Drug-Induced Liver Injury - Pathways

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	Disease	Pathway	Pathway ID	Association inferred via
1.	Drug-Induced Liver Injury	Metabolism	REACT:R-HSA-1430728	66 genes: ABCB1 \| ABCC1 \| ADIPOQ \| AHR \| ALB \| ALDOB \| APOA1 \| APOE \| ARG1 \| ARNT \| BDH1 \| BTD \| CAT \| CDS1 \| CHRM3 \| CYP2A6 \| CYP2C19 \| CYP2C9 \| CYP2E1 \| CYP8B1 \| DGAT2 \| DHFR \| ENO1 \| EPHX1 \| FADS1 \| FADS2 \| FASN \| FMO3 \| GC \| GCLC \| GOT1 \| GPT \| GSR \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| HACL1 \| HADHA \| HAO2 \| HMOX1 \| HPD \| ITPR1 \| LRAT \| MDH1 \| MED1 \| MTHFR \| NAT2 \| NR1H3 \| NR1H4 \| PCYT1A \| PDK4 \| PEX11A \| PNP \| PON1 \| PPARA \| PTGS2 \| RBP1 \| SORD \| SULT1E1 \| TALDO1 \| TTR \| UGT1A9 \| WASL
2.	Drug-Induced Liver Injury	Immune System	REACT:R-HSA-168256	53 genes: ADAM8 \| ANXA2 \| ARG1 \| ATG5 \| ATP6V1D \| C3 \| CAT \| CCL2 \| CCR2 \| CLU \| CSF3 \| CTNNB1 \| CTSE \| CXCL1 \| CXCL10 \| FGA \| GGH \| GSN \| GSTP1 \| HLA-A \| HLA-B \| HLA-DQB1 \| HLA-DRB1 \| HMGB1 \| HMOX1 \| IFNA2 \| IFNG \| IL11 \| IL17A \| IL18 \| IL1A \| IL1B \| IL1R2 \| IL22 \| IL4 \| IL6 \| ITPR1 \| LBP \| LCN2 \| LGALS3 \| LTF \| MMP2 \| PNP \| PRKDC \| PTGS2 \| S100A11 \| SLPI \| TNF \| TTR \| UBA5 \| UNC93B1 \| VIM \| WASL
3.	Drug-Induced Liver Injury	Metabolic pathways	KEGG:hsa01100	34 genes: ALDOB \| ARG1 \| ATP6V1D \| BDH1 \| BTD \| CDS1 \| CYP2A6 \| CYP2C19 \| CYP2C9 \| CYP2E1 \| CYP8B1 \| DGAT2 \| DHFR \| ENO1 \| FASN \| GCLC \| GOT1 \| GPT \| HADHA \| HAO2 \| HMOX1 \| HPD \| MDH1 \| MTHFR \| NAT2 \| PCYT1A \| PNP \| POLG \| PON1 \| PTGS2 \| RGN \| SORD \| TALDO1 \| UGT1A9
4.	Drug-Induced Liver Injury	Innate Immune System	REACT:R-HSA-168249	32 genes: ADAM8 \| ANXA2 \| ARG1 \| ATG5 \| ATP6V1D \| C3 \| CAT \| CCR2 \| CLU \| CTNNB1 \| CXCL1 \| FGA \| GGH \| GSN \| GSTP1 \| HLA-A \| HLA-B \| HMGB1 \| IFNA2 \| IL1B \| ITPR1 \| LBP \| LCN2 \| LGALS3 \| LTF \| PNP \| PRKDC \| S100A11 \| SLPI \| TTR \| UNC93B1 \| WASL
5.	Drug-Induced Liver Injury	Signal Transduction	REACT:R-HSA-162582	31 genes: APOA1 \| APOE \| ATP6V1D \| C3 \| CCR2 \| CHRM3 \| CTNNB1 \| CXCL1 \| CXCL10 \| ERLEC1 \| F2RL3 \| FGA \| FLT1 \| HRH2 \| IGF1 \| IL6 \| ITPR1 \| KNG1 \| LRAT \| MST1R \| PDK4 \| PLAT \| PLG \| RBP1 \| RDH13 \| REEP5 \| SPP1 \| TBXA2R \| TNF \| TTR \| WASL
6.	Drug-Induced Liver Injury	Cytokine Signaling in Immune system	REACT:R-HSA-1280215	28 genes: CCL2 \| CCR2 \| CSF3 \| CXCL1 \| CXCL10 \| FGA \| HLA-A \| HLA-B \| HLA-DQB1 \| HLA-DRB1 \| HMOX1 \| IFNA2 \| IFNG \| IL11 \| IL17A \| IL18 \| IL1A \| IL1B \| IL1R2 \| IL22 \| IL4 \| IL6 \| LBP \| LCN2 \| MMP2 \| PTGS2 \| TNF \| VIM
7.	Drug-Induced Liver Injury	Metabolism of lipids and lipoproteins	REACT:R-HSA-556833	27 genes: ABCC1 \| AHR \| ALB \| APOA1 \| APOE \| ARNT \| BDH1 \| CDS1 \| CYP2C19 \| CYP2C9 \| CYP8B1 \| DGAT2 \| FADS1 \| FADS2 \| FASN \| HACL1 \| HADHA \| HAO2 \| MED1 \| NR1H3 \| NR1H4 \| PCYT1A \| PEX11A \| PON1 \| PPARA \| PTGS2 \| UGT1A9
8.	Drug-Induced Liver Injury	Signaling by Interleukins	REACT:R-HSA-449147	22 genes: CCL2 \| CCR2 \| CSF3 \| CXCL1 \| CXCL10 \| FGA \| HMOX1 \| IL11 \| IL17A \| IL18 \| IL1A \| IL1B \| IL1R2 \| IL22 \| IL4 \| IL6 \| LBP \| LCN2 \| MMP2 \| PTGS2 \| TNF \| VIM
9.	Drug-Induced Liver Injury	Biological oxidations	REACT:R-HSA-211859	20 genes: AHR \| ARNT \| CYP2A6 \| CYP2C19 \| CYP2C9 \| CYP2E1 \| CYP8B1 \| EPHX1 \| FMO3 \| GCLC \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| NAT2 \| NR1H4 \| SULT1E1 \| UGT1A9
10.	Drug-Induced Liver Injury	Neutrophil degranulation	REACT:R-HSA-6798695	20 genes: ADAM8 \| ANXA2 \| ARG1 \| ATP6V1D \| C3 \| CAT \| CXCL1 \| GGH \| GSN \| GSTP1 \| HLA-A \| HLA-B \| HMGB1 \| LCN2 \| LGALS3 \| LTF \| PNP \| S100A11 \| SLPI \| TTR
11.	Drug-Induced Liver Injury	Fluid shear stress and atherosclerosis	KEGG:hsa05418	19 genes: CCL2 \| CTNNB1 \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| HMOX1 \| IFNG \| IL1A \| IL1B \| IL1R2 \| MAP3K5 \| MIR10A \| MMP2 \| NFE2L2 \| PLAT \| TNF
12.	Drug-Induced Liver Injury	MicroRNAs in cancer	KEGG:hsa05206	19 genes: ABCB1 \| ABCC1 \| CDC25B \| HMOX1 \| MIR107 \| MIR10A \| MIR10B \| MIR122 \| MIR141 \| MIR181C \| MIR192 \| MIR19A \| MIR200C \| MIR27B \| MIR29B2 \| MIR30A \| MIR34C \| PTGS2 \| VIM
13.	Drug-Induced Liver Injury	Cytokine-cytokine receptor interaction	KEGG:hsa04060	18 genes: CCL2 \| CCR2 \| CSF3 \| CXCL1 \| CXCL10 \| FLT1 \| IFNA2 \| IFNG \| IL11 \| IL17A \| IL18 \| IL1A \| IL1B \| IL1R2 \| IL22 \| IL4 \| IL6 \| TNF
14.	Drug-Induced Liver Injury	Hemostasis	REACT:R-HSA-109582	18 genes: ALB \| ANXA2 \| APOA1 \| APOH \| CLU \| F2RL3 \| FGA \| IFNA2 \| IGF1 \| ITPR1 \| KNG1 \| PLAT \| PLG \| SERPING1 \| SOD1 \| TAGLN2 \| TBXA2R \| TF
15.	Drug-Induced Liver Injury	Metabolism of proteins	REACT:R-HSA-392499	16 genes: APOA1 \| CCL2 \| CTNNB1 \| DNAJB9 \| EDEM1 \| FGA \| GSN \| IGF1 \| LTF \| MMP2 \| PLG \| PRKDC \| SORL1 \| SRP72 \| TMED7 \| TTR
16.	Drug-Induced Liver Injury	Chemical carcinogenesis	KEGG:hsa05204	15 genes: ARNT \| CYP2A6 \| CYP2C19 \| CYP2C9 \| CYP2E1 \| EPHX1 \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| NAT2 \| PTGS2 \| UGT1A9
17.	Drug-Induced Liver Injury	Platelet activation, signaling and aggregation	REACT:R-HSA-76002	15 genes: ALB \| APOA1 \| APOH \| CLU \| F2RL3 \| FGA \| IGF1 \| ITPR1 \| KNG1 \| PLG \| SERPING1 \| SOD1 \| TAGLN2 \| TBXA2R \| TF
18.	Drug-Induced Liver Injury	Interleukin-4 and 13 signaling	REACT:R-HSA-6785807	14 genes: CCL2 \| HMOX1 \| IL17A \| IL18 \| IL1A \| IL1B \| IL4 \| IL6 \| LBP \| LCN2 \| MMP2 \| PTGS2 \| TNF \| VIM
19.	Drug-Induced Liver Injury	Rheumatoid arthritis	KEGG:hsa05323	14 genes: ATP6V1D \| CCL2 \| CXCL1 \| FLT1 \| HLA-DQB1 \| HLA-DRB1 \| IFNG \| IL11 \| IL17A \| IL18 \| IL1A \| IL1B \| IL6 \| TNF
20.	Drug-Induced Liver Injury	Cellular responses to stress	REACT:R-HSA-2262752	13 genes: ARNT \| ATG5 \| CAT \| GSR \| GSTP1 \| IL1A \| IL6 \| MAP1LC3B \| MAP3K5 \| NOX4 \| SOD1 \| SOD2 \| SOD3
21.	Drug-Induced Liver Injury	Fatty acid, triacylglycerol, and ketone body metabolism	REACT:R-HSA-535734	13 genes: AHR \| APOA1 \| ARNT \| BDH1 \| DGAT2 \| FADS1 \| FASN \| HADHA \| MED1 \| NR1H4 \| PEX11A \| PPARA \| UGT1A9
22.	Drug-Induced Liver Injury	Gene Expression	REACT:R-HSA-74160	13 genes: APOE \| BAX \| GADD45A \| GSR \| MED1 \| NR1H3 \| NR1H4 \| NR1I2 \| NR1I3 \| PAN2 \| PPARA \| SESN2 \| SRP72
23.	Drug-Induced Liver Injury	Influenza A	KEGG:hsa05164	13 genes: CCL2 \| CXCL10 \| EIF2AK1 \| HLA-DQB1 \| HLA-DRB1 \| IFNA2 \| IFNG \| IL18 \| IL1A \| IL1B \| IL6 \| PLG \| TNF
24.	Drug-Induced Liver Injury	Interleukin-10 signaling	REACT:R-HSA-6783783	13 genes: CCL2 \| CCR2 \| CSF3 \| CXCL1 \| CXCL10 \| IL18 \| IL1A \| IL1B \| IL1R2 \| IL4 \| IL6 \| PTGS2 \| TNF
25.	Drug-Induced Liver Injury	Metabolism of vitamins and cofactors	REACT:R-HSA-196854	13 genes: ABCC1 \| APOA1 \| APOE \| BTD \| CYP8B1 \| DHFR \| FASN \| GC \| LRAT \| MTHFR \| PTGS2 \| RBP1 \| TTR
26.	Drug-Induced Liver Injury	Transmembrane transport of small molecules	REACT:R-HSA-382551	13 genes: ABCB1 \| ABCC1 \| ABCC2 \| ALB \| APOA1 \| ATP6V1D \| CP \| ERLEC1 \| HMOX1 \| LCN2 \| SLC13A4 \| SLC22A8 \| TF
27.	Drug-Induced Liver Injury	Drug metabolism - cytochrome P450	KEGG:hsa00982	12 genes: CYP2A6 \| CYP2C19 \| CYP2C9 \| CYP2E1 \| FMO3 \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| UGT1A9
28.	Drug-Induced Liver Injury	Herpes simplex infection	KEGG:hsa05168	12 genes: C3 \| CCL2 \| EIF2AK1 \| HLA-A \| HLA-B \| HLA-DQB1 \| HLA-DRB1 \| IFNA2 \| IFNG \| IL1B \| IL6 \| TNF
29.	Drug-Induced Liver Injury	IL-17 signaling pathway	KEGG:hsa04657	12 genes: CCL2 \| CSF3 \| CXCL1 \| CXCL10 \| IFNG \| IL17A \| IL1B \| IL4 \| IL6 \| LCN2 \| PTGS2 \| TNF
30.	Drug-Induced Liver Injury	Platelet degranulation	REACT:R-HSA-114608	12 genes: ALB \| APOA1 \| APOH \| CLU \| FGA \| IGF1 \| KNG1 \| PLG \| SERPING1 \| SOD1 \| TAGLN2 \| TF
31.	Drug-Induced Liver Injury	Response to elevated platelet cytosolic Ca2+	REACT:R-HSA-76005	12 genes: ALB \| APOA1 \| APOH \| CLU \| FGA \| IGF1 \| KNG1 \| PLG \| SERPING1 \| SOD1 \| TAGLN2 \| TF
32.	Drug-Induced Liver Injury	Signaling by GPCR	REACT:R-HSA-372790	12 genes: C3 \| CCR2 \| CHRM3 \| CXCL1 \| CXCL10 \| F2RL3 \| FGA \| HRH2 \| ITPR1 \| KNG1 \| REEP5 \| TBXA2R
33.	Drug-Induced Liver Injury	Tuberculosis	KEGG:hsa05152	12 genes: BAX \| C3 \| HLA-DQB1 \| HLA-DRB1 \| IFNA2 \| IFNG \| IL18 \| IL1A \| IL1B \| IL6 \| LBP \| TNF
34.	Drug-Induced Liver Injury	Carbon metabolism	KEGG:hsa01200	11 genes: ALDOB \| CAT \| ENO1 \| GOT1 \| GPT \| HADHA \| HAO2 \| MDH1 \| MTHFR \| RGN \| TALDO1
35.	Drug-Induced Liver Injury	Developmental Biology	REACT:R-HSA-1266738	11 genes: ADIPOQ \| CTNNB1 \| DSC2 \| FGA \| KRT18 \| MED1 \| MMP2 \| PPARA \| PTF1A \| TNF \| WASL
36.	Drug-Induced Liver Injury	Generic Transcription Pathway	REACT:R-HSA-212436	11 genes: APOE \| BAX \| GADD45A \| GSR \| MED1 \| NR1H3 \| NR1H4 \| NR1I2 \| NR1I3 \| PPARA \| SESN2
37.	Drug-Induced Liver Injury	GPCR downstream signaling	REACT:R-HSA-388396	11 genes: C3 \| CCR2 \| CHRM3 \| CXCL1 \| CXCL10 \| F2RL3 \| HRH2 \| ITPR1 \| KNG1 \| REEP5 \| TBXA2R
38.	Drug-Induced Liver Injury	Inflammatory bowel disease (IBD)	KEGG:hsa05321	11 genes: HLA-DQB1 \| HLA-DRB1 \| IFNG \| IL17A \| IL18 \| IL1A \| IL1B \| IL22 \| IL4 \| IL6 \| TNF
39.	Drug-Induced Liver Injury	Metabolism of xenobiotics by cytochrome P450	KEGG:hsa00980	11 genes: CYP2A6 \| CYP2C9 \| CYP2E1 \| EPHX1 \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| UGT1A9
40.	Drug-Induced Liver Injury	Vesicle-mediated transport	REACT:R-HSA-5653656	11 genes: ALB \| AMBP \| APOA1 \| APOE \| COL3A1 \| HPX \| MAP1LC3B \| SNX18 \| TF \| TMED7 \| WASL
41.	Drug-Induced Liver Injury	Disease	REACT:R-HSA-1643685	10 genes: ALB \| CDC25B \| CTNNB1 \| ERLEC1 \| FGA \| HLA-A \| LTF \| RBP1 \| SOD2 \| TTR
42.	Drug-Induced Liver Injury	Hematopoietic cell lineage	KEGG:hsa04640	10 genes: CSF3 \| HLA-DQB1 \| HLA-DRB1 \| IL11 \| IL1A \| IL1B \| IL1R2 \| IL4 \| IL6 \| TNF
43.	Drug-Induced Liver Injury	Non-alcoholic fatty liver disease (NAFLD)	KEGG:hsa04932	10 genes: ADIPOQ \| BAX \| CYP2E1 \| IL1A \| IL1B \| IL6 \| MAP3K5 \| NR1H3 \| PPARA \| TNF
44.	Drug-Induced Liver Injury	Phase 1 - Functionalization of compounds	REACT:R-HSA-211945	10 genes: AHR \| ARNT \| CYP2A6 \| CYP2C19 \| CYP2C9 \| CYP2E1 \| CYP8B1 \| EPHX1 \| FMO3 \| NR1H4
45.	Drug-Induced Liver Injury	Phase II conjugation	REACT:R-HSA-156580	10 genes: GCLC \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| NAT2 \| SULT1E1 \| UGT1A9
46.	Drug-Induced Liver Injury	Class A/1 (Rhodopsin-like receptors)	REACT:R-HSA-373076	9 genes: C3 \| CCR2 \| CHRM3 \| CXCL1 \| CXCL10 \| F2RL3 \| HRH2 \| KNG1 \| TBXA2R
47.	Drug-Induced Liver Injury	Extracellular matrix organization	REACT:R-HSA-1474244	9 genes: ADAM8 \| COL14A1 \| COL3A1 \| FGA \| MMP2 \| PCOLCE \| PLG \| SPP1 \| TTR
48.	Drug-Induced Liver Injury	GPCR ligand binding	REACT:R-HSA-500792	9 genes: C3 \| CCR2 \| CHRM3 \| CXCL1 \| CXCL10 \| F2RL3 \| HRH2 \| KNG1 \| TBXA2R
49.	Drug-Induced Liver Injury	Graft-versus-host disease	KEGG:hsa05332	9 genes: HLA-A \| HLA-B \| HLA-DQB1 \| HLA-DRB1 \| IFNG \| IL1A \| IL1B \| IL6 \| TNF
50.	Drug-Induced Liver Injury	HTLV-I infection	KEGG:hsa05166	9 genes: BAX \| CTNNB1 \| HLA-A \| HLA-B \| HLA-DQB1 \| HLA-DRB1 \| IL1R2 \| IL6 \| TNF

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