IL1B \| IL6 \| INS \| ITGB1 \| NOS3 \| NPPA \| NR3C2 \| PDPK1 \| PEBP1 \| POMC \| PRL \| RAC1 \| SOD1 \| TNF \| TNFRSF1A \| TRP53 \| VEGFA \| VWF \| XDH	15.72	55
19.	Scopolamine Hydrobromide	Learning Disorders	M	9 genes: ACHE \| APP \| BCL2 \| HTR1A \| IL1B \| IL1RN \| MAPT \| SIGMAR1 \| SYP	15.46	63
20.	Cocaine	Bipolar Disorder	M	23 genes: BDNF \| BHLHE40 \| CPLX1 \| DRD1 \| DRD5 \| GAD1 \| GAD2 \| GRIK2 \| GSK3A \| GSK3B \| HTR2A \| INS \| NDUFV2 \| NR3C1 \| NTRK2 \| POMC \| PVALB \| S100B \| SLC5A3 \| SLC6A4 \| TAC1 \| TACR1 \| TENM4	15.44	21
21.	Cocaine	Pancreatic Neoplasms	M	22 genes: ATM \| ATRX \| BCL2L1 \| CD44 \| CDH1 \| CFLAR \| CNR1 \| CNR2 \| CTNNB1 \| CXCL8 \| EGFR \| HIF1A \| KLF5 \| MMP9 \| NFKBIA \| NRP1 \| PTEN \| SSTR1 \| SSTR2 \| TNF \| TNFRSF10B \| TRP53	15.24	22
22.	Cocaine	Myocardial Infarction	M	34 genes: ACE \| ADORA1 \| AGT \| ATM \| BAX \| BCL2 \| BCL2L1 \| CASP3 \| CAT \| CKB \| CKM \| CREB1 \| CREM \| DAB2IP \| DDIT3 \| GCLM \| GSK3B \| HSPA5 \| ICAM1 \| IL10 \| IL1B \| IL6 \| ITGB3 \| MMP9 \| MYH7 \| NOS3 \| NPPA \| NR3C2 \| PRKCE \| S100B \| SOD1 \| TNF \| TNNI3 \| TRP53	14.15	168
23.	Cocaine	HIV Infections	M	19 genes: BAG3 \| BAX \| CCL2 \| CCL3 \| CLIC1 \| EIF3B \| HSP90AA1 \| HSP90AB1 \| HSPA9 \| HSPD1 \| IFNG \| IL10 \| IL2 \| IL2RA \| KPNB1 \| NUP88 \| PPIB \| PSME4 \| SIGMAR1	14.12	7
24.	epibatidine	Seizures	M	5 genes: CHRNA3 \| CHRNA4 \| CHRNA5 \| CHRNA7 \| CHRNB4	14.12	8
25.	Cocaine	Disease Models, Animal	M	22 genes: AKT1 \| APP \| BSCL2 \| CLDN11 \| FAS \| FOS \| GFAP \| GRIN1 \| IFNG \| IL1B \| KL \| MAPK1 \| MAPK3 \| MAPK8 \| MMP9 \| PIM1 \| PRKCG \| S100B \| SNCA \| SOD1 \| TNF \| TRP53	13.69	26
26.	Cocaine	Autoimmune Diseases	M	13 genes: COL1A1 \| CRYBB2 \| EGR1 \| FAS \| HSPA9 \| IFNG \| IL4 \| IL6 \| ITGB6 \| PECAM1 \| PF4 \| TGFB2 \| TNFRSF1A	13.40	13
27.	Atropine	Myocardial Infarction	M	10 genes: BAX \| CASP3 \| CREB1 \| ICAM1 \| IL1B \| IL6 \| NOS2 \| NPPA \| TGFB1 \| TNF	13.28	11
28.	Penicillin G	Drug-Induced Liver Injury	M	13 genes: ABCC2 \| CCL2 \| CCR2 \| DGAT2 \| FASN \| IFNG \| IL18 \| IL1A \| IL1B \| IL6 \| LBP \| SLC22A8 \| TNF	11.80	16
29.	Cocaine	Cardiomyopathy, Dilated	M	13 genes: ADRB1 \| ATM \| EGFR \| FAS \| ITGB1 \| MYH6 \| MYH7 \| NPPA \| NR3C2 \| RAC1 \| RAF1 \| TMPO \| TNNI3	11.59	26
30.	Crack Cocaine	Brain Ischemia	M	6 genes: ACE \| HIF1A \| IL6 \| MAP2K1 \| MAPK3 \| SOD1	10.81	10
31.	Cocaine	Substance-Related Disorders	M	20 genes: CHRNA5 \| CNR1 \| DNAH8 \| DRD2 \| GRIA4 \| GRIK2 \| GRM5 \| GRM7 \| NME7 \| NPY \| OPRD1 \| OPRM1 \| PARVA \| PBX1 \| PRKCE \| SLC6A4 \| SLK \| SYNE1 \| TENM2 \| TIAM2	10.72	21
32.	Ampicillin	Colitis	M	5 genes: IL1B \| MPO \| NOS2 \| PTGS2 \| TNF	10.65	6
33.	Penicillin G	Dermatitis, Allergic Contact	M	6 genes: CCR2 \| CD36 \| IFNG \| IL18 \| IL1A \| TNF	10.26	7
34.	Dicloxacillin	Drug-Induced Liver Injury	M	6 genes: CXCL1 \| GPT \| HMGB1 \| IL1B \| IL4 \| NR1I2	9.84	14
35.	Cocaine	Developmental Disabilities	M	9 genes: AS3MT \| CHRNA4 \| DRD2 \| KCNT1 \| MECP2 \| NTRK2 \| PTEN \| SHANK3 \| SLC4A4	9.79	18
36.	Cocaine	Kidney Failure, Chronic	M	14 genes: ACE \| CAT \| CCL2 \| CRP \| CYBA \| CYBB \| IL6 \| MYH9 \| NCF1 \| NFKB1 \| NGF \| RELA \| SCARB1 \| TNF	9.72	12
37.	Scopolamine Hydrobromide	Disease Models, Animal	M	6 genes: APP \| FOS \| IFNG \| IL1B \| MAPT \| TNF	9.54	8
38.	Cocaine	Vomiting	M	2 genes: IFNG \| TACR1	9.25	8
39.	RTI 55	Cocaine-Related Disorders	M	2 genes: SLC6A3 \| SLC6A4	9.19	5
40.	Cocaine	Asthma	M	19 genes: ADCY2 \| ALDH2 \| BCL2 \| CAT \| CCL2 \| EDN1 \| GSTP1 \| ICAM1 \| IL1B \| IL4 \| KIF3A \| MMP9 \| NPY \| PARP1 \| PPP2CA \| PTEN \| SOD1 \| TNF \| VEGFA	8.79	31
41.	Cocaine	Hypertension	M	49 genes: ACE \| ADRB1 \| AGT \| ATP1A1 \| BCL2 \| CAT \| CCL2 \| COL1A1 \| COL3A1 \| CRP \| CTGF \| CYBA \| CYBB \| CYP1A1 \| DRD2 \| EDN1 \| EDNRA \| FOS \| GAL \| GRK2 \| GSK3B \| GUCY1A3 \| HIF1A \| ICAM1 \| IKBKB \| IL1B \| IL6 \| INS \| JUN \| MDH1 \| MMP9 \| NCF1 \| NEDD4L \| NOS3 \| NPPA \| NR3C1 \| POMC \| PPBP \| PTEN \| RELA \| RGS2 \| SELP \| SLC6A2 \| SOD1 \| TACR1 \| TH \| TNF \| VCAM1 \| VWF	8.76	245
42.	Cocaine	Cardiomegaly	M	19 genes: ADRA1B \| AGT \| AKT1 \| CYP1A1 \| EDN1 \| FGF2 \| GLRX3 \| GRK2 \| GSK3B \| HIF1A \| IL1B \| NOS3 \| NPPA \| PLD2 \| POMC \| PRKCA \| PRKCB \| SRC \| TNF	8.65	50
43.	Penicillin G	Fever	M	6 genes: CXCL8 \| IFNG \| IL1A \| IL1B \| IL6 \| TNF	8.64	11
44.	Penicillin G	Status Epilepticus	M	5 genes: ABCC2 \| CCL2 \| CCR2 \| JUN \| TNF	8.57	8
45.	Cocaine	Pregnancy Complications, Cardiovascular	M	4 genes: FAS \| IL6 \| PRL \| TNF	8.41	4
46.	Cocaine	Atherosclerosis	M	17 genes: AGT \| CCL2 \| CCL3 \| CNR2 \| CRP \| CYBA \| HSPA1B \| ICAM1 \| IFNG \| IGF2 \| IL6 \| NOS3 \| PARP1 \| SOD1 \| TNF \| VCAM1 \| VEGFA	8.31	21
47.	Cocaine	Neurodevelopmental Disorders	M	9 genes: CTNNB1 \| DLG4 \| GRIN2B \| ITPR1 \| KMT2E \| MECP2 \| PTEN \| STXBP1 \| TCF4	8.15	2
48.	Ceftriaxone	Brain Ischemia	M	4 genes: ALB \| CAT \| IL1B \| TNF	7.82	7
49.	Scopolamine Hydrobromide	Cognition Disorders	M	6 genes: AGT \| APP \| EIF2S1 \| MAPT \| PTGS2 \| VIP	7.82	33
50.	Cocaine	Nausea	M	4 genes: IFNG \| OPRM1 \| POMC \| TNF	7.74	8

1–50 of 15,906 results.

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