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Chemical Acetaminophen

1–50 of 924 results.
  Curated. Reference Cited Chemicals Cited Genes Cited Diseases
1. Curated.
Alanazi A, et al.
Therapeutic potential of carfilzomib, an irreversible proteasome inhibitor, against acetaminophen-induced hepatotoxicity in mice.
J Biochem Mol Toxicol. 2017 Apr;31(4).
 Acetaminophen | carfilzomib GPT | NOS2 | PTGS2 | TNF Drug-Induced Liver Injury
2. Curated.
Bai Q, et al.
Long-term acetaminophen treatment induced liver fibrosis in mice and the involvement of Egr-1.
Toxicology. 2017 May 1;382:47-58.
 Acetaminophen | Carbon Tetrachloride | N-acetyl-4-benzoquinoneimine ACTA2 | BMP2 | COL1A1 | COL1A2 | COL3A1 | EGR1 | GPT | MAPK1 | MAPK3 | MMP2 | TGFB1 | TIMP1 Drug-Induced Liver Injury
3. Curated.
Bandeira AC, et al.
Lycopene inhibits reactive oxygen species production in SK-Hep-1 cells and attenuates acetaminophen-induced liver injury in C57BL/6 mice.
Chem Biol Interact. 2017 Feb 1;263:7-17.
 Acetaminophen | lycopene CAT | GPT | MMP2 Drug-Induced Liver Injury | Necrosis
4. Curated.
Bhushan B, et al.
Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.
Toxicol Sci. 2017 Feb;155(2):363-378.
 Acetaminophen | Acetylcysteine | Canertinib | Glutathione | phorone AIFM1 | CCND1 | CDK4 | DIABLO | EGFR | ENDOG | RB1 Drug-Induced Liver Injury
5. Curated.
Dash A, et al.
Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system.
Toxicol In Vitro. 2017 Mar;39:93-103.
 6 beta-hydroxytestosterone | 6-ethylchenodeoxycholic acid | Acetaminophen | Phenacetin | Testosterone A2M | ABCA1 | ABCB11 | ABCB4 | ABCG1 | ACAA1 | ACAA2 | ACACA | ACOT9 | ACOX1 | ACOX2 | ACOX3 | ACSL1 | ACSL4 | ACSL5 | ACSL6 | ADAMTSL2 | ADCY1 | ADH1C | AGPAT2 | AGPAT5 | AKR1D1 | AKT1 | AKT2 | ALB | ALDOA | ALDOB | ALDOC | AMN | AOC4P | APOA1 | APOA2 | APOB | APOC2 | APOC3 | APOE | ASPG | BAD | BCL2 | BID | BIRC3 | C14ORF80 | C5AR2 | CA14 | CASP10 | CASP8 | CCS | CD14 | CLIC4 | COL1A1 | CPT1A | CPT2 | CRCT1 | CREB3L1 | CREB3L3 | CRP | CTAGE15 | CYP19A1 | CYP1A1 | CYP1A2 | CYP21A2 | CYP27A1 | CYP2A6 | CYP2C8 | CYP2C9 | CYP2D6 | CYP2E1 | CYP2R1 | CYP2S1 | CYP2U1 | CYP39A1 | CYP3A4 | CYP3A43 | CYP3A5 | CYP3A7 | CYP4A11 | CYP4F11 | CYP4F12 | CYP4F22 | CYP4F3 | CYP51A1 | CYP7A1 | CYP8B1 | DGAT2 | DHCR7 | DNAJB11 | DPYD | DUSP6 | ECSIT | ELOVL1 | ELOVL2 | ELOVL6 | ELOVL7 | ENC1 | ENO1 | ENO3 | FADD | FASN | FBP1 | FDPS | FETUB | FGF19 | FGFR4 | FOS | FOXP3 | GAPDH | GK | GPAM | GPD1 | GPX2 | GPX3 | GSR | GSTP1 | GSTT1 | GYS2 | HIST1H2BJ | HMGCR | HMGCS1 | HRAS | HSD17B7 | HSD3B7 | HSPG2 | ID2 | IDI1 | IGFALS | IL6R | IL6ST | INHBB | IRAK1 | IRAK2 | JUN | JUNB | KRT16P2 | KRT16P3 | LBR | LCAT | LDLR | LENG8 | LGI4 | LIME1 | LINC00870 | LIPC | LPA | LPIN1 | LPIN2 | LSS | MAF | MAFF | MAP2K3 | MAP2K6 | MAP2K7 | MAP3K14 | MAP3K5 | MAP3K8 | MAPK11 | MAPK12 | MDH1 | METRNL | MFSD2A | MKL2 | MLKL | MLLT11 | MSMO1 | MT1H | MVD | MVK | MYC | NFE2L2 | NFKB1 | NFKB2 | NPW | NR0B2 | NR5A2 | P4HB | PC | PCK1 | PFKFB1 | PGM1 | PIK3CD | PIK3R1 | PKD1P1 | PLTP | PPP1R3C | PPP2CB | PPP2R1B | PRDX1 | PRDX6 | PRKCA | PRKCE | PTBP2 | ROS1 | RPS6KA2 | RPS6KA4 | RPS6KA5 | RRAS2 | RTP3 | RXRA | S100A3 | SAA1 | SC5D | SCARB1 | SDC1 | SERPINA1 | SERPINE1 | SFN | SIGIRR | SLC13A5 | SLC25A1 | SLC25A10 | SLC25A12 | SLC27A5 | SLC51A | SLC51B | SLCO1B1 | SLCO1B3 | SOCS2 | SOD2 | SREBF1 | SREBF2 | SZRD1 | TAB1 | TAPBP | TCEA2 | TECR | TGFB1 | TGFB2 | TGFB3 | TGFBR1 | TIMP1 | TK1 | TNFRSF1B | TRAF2 | TXN | TXNRD2 | TYK2 | TYMP | UBE2E3 | UBXN10 | UCKL1 | UGP2 | UGT1A1 | UGT1A4 | UGT1A6 | UGT1A7 | UGT1A9 | UGT2B10 | UGT2B11 | UGT2B15 | UGT2B7 | UPB1 | UPP1 | UPP2 | UROC1 | XDH  
6. Curated.
Hauschke M, et al.
Neutrophil gelatinase-associated lipocalin production negatively correlates with HK-2 cell impairment: Evaluation of NGAL as a marker of toxicity in HK-2 cells.
Toxicol In Vitro. 2017 Mar;39:52-57.
 Acetaminophen | tert-Butylhydroperoxide | Cadmium Chloride | Cisplatin | Gentamicins | Mercuric Chloride LCN2 Acute Kidney Injury
7. Curated.
Kim SJ, et al.
Sestrin2 protects against acetaminophen-induced liver injury.
Chem Biol Interact. 2017 May 1;269:50-58.
 Acetaminophen CASP3 | GPT | IL1B | IL6 | MAPK1 | MAPK3 | SESN2 | TNF Drug-Induced Liver Injury | Hepatomegaly
8. Curated.
Poon KL, et al.
Editor''s Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models.
Toxicol Sci. 2017 Mar 1;156(1):133-148.
 Acetaminophen | Amiodarone | Diclofenac | Flutamide | rosiglitazone | troglitazone CYP2K18 | GSR | GSTT1B Drug-Induced Liver Injury
9. Curated.
Poon KL, et al.
Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates.
Arch Toxicol. 2017 Mar;91(3):1187-1197.
 1-hydroxymethylmidazolam | 1-hydroxymethylmidazolam glucuronide | 4-hydroxymidazolam | Acetaminophen | Amiodarone | Aspirin | Carbamazepine | Chlorpromazine | Clotrimazole | Desipramine | Diclofenac | Flutamide | Glutathione | hydroxynefazodone | Imipramine | Indomethacin | Ketoconazole | Midazolam | mono-N-desethylamiodarone | nefazodone | pioglitazone | Propafenone | rosiglitazone | Tacrine | troglitazone | Verapamil CYP3A4 Drug-Induced Liver Injury | Drug-Related Side Effects and Adverse Reactions
10. Curated.
Vispute SG, et al.
Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction.
Toxicology. 2017 Mar 1;378:95-106.
 Acetaminophen | Dexamethasone | Mifepristone CYP3A11 | FGF21 | GPT | NR1I2 Drug-Induced Liver Injury
11. Curated.
Wang JX, et al.
Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases.
Toxicol Lett. 2017 Jan 4;265:38-46.
 Acetaminophen | rosiglitazone CRP | CXCL1 | CYBB | GSR | MAPK1 | MAPK3 | NOX4 | TNF Drug-Induced Liver Injury | Hepatomegaly | Necrosis
12. Curated.
Wink S, et al.
High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities.
Arch Toxicol. 2017 Mar;91(3):1367-1383.
 2-bromoethylamine | Acetaminophen | allyl alcohol | Azathioprine | Brefeldin A | Buthionine Sulfoximine | Butylated Hydroxyanisole | Colchicine | Cyclosporine | Danazol | Cisplatin | Diclofenac | diethyl maleate | 2,4-Dinitrophenol | Etoposide | Indomethacin | Iodoacetamide | Lomustine | Methapyrilene | methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate | Omeprazole | Phenobarbital | Propylthiouracil | Sulindac | Tacrine | Thapsigargin | Tunicamycin ATF4 | ATF6 | BTG2 | CDKN1A | DDIT3 | EIF2AK3 | HSPA5 | KEAP1 | NFE2L2 | SRXN1 | TP53 | TP53BP1 | XBP1  
13. Curated.
Ajiboye TO.
Lophirones B and C Attenuate Acetaminophen-Induced Liver Damage in Mice: Studies on Hepatic, Oxidative Stress and Inflammatory Biomarkers.
J Biochem Mol Toxicol. 2016 Oct;30(10):497-505.
 Acetaminophen | Biflavonoids ALB | CAT | CXCL8 | GSR | IL6 | TNF Drug-Induced Liver Injury
14. Curated.
Alotaibi SA, et al.
Prophylactic and Therapeutic Potential of Acetyl-l-carnitine against Acetaminophen-Induced Hepatotoxicity in Mice.
J Biochem Mol Toxicol. 2016 Jan;30(1):5-11.
 Acetaminophen | Acetylcarnitine | Acetylcysteine GSR Drug-Induced Liver Injury
15. Curated.
Calvano J, et al.
Serum microRNAs-217 and -375 as biomarkers of acute pancreatic injury in rats.
Toxicology. 2016 Aug 10;368-369:1-9.
 Acetaminophen | Ceruletide | Streptozocin MIR216A | MIR216B | MIR217 | MIR375 Drug-Induced Liver Injury | Hemorrhage | Necrosis | Pancreatic Diseases
16. Curated.
Duan L, et al.
Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J.
Food Chem Toxicol. 2016 Dec;98(Pt B):107-118.
 Acetaminophen AIFM1 | BAX | DIABLO | GPT | SH3BP5 Drug-Induced Liver Injury
17. Curated.
Du K, et al.
Editor''s Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
Toxicol Sci. 2016 Dec;154(2):214-226.
 Acetaminophen | Metformin AIFM1 | BAX | DIABLO | GPT Drug-Induced Liver Injury
18. Curated.
Holman NS, et al.
Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?
Toxicol Sci. 2016 Jun;151(2):365-75.
 Acetaminophen ALB | MIR122  
19. Curated.
Holm JB, et al.
Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility.
Toxicol Sci. 2016 Mar;150(1):178-89.
 Acetaminophen   Infertility, Female
20. Curated.
Huang L, et al.
Development of an optimized cytotoxicity assay system for CYP3A4-mediated metabolic activation via modified piggyBac transposition.
Toxicol In Vitro. 2016 Apr;32:132-7.
 Acetaminophen | troglitazone CYP3A4  
21. Curated.
Khayyat A, et al.
N-acetylcysteine amide, a promising antidote for acetaminophen toxicity.
Toxicol Lett. 2016 Jan 22;241:133-42.
 Acetaminophen | Acetylcysteine | N-Acetylcysteinamide GPT | GSR Drug-Induced Liver Injury
22. Curated.
Mathur A, et al.
PHLPP2 down regulation influences nuclear Nrf2 stability via Akt-1/Gsk3β/Fyn kinase axis in acetaminophen induced oxidative renal toxicity: Protection accorded by morin.
Food Chem Toxicol. 2016 Mar;89:19-31.
 Acetaminophen | morin AKT1 | BAX | BCL2 | CASP3 | CASP9 | CAT | GCLC | GSK3B | HMOX1 | MAPK9 | NFE2L2 | NQO1 | PHLPP2 Kidney Diseases
23. Curated.
Michaut A, et al.
A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.
Toxicol Appl Pharmacol. 2016 Feb 1;292:40-55.
 6 beta-hydroxytestosterone | 6-hydroxychlorzoxazone | Acetaminophen | acetaminophen glucuronide | Adenosine Triphosphate | Chlorzoxazone | Glutathione | Oleic Acid | stearic acid | Testosterone ALDH1A1 | APOA4 | CYP2E1 | CYP3A4 | FABP4 | HMOX1 | INS | NFE2L2 | PDK4 | PKLR | PLIN1 | PLIN2 | TRIB3 Drug-Induced Liver Injury | Non-alcoholic Fatty Liver Disease
24. Curated.
Pang C, et al.
Caffeic acid attenuated acetaminophen-induced hepatotoxicity by inhibiting ERK1/2-mediated early growth response-1 transcriptional activation.
Chem Biol Interact. 2016 Dec 25;260:186-195.
 Acetaminophen | Acetylcysteine | caffeic acid EGR1 | F3 | GADD45A | GPT | IL1B | IL6 | MAPK1 | MAPK3 | RAF1 | SERPINE1 Drug-Induced Liver Injury
25. Curated.
Rodrigues RM, et al.
Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems.
Toxicol Lett. 2016 Jan 5;240(1):50-9.
 Acetaminophen AGPS | AK9 | APOB | BRD2 | CYP3A4 | CYP3A5 | CYP3A7 | EFR3B | ELL2 | FNBP1 | GLS | GTF2H2B | HNRNPD | HNRNPU | HSBP1L1 | IGF1 | KLHL5 | MGAT4A | NEAT1 | NNMT | NUDT21 | OSBPL8 | PAIP1 | PARP9 | PDSS2 | PGM2L1 | PSMC2 | SLC4A7 | SLFN5 | TM9SF3 | TNPO1 | XRCC5  
26. Curated.
Saito J, et al.
High content analysis assay for prediction of human hepatotoxicity in HepaRG and HepG2 cells.
Toxicol In Vitro. 2016 Jun;33:63-70.
 Acetaminophen | Amodiaquine | Benzbromarone | Diclofenac | Flutamide | nefazodone | Ticlopidine | Ticrynafen | troglitazone | Valproic Acid | zomepirac   Drug-Induced Liver Injury
27. Curated.
Soldatow V, et al.
Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation.
Toxicol In Vitro. 2016 Oct;36:224-37.
 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | Acetaminophen | Phenobarbital CYP2B1 | CYP2B10 | CYP2B6 | CYP3A11 | CYP3A23/3A1 | CYP3A4 | HGF | IL6 | NR1I3 | TGFA Drug-Induced Liver Injury
28. Curated.
Vatakuti S, et al.
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Chem Res Toxicol. 2016 Mar 21;29(3):342-51.
 Acetaminophen | benziodarone | Chloramphenicol | Chlorpromazine | Colchicine | Cyclosporine | Diethylnitrosamine | Ethinyl Estradiol | Methyltestosterone | 1-Naphthylisothiocyanate CADPS2 | DNAJB9 | DNAJC12 | ERLEC1 | HACL1 | NFXL1 | PAN2 | REEP5 | SLC10A7 | SORL1 | SRP72 | TMED7 | TMEM117 | UBA5 Cholestasis | Drug-Induced Liver Injury | Necrosis
29. Curated.
Xie W, et al.
Protective effect of hyperoside against acetaminophen (APAP) induced liver injury through enhancement of APAP clearance.
Chem Biol Interact. 2016 Feb 25;246:11-9.
 Acetaminophen | hyperoside CYP2E1 | GPT | NFE2L2 | SULT1A1 | SULT2A1 | UGT1A1 | UGT1A10 | UGT1A6 | UGT2B1 Drug-Induced Liver Injury | Necrosis
30. Curated.
Zhang Y, et al.
Protective effect of allyl methyl disulfide on acetaminophen-induced hepatotoxicity in mice.
Chem Biol Interact. 2016 Apr 5;249:71-7.
 Acetaminophen | allyl methyl disulfide GPT | IL6 | PTPRC | TNF Drug-Induced Liver Injury | Necrosis
31. Curated.
Driessen M, et al.
A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen.
Toxicol Lett. 2015 Jan 22;232(2):403-12.
 Acetaminophen | Amiodarone | Cyclosporine CYP8B1 Cholestasis | Drug-Induced Liver Injury | Fatty Liver | Massive Hepatic Necrosis
32. Curated.
Hagiya Y, et al.
Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.
Toxicol Appl Pharmacol. 2015 Jan 15;282(2):195-206.
 Acetaminophen ACLY | ACSL1 | ADK | ALB | ALDH1L1 | ALDH4A1 | APOA1 | ARIH2 | C3 | CAR3 | CAT | CBS | CES1C | CPS1 | CTH | DHDH | EEF2 | EIF5A | ENO1 | FBP1 | FGB | GCLC | GCLM | GPT | GSN | GSS | GSTA1 | GSTM1 | GSTP1 | GSTT1 | GSTZ1 | HAAO | HMGCS2 | HMOX1 | HPD | HSPA9 | INMT | KEAP1 | KRT8 | LDHA | MAT1A | NFE2L2 | PAH | PCX | PGAM1 | PPA1 | PRDX1 | PRDX6 | RASL12 | RGN | SDHA | SOD1 | SORD | TRF  
33. Curated.
Hur J, et al.
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
Chem Res Toxicol. 2015 May 18;28(5):927-34.
 10-propargyl-10-deazaaminopterin | abacavir | Acetaminophen | Acetazolamide | Acyclovir | Albendazole | aldesleukin | Alendronate | aliskiren | Allopurinol | alogliptin | Alprazolam | Amifostine | Amiodarone | Amoxicillin | amprenavir | Angiotensin-Converting Enzyme Inhibitors | aprepitant | armodafinil | Atazanavir Sulfate | Atorvastatin Calcium | Atovaquone | Azithromycin | Aztreonam | benazepril | Bendamustine Hydrochloride | Bortezomib | brinzolamide | Bumetanide | Bupropion | Carbamazepine | carvedilol | caspofungin | Cefaclor | Cefadroxil | Cefazolin | cefdinir | cefditoren | cefepime | Cefixime | Cefotaxime | Cefotetan | Cefoxitin | cefpodoxime | cefprozil | Ceftazidime | Ceftriaxone | Cefuroxime | Celecoxib | Cephalexin | cerivastatin | Chlorambucil | Cladribine | Chlorothiazide | cilostazol | Cinoxacin | Ciprofloxacin | Citalopram | Clarithromycin | Clindamycin | clobazam | clofarabine | clopidogrel | Clozapine | Cyclophosphamide | Cysteamine | Dactinomycin | Danazol | Daptomycin | Darunavir | Delavirdine | Desvenlafaxine Succinate | Diclofenac | Diflunisal | Diltiazem | docetaxel | doripenem | dorzolamide | Doxorubicin | Doxycycline | Duloxetine Hydrochloride | efavirenz | Enalapril | Erlotinib Hydrochloride | Erythromycin | Esomeprazole | Ethosuximide | ethotoin | Etidronic Acid | etiracetam | Etodolac | Etoposide | etravirine | famciclovir | Famotidine | felbamate | Fenofibrate | Fenoprofen | Fluconazole | fludarabine | Fluoxetine | Flurbiprofen | fluvastatin | Fluvoxamine | fosamprenavir | Foscarnet | fosphenytoin | Furosemide | gabapentin | Ganciclovir | gefitinib | gemifloxacin | glimepiride | Griseofulvin | Hydrochlorothiazide | Hydroxychloroquine | Ibuprofen | icodextrin | Ifosfamide | Indapamide | Indinavir | Indomethacin | interferon alfacon-1 | iopromide | Itraconazole | Ivermectin | Ketoprofen | Ketorolac | lamotrigine | Lansoprazole | latanoprost | leflunomide | lenalidomide | letrozole | Levobunolol | Levofloxacin | Lincomycin | Lisdexamfetamine Dimesylate | Lisinopril | lomefloxacin | Loperamide | Lovastatin | maraviroc | Mefenamic Acid | Mefloquine | meloxicam | meropenem | Methotrexate | methsuximide | Metolazone | Metronidazole | micafungin | Minocycline | mirabegron | mirtazapine | modafinil | montelukast | moxifloxacin | N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine | nabumetone | Naproxen | Nevirapine | Nifedipine | Nitrofurantoin | Norfloxacin | Ofloxacin | Omeprazole | Oseltamivir | oxaprozin | oxcarbazepine | Paclitaxel | pantoprazole | Paroxetine | peginterferon alfa-2a | peginterferon alfa-2b | Pemetrexed | Penicillamine | Pentamidine | Phenytoin | Piperacillin | Piroxicam | PLX4032 | Pravastatin | Pregabalin | Propranolol | Pyrimethamine | Quetiapine Fumarate | Quinine | Rabeprazole | Raltegravir Potassium | Ramipril | regorafenib | repaglinide | Isotretinoin | Ribavirin | Rifampin | Ritonavir | Rivaroxaban | Rivastigmine | rizatriptan | rofecoxib | rosiglitazone | Saquinavir | Sertraline | Silver Sulfadiazine | Simvastatin | Sitagliptin Phosphate | sorafenib | sparfloxacin | Spironolactone | Sulfacetamide | Sulfamethoxazole | Sulfasalazine | Sulindac | Tacrolimus | Tadalafil | Tamoxifen | tamsulosin | telaprevir | temozolomide | temsirolimus | terbinafine | teriflunomide | Thalidomide | Thiabendazole | tiagabine | Ticlopidine | tigecycline | Tinidazole | tinzaparin | Tolmetin | topiramate | torsemide | Tramadol | trandolapril | Trimethoprim | trospium chloride | valdecoxib | Valproic Acid | Vancomycin | Varenicline | Venlafaxine Hydrochloride | Verapamil | Voriconazole | Zanamivir | Zidovudine | zonisamide ARHGAP45 | CAV1 | CD74 | CELF2 | CIITA | COPS5 | CTNNB1 | CUL1 | CUL4A | DERL1 | ELMO1 | EP300 | FBXO6 | HLA-A | HLA-B | HLA-DMA | HLA-DMB | HLA-DOA | HLA-DOB | HLA-DPA1 | HLA-DQA1 | HLA-DQB1 | HLA-DQB2 | HLA-DRA | HLA-DRB1 | HLA-DRB3 | HLA-DRB6 | HLA-E | HLA-F | HLA-G | HLA-K | IFNA2 | IFNG | MR1 | NEDD4 | NUCB1 | PARP1 | PML | PSMC5 | PTGIS | RB1 | RBX1 | SELS | VCP Stevens-Johnson Syndrome
34. Curated.
Jaeschke H.
Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid.
Chem Biol Interact. 2015 Sep 10.
 Acetaminophen | Chlorogenic Acid   Drug-Induced Liver Injury
35. Curated.
Jetten MJ, et al.
Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.
Arch Toxicol. 2015 Jun 24.
 Acetaminophen ACOT7 | ACOX3 | ACVR2A | ADIPOR1 | AHSA1 | AIMP2 | ALYREF | ANKRD28 | ARPC4 | ATP5D | ATP6V0E2 | BCS1L | C1ORF122 | CANT1 | CAPN11 | CCND1 | CDC5L | CFAP20 | CHFR | CNNM3 | CXXC5 | CYB561D2 | CYB5R1 | CYP1B1 | DAP | DDX56 | EFTUD2 | EIF4E2 | EPS8L2 | GEM | GMPR | JTB | KYAT3 | LAGE3 | LINC00888 | LONP1 | MAP7D1 | MIF4GD | MLLT6 | MRPS26 | MTMR9 | MYADM | MYD88 | MYDGF | MYL6B | NANS | NOP16 | PAAF1 | PACSIN2 | PFDN1 | PIK3C2B | PIN1 | PKIG | PLEKHJ1 | PLOD3 | PNPLA8 | PPP2R3A | PREP | PRKCI | PRMT1 | PRRG4 | PSMB10 | PSMB8 | PTPMT1 | PTPRK | RAB20 | RBPMS-AS1 | RILPL2 | RNF125 | RTN3 | SDCCAG3 | SEC61A1 | SELENOM | SLC29A3 | SLC38A7 | SMIM20 | SMYD3 | STARD7 | SUMO3 | SWI5 | TCF20 | TIMM9 | TMEM139 | TMEM177 | TMEM199 | TMEM9 | TRIM15 | TRMT112 | TSPAN13 | TSTA3 | TTC14 | UBAC1 | UNC45A | WASHC4 | WBP2 | WIPI1 | WIPI2 | ZBTB38 | ZNF24  
36. Curated.
Jiang J, et al.
Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.
Toxicol Lett. 2015 Apr 16;234(2):139-50.
 Acetaminophen AADAT | ABAT | ABCB10 | ABCE1 | ACAD8 | ACADSB | ACADVL | ACAT1 | ACBD3 | ACO2 | ACOT13 | ACOT7 | ACP6 | ACSF2 | ACSL1 | ACSL3 | ACSL5 | ACSM3 | ACSM5 | ACSS1 | ADH5 | AFG3L2 | AGK | AGMAT | AGPAT5 | AGPS | AGXT | AIFM1 | AIFM2 | AK2 | AK4 | AKAP1 | AKR7A2 | ALDH18A1 | ALDH1B1 | ALDH2 | ALDH3A2 | ALDH5A1 | ALDH6A1 | AMT | APEX2 | ARAF | ARG2 | ARL2BP | ARSB | ASAH2B | ATP5B | ATP5D | ATP5E | ATP5G1 | ATP5I | ATP5L | ATP5S | ATP6V1E1 | ATP7B | ATPAF2 | ATPIF1 | AUH | AZIN2 | BAD | BCL2L11 | BCL2L13 | BCL2L2 | BDH1 | BID | BIK | BNIP3 | BNIP3L | BPHL | BRD8 | C10ORF10 | C12ORF10 | C14ORF159 | C1QBP | CA5A | CAPRIN2 | CARS2 | CAT | CCDC90B | CDK7 | CEP89 | CHAF1B | CHDH | CISD1 | CKMT2 | CLN3 | CLPP | CLPX | CLU | CLYBL | COA3 | COA6 | COG8 | COL4A3BP | COQ10A | COQ10B | COQ2 | COQ3 | COQ4 | COQ5 | COQ8A | COX10 | COX11 | COX15 | COX5A | COX6B1 | COX6C | COX7A2 | COX7A2L | COX7B | COX8A | CPOX | CPS1 | CRLS1 | CRY1 | CSDE1 | CTSA | CTSB | CXORF23 | CYB5A | CYB5B | CYBA | CYC1 | CYCS | CYP1A1 | CYP24A1 | CYP27A1 | CYP27B1 | DAP3 | DARS2 | DECR1 | DGUOK | DHODH | DHRS1 | DHRS2 | DHTKD1 | DHX30 | DIABLO | DLAT | DNA2 | DNAJA3 | DNAJC11 | DNAJC19 | DNM1L | DPYSL2 | DTD1 | DUT | E2F1 | EARS2 | ECH1 | ECHDC2 | ECI2 | EHHADH | ELOVL6 | EMC8 | ENDOG | ENOSF1 | ETFB | ETFDH | ETHE1 | FAHD1 | FAM110B | FAM136A | FANCG | FDX1L | FDXR | FECH | FEN1 | FIS1 | FPGS | FRMD6 | FUNDC2 | FXN | GARS | GATB | GATM | GCAT | GCDH | GFER | GLDC | GLOD4 | GLS | GLS2 | GLT8D1 | GLUD2 | GLYCTK | GM2A | GPAM | GPRC5C | GPX4 | GRN | GRPEL1 | GRPEL2 | GSTK1 | GSTZ1 | GTF3C2 | HAGH | HARS2 | HEBP1 | HEBP2 | HIBADH | HINT2 | HK1 | HKDC1 | HMBS | HMGCL | HSD17B10 | HSD17B4 | HSDL2 | HSPA1A | HSPA1B | HSPA9 | HSPE1 | HTRA2 | IARS2 | IDH2 | IDH3A | IDH3B | IFI6 | ILF3 | IMMP1L | IMMT | ISCA2 | ISCU | ISOC2 | IVD | KARS | KIAA0391 | KIF1BP | KYNU | L2HGDH | LACTB | LAP3 | LARS2 | LDHD | LETM1 | LIMK2 | LONP1 | LRRC59 | LRRC75A-AS1 | LYPLA1 | LYRM4 | MAIP1 | MAOA | MAOB | MARC1 | MARC2 | MCCC1 | MCCC2 | MCEE | ME2 | METAP1D | METTL12 | METTL17 | MGST1 | MIEF1 | MIPEP | MMADHC | MPC1 | MPC2 | MPV17 | MRPL1 | MRPL10 | MRPL11 | MRPL12 | MRPL15 | MRPL16 | MRPL19 | MRPL22 | MRPL23 | MRPL24 | MRPL27 | MRPL28 | MRPL3 | MRPL32 | MRPL34 | MRPL35 | MRPL39 | MRPL4 | MRPL40 | MRPL41 | MRPL43 | MRPL44 | MRPL46 | MRPL48 | MRPL50 | MRPL54 | MRPL9 | MRPS10 | MRPS11 | MRPS12 | MRPS15 | MRPS18B | MRPS2 | MRPS21 | MRPS23 | MRPS26 | MRPS27 | MRPS28 | MRPS30 | MRPS33 | MRPS34 | MRPS35 | MRPS36 | MRPS5 | MRPS7 | MRPS9 | MRS2 | MSRB3 | MTCH1 | MTCH2 | MTERF2 | MTERF3 | MTFMT | MTHFD1 | MTHFD1L | MTHFD2 | MTIF3 | MTO1 | MTOR | MTPAP | MTRF1 | MTRR | MTX2 | MTX3 | NADK2 | NAGS | NARS2 | NDFIP2 | NDUFA1 | NDUFA2 | NDUFA7 | NDUFA8 | NDUFA9 | NDUFAF1 | NDUFAF4 | NDUFAF5 | NDUFAF6 | NDUFAF7 | NDUFB1 | NDUFB10 | NDUFB2 | NDUFB3 | NDUFB5 | NDUFB6 | NDUFB7 | NDUFB9 | NDUFC1 | NDUFC2 | NDUFS1 | NDUFS2 | NDUFS5 | NDUFS6 | NDUFS8 | NDUFV3 | NEK9 | NELFE | NIPSNAP1 | NLN | NMNAT3 | NOA1 | NR3C1 | NSD3 | NTHL1 | OAT | OGDH | OGDHL | OGG1 | OPA1 | OXA1L | OXCT1 | OXR1 | OXSM | P4HA1 | PABPN1 | PACS2 | PANK2 | PARK7 | PARL | PARS2 | PCCA | PCCB | PCK2 | PCLAF | PDHA1 | PDHX | PDK1 | PDK2 | PDK3 | PDP1 | PEBP1 | PECR | PEMT | PERP | PEX11B | PHB | PHB2 | PHYKPL | PINK1 | PITRM1 | PMAIP1 | PMPCA | PMPCB | PNPT1 | POLDIP2 | POLG | PPA2 | PPIF | PPL | PPM1K | PPP3CA | PPP3CB | PRDX1 | PRDX4 | PRDX5 | PRELID1 | PRKACA | PRKCA | PSAP | PSEN1 | PSMA6 | PSMC4 | PTCD3 | PYCR1 | PYURF | QTRT1 | RAB32 | RAF1 | RAI14 | RALGAPA1 | RARS2 | REEP1 | REXO2 | RHOT1 | RIPK1 | RMDN3 | RSAD1 | RTN4IP1 | SARDH | SARS2 | SCO1 | SCO2 | SFXN2 | SFXN3 | SFXN4 | SH3BP5 | SH3GLB1 | SHC1 | SHMT2 | SIRT4 | SIRT7 | SIVA1 | SLC25A1 | SLC25A10 | SLC25A11 | SLC25A12 | SLC25A13 | SLC25A14 | SLC25A15 | SLC25A16 | SLC25A19 | SLC25A22 | SLC25A23 | SLC25A28 | SLC25A29 | SLC25A30 | SLC25A32 | SLC25A33 | SLC25A36 | SLC25A38 | SLC25A39 | SLC25A4 | SLC25A40 | SLC25A43 | SLC25A44 | SLC25A45 | SLC25A47 | SLC25A5 | SLC25A51 | SLC25A6 | SLC27A2 | SLC35B3 | SLC9A6 | SLC9B2 | SLIRP | SMDT1 | SOD1 | SOD2 | SPG7 | SRGAP2 | SSBP1 | STARD13 | STOML2 | STXBP1 | SUCLG2 | SUOX | SUPV3L1 | SURF1 | SYNJ2 | TAMM41 | TAOK3 | TARS2 | TAT | TAZ | TCAIM | TFAM | TFB1M | TFB2M | TFRC | TGM2 | THG1L | TIMM10 | TIMM10B | TIMM44 | TIMM8A | TIMM9 | TIMMDC1 | TMEM143 | TMEM256 | TMEM8B | TMX4 | TNFRSF19 | TOMM20 | TOMM22 | TOMM34 | TOMM40L | TOMM5 | TOMM70 | TP53 | TPP1 | TRAP1 | TRIT1 | TRMT10C | TRMU | TRNT1 | TSC22D3 | TSFM | TST | TWNK | TXN2 | TXNDC12 | TXNIP | UCP2 | UNG | UQCR10 | UQCRQ | UROS | USP30 | VAMP1 | VARS | VARS2 | VDAC3 | WARS2 | XAF1 | XPNPEP3 | YARS2 | YME1L1 | YRDC | ZFHX3  
37. Curated.
Jiang Y, et al.
Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.
Toxicol Sci. 2015 Jan;143(1):107-15.
 Acetaminophen | schizandrol B BCL2 | CCND1 | CDK4 | CDKN1A | CYP2E1 | CYP3A11 | PCNA | TRP53 Drug-Induced Liver Injury
38. Curated.
Jiang Y, et al.
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.
Chem Biol Interact. 2015 Apr 25;231:83-9.
 Acetaminophen | schisandrol A | schizandrer A | schizandrin A | schizandrin B | schizandrin C | schizandrol B CYP1A2 | CYP2E1 | CYP3A11 Drug-Induced Liver Injury | Liver Failure, Acute
39. Curated.
Ji LL, et al.
The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.
Free Radic Biol Med. 2015 Aug;85:12-23.
 Acetaminophen | anthra(1,9-cd)pyrazol-6(2H)-one | Carbon Tetrachloride | clivorine | Ethanol | Quercetin | SB 203580 | toosendanin GCLC | GCLM | HMOX1 | KEAP1 | MAPK1 | MAPK3 | NFE2L2 | SQSTM | SQSTM1 Drug-Induced Liver Injury
40. Curated.
Kia R, et al.
MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity.
Toxicol Sci. 2015 Mar;144(1):173-85.
 Acetaminophen | Diclofenac MIR122 Drug-Induced Liver Injury
41. Curated.
Kimura M, et al.
Disruption of spindle checkpoint function ahead of facilitation of cell proliferation by repeated administration of hepatocarcinogens in rats.
J Toxicol Sci. 2015;40(6):855-71.
 Acetaminophen | beta-Naphthoflavone | Carbadox | leucomalachite green | Methapyrilene | oxfendazole | Promethazine | Thioacetamide CASP3 | CDKN1A | CHEK1 | MAD2L1 | MDM2 | MKI67 | RBL2 | TOP2A | TP53 Hepatomegaly | Hypertrophy | Weight Loss
42. Curated.
Krauskopf J, et al.
Application of High-Throughput Sequencing to Circulating microRNAs Reveals Novel Biomarkers for Drug-Induced Liver Injury.
Toxicol Sci. 2015 Feb;143(2):268-76.
 Acetaminophen MIR107 | MIR122 | MIR130A | MIR148A | MIR192 | MIR22 | MIR27B | MIR30A Drug-Induced Liver Injury
43. Curated.
Lichtensteiger W, et al.
Differential gene expression patterns in developing sexually dimorphic rat brain regions exposed to antiandrogenic, estrogenic, or complex endocrine disruptor mixtures: glutamatergic synapses as target.
Endocrinology. 2015 Apr;156(4):1477-93.
 Acetaminophen | Androgen Antagonists | bisphenol A | butylparaben | Dibutyl Phthalate | Dichlorodiphenyl Dichloroethylene | Diethylhexyl Phthalate | enzacamene | epoxiconazole | Linuron | octylmethoxycinnamate | prochloraz | procymidone | vinclozolin ABAT | ACTN1 | ADAM17 | BACE1 | BACE2 | BDNF | BSN | CACNA1A | CACNA1B | CACNA1C | CACNA1D | CACNA1E | CACNA1F | CACNA1G | CACNA1H | CACNA1I | CACNA2D1 | CACNA2D2 | CACNA2D3 | CACNB1 | CACNB2 | CACNB3 | CACNG2 | CACNG5 | CACNG6 | CACNG7 | CACNG8 | CADM1 | CAMK2B | CAMK2G | CASK | CD44 | CD81 | CHGA | CHRDL1 | CNTN3 | CNTN4 | COPS2 | CYP11B1 | CYP17A1 | CYP19A1 | DCC | DLG1 | DLG4 | DLGAP3 | DLGAP4 | DNMT3A | DOC2A | DPP10 | DPP6 | DPYD | EGF | EGFR | ERBB2 | ERBB3 | ERBB4 | FGFR1 | FGFR2 | FMR1 | FYN | GABRA4 | GABRB1 | GDNF | GLS | GRIA2 | GRIA4 | GRIK1 | GRIK2 | GRIK4 | GRIK5 | GRIN1 | GRIN2B | GRIN2C | GRIN2D | GRIN3A | GRIP1 | HES6 | HR | HSD17B10 | HSD17B8 | HSD3B6 | IGF1R | IGF2R | IL1RAPL1 | JAG1 | LIN7A | LRRC7 | MAGI2 | MDGA2 | MET | NF1 | NLGN1 | NOTCH2 | NOTCH3 | NOTCH4 | NR3C2 | NRCAM | NRG1 | NRXN1 | NRXN2 | NTRK1 | NTRK2 | NTRK3 | NXPH3 | PGR | PRKN | RELN | ROBO1 | RXRA | SHANK1 | SHANK2 | SHANK3 | SLC17A7 | SLC1A1 | SLC1A2 | SLC1A3 | SLC1A6 | SLIT1 | SPTBN2 | STMN2 | STS | STX1B | STXBP1 | SYNGAP1 | SYP | SYT6 | TGFB1 | TSC2 | TSNAX | UNC5A | UNC5B | UNC5C | VEGFA | VLDLR  
44. Curated.
Limonciel A, et al.
Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing.
Toxicol In Vitro. 2015 Jan 13.
 1-(2-trifluoromethoxyphenyl)-2-nitroethanone | Acetaminophen | adefovir dipivoxil | Cadmium Chloride | chloroacetaldehyde | Chlorpromazine | cidofovir | Clodronic Acid | Cyclosporine | Cisplatin | Fenofibrate | Ibuprofen | Ifosfamide | Metformin | Oxygen | rosiglitazone | troglitazone | Valproic Acid | zoledronic acid AARS | ABCB6 | ABCB9 | ABCC3 | ABCG1 | ABHD4 | ACSL1 | ADCY1 | AGRN | AGRP | AHR | AIFM2 | AK3 | AK4 | AKR1C2 | ALDH18A1 | ALDH1A3 | ALDOA | ALS2CL | AMBP | ANGPTL4 | ANKRA2 | ARFGEF2 | ARHGEF10 | ARL1 | ARL10 | ASNS | ASTN2 | ATAD2 | ATF3 | ATF4 | ATXN1 | AURKB | AXL | BATF | BAX | BBC3 | BCAR3 | BCAT1 | BCAT2 | BCL3 | BEND5 | BEND6 | BHLHE40 | BMF | BNIP3 | BRD2 | BTG2 | C17ORF82 | C4ORF3 | C8ORF58 | CACNA1D | CAMKK2 | CARS | CCDC90B | CCNE2 | CCNG2 | CDK6 | CDKN1A | CERS5 | CHSY1 | CLIP4 | CMBL | COCH | COL24A1 | COL4A1 | COLEC12 | CP | CRISPLD2 | CTDP1 | CTH | CTSC | CTTN | CYP1A1 | CYP1A2 | CYP1B1 | DDB2 | DDIT3 | DDIT4 | DDX17 | DDX24 | DGKA | DHX37 | DLGAP5 | DLL1 | DLX1 | DNAJB2 | DNAJB9 | DNAJC5B | DNMBP | DPM3 | DPP9 | DPYSL3 | DUSP22 | DUSP5 | EBLN2 | EDA2R | EDC3 | EFNA1 | EIF1 | EIF2S2 | EIF3C | ELF4 | ELK4 | ENO1 | ENO2 | ENOSF1 | ENTPD7 | EP400 | EPRS | ERO1L | EXOC7 | FABP3 | FABP4 | FAM162A | FAM167A | FAM210A | FAM210B | FAM212B | FAM214A | FAM32A | FAM84B | FAM89A | FAS | FBXO22 | FBXO30 | FECH | FGR | FLVCR2 | FOSL1 | FOSL2 | FREM2 | FTH1 | GABARAPL1 | GADD45A | GALNT16 | GARS | GBE1 | GCLC | GCLM | GCNT3 | GDF15 | GOLIM4 | GORASP1 | GOT1 | GPA33 | GPAT3 | GPHN | GPNMB | GPR87 | GPR88 | GSR | HERC3 | HIF1A | HIST1H1C | HMOX1 | HRASLS2 | HSPA1B | HSPA5 | HTATIP2 | IARS | IDS | IGF1R | IGF2R | IL17RB | INSIG1 | INSIG2 | ISCU | ITFG2 | ITGB1 | KAT6B | KCNK13 | KDM3A | KEAP1 | KRT15 | KRT19 | LAMA1 | LAMA3 | LARS | LMCD1 | LTA | LTN1 | MAFG | MAN1A2 | MAP3K8 | MAPRE2 | MCOLN2 | MDM2 | ME1 | MMP19 | MSC | MT2A | MTDH | MTFP1 | MXI1 | NAMPT | NARS | NCAPD2 | NEDD9 | NFE2L2 | NIN | NINJ1 | NMUR1 | NPY1R | NQO1 | NR3C1 | NREP | NTPCR | NUAK1 | ORAI3 | OSGIN1 | OXSM | P4HA1 | PANK1 | PCLO | PDE8A | PDE9A | PDIA5 | PDK1 | PDK4 | PDLIM1 | PFKFB4 | PHGDH | PHLDA3 | PIDD1 | PIP5K1C | PIR | PLEC | PLIN2 | PLK3 | PMAIP1 | PMEPA1 | PNPLA6 | PODXL | POLR3F | PPAN | PPAN-P2RY11 | PPARG | PPFIBP1 | PPIG | PPM1D | PPP1R15A | PPP4R2 | PRC1 | PRDM1 | PRKAB1 | PRKAB2 | PRPS1 | PSAT1 | PSPC1 | PYCR1 | PYGL | RAB26 | RAB31 | RAB33A | RARA | RFFL | RIPOR3 | RIT1 | RLF | RND1 | RND3 | RNF121 | RPS27L | RRM2B | RRP12 | RSL1D1 | RSRC2 | RUNX1 | RUNX2 | RXRA | SARM1 | SARS | SAT1 | SCAMP1 | SDF2L1 | SECTM1 | SERPINB5 | SERTAD1 | SESN1 | SETX | SFN | SH3TC1 | SHANK3 | SIAH2 | SIK1 | SIPA1L2 | SIVA1 | SLC12A8 | SLC16A6 | SLC1A4 | SLC1A5 | SLC1A7 | SLC25A20 | SLC27A2 | SLC2A1 | SLC2A11 | SLC3A2 | SLC6A6 | SLC6A9 | SLC7A1 | SLC7A11 | SLC7A5 | SLCO2B1 | SMAP1 | SON | SORL1 | SPRY1 | SPSB1 | SQSTM1 | SRD5A3 | SRXN1 | STRBP | SULF2 | TALDO1 | TAOK1 | TARS | TBXAS1 | TFAP2A | TFE3 | THBS2 | TIGAR | TIMM17B | TINAG | TIPARP | TLR4 | TMEM45A | TMEM45B | TMEM94 | TMTC2 | TNFAIP8 | TNFRSF10B | TNFRSF21 | TNFSF9 | TOP1 | TP53 | TP53I3 | TP53INP1 | TP53TG1 | TPCN1 | TPD52L1 | TRAFD1 | TRIAP1 | TRIM69 | TROVE2 | TRUB2 | TSPAN12 | TXN | TXN1 | TXNRD1 | UBE2G2 | UBE2O | UNKL | USP3 | VARS | VDR | VEGFB | VIPR1 | VTCN1 | VWCE | WARS | WDR63 | WDR7 | WDR81 | WWC2 | XBP1 | XPC | YARS | YEATS2 | YTHDC2 | ZFX | ZMAT3 | ZNF292 | ZNF561  
45. Curated.
Lu X, et al.
Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats.
PLoS One. 2015;10(10):e0141750.
 Acetaminophen INCENP | MMP12 | SBF1 Drug-Induced Liver Injury
46. Curated.
Noh JR, et al.
Sulforaphane protects against acetaminophen-induced hepatotoxicity.
Food Chem Toxicol. 2015 Jun;80:193-200.
 Acetaminophen | sulforafan GCLC | GCLM | HMOX1 | NFE2L2 | NQO1 | SOD1 Drug-Induced Liver Injury
47. Curated.
Oshida K, et al.
Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium.
Nucl Recept Signal. 2015;13:e002.
 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | 2,4,5,2',4',5'-hexachlorobiphenyl | 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | Acetaminophen | AGN 194204 | aroclor 1260 | beta-Naphthoflavone | Benzo(a)pyrene | ciprofibrate | Cobalt | cyproconazole | Diethylhexyl Phthalate | epoxiconazole | Fenofibrate | Lipopolysaccharides | perfluorohexanesulfonic acid | perfluorononanoic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid | Phenobarbital | phenylhydrazine | pirinixic acid | Pregnenolone Carbonitrile | propiconazole | Silicon Dioxide | systhane | Tetrachlorodibenzodioxin | triadimefon ACOX1 | AHR | AKR1B7 | BIRC5 | CYP2B10 | CYP3A11 | CYP3A13 | CYP4A10 | CYP51 | EGFR | GSTA2 | GSTM3 | JUN | NR1H3 | NR1I2 | NR1I3 | PPARA | RELA Hepatomegaly
48. Curated.
Oshida K, et al.
Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium.
PLoS One. 2015;10(2):e0112655.
 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole | 4-dichlorobenzene | Acetaminophen | AGN 194204 | benzofuran | Bezafibrate | bisphenol A | Cholesterol | ciprofibrate | Dietary Fats | Diethylhexyl Phthalate | epoxiconazole | Estrogens | Ethylnitrosourea | Fenofibrate | Fish Oils | Galactosamine | GW 4064 | GW 501516 | Levofloxacin | Lipopolysaccharides | Malathion | naphthalene | oltipraz | perfluorobutanesulfonic acid | perfluorononanoic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid | Phenobarbital | pirinixic acid | Pregnenolone Carbonitrile | rosiglitazone | systhane | Tetrachlorodibenzodioxin | trovafloxacin CYP4A10 | NR1H4 | NR1I2 | NR1I3 | PDK4 | PPARA  
49. Curated.
Ramachandran A, et al.
Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice.
Arch Toxicol. 2015 May;89(5):773-83.
 Acetaminophen | Glutathione AIFM1 | BCL2L1 | DDIT3 | GSTM3 | TXN2 Drug-Induced Liver Injury
50. Curated.
Smith GJ, et al.
Effect of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice.
Environ Health Perspect. 2015 Oct 9.
 Acetaminophen | Tobacco Smoke Pollution GCLC | NQO1  
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