Liver Cirrhosis - References

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	Reference	Cited Chemicals	Cited Genes	Cited Diseases
1.	Cui X, et al. Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice. Toxicol Lett. 2017 Jan 4;265:17-22.	Carbon Tetrachloride	ACTA2 \| COL1A1 \| RDH13 \| TGFB1 \| TIMP1	Drug-Induced Liver Injury \| Liver Cirrhosis, Experimental \| Necrosis
2.	Duval C, et al. Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model. Environ Health Perspect. 2017 Mar;125(3):428-436.	Dietary Fats \| Tetrachlorodibenzodioxin	ACACA \| CCL2 \| CD36 \| CD68 \| COL1A1 \| COL3A1 \| CPT1A \| DGAT1 \| DGAT2 \| FASN \| G6PC \| GYS2 \| IL1B \| ITGAM \| LEP \| MLXIPL \| MOGAT1 \| MTTP \| PCK1 \| PKLR \| PPARA \| PPARG \| SCD1 \| SLC2A2 \| SREBF1 \| TGFB1	Drug-Induced Liver Injury \| Hepatomegaly \| Liver Cirrhosis \| Non-alcoholic Fatty Liver Disease \| Obesity
3.	Eslam M, et al. IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis. Nat Genet. 2017 May;49(5):795-800.		IFNL3	Hepatic Fibrosis, Congenital \| Inflammation
4.	Ganai AA, et al. Genistein attenuates D-GalN induced liver fibrosis/chronic liver damage in rats by blocking the TGF-β/Smad signaling pathways. Chem Biol Interact. 2017 Jan 5;261:80-85.	Galactosamine \| Genistein	ACTA2 \| COL1A1 \| COL3A1 \| GPT \| SMAD2 \| SMAD3 \| SMAD7 \| TGFB1	Drug-Induced Liver Injury \| Liver Cirrhosis \| Liver Failure
5.	Joshi N, et al. Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis. Toxicology. 2017 Feb 15;377:73-80.	1-Naphthylisothiocyanate	ALPL \| COL1A1 \| ITGB6 \| RAG1 \| TGFB2	Drug-Induced Liver Injury \| Hyperplasia \| Liver Cirrhosis, Biliary
6.	Li WX, et al. Hesperitin derivative-11 suppress hepatic stellate cell activation and proliferation by targeting PTEN/AKT pathway. Toxicology. 2017 Apr 15;381:75-86.	bisperoxovanadium \| Carbon Tetrachloride \| hesperetin	ACTA2 \| CCND1 \| COL1A1 \| MYC \| PTEN \| TGFB1	Liver Cirrhosis, Experimental
7.	Nault R, et al. Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Chem Res Toxicol. 2017 Apr 17;30(4):1060-1075.	Tetrachlorodibenzodioxin	AADAC \| ABCG1 \| ABCG5 \| ABHD5 \| ACSL1 \| AGPAT1 \| AGPAT2 \| AGPAT4 \| AGPAT6 \| APOB \| APOBEC3 \| CAV1 \| CAV2 \| CD36 \| CDIPT \| CERS2 \| CERS4 \| CERS5 \| CERS6 \| CES1B \| CES1C \| CES1D \| CES1E \| CES1G \| CES2A \| CES2B \| CES2C \| CES2E \| CES2H \| CES3A \| CES3B \| CES4A \| CHKA \| CHPT1 \| CYP51 \| DEGS2 \| DGAT2 \| ELOVL2 \| ELOVL3 \| ELOVL5 \| ELOVL7 \| EPT1 \| ETNK1 \| FABP1 \| FABP12 \| FABP2 \| FABP4 \| FABP5 \| FADS1 \| FADS2 \| FADS3 \| FADS6 \| FDFT1 \| G0S2 \| GPAT3 \| GPIHBP1 \| HMGCR \| HMGCS2 \| IDI1 \| KDSR \| LCAT \| LDLR \| LIPA \| LIPC \| LIPE \| LIPG \| LMF1 \| LPIN2 \| LPIN3 \| LPL \| LRPAP1 \| MGLL \| MOGAT1 \| MOGAT2 \| MTTP \| NPC1L1 \| PCSK9 \| PCYT2 \| PEMT \| PGS1 \| PNPLA2 \| PTDSS1 \| SCARB1 \| SCD1 \| SCD2 \| SCD3 \| SERPINF1 \| SGMS2 \| SOAT1 \| SOAT2 \| SPTLC2 \| SQLE \| SREBF2 \| VLDLR	Fatty Liver \| Liver Cirrhosis
8.	Wahlang B, et al. A compromised liver alters polychlorinated biphenyl-mediated toxicity. Toxicology. 2017 Apr 1;380:11-22.	3,4,5,3',4'-pentachlorobiphenyl \| aroclor 1260 \| Choline \| Methionine	CCL2 \| CD36 \| CPT1A \| CYP1A2 \| CYP2B10 \| CYP3A11 \| FASN \| FGF21 \| FMO3 \| G6PC \| HMOX1 \| ICAM1 \| INS1 \| NPPA \| NQO1 \| PCK1 \| PECAM1 \| PPARA \| RETN \| SELP \| SERPINE1 \| THBD \| TIMP1 \| TNF	Fatty Liver \| Liver Cirrhosis \| Wasting Syndrome
9.	Wu Y, et al. Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis. Toxicol Appl Pharmacol. 2017 Jan 15;315:35-49.	Carbon Tetrachloride \| decitabine	ACTA2 \| COL1A1 \| DNMT3A \| SEPT9	Disease Models, Animal \| Hepatomegaly \| Liver Cirrhosis
10.	Wu YS, et al. Preventive effects of Ophiocordyceps sinensis mycelium on the liver fibrosis induced by thioacetamide. Environ Toxicol. 2017 Jun;32(6):1792-1800.	Thioacetamide	ACTA2 \| AKT1 \| CAT \| COL1A1 \| GPT \| IL1B \| NFKB1 \| PTGS2 \| RNF138 \| TGFB1 \| TGFBR1 \| TGFBR2 \| TNF	Hepatomegaly \| Liver Cirrhosis
11.	Chen PJ, et al. PTP1B confers liver fibrosis by regulating the activation of hepatic stellate cells. Toxicol Appl Pharmacol. 2016 Feb 1;292:8-18.	Carbon Tetrachloride \| Dexamethasone \| 1-Methyl-3-isobutylxanthine	ACTA2 \| COL1A1 \| INS \| PTPN1 \| TGFB1	Fatty Liver \| Liver Cirrhosis, Experimental \| Necrosis
12.	Dong S, et al. Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis. J Toxicol Sci. 2016;41(4):561-72.	Carbon Tetrachloride	GPT	Liver Cirrhosis
13.	Ganai AA, et al. Regression of fibrosis/cirrhosis by Glycine propionyl-l-carnitine treatment in d-Galactosamine induced chronic liver damage. Chem Biol Interact. 2016 Dec 25;260:117-128.	Galactosamine \| glycine propionyl carnitine	ACTA2 \| CAT \| IL6 \| TGFB1 \| TNF	Drug-Induced Liver Injury \| Liver Cirrhosis \| Weight Loss
14.	Getachew Y, et al. The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury. Toxicol Sci. 2016 Jan;149(1):111-20.	2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide \| Carbon Tetrachloride	ACTA2 \| COL1A1 \| CYP2E1 \| HMOX1 \| IL10 \| IL6 \| MMP10 \| MMP2 \| NFE2L2 \| SPP1 \| TGFB1 \| TGFBR3 \| TIMP1 \| TLR4 \| TNF	Ascites \| Carcinoma, Hepatocellular \| End Stage Liver Disease \| Liver Cirrhosis
15.	Ippolito DL, et al. Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. Toxicol Sci. 2016 Jan;149(1):67-88.	4,4'-diaminodiphenylmethane \| allyl alcohol \| Carbon Tetrachloride	A2M \| ARRB1 \| C1QB \| CD9 \| COL1A1 \| COL1A2 \| COL5A2 \| CP \| CTGF \| FBN1 \| IGFBP1 \| IGFBP2 \| LAMC2 \| LGALS1 \| LGALS3BP \| LOX \| LUM \| MMP2 \| PCOLCE \| PLAU \| PLOD2 \| SERPING1 \| VIM \| VTN	Bile Duct Diseases \| Hyperplasia \| Inflammation \| Liver Cirrhosis \| Liver Diseases \| Necrosis
16.	Jang CH, et al. The Role of Lipin-1 in the Regulation of Fibrogenesis and TGF-β Signaling in Hepatic Stellate Cells. Toxicol Sci. 2016 Sep;153(1):28-38.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde \| Carbon Tetrachloride \| resveratrol	ACTA2 \| COL1A1 \| LPIN1 \| SERPINE1 \| SMAD3 \| TGFB1	Liver Cirrhosis
17.	Kot M, et al. The impact of serotonergic system dysfunction on the regulation of P4501A isoforms during liver insufficiency and consequences for thyroid hormone homeostasis. Food Chem Toxicol. 2016 Nov;97:70-81.	Diethylnitrosamine	A2M \| AFP \| AHR \| CYP1A1 \| CYP1A2 \| CYP1B1 \| GPT \| HNF4A \| HTR2B \| MAPK1 \| MAPK3 \| THRA \| THRB \| TSHB \| UGT1A	Cholestasis \| Drug-Induced Liver Injury \| Liver Cirrhosis \| Non-alcoholic Fatty Liver Disease
18.	Lamb CL, et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) increases necroinflammation and hepatic stellate cell activation but does not exacerbate experimental liver fibrosis in mice. Toxicol Appl Pharmacol. 2016 Nov 15;311:42-51.	Carbon Tetrachloride \| Tetrachlorodibenzodioxin	ACTA2 \| COL1A1 \| DES \| DLK1 \| SERPINE1 \| TGFB1 \| TIMP1	Drug-Induced Liver Injury \| Hepatomegaly \| Inflammation \| Liver Cirrhosis, Experimental \| Necrosis
19.	Liu X, et al. Role of NLRC5 in progression and reversal of hepatic fibrosis. Toxicol Appl Pharmacol. 2016 Mar 1;294:43-53.	Carbon Tetrachloride \| Dexamethasone \| 1-Methyl-3-isobutylxanthine	ACTA2 \| COL1A1 \| INS \| NFKBIA \| NLRC5 \| RELA \| TGFB1	Liver Cirrhosis, Experimental
20.	Li X, et al. Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways. Toxicol Lett. 2016 Nov 2;261:1-12.	Carbon Tetrachloride \| Quercetin	ACTA2 \| COL1A1 \| HMGB1 \| NFKBIA \| RELA \| TGFB1 \| TLR2 \| TLR4	Drug-Induced Liver Injury \| Liver Cirrhosis, Experimental
21.	Li X, et al. Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis. Toxicol Appl Pharmacol. 2016 Sep 1;306:58-68.	Carbon Tetrachloride \| Dexamethasone \| 1-Methyl-3-isobutylxanthine \| trichostatin A	ACTA2 \| COL1A1 \| HDAC1 \| HDAC10 \| HDAC11 \| HDAC2 \| HDAC4 \| HDAC5 \| HDAC6 \| HDAC8 \| HDAC9 \| INS1 \| TGFB1	Disease Models, Animal \| Fatty Liver \| Liver Cirrhosis
22.	Lu C, et al. Nrf2 knockdown attenuates the ameliorative effects of ligustrazine on hepatic fibrosis by targeting hepatic stellate cell transdifferentiation. Toxicology. 2016 Jul 15;365:35-47.	Carbon Tetrachloride \| IWR-1 compound \| tetramethylpyrazine	ACTA2 \| COL1A1 \| COL3A1 \| CTNNB1 \| EGFR \| FN1 \| GCLC \| GCLM \| IFNG \| IL6 \| NFE2L2 \| NFKBIA \| NLRP3 \| PDGFRB \| TGFBR1 \| TNF	Liver Cirrhosis
23.	Miura K, et al. Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-Related Hepatocellular Carcinoma in Mice. J Biol Chem. 2016 Mar 28.	Acetylcysteine \| Anti-Bacterial Agents \| Clodronic Acid \| Hydrogen Peroxide \| Lipopolysaccharides	CD68 \| COL1A1 \| GPT \| IL6 \| PTEN \| TGFB1 \| TIMP1 \| TLR4 \| TNF	Adenoma, Liver Cell \| Carcinoma, Hepatocellular \| Cholangiocarcinoma \| Fatty Liver \| Liver Cirrhosis
24.	Nault R, et al. Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis. Toxicol Sci. 2016 Dec;154(2):253-266.	Tetrachlorodibenzodioxin	ADAMTS14 \| AGXT \| CCL2 \| CCL3 \| CCL4 \| CD36 \| CDH1 \| CDH2 \| COL4A3 \| COL4A4 \| COL9A2 \| CXCL16 \| CYP1A1 \| CYP1B1 \| FGF21 \| FN1 \| GCK \| GFPT1 \| GFPT2 \| GLS \| GOT1 \| GOT2 \| GPNMB \| GRHPR \| GULO \| GYS2 \| HAO1 \| HK2 \| HK3 \| HMGA2 \| HOGA1 \| IFNG \| IL10 \| IL1A \| IL1B \| IL2 \| IL4 \| IL6 \| LOX \| LOXL1 \| LOXL2 \| LOXL3 \| LOXL4 \| LRP1 \| OVOL1 \| P4HA2 \| PCK1 \| PEPD \| PGM \| PKM \| PKP1 \| PLAT \| PLAU \| PRODH \| PRODH2 \| PYCR2 \| PYGL \| RGN \| SDC1 \| SDC2 \| SELL \| SELP \| SERPINE1 \| SERPINH1 \| SLC1A5 \| SLC26A1 \| SLC2A2 \| TGFB2 \| TGM1 \| TGM2 \| TGM3 \| TNC \| TNF \| UAP1L1 \| UGDH \| UGT1A6A \| VCAN \| VIM \| ZEB1 \| ZEB2	Liver Cirrhosis
25.	Singh N, et al. Hepatoprotective effects of sesamol loaded solid lipid nanoparticles in carbon tetrachloride induced sub-chronic hepatotoxicity in rats. Environ Toxicol. 2016 May;31(5):520-32.	Carbon Tetrachloride \| Lipids \| sesamol \| Silymarin	TNF	Drug-Induced Liver Injury \| Fatty Liver \| Inflammation \| Liver Cirrhosis, Experimental
26.	Tabet E, et al. Chlordecone potentiates hepatic fibrosis in chronic liver injury induced by carbon tetrachloride in mice. Toxicol Lett. 2016 Jul 25;255:1-10.	Carbon Tetrachloride \| Chlordecone	ACTA2 \| COL1A2 \| GPT \| MMP2 \| TIMP1	Hepatomegaly \| Liver Cirrhosis
27.	Wu YL, et al. Cucurbitacin E ameliorates hepatic fibrosis in vivo and in vitro through activation of AMPK and blocking mTOR-dependent signaling pathway. Toxicol Lett. 2016 Sep 6;258:147-58.	AICA ribonucleotide \| cucurbitacin E \| Curcumin \| Metformin \| Thioacetamide	ACTA2 \| BAX \| BCL2 \| CASP3 \| COL1A1 \| MAPK1 \| MAPK3 \| MTOR \| PARP1 \| RPS6KB1 \| TIMP1	Drug-Induced Liver Injury \| Liver Cirrhosis, Experimental
28.	Yang JH, et al. Isorhamnetin attenuates liver fibrosis by inhibiting TGF-β/Smad signaling and relieving oxidative stress. Eur J Pharmacol. 2016 Jul 15;783:92-102.	3-methylquercetin \| Carbon Tetrachloride	ACTA2 \| COL1A1 \| GPT \| HMOX1 \| NFE2L2 \| SERPINE1 \| SMAD2 \| SMAD3 \| TGFB1	Drug-Induced Liver Injury \| Liver Cirrhosis
29.	Yang JJ, et al. MeCP2 silencing of LncRNA H19 controls hepatic stellate cell proliferation by targeting IGF1R. Toxicology. 2016 Jun 1;359-360:39-46.	Carbon Tetrachloride \| decitabine	ACTA2 \| COL1A1 \| H19 \| IGF1R \| MECP2 \| TGFB1	Liver Cirrhosis, Experimental
30.	Zhang Y, et al. Calcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis. Toxicol Appl Pharmacol. 2016 Jun 15;301:50-60.	Deferoxamine \| Diltiazem \| ferrous sulfate \| Iron-Dextran Complex \| Nimodipine \| Verapamil	CACNA1C \| COL1A1 \| FTH1 \| HAMP \| MMP13 \| SLC11A2 \| TFR2 \| TIMP1	Drug-Induced Liver Injury \| Liver Cirrhosis
31.	Balta C, et al. Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway. Chem Biol Interact. 2015 Oct 5;240:94-101.	Carbon Tetrachloride \| chrysin \| Silymarin	ACTA2 \| SMAD2 \| SMAD3 \| TGFB1	Liver Cirrhosis
32.	Buch S, et al. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat Genet. 2015 Dec;47(12):1443-8.		MBOAT7 \| PNPLA3 \| TM6SF2	Liver Cirrhosis, Alcoholic
33.	Chatterjee N, et al. Leishmanial lipid affords protection against oxidative stress induced hepatic injury by regulating inflammatory mediators and confining apoptosis progress. Toxicol Lett. 2015 Jan 22;232(2):499-512.	Carbon Tetrachloride \| Lipids	BAD \| BAX \| BCL2 \| CASP3 \| CASP9 \| CAT \| CXCL1 \| CYP2E1 \| EDN1 \| EGF \| GSR \| HGF \| IL10 \| IL1B \| IL6 \| NOS2 \| PCNA \| PTGS2 \| RELA \| TNF \| TRP53	Drug-Induced Liver Injury \| Inflammation \| Liver Cirrhosis, Experimental
34.	Elbe H, et al. Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic rats. Hum Exp Toxicol. 2015 Sep;34(9):859-68.	Melatonin \| Quercetin \| resveratrol \| Streptozocin	CAT	Diabetes Mellitus, Experimental \| Drug-Induced Liver Injury \| Hyperglycemia \| Liver Cirrhosis
35.	Guo SB, et al. Octreotide attenuates liver fibrosis by inhibiting hepatic heme oxygenase-1 expression. Mol Med Rep. 2015 Jan;11(1):83-90.	cobaltiprotoporphyrin \| Octreotide	GPT \| HMOX1	Liver Cirrhosis
36.	Harris TR, et al. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol. 2015 Jul 15;286(2):102-11.	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea \| Carbon Tetrachloride	ACTA2 \| ATF4 \| ATF6 \| BCL2 \| CASP3 \| CCL12 \| CCL2 \| CCL3 \| COL1A2 \| COL3A1 \| CXCR4 \| DCN \| DDIT3 \| EDN1 \| EGF \| EIF2AK3 \| EIF2S1 \| ERN1 \| GREM1 \| HGF \| HSPA5 \| IFNG \| IL13 \| IL13RA2 \| IL1B \| IL4 \| IL5 \| INHBE \| ITGA2 \| ITGB5 \| ITGB6 \| ITGB8 \| JUN \| LOX \| LTBP1 \| MMP13 \| MMP14 \| MMP1A \| MMP2 \| MMP3 \| MMP8 \| MMP9 \| MYC \| PDGFA \| PLAT \| PLAU \| SERPINE1 \| SERPINH1 \| SMAD3 \| SMAD6 \| SMAD7 \| SNAI1 \| TGFB1 \| TGFB2 \| TGFB3 \| TGFBR2 \| THBS1 \| THBS2 \| TIMP1 \| TIMP2 \| TIMP3 \| TNF \| XBP1	Drug-Induced Liver Injury \| Liver Cirrhosis, Experimental
37.	Heebøll S, et al. Effect of resveratrol on experimental non-alcoholic steatohepatitis. Pharmacol Res. 2015;95-96:34-41.	Cholates \| Cholesterol, Dietary \| cocoa butter \| resveratrol	A2M \| COL1A1 \| PPARGC1A \| SREBF1 \| TGFB1 \| TNF \| TNFAIP3	Disease Models, Animal \| Hepatomegaly \| Hypercholesterolemia \| Liver Cirrhosis, Experimental \| Non-alcoholic Fatty Liver Disease
38.	Lee HI, et al. Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats. Toxicol Lett. 2015 Sep 17;237(3):210-8.	Alcohols \| Ethanol \| Scopoletin \| Silymarin	ACAA1A \| ACACA \| ACOX1 \| ACSL1 \| ADIPOQ \| ADIPOR2 \| CIDEA \| FASN \| GPT \| IL10 \| IL6 \| LIPE \| MYD88 \| PNPLA2 \| PPARA \| SREBF1 \| TICAM1 \| TLR4 \| TNF	Hepatomegaly \| Liver Cirrhosis, Experimental \| Weight Loss
39.	Shen K, et al. Epigallocatechin 3-gallate ameliorates bile duct ligation induced liver injury in mice by modulation of mitochondrial oxidative stress and inflammation. PLoS One. 2015;10(5):e0126278.	epigallocatechin gallate	ACTA2 \| CCL3 \| CTGF \| CXCL2 \| FN1 \| IL1B \| PARP1 \| SOD2 \| TNF	Liver Cirrhosis
40.	Tu X, et al. MicroRNA-30 Protects Against Carbon Tetrachloride-induced Liver Fibrosis by Attenuating Transforming Growth Factor Beta Signaling in Hepatic Stellate Cells. Toxicol Sci. 2015 Jul;146(1):157-69.	Carbon Tetrachloride	KLF11 \| MIR30A \| MIR30B \| MIR30C \| MIR30D \| MIR30E \| SMAD7	Liver Cirrhosis
41.	Vatakuti S, et al. Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices. Toxicol In Vitro. 2015 Aug;29(5):1012-20.	Acetaminophen \| Carbon Tetrachloride	ACOX1 \| AKT1 \| BRCA1 \| EDN1 \| EGF \| ERN1 \| FGF2 \| HNF1A \| HNF4A \| IL1A \| IL1B \| NUPR1 \| PKD1 \| PPARA \| PPARD \| PPARG \| RXRA \| STAT1 \| TFAM \| TGFA \| TGFB1 \| TNF \| TP53	Drug-Induced Liver Injury \| Liver Cirrhosis
42.	Wezynfeld NE, et al. Ni(ii) ions cleave and inactivate human alpha-1 antitrypsin hydrolytically, implicating nickel exposure as a contributing factor in pathologies related to antitrypsin deficiency. Metallomics. 2015 Apr;7(4):596-604.	Nickel	SERPINA1	Emphysema \| Liver Cirrhosis \| Pulmonary Disease, Chronic Obstructive
43.	Wu Y, et al. Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):163-76.	Carbon Tetrachloride \| Dexamethasone \| 1-Methyl-3-isobutylxanthine	ACTA2 \| COL1A1 \| INS \| MALAT1 \| SIRT1 \| TGFB1	Liver Cirrhosis, Experimental
44.	AbdulHameed MD, et al. Systems level analysis and identification of pathways and networks associated with liver fibrosis. PLoS One. 2014;9(11):e112193.	4,4'-diaminodiphenylmethane \| allyl alcohol \| Carbon Tetrachloride \| Carmustine \| Dimethylformamide \| Dimethylnitrosamine \| lipopolysaccharide, E coli O55-B5 \| 1-Naphthylisothiocyanate \| Vinblastine	A2M \| AADAC \| AADAT \| ABAT \| ABCA8A \| ABCC2 \| ABCC5 \| ABCG1 \| ABCG5 \| ABCG8 \| ABLIM3 \| ACAT1 \| ACBD4 \| ACKR3 \| ACOT9 \| ACOX2 \| ACP5 \| ACSL1 \| ACTN1 \| ADA \| ADAM17 \| ADD3 \| ADGRE1 \| ADH1 \| ADHFE1 \| ADORA3 \| ADRA1B \| AEN \| AFM \| AGFG1 \| AGL \| AGTR1A \| AHNAK \| AIDA \| AIF1 \| AKR1B1 \| AKR1C1 \| AKR1C19 \| AKR1C3 \| AKTIP \| ALDH1A7 \| ALDH1B1 \| ALDH1L2 \| AMACR \| ANGPTL3 \| ANO6 \| ANXA1 \| ANXA2 \| ANXA3 \| ANXA4 \| ANXA5 \| AP1S2 \| AP3S1 \| APAF1 \| APBB1IP \| APMAP \| APOA4 \| APOBEC1 \| APOL9A \| APON \| APP \| APPL1 \| AQP7 \| ARHGAP30 \| ARHGAP9 \| ARHGDIB \| ARL11 \| ARL8A \| ARMCX1 \| ARPC1B \| ARRB2 \| ASAH1 \| ASNS \| ASPN \| ATF3 \| ATP10D \| ATP6V1D \| ATRN \| AXL \| B4GALT5 \| B9D1 \| BBOX1 \| BCL2A1D \| BCR \| BDH1 \| BGN \| BICD2 \| BIRC3 \| BLOC1S2 \| BLVRA \| BMF \| C1QA \| C1QB \| C1QC \| C5AR1 \| C7 \| C8G \| CAMK2D \| CAPG \| CAR3 \| CAR5A \| CASP1 \| CASP12 \| CASP4 \| CASP7 \| CAV1 \| CCDC126 \| CCL5 \| CCL6 \| CCNA2 \| CCNB2 \| CCNG1 \| CD163 \| CD200R1 \| CD200R2 \| CD24 \| CD276 \| CD36 \| CD38 \| CD48 \| CD53 \| CD5L \| CD63 \| CD68 \| CD7 \| CD74 \| CD83 \| CD86 \| CDC42SE1 \| CDH5 \| CDK1 \| CDKN1A \| CDKN2AIPNL \| CDKN3 \| CEBPD \| CELA1 \| CELF2 \| CERK \| CFD \| CFP \| CHSY1 \| CIDEA \| CKLF \| CLEC4A \| CLEC4A1 \| CLEC4A3 \| CLEC4F \| CLIC1 \| CLIC2 \| CLP1 \| CMTM3 \| CNDP1 \| CNP \| CNPY4 \| COL12A1 \| COL1A1 \| COL1A2 \| COL3A1 \| COL4A1 \| COL4A2 \| COL5A1 \| COL5A2 \| COL6A1 \| COL6A2 \| COLEC12 \| COQ10A \| COTL1 \| CPQ \| CRIP \| CROT \| CRTAP \| CRY1 \| CRYAB \| CSF1R \| CSGALNACT1 \| CTGF \| CTLA2A \| CTSE \| CTSS \| CTSZ \| CTTNBP2NL \| CXADR \| CXCL1 \| CXCL10 \| CXCL12 \| CXCL13 \| CXCL16 \| CXCL9 \| CYBA \| CYBB \| CYP26A1 \| CYP2A2 \| CYP2C11 \| CYP2D4 \| CYP2T1 \| CYP3A9 \| CYSTM1 \| DAO \| DBNDD2 \| DCXR \| DDC \| DEPDC7 \| DHRS3 \| DHRS7 \| DHTKD1 \| DIO1 \| DOCK10 \| DOCK7 \| DPP7 \| DPYS \| DRAM1 \| DUS1L \| DUSP16 \| DUSP6 \| DYSF \| ECT2 \| EGF \| EIF4E3 \| ELOVL5 \| EMB \| EMP1 \| ENC1 \| ENPEP \| EPB41L2 \| EPCAM \| ERAP1 \| EXTL1 \| EZR \| F2R \| FABP2 \| FABP7 \| FAHD1 \| FAM102B \| FAM105A \| FAM115C \| FAM167B \| FAM198B \| FAM43A \| FAM49A \| FAM49B \| FAM89A \| FAT1 \| FBN1 \| FBXO9 \| FCER1G \| FCGR1A \| FCGR3A \| FCN1 \| FGL2 \| FGR \| FHL1 \| FHL2 \| FKBP1A \| FLI1 \| FLNA \| FMNL1 \| FMO1 \| FOLR2 \| FOS \| FOXA2 \| FRY \| FSTL1 \| FTCD \| FXYD2 \| FXYD5 \| FXYD6 \| FYN \| FZD8 \| G0S2 \| G6PC \| GALC \| GBP2 \| GBP4 \| GC \| GCAT \| GCHFR \| GCNT1 \| GFRA1 \| GGH \| GGTA1 \| GHR \| GJA1 \| GJA4 \| GK \| GLIPR1 \| GLS \| GLS2 \| GLT8D1 \| GMFG \| GNA14 \| GNAI2 \| GNGT2 \| GNPDA1 \| GPAM \| GPNMB \| GPR68 \| GPX8 \| GRN \| GSN \| GSTA3 \| GULP1 \| GZMA \| HAGH \| HAL \| HAO1 \| HAO2 \| HCK \| HELLS \| HEXIM1 \| HFE2 \| HIP1 \| HMGCR \| HMGN5B \| HMOX1 \| HOPX \| HOXA3 \| HPCAL1 \| HPGDS \| HSD17B2 \| HYKK \| ICAM2 \| ID4 \| IFI204 \| IFI27L2B \| IFI35 \| IFITM1 \| IFNGR1 \| IFRD1 \| IGF2BP3 \| IGF2R \| IGFALS \| IGFBP1 \| IGFBP2 \| IGFBP3 \| IGFBP7 \| IGSF6 \| IL18 \| IL18BP \| IL2RB \| IL2RG \| IL33 \| IL7R \| INHBC \| INHBE \| INMT \| INPP5D \| INPPL1 \| INSIG2 \| IQGAP1 \| IRF8 \| ISG20 \| ISYNA1 \| ITGA2B \| ITGAL \| ITGB1 \| ITGB2 \| ITGB3 \| IVD \| IYD \| JAK2 \| JDP2 \| KANK1 \| KCNJ8 \| KLF6 \| KMO \| KRT18 \| KRT19 \| KRT8 \| KTN1 \| KYNU \| L3HYPDH \| LAPTM5 \| LBH \| LBP \| LCN2 \| LCP1 \| LCP2 \| LDHB \| LGALS1 \| LGALS2 \| LGALS3 \| LGALSL \| LGMN \| LHFPL6 \| LIMK2 \| LIN7A \| LMO2 \| LOX \| LOXL2 \| LPL \| LPXN \| LRAT \| LRRC28 \| LRRFIP1 \| LTA4H \| LTB \| LTBP1 \| LUM \| LURAP1L \| LY86 \| LY96 \| MAGEE1 \| MAP1LC3A \| MAP3K8 \| MDH1 \| MEOX2 \| METRNL \| MFAP4 \| MGMT \| MGP \| MID1IP1 \| MINDY3 \| MIS12 \| MKI67 \| MMP15 \| MMP2 \| MOB3A \| MRO \| MSN \| MT1A \| MT2A \| MTMR7 \| MVP \| MYADM \| MYC \| MYL9 \| MYO1C \| MYO1F \| MYO5A \| MYOC \| NAGK \| NAP1L5 \| NAT8 \| NBEA \| NCKAP1L \| NCOR2 \| NDRG1 \| NDRG2 \| NECTIN2 \| NEK6 \| NFKBIE \| NFKBIZ \| NID1 \| NID2 \| NIPAL2 \| NMI \| NOCT \| NOX4 \| NPAS2 \| NPDC1 \| NQO2 \| NREP \| NRG1 \| NRROS \| NSMF \| NUDT16 \| NUPR1 \| OAT \| OLFML2B \| OLFML3 \| OLR59 \| OSGIN1 \| OTC \| OTUB2 \| PALMD \| PAMR1 \| PAQR9 \| PCK2 \| PDGFA \| PDGFRA \| PDZRN3 \| PEA15A \| PFKP \| PFN1 \| PKD2 \| PKLR \| PLA2G12A \| PLA2G4A \| PLAC8 \| PLAT \| PLAU \| PLD4 \| PLEK \| PLEKHB1 \| PLEKHH1 \| PLIN2 \| PLIN3 \| PLOD2 \| PLPP2 \| PLSCR1 \| PLSCR2 \| PLTP \| PMEPA1 \| PPAP2A \| PPP1R18 \| PPP1R3B \| PPP1R3C \| PQLC3 \| PRAF2 \| PRKCB \| PRKCD \| PRLR \| PRNP \| PROCR \| PRODH \| PRODH2 \| PRR13 \| PRTFDC1 \| PRTG \| PRUNE2 \| PSMB10 \| PSMB8 \| PSMB9 \| PSME2 \| PSTPIP1 \| PTAFR \| PTER \| PTGER2 \| PTGS1 \| PTN \| PTPN18 \| PTPRC \| PTPRD \| PTPRO \| PTRH1 \| PTRHD1 \| PXDN \| PYCARD \| PYCR1 \| R3HDM2 \| RAB30 \| RAB31 \| RAB32 \| RAB40B \| RAB8B \| RABGAP1L \| RAC2 \| RAMP1 \| RARRES1 \| RASSF4 \| RBL2 \| RBM3 \| RCN1 \| RCN2 \| RCSD1 \| RDH10 \| RECK \| REEP5 \| RELL1 \| RGD1305347 \| RGD1307603 \| RGD1309079 \| RGD1309104 \| RGD1309534 \| RGD1560248 \| RGD1561149 \| RGD1562339 \| RGD1563818 \| RGD1564865 \| RGD1566227 \| RGN \| RGS10 \| RGS2 \| RGS3 \| RGS5 \| RHOQ \| RIT1 \| RMDN2 \| RMND5B \| RNASEL \| RNF39 \| ROBO2 \| RSRP1 \| RT1-BA \| RT1-CE5 \| RT1-DA \| RT1-DB1 \| RT1-DMA \| RT1-DMB \| RT1-M3-1 \| RTN4 \| RTP3 \| S100A10 \| S100A11 \| S100A6 \| S100A9 \| S1PR1 \| SAMD11 \| SASH3 \| SCD2 \| SDR42E1 \| SDS \| SECTM1B \| SELENOM \| SELENOP \| SELENOW \| SEMA6D \| SERPINA3M \| SERPINA4 \| SERPINA6 \| SERPINA7 \| SERPINB9 \| SERPINH1 \| SEZ6 \| SGCB \| SGK2 \| SH3BGRL3 \| SHCBP1 \| SHISA3 \| SIGLEC5 \| SKAP2 \| SLA \| SLAMF9 \| SLC15A3 \| SLC17A1 \| SLC17A2 \| SLC19A2 \| SLC20A1 \| SLC22A23 \| SLC22A8 \| SLC23A1 \| SLC25A13 \| SLC25A24 \| SLC25A30 \| SLC25A4 \| SLC39A6 \| SLC39A8 \| SLC43A2 \| SLC44A2 \| SLC46A1 \| SLC4A4 \| SLC7A1 \| SLFN2 \| SMARCC1 \| SMC2 \| SMC5 \| SMOC1 \| SMOC2 \| SNAP23 \| SNAP29 \| SNX7 \| SOAT1 \| SOCS2 \| SOX4 \| SP140 \| SPARC \| SPNA2 \| SPSB4 \| SRD5A1 \| SREBF1 \| SRGN \| SRI \| SRR \| ST14 \| STAC3 \| STARD13 \| STAU2 \| STEAP4 \| STK10 \| SYNRG \| TAGLN2 \| TAP2 \| TAX1BP3 \| TBC1D9 \| TCF20 \| TCF4 \| TES \| TFEC \| TFPI2 \| TGFB3 \| THBD \| THYN1 \| TIAL1 \| TIMP1 \| TIMP2 \| TKFC \| TLR4 \| TM6SF1 \| TMBIM1 \| TMEM106A \| TMEM165 \| TMEM178 \| TMEM184B \| TMEM2 \| TMEM43 \| TMEM65 \| TMSB10 \| TNFAIP8 \| TNFRSF12A \| TOR4A \| TPM1 \| TPM3 \| TPM4 \| TRAFD1 \| TRAK2 \| TRIB3 \| TRIM24 \| TRIM59 \| TSC22D1 \| TSPAN8 \| TSPO \| TSTD3 \| TTC36 \| TUBB6 \| TUSC3 \| TYROBP \| U2SURP \| UBD \| UGCG \| UGT2B \| UNC5CL \| UNC93B1 \| UST5R \| VASP \| VAV1 \| VIM \| VIPR1 \| VOPP1 \| VSIR \| WFDC2 \| WFDC21 \| WIPF1 \| WLS \| WRB \| XPNPEP2 \| YPEL3 \| YWHAG \| YWHAZ \| ZBTB4 \| ZDHHC13 \| ZDHHC2 \| ZEB2 \| ZFP37 \| ZFYVE16	Liver Cirrhosis, Experimental
45.	Abhilash PA, et al. Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):215-24.	Ascorbic Acid \| Ethanol \| Silymarin	ACTA2 \| CD14 \| CLDN1 \| COL1A1 \| IKBKB \| IL6 \| LBP \| NFKBIA \| OCLN \| RELA \| TGFB1 \| TJP1 \| TLR4 \| TNF	Endotoxemia \| Liver Cirrhosis
46.	Ahmad A, et al. Resveratrol mitigate structural changes and hepatic stellate cell activation in N''-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage. Chem Biol Interact. 2014 Sep 25;221:1-12.	Dimethylnitrosamine \| resveratrol	ACTA2	Liver Cirrhosis
47.	Ali SO, et al. Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. Chem Biol Interact. 2014 Jun 5;216:26-33.	Curcumin \| silybin-phytosome \| Thioacetamide \| Thioctic Acid	ACTA2 \| ALB \| GGT1 \| GPT \| SERPINH1 \| TGFB1	Hepatomegaly \| Liver Cirrhosis, Experimental
48.	Bian EB, et al. Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats. Toxicol Lett. 2014 Jan 13;224(2):175-85.	Carbon Tetrachloride \| decitabine	ACTA2 \| COL1A1 \| DNMT1 \| SMAD2 \| SMAD3 \| SMAD7 \| TGFB1	Disease Models, Animal \| Liver Cirrhosis, Experimental
49.	Cao W, et al. iTRAQ-based proteomic analysis of combination therapy with taurine, epigallocatechin gallate, and genistein on carbon tetrachloride-induced liver fibrosis in rats. Toxicol Lett. 2014 Nov 13;232(1):233-245.	Carbon Tetrachloride \| epigallocatechin gallate \| Genistein \| Taurine	TGFB1	Liver Cirrhosis, Experimental
50.	Fang L, et al. TGF-β1-elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGF-β1/Smad pathway. Toxicol Appl Pharmacol. 2014 Oct 15;280(2):335-44.	2-aminoethoxydiphenyl borate \| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide \| 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride \| Carbon Tetrachloride	ACTA2 \| COL1A1 \| MMP2 \| SMAD2 \| SMAD3 \| SMAD4 \| TGFB1 \| TIMP1 \| TIMP2 \| TRPM7	Liver Cirrhosis

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