| Interacting Gene | Interactions | Organisms | |
|---|---|---|---|
| 1. | FOS | 191 | 4 |
| 2. | SLC6A3 | 69 | 6 |
| 3. | MAPK1 | 52 | 3 |
| 4. | MAPK3 | 52 | 3 |
| 5. | CHRM1 | 47 | 3 |
| 6. | CHRNB2 | 45 | 4 |
| 7. | CHRNA4 | 44 | 4 |
| 8. | BDNF | 43 | 3 |
| 9. | TNF | 43 | 3 |
| 10. | ACHE | 41 | 5 |
| 11. | CHRM2 | 41 | 4 |
| 12. | GRIA1 | 38 | 3 |
| 13. | PDYN | 37 | 5 |
| 14. | DRD1 | 35 | 5 |
| 15. | FOSB | 34 | 3 |
| 16. | GABRG2 | 32 | 1 |
| 17. | CASP3 | 31 | 3 |
| 18. | CHRNA7 | 31 | 3 |
| 19. | RDL | 31 | 2 |
| 20. | DRD3 | 30 | 4 |
| 21. | BCHE | 28 | 4 |
| 22. | CHRM3 | 28 | 3 |
| 23. | GABRA1 | 28 | 2 |
| 24. | GABRB2 | 28 | 1 |
| 25. | IL1B | 27 | 3 |
| 26. | BAX | 25 | 3 |
| 27. | DRD2 | 25 | 3 |
| 28. | AGO2 | 23 | 2 |
| 29. | CHRM4 | 23 | 4 |
| 30. | SIGMAR1 | 23 | 2 |
| 31. | SLC22A8 | 23 | 2 |
| 32. | CHRM5 | 22 | 3 |
| 33. | RELA | 22 | 3 |
| 34. | EGR1 | 21 | 3 |
| 35. | PPP1R1B | 21 | 2 |
| 36. | CES1 | 20 | 1 |
| 37. | GABRB3 | 20 | 2 |
| 38. | CHRNA3 | 19 | 4 |
| 39. | CREB1 | 19 | 2 |
| 40. | GRIN1 | 19 | 4 |
| 41. | CHRNB4 | 18 | 3 |
| 42. | HDAC5 | 17 | 1 |
| 43. | NOS2 | 17 | 3 |
| 44. | AR | 16 | 2 |
| 45. | CCL2 | 16 | 3 |
| 46. | CYP3A4 | 16 | 1 |
| 47. | NTRK2 | 16 | 3 |
| 48. | OPRM1 | 16 | 5 |
| 49. | TRPV1 | 16 | 2 |
| 50. | CASP9 | 15 | 3 |