Acetaminophen - Diseases

These diseases are associated with Acetaminophen or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Acetaminophen	Nausea	M	4 genes: ABCB1 \| IFNG \| POMC \| TNF	72.35	8
2.	Acetaminophen	Autistic Disorder	M	141 genes: ABAT \| ACADSB \| ADA \| ADM \| ADNP \| ADRB2 \| ADSL \| AGAP1 \| APC \| AQP4 \| AR \| ASTN2 \| AVPR1A \| BCL2 \| BDNF \| C3ORF58 \| CACNA1C \| CADM1 \| CALCA \| CAT \| CHRNA4 \| CHRNB2 \| CNTN3 \| CNTN4 \| COMT \| CP \| CUL7 \| CYP19A1 \| DAO \| DHCR7 \| DHFR \| DIXDC1 \| DLX2 \| DPYD \| DRD1 \| EGF \| EGR2 \| EXT1 \| FARP2 \| GABBR1 \| GABRA4 \| GABRB1 \| GAD1 \| GHR \| GLO1 \| GPR155 \| GPX1 \| GRIK2 \| GSTM1 \| GSTP1 \| GZMB \| HRAS \| HTR1B \| HTR1D \| HTR2A \| IFNG \| IGF1 \| IGFBP3 \| IL10 \| IL13 \| IL15 \| IL1RAPL1 \| IL2 \| IL4 \| IL6 \| IMMP2L \| INPP1 \| ITGA4 \| ITGB3 \| JMJD1C \| LAMB1 \| LASP1 \| LEP \| MAOA \| MAOB \| MARK1 \| MBD3 \| MBD4 \| MCC \| MECP2 \| MET \| MIF \| MTHFR \| MYO1D \| NF1 \| NLGN1 \| NOS2 \| NRCAM \| NRXN1 \| NSD1 \| NTF3 \| NTRK2 \| OXT \| PASK \| PDE4A \| PDE4B \| PECAM1 \| PER1 \| PLAUR \| POMC \| PON1 \| PRKCB \| PRKN \| PRLR \| PTGS2 \| REEP3 \| RELN \| RFWD2 \| ROBO1 \| ROBO4 \| RORA \| SCT \| SERPINE1 \| SHANK1 \| SHANK2 \| SLC19A1 \| SLC1A3 \| SLC25A12 \| SLC40A1 \| SLC6A4 \| SLC6A8 \| SND1 \| SNTG2 \| ST8SIA2 \| STK39 \| STX1A \| STXBP6 \| TCN2 \| TDO2 \| TF \| TNFRSF1B \| TSC1 \| TSC2 \| UBE2H \| UBE3A \| UPB1 \| VLDLR \| VWA8 \| WNT2 \| XDH \| XPC	71.58	137
3.	Acetaminophen	Vomiting	M	3 genes: ABCB1 \| ASPG \| IFNG	64.92	4
4.	Acetaminophen	Headache	M	3 genes: CSF3 \| IL6 \| OXT	61.70	5
5.	Acetaminophen	Bradycardia	M	13 genes: ADORA1 \| AGT \| CYP1A1 \| EDN1 \| EDN2 \| EDN3 \| GNAI2 \| KNG1 \| LHB \| NTS \| POMC \| TAC1 \| UTS2	50.67	16
6.	Acetaminophen	Carcinoma, Renal Cell	M	84 genes: ACHE \| ACY1 \| AHNAK \| AKAP13 \| ALAD \| ALDH1A1 \| ANXA4 \| AP5M1 \| APAF1 \| BAP1 \| BIRC5 \| BTG3 \| CAPG \| CASP2 \| CNN2 \| CPQ \| CRADD \| CRYAB \| CTSB \| CTSD \| CUL7 \| DAPK1 \| DIRC2 \| EEF2 \| ELOC \| ERBB2 \| FLCN \| FLT1 \| GJB1 \| GRB7 \| GSTM1 \| GSTP1 \| GSTT1 \| HARS \| HNF1A \| HNF1B \| HSPA9 \| HSPB1 \| HSPD1 \| IL13 \| IL6 \| IL6R \| KEAP1 \| KRT8 \| LDHB \| LMAN2L \| M6PR \| MET \| MITF \| MLLT10 \| MSGN1 \| MTOR \| NDRG1 \| NF2 \| OGG1 \| PDHB \| PDXDC1 \| PEBP1 \| PGK1 \| PIDD1 \| PIK3CA \| PNKD \| POMC \| PRCC \| PTGS2 \| RELA \| RNF139 \| RPL14 \| RYR1 \| SCARB1 \| SETD2 \| SHANK1 \| SLC2A1 \| SLC5A3 \| SOD2 \| SPTBN4 \| SYNE2 \| TAGLN2 \| TGM2 \| TNFSF10 \| TP53 \| TSC1 \| UNC5C \| VHL	48.55	43
7.	Acetaminophen	Necrosis	M	46 genes: AGT \| AHR \| AIFM1 \| ARG2 \| ATF4 \| ATG5 \| ATG7 \| BCL2 \| CAST \| CAT \| CDC42 \| CTF1 \| CTSB \| CYP2B1 \| CYP2E1 \| DMD \| FAS \| FASL \| GAPDH \| GATM \| GSTP1 \| HAVCR1 \| HMGB1 \| IFNG \| IL1B \| IL6 \| KRT18 \| LGALS3 \| LPL \| MGMT \| MIR192 \| MTHFR \| MYCN \| NFE2L2 \| NOS2 \| POMC \| PRNP \| PUF60 \| RBP4 \| SLC31A1 \| SOD1 \| SOD2 \| SOD3 \| SPARC \| TBXA2R \| TNF	47.09	112
8.	Acetaminophen	Hepatomegaly	M	9 genes: ATG5 \| CYP1A2 \| LEPR \| NR1I2 \| NR1I3 \| PEPD \| PPARA \| SESN2 \| SLC29A3	27.18	16
9.	Acetaminophen	Exanthema	M	2 genes: C1QA \| MVK	26.12	3
10.	Acetaminophen	Tachycardia, Ventricular	M	5 genes: EPO \| KCNJ2 \| LMNA \| NOS3 \| RYR2	25.77	7
11.	Acetaminophen	Abnormalities, Drug-Induced	M	4 genes: CAT \| EPHX1 \| RHOA \| WNT11	25.03	5
12.	Acetaminophen	Pruritus	M	2 genes: ABCB11 \| TAC1	24.93	3
13.	Acetaminophen	Kidney Diseases	M	60 genes: ABCB1A \| ACKR3 \| ACTA2 \| ADRA1B \| AGT \| AGTR1 \| AGTR1A \| ALAD \| ALB \| ANXA1 \| B2M \| CASP1 \| CDKN1A \| CLU \| CSF3 \| CTF1 \| CTSD \| CYBB \| CYP3A5 \| EDN1 \| EGF \| EPO \| FGA \| FGF2 \| GATM \| GSTP1 \| HAVCR1 \| IGF1 \| IL33 \| LCN2 \| LEPR \| MIR192 \| MPO \| MTHFR \| NEK8 \| NFE2L2 \| NOS2 \| NPHP1 \| NQO1 \| NR4A1 \| PARP1 \| PCSK5 \| POMC \| PPARA \| PTGS2 \| PYCARD \| RBP4 \| REN \| RGN \| RRM2B \| SLC12A3 \| SLC22A2 \| SLC47A1 \| SOD2 \| SPARC \| SPP1 \| TFF3 \| TGFB1 \| THG1L \| UMOD	24.33	101
14.	Acetaminophen	Long QT Syndrome	M	3 genes: CYP1A1 \| KCNE2 \| POMC	24.13	6
15.	Acetaminophen	Coma	M	2 genes: CPS1 \| OXT	23.96	7
16.	Acetaminophen	Hallucinations	M	1 gene: HOMER1	22.74	2
17.	Acetaminophen	Pulmonary Edema	M	3 genes: CAT \| NOS3 \| TNF	21.86	4
18.	Acetaminophen	Substance Withdrawal Syndrome	M	26 genes: ADORA1 \| ADORA2A \| ARL6IP5 \| BDNF \| CHRNA6 \| CHRNB2 \| CNR1 \| CREB1 \| CRP \| FAAH \| FOS \| GNAI1 \| GRIA2 \| MAPK1 \| MAPK3 \| MMP9 \| NOS2 \| NPY \| NPY2R \| OPRL1 \| PER1 \| PER2 \| PER3 \| POMC \| REN \| SLC6A4	21.45	30
19.	Acetaminophen	Liver Cirrhosis	M	78 genes: A2M \| ABCB4 \| ACTA2 \| AGT \| ALAD \| ALB \| ANKS6 \| ARRB1 \| ATP7B \| C1QB \| CCL2 \| CD14 \| CD9 \| CNR1 \| COL1A1 \| COL1A2 \| COL3A1 \| COL5A2 \| COMMD1 \| CP \| CTGF \| CTNNB1 \| CXCL15 \| CYBA \| CYP1A2 \| CYP27A1 \| CYP2R1 \| DHCR7 \| F2 \| F2R \| F3 \| F5 \| FBN1 \| FGF2 \| FGFR2 \| FLT1 \| GC \| HGF \| HSD11B2 \| IGFBP1 \| IGFBP2 \| IL6 \| JUND \| KRT18 \| KRT8 \| LAMC2 \| LGALS1 \| LGALS3BP \| LOX \| MIR29C \| MIR503 \| MIR764 \| MMP2 \| NFE2L2 \| NPC1 \| OBP3 \| PLOD2 \| REN \| RGN \| SERPINA1 \| SERPINA6 \| SERPING1 \| SERPINH1 \| SLC17A2 \| SLC22A8 \| SMAD3 \| SPARC \| SPP1 \| STAT1 \| TAGLN2 \| TGFB1 \| THBS1 \| TNFRSF1B \| TRPM7 \| UNC93B1 \| VEGFA \| VIM \| VTN	19.93	51
20.	Acetaminophen	Anorexia	M	7 genes: CCK \| IL1B \| IL2 \| NPY \| TNF \| TNFRSF1A \| UCN2	19.81	10
21.	Acetaminophen	Myoclonus	M	1 gene: MECP2	19.40	3
22.	Acetaminophen	Hemorrhage	M	13 genes: CYP2C9 \| F2 \| F7 \| FOS \| IL11 \| ITGB3 \| NQO1 \| PLAT \| PODXL \| POMC \| REN \| SERPINA1 \| VKORC1	18.95	28
23.	Acetaminophen	Eosinophilia	M	3 genes: MYD88 \| TLR2 \| TLR4	18.33	2
24.	Acetaminophen	Postoperative Complications	M	2 genes: F7 \| POMC	17.87	3
25.	Acetaminophen	Hypokalemia	M	6 genes: ADRB2 \| AGT \| INS \| NR3C1 \| POMC \| SST	16.96	20
26.	Acetaminophen	Drug Eruptions	M	12 genes: ALOX5 \| APOA1 \| APOC2 \| CYP1A1 \| CYP2E1 \| IL18 \| IL4 \| KNG1 \| MPO \| MTHFR \| TAC1 \| TTR	16.95	11
27.	Acetaminophen	Kidney Tubular Necrosis, Acute	M	4 genes: FABP1 \| POMC \| PPARA \| SOD2	16.63	29
28.	Acetaminophen	Leukopenia	M	6 genes: ASPG \| CSF3 \| IL2 \| MTHFR \| NAT2 \| TPMT	16.43	12
29.	Acetaminophen	Nephritis, Interstitial	M	8 genes: ALB \| CCL2 \| CCL7 \| CRP \| CYP2C9 \| DCN \| NGF \| THBS1	16.38	17
30.	Acetaminophen	Drug-Related Side Effects and Adverse Reactions	M	55 genes: ABCB1 \| ABCB1A \| ABCC1 \| ABCC12 \| ABCC2 \| ABCC4 \| ABCG2 \| ACHE \| ADORA1 \| ADORA2A \| ALB \| ATIC \| CES2 \| CLU \| COMMD1 \| CSF2 \| CSF3 \| CYP1A2 \| CYP2C9 \| CYP2E1 \| DHFR \| EPHX2 \| FGA \| HAVCR1 \| HMGB1 \| HMOX1 \| HOMER1 \| HSPB6 \| HTR2B \| IGF1 \| IGFBP1 \| KITLG \| MTHFR \| MTR \| MTRR \| NAT1 \| NAT2 \| NFE2L2 \| PLK2 \| PPARA \| PTGS2 \| REN \| SHMT1 \| SLC19A1 \| SLCO2A1 \| SPP1 \| TCN2 \| THBD \| TLR1 \| TLR2 \| TRP53 \| TXN1 \| TYMS \| UGT1A1 \| VKORC1	15.88	56
31.	Acetaminophen	Urticaria	M	12 genes: ALB \| ALOX5 \| GSTM1 \| HNMT \| ICAM1 \| IL18 \| IL1B \| MPO \| SELE \| TGFB1 \| TNF \| VCAM1	15.16	13
32.	Acetaminophen	Anaphylaxis	M	4 genes: ASPG \| KNG1 \| LTB4R \| NLRP3	14.82	6
33.	Acetaminophen	Torsades de Pointes	M	1 gene: CYP3A4	14.77	2
34.	Acetaminophen	Learning Disorders	M	17 genes: ACHE \| BCL2 \| HMOX1 \| IL1B \| MAPT \| MECP2 \| MT1 \| MT2 \| NF1 \| PARK2 \| PDE1B \| POR \| PSEN1 \| RNF135 \| SIGMAR1 \| SLC17A7 \| VEGFA	14.55	18
35.	Acetaminophen	Stevens-Johnson Syndrome	M	20 genes: ALB \| CAV1 \| CELF2 \| COPS5 \| CSF3 \| CTNNB1 \| CUL1 \| CUL4A \| DERL1 \| ELMO1 \| FBXO6 \| IFNG \| MIF \| NEDD4 \| NOS2 \| PARP1 \| PTGIS \| RB1 \| RBX1 \| VCP	13.69	5
36.	Acetaminophen	Anemia	M	23 genes: AGT \| ASPG \| ATG5 \| ATG7 \| ATP7A \| CSF2 \| CSF3 \| EPO \| GSR \| HAMP \| HP \| IL2 \| KRAS \| MTHFR \| NUP98 \| PARP1 \| REN \| SLC25A37 \| SLC40A1 \| SLC46A1 \| SOD2 \| TNF \| TYMS	13.55	88
37.	Acetaminophen	Acute Kidney Injury	M	55 genes: A2M \| ALB \| AMBP \| ATP5B \| B2M \| BAX \| CCR5 \| CD44 \| CLU \| CYP2C9 \| CYP3A23/3A1 \| EDN1 \| EGFR \| EPHX2 \| EPO \| FSTL1 \| G6PD \| GAS6 \| GFER \| GPNMB \| GSK3B \| GSTM2 \| GSTP1 \| HAVCR1 \| HBEGF \| HEXB \| HMOX1 \| HSPA1A \| IGF1 \| IGFBP1 \| IL10 \| IL6 \| INS \| KNG1 \| LCN2 \| MPO \| MTHFR \| NFE2L2 \| NOS2 \| NOS3 \| NQO1 \| PPARG \| RAPGEF3 \| SIRT1 \| SLC11A1 \| SPP1 \| TFF3 \| TGFB1 \| TNF \| TNFRSF12A \| TP53 \| UGT1A1 \| UGT1A9 \| UOX \| VEGFA	13.08	97
38.	Acetaminophen	Hepatitis	M	13 genes: ALB \| ATP7B \| CAT \| F2R \| GNMT \| GZMB \| HMOX1 \| IFNG \| INS \| KEAP1 \| PARP1 \| SPARC \| TF	12.99	14
39.	Acetaminophen	Drug Hypersensitivity	M	21 genes: ABCC2 \| ADORA1 \| ADORA2A \| CYP2C9 \| FCER1G \| GSTM1 \| GSTP1 \| GZMB \| HNMT \| HSPA1A \| HSPA1L \| IL10 \| IL13 \| IL4 \| NAT2 \| NLRP3 \| POSTN \| PTGS1 \| TAC1 \| TBXAS1 \| TNF	12.78	19
40.	Acetaminophen	Mental Disorders	M	8 genes: ABCB1 \| COMT \| DDC \| DTNBP1 \| LMX1B \| MAOA \| NOS1 \| POMC	12.71	9
41.	Acetaminophen	Urinary Bladder Neoplasms	M	76 genes: AMFR \| ANKFY1 \| ANPEP \| APOBEC3B \| AQP3 \| ARID1A \| AS3MT \| ASXL2 \| ATM \| ATP5D \| BAP1 \| BIRC3 \| BPTF \| CALHM1 \| CCNE1 \| CDH1 \| CDKN1A \| CLPTM1L \| CREBBP \| CSF3 \| CXCL8 \| CYP4B1 \| EGFR \| ERCC4 \| ESPL1 \| ESR1 \| FANCA \| FAS \| FGFR3 \| GGH \| GPX1 \| GSTM1 \| GSTO2 \| GSTP1 \| GSTZ1 \| HDAC4 \| HRAS \| IGF1 \| IGFBP3 \| IGFBP5 \| IL2 \| KMT2C \| KMT2D \| KRAS \| LIG1 \| LOXL1 \| MPO \| MT1A \| MTHFR \| MYC \| NAT1 \| NAT2 \| NCOR1 \| NQO1 \| NRSN1 \| PABPC1 \| POLB \| POR \| PRDM2 \| PSMB2 \| PTGS2 \| RASSF1 \| RB1 \| RHOA \| SLC12A7 \| SLC19A1 \| SMC1A \| SOD2 \| SRC \| STAG2 \| TACC3 \| TFRC \| TNF \| TP53 \| TRP53 \| TYMP	12.51	73
42.	Acetaminophen	Drug Overdose	M	1 gene: AGT	12.42	18
43.	Acetaminophen	Anemia, Hemolytic	M	9 genes: EPO \| G6PD \| GCLC \| GPI \| GSR \| HMOX1 \| ITPA \| SLC4A1 \| TPI1	12.06	16
44.	Acetaminophen	Rhabdomyolysis	M	1 gene: INS	12.05	2
45.	Acetaminophen	Respiratory Insufficiency	M	8 genes: FBLN5 \| IFT80 \| IGF1R \| MAPT \| MECP2 \| MGME1 \| PLAT \| SLC23A1	11.86	9
46.	Acetaminophen	Brain Diseases	M	17 genes: ALB \| CP \| CTC1 \| CYP2A6 \| IFNG \| KCNQ2 \| LAMC3 \| MAT1A \| MPO \| OGG1 \| OTC \| SCO1 \| SLC1A1 \| TREX1 \| TSC1 \| TSC2 \| TYMS	10.94	17
47.	Acetaminophen	Neurobehavioral Manifestations	M	6 genes: CCK \| FKBP5 \| MAGI2 \| NGF \| NOS1 \| SELP	10.93	7
48.	Acetaminophen	Hemolysis	M	6 genes: ATP7A \| G6PD \| HMOX1 \| HP \| SLC40A1 \| SOD1	10.92	6
49.	Acetaminophen	Epilepsy, Tonic-Clonic	M	8 genes: BDNF \| FGF2 \| HBEGF \| NES \| NGF \| NTF3 \| OXT \| POMC	10.32	7
50.	Acetaminophen	Lethargy	M	4 genes: ABAT \| ATG5 \| ATG7 \| IL1B	9.55	4

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