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Illuminating how chemicals affect human health.
AcetaminophenThese pathways are enriched significantly among genes that interact with Acetaminophen or its descendants. We show only terms with a corrected p-value <0.01.
| Pathway | Pathway ID | P-value | Corrected P-value | Annotated Genes | Genome Frequency | |
|---|---|---|---|---|---|---|
| 1. | Disease | REACT:116125 | 0 | 0 | 774 | 1229/42469 genes: 2.89% |
| 2. | Immune System | REACT:6900 | 0 | 0 | 696 | 1142/42469 genes: 2.69% |
| 3. | Metabolic pathways | KEGG:01100 | 0 | 0 | 794 | 1211/42469 genes: 2.85% |
| 4. | Metabolism | REACT:111217 | 0 | 0 | 1,031 | 1497/42469 genes: 3.52% |
| 5. | Signal Transduction | REACT:111102 | 4.90e-324 | 1.43e-321 | 864 | 1921/42469 genes: 4.52% |
| 6. | Cell Cycle | REACT:115566 | 1.10e-222 | 3.18e-220 | 375 | 548/42469 genes: 1.29% |
| 7. | Gene Expression | REACT:71 | 1.32e-213 | 3.81e-211 | 530 | 1091/42469 genes: 2.57% |
| 8. | Metabolism of proteins | REACT:17015 | 1.44e-209 | 4.17e-207 | 395 | 639/42469 genes: 1.50% |
| 9. | Hemostasis | REACT:604 | 2.11e-180 | 6.10e-178 | 321 | 492/42469 genes: 1.16% |
| 10. | Developmental Biology | REACT:111045 | 1.03e-146 | 2.96e-144 | 286 | 475/42469 genes: 1.12% |
| 11. | Transmembrane transport of small molecules | REACT:15518 | 7.45e-144 | 2.15e-141 | 301 | 532/42469 genes: 1.25% |
| 12. | Pathways in cancer | KEGG:05200 | 5.94e-135 | 1.72e-132 | 228 | 333/42469 genes: 0.78% |
| 13. | Mitotic M-M/G1 phases | REACT:21300 | 1.88e-133 | 5.45e-131 | 230 | 342/42469 genes: 0.81% |
| 14. | Cellular responses to stress | REACT:120956 | 2.88e-104 | 8.31e-102 | 176 | 257/42469 genes: 0.61% |
| 15. | MAPK signaling pathway | KEGG:04010 | 5.09e-104 | 1.47e-101 | 186 | 286/42469 genes: 0.67% |
| 16. | Metabolism of RNA | REACT:21257 | 2.02e-97 | 5.84e-95 | 164 | 239/42469 genes: 0.56% |
| 17. | Extracellular matrix organization | REACT:118779 | 4.35e-82 | 1.26e-79 | 160 | 266/42469 genes: 0.63% |
| 18. | Endocytosis | KEGG:04144 | 6.33e-81 | 1.83e-78 | 143 | 218/42469 genes: 0.51% |
| 19. | Apoptosis | REACT:578 | 1.97e-76 | 5.69e-74 | 117 | 157/42469 genes: 0.37% |
| 20. | Huntington's disease | KEGG:05016 | 4.91e-76 | 1.42e-73 | 128 | 187/42469 genes: 0.44% |
| 21. | Focal adhesion | KEGG:04510 | 6.26e-76 | 1.81e-73 | 136 | 210/42469 genes: 0.49% |
| 22. | Regulation of actin cytoskeleton | KEGG:04810 | 4.21e-75 | 1.22e-72 | 139 | 221/42469 genes: 0.52% |
| 23. | Cell cycle | KEGG:04110 | 1.32e-72 | 3.82e-70 | 102 | 127/42469 genes: 0.30% |
| 24. | Protein processing in endoplasmic reticulum | KEGG:04141 | 4.31e-70 | 1.25e-67 | 121 | 181/42469 genes: 0.43% |
| 25. | Alzheimer's disease | KEGG:05010 | 3.00e-68 | 8.67e-66 | 117 | 174/42469 genes: 0.41% |
| 26. | Membrane Trafficking | REACT:11123 | 6.26e-68 | 1.81e-65 | 126 | 201/42469 genes: 0.47% |
| 27. | Mus musculus biological processes | REACT:200794 | 8.30e-67 | 2.40e-64 | 122 | 192/42469 genes: 0.45% |
| 28. | Purine metabolism | KEGG:00230 | 1.77e-63 | 5.11e-61 | 113 | 174/42469 genes: 0.41% |
| 29. | DNA Repair | REACT:216 | 2.83e-61 | 8.18e-59 | 88 | 112/42469 genes: 0.26% |
| 30. | Cytokine-cytokine receptor interaction | KEGG:04060 | 1.18e-57 | 3.40e-55 | 139 | 278/42469 genes: 0.65% |
| 31. | Insulin signaling pathway | KEGG:04910 | 1.31e-57 | 3.78e-55 | 99 | 148/42469 genes: 0.35% |
| 32. | Ubiquitin mediated proteolysis | KEGG:04120 | 1.19e-56 | 3.44e-54 | 95 | 139/42469 genes: 0.33% |
| 33. | Neuronal System | REACT:13685 | 2.26e-55 | 6.52e-53 | 137 | 280/42469 genes: 0.66% |
| 34. | Osteoclast differentiation | KEGG:04380 | 7.76e-55 | 2.24e-52 | 91 | 132/42469 genes: 0.31% |
| 35. | DNA Replication | REACT:383 | 2.01e-53 | 5.81e-51 | 78 | 101/42469 genes: 0.24% |
| 36. | Peroxisome | KEGG:04146 | 4.39e-53 | 1.27e-50 | 70 | 83/42469 genes: 0.20% |
| 37. | Parkinson's disease | KEGG:05012 | 2.25e-52 | 6.49e-50 | 89 | 132/42469 genes: 0.31% |
| 38. | Lysosome | KEGG:04142 | 5.01e-52 | 1.45e-49 | 88 | 130/42469 genes: 0.31% |
| 39. | RNA transport | KEGG:03013 | 1.92e-51 | 5.54e-49 | 99 | 164/42469 genes: 0.39% |
| 40. | Measles | KEGG:05162 | 2.02e-51 | 5.84e-49 | 91 | 140/42469 genes: 0.33% |
| 41. | Transcription | REACT:1788 | 2.29e-51 | 6.61e-49 | 96 | 155/42469 genes: 0.36% |
| 42. | Tight junction | KEGG:04530 | 7.22e-50 | 2.09e-47 | 90 | 141/42469 genes: 0.33% |
| 43. | 3' -UTR-mediated translational regulation | REACT:1762 | 1.52e-49 | 4.38e-47 | 76 | 103/42469 genes: 0.24% |
| 44. | Chromatin organization | REACT:172623 | 1.97e-49 | 5.68e-47 | 113 | 217/42469 genes: 0.51% |
| 45. | Wnt signaling pathway | KEGG:04310 | 2.69e-49 | 7.78e-47 | 97 | 164/42469 genes: 0.39% |
| 46. | Neurotrophin signaling pathway | KEGG:04722 | 3.35e-49 | 9.68e-47 | 86 | 131/42469 genes: 0.31% |
| 47. | Oxidative phosphorylation | KEGG:00190 | 1.80e-46 | 5.21e-44 | 85 | 135/42469 genes: 0.32% |
| 48. | Toxoplasmosis | KEGG:05145 | 4.28e-46 | 1.24e-43 | 85 | 136/42469 genes: 0.32% |
| 49. | Chemokine signaling pathway | KEGG:04062 | 6.19e-46 | 1.79e-43 | 103 | 195/42469 genes: 0.46% |
| 50. | Tuberculosis | KEGG:05152 | 7.59e-46 | 2.19e-43 | 100 | 185/42469 genes: 0.44% |