Drug-Induced Liver Injury - References

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	Reference	Cited Chemicals	Cited Genes	Cited Diseases
1.	Alanazi A, et al. Therapeutic potential of carfilzomib, an irreversible proteasome inhibitor, against acetaminophen-induced hepatotoxicity in mice. J Biochem Mol Toxicol. 2017 Apr;31(4).	Acetaminophen \| carfilzomib	GPT \| NOS2 \| PTGS2 \| TNF	Drug-Induced Liver Injury
2.	Awoyemi OV, et al. Cobalt chloride exposure dose-dependently induced hepatotoxicity through enhancement of cyclooxygenase-2 (COX-2)/B-cell associated protein X (BAX) signaling and genotoxicity in Wistar rats. Environ Toxicol. 2017 Mar 17.	cobaltous chloride	BAX \| CAT \| GPT \| PTGS2	Drug-Induced Liver Injury \| Micronuclei, Chromosome-Defective
3.	Bai Q, et al. Long-term acetaminophen treatment induced liver fibrosis in mice and the involvement of Egr-1. Toxicology. 2017 May 1;382:47-58.	Acetaminophen \| Carbon Tetrachloride \| N-acetyl-4-benzoquinoneimine	ACTA2 \| BMP2 \| COL1A1 \| COL1A2 \| COL3A1 \| EGR1 \| GPT \| MAPK1 \| MAPK3 \| MMP2 \| TGFB1 \| TIMP1	Drug-Induced Liver Injury
4.	Bandeira AC, et al. Lycopene inhibits reactive oxygen species production in SK-Hep-1 cells and attenuates acetaminophen-induced liver injury in C57BL/6 mice. Chem Biol Interact. 2017 Feb 1;263:7-17.	Acetaminophen \| lycopene	CAT \| GPT \| MMP2	Drug-Induced Liver Injury \| Necrosis
5.	Bhushan B, et al. Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice. Toxicol Sci. 2017 Feb;155(2):363-378.	Acetaminophen \| Acetylcysteine \| Canertinib \| Glutathione \| phorone	AIFM1 \| CCND1 \| CDK4 \| DIABLO \| EGFR \| ENDOG \| RB1	Drug-Induced Liver Injury
6.	Cui X, et al. Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice. Toxicol Lett. 2017 Jan 4;265:17-22.	Carbon Tetrachloride	ACTA2 \| COL1A1 \| RDH13 \| TGFB1 \| TIMP1	Drug-Induced Liver Injury \| Liver Cirrhosis, Experimental \| Necrosis
7.	Dunnick JK, et al. Hepatic transcriptomic alterations for N,N-dimethyl-p-toluidine (DMPT) and p-toluidine after 5-day exposure in rats. Arch Toxicol. 2017 Apr;91(4):1685-1696.	4-toluidine \| dimethyl-4-toluidine \| phenylhydroxylamine	AASS \| ABCB6 \| ABCC3 \| ABHD1 \| ABHD17A \| ABHD5 \| ABTB1 \| ACAD10 \| ACAD11 \| ACAD9 \| ACADVL \| ACBD3 \| ACO1 \| ACOT1 \| ACOX2 \| ACP2 \| ACP6 \| ACSM2A \| ADH1 \| ADH1C \| ADH5 \| ADORA1 \| ADPRM \| ADSS \| ADTRP \| AGA \| AGMAT \| AGTPBP1 \| AGTR1A \| AK3 \| AKAP11 \| AKR1A1 \| AKR1B8 \| AKR1E2 \| AKR7A3 \| AKT1 \| AKT2 \| ALDH1A1 \| ALDH1L1 \| ALDH3B1 \| ALDH6A1 \| ALG12 \| ALYREF \| ANG \| ANKRD11 \| ANKRD28 \| ANO10 \| ANXA2 \| ANXA4 \| ANXA7 \| AOX1 \| AP4S1 \| APCS \| APOA4 \| APOC3 \| ARFGAP2 \| ARHGAP18 \| ARHGDIA \| ARHGEF1 \| ARHGEF37 \| ARID1B \| ARL4D \| ARL6 \| ARMC1 \| ARMT1 \| ARPC1B \| ARPC2 \| ARSA \| ARSE \| ASAH1 \| ASAH2 \| ASB5 \| ASGR1 \| ASGR2 \| ATE1 \| ATF3 \| ATF4 \| ATOH8 \| ATP1A1 \| ATP5C1 \| ATP5E \| ATP5H \| ATP5L \| ATP6V0C \| ATPIF1 \| ATRN \| AVPR1A \| AZGP1 \| AZIN1 \| B2M \| BCL6B \| BDH2 \| BLOC1S6 \| BNIP3 \| BTBD1 \| C11ORF96 \| C18ORF32 \| C1GALT1 \| C1R \| C1S \| C2CD2 \| C3 \| C4BPB \| C8G \| CA2 \| CALM1 \| CAMTA2 \| CANX \| CAPN1 \| CAR2 \| CASD1 \| CASP6 \| CAT \| CAV2 \| CBX5 \| CCDC101 \| CCDC163 \| CCDC28A \| CCDC43 \| CCDC50 \| CCDC58 \| CCDC77 \| CCDC92 \| CCL4 \| CCND1 \| CCNG1 \| CCNJ \| CCT8 \| CD164 \| CD276 \| CD47 \| CD99L2 \| CDC42EP1 \| CDK2AP1 \| CDKN1A \| CDR2 \| CDS1 \| CEACAM1 \| CELA1 \| CEP83 \| CES1C \| CGNL1 \| CHCHD1 \| CIAO1 \| CLDN14 \| CLU \| CLUH \| CMTM4 \| CNIH4 \| CNN3 \| CNPPD1 \| CNPY4 \| COA3 \| COBL \| COL18A1 \| COPZ1 \| COPZ2 \| CORO6 \| CORT \| COX4I1 \| COX5A \| CPB2 \| CPPED1 \| CPSF6 \| CRELD2 \| CRIP2 \| CROT \| CRYM \| CSNK2B \| CSRP2 \| CTAGE5 \| CTBS \| CTDSP2 \| CTNNA1 \| CTPS1 \| CTPS2 \| CXCL12 \| CYFIP2 \| CYP1A2 \| CYP2J3 \| CYP3A2 \| CYP4A3 \| CYP4F1 \| CYP4F5 \| CYSTM1 \| DACT3 \| DAP \| DCAF6 \| DCAKD \| DCTN1 \| DDAH1 \| DDX19B \| DEK \| DERA \| DERL1 \| DERL2 \| DHRS1 \| DHRS13 \| DHRS4 \| DHX36 \| DIABLO \| DNAJA4 \| DNAJB11 \| DNAJC2 \| DNAJC22 \| DNAJC24 \| DNAJC3 \| DNAJC30 \| DNLZ \| DOLK \| DPYD \| DRD2 \| DUSP22 \| DYNC2H1 \| DYNLL1 \| ECHS1 \| EDF1 \| EGF \| EID1 \| EIF1B \| EIF4E \| EIF4G2 \| ELAVL1 \| ELOVL2 \| ELOVL5 \| ENPP5 \| EPB41 \| EPB41L1 \| EPCAM \| EPHX1 \| EPRS \| EPS8L2 \| ERMP1 \| ETFRF1 \| ETHE1 \| ETNK1 \| ETS1 \| EXOSC4 \| F10 \| FAAP20 \| FADS1 \| FAM102A \| FAM126B \| FAM213B \| FBXL6 \| FBXO33 \| FBXO5 \| FBXO6 \| FBXW11 \| FBXW2 \| FBXW9 \| FDX1 \| FEN1 \| FGFR4 \| FGGY \| FGL1 \| FHIT \| FLOT1 \| FLYWCH1 \| FN3K \| FNTA \| FRYL \| FUBP3 \| FUOM \| FZD8 \| G6PD \| GADD45GIP1 \| GAK \| GAL \| GALK1 \| GALNT1 \| GALNT11 \| GAMT \| GARNL3 \| GAS2 \| GATC \| GBE1 \| GC \| GCA \| GCKR \| GCLM \| GCS1 \| GDA \| GFER \| GGA2 \| GHDC \| GHR \| GID4 \| GIPC2 \| GLDC \| GLYATL2 \| GMCL1 \| GMPPB \| GNB1 \| GNPTG \| GOSR1 \| GOT2 \| GPX1 \| GPX2 \| GREM2 \| GSR \| GSTA1 \| GSTA3 \| GSTA4 \| GSTM1 \| GSTP1 \| GSTT1 \| GSTT3 \| GTPBP4 \| GUCY1A3 \| GUCY2C \| GUK1 \| GULO \| HADH \| HAMP \| HAUS4 \| HAUS7 \| HDAC3 \| HDHD3 \| HGFAC \| HINT1 \| HINT2 \| HINT3 \| HIP1 \| HIVEP1 \| HMCN1 \| HMGCS2 \| HMGN3 \| HNRNPAB \| HNRNPDL \| HNRNPM \| HNRNPUL1 \| HOGA1 \| HPRT1 \| HRAS \| HSD11B1 \| HSP90AA1 \| HSPA5 \| HSPA8 \| HSPA9 \| HSPB8 \| HTRA1 \| IBA57 \| ICA1 \| ICMT \| ICOSLG \| ICT1 \| ID2 \| ID4 \| IDH1 \| IFI27L2B \| IGF2R \| IGFBP3 \| IMPAD1 \| ING1 \| INHBA \| INHBC \| INMT \| INO80C \| INSIG2 \| IPO13 \| IRAK1 \| IRGM \| ISG20 \| ISG20L2 \| ISYNA1 \| ITGB1BP1 \| ITIH1 \| ITIH2 \| ITIH4 \| ITPK1 \| IVNS1ABP \| JPT2 \| KCNJ6 \| KIFC3 \| KLC4 \| KLF3 \| KYNU \| L3MBTL3 \| LAMA3 \| LBH \| LCAT \| LCLAT1 \| LECT2 \| LEO1 \| LEPROT \| LEPROTL1 \| LETM1 \| LETMD1 \| LGALS2 \| LGALSL \| LIN7A \| LRIG3 \| LRP1 \| LRP5 \| LRRFIP1 \| LSM7 \| LSR \| LTBP1 \| LTBR \| LTV1 \| LYPLAL1 \| MACROD1 \| MAGED1 \| MAL2 \| MAN1B1 \| MAN2A1 \| MAOA \| MAPK1 \| MARC2 \| MARCH8 \| MARCKS \| MAT2B \| MBTD1 \| MCM7 \| MCRIP1 \| MDH1 \| MED21 \| MED9 \| METTL18 \| METTL9 \| MFN1 \| MGARP \| MGMT \| MGST2 \| MIF \| MIF4GD \| MINDY1 \| MIPEP \| MKLN1 \| MKNK2 \| MMD \| MPP1 \| MPP6 \| MPV17L \| MREG \| MRLN \| MRPL24 \| MRPL32 \| MRPL41 \| MRPL42 \| MRPL46 \| MRPL48 \| MRPS2 \| MRPS28 \| MRRF \| MSANTD3 \| MSL1 \| MTCH1 \| MTDH \| MTPAP \| MTPN \| MTX1 \| MYBBP1A \| MYBL1 \| MYDGF \| MYRF \| NAA50 \| NANS \| NAP1L1 \| NAXE \| NCK2 \| NCOA1 \| NCOA5 \| NDNL2 \| NDRG2 \| NDUFA6 \| NDUFA7 \| NDUFB7 \| NDUFV3 \| NEK6 \| NELFE \| NEU2 \| NFE2L1 \| NFIC \| NFIX \| NFX1 \| NGEF \| NGFRAP1 \| NID1 \| NIPBL \| NIPSNAP1 \| NIPSNAP3A \| NIPSNAP3B \| NIT1 \| NME7 \| NOL12 \| NOMO1 \| NPAS2 \| NPDC1 \| NPEPL1 \| NQO1 \| NR2F6 \| NR5A2 \| NREP \| NRF1 \| NSD2 \| NSFL1C \| NT5E \| NUBP1 \| NUDT15 \| NUDT2 \| NUMA1 \| OAF \| OAT \| OBFC1 \| OLR59 \| OPA1 \| OXA1L \| PAK1 \| PAK2 \| PALD1 \| PAM16 \| PAPOLA \| PAQR9 \| PCK2 \| PCSK6 \| PDCD4 \| PDGFRA \| PDGFRB \| PDIA5 \| PEMT \| PEPD \| PEX19 \| PEX6 \| PFAS \| PFDN2 \| PGAM1 \| PGRMC1 \| PGRMC2 \| PHLDA3 \| PI4KA \| PIGO \| PIGY \| PIM2 \| PKDCC \| PKLR \| PKP3 \| PKP4 \| PLA1A \| PLA2G3 \| PLA2G6 \| PLAA \| PLBD1 \| PLCXD2 \| PLEKHB2 \| PLIN3 \| PNPLA8 \| POP7 \| PPID \| PPL \| PPME1 \| PPOX \| PPP1R14B \| PPP1R3C \| PPP2R5D \| PQLC1 \| PQLC3 \| PRDX1 \| PRDX2 \| PRDX4 \| PRKCSH \| PRSS1 \| PSMB1 \| PSMB7 \| PSMC6 \| PSMD14 \| PSMD5 \| PSMD7 \| PTGR1 \| PTMS \| PTPRK \| PTPRS \| PUF60 \| PUM3 \| PVT1 \| PXMP2 \| QPRT \| RAB6A \| RAD18 \| RAD23A \| RALGPS2 \| RARRES2 \| RBM33 \| RBM47 \| RBM48 \| RCAN2 \| RDX \| REEP5 \| REEP6 \| RELN \| REPS2 \| RFX7 \| RGD1309350 \| RGD1310495 \| RGD1560065 \| RGD1563888 \| RGD1565616 \| RGD1565784 \| RGD735029 \| RGD735065 \| RHEB \| RMDN2 \| RMND1 \| RNASE4 \| RNF121 \| RNF128 \| RNF2 \| RNF5 \| RNPEP \| RNPEPL1 \| RPIA \| RPL19 \| RPL7 \| RPN1 \| RPP21 \| RPRM \| RPS27L \| RRM1 \| RRP12 \| RT1-EC2 \| RYBP \| S100G \| SAMD11 \| SAP30L \| SDC2 \| SDCBP \| SDF4 \| SELENBP1 \| SERBP1 \| SERPINA1 \| SERPINA3M \| SERPINA4 \| SERPINA5 \| SERPINA6 \| SERPINC1 \| SERPIND1 \| SERPINF1 \| SEZ6 \| SF3B3 \| SF3B4 \| SFT2D2 \| SFXN1 \| SGK1 \| SGMS1 \| SGPP1 \| SH3BGRL \| SHMT2 \| SIK3 \| SKA3 \| SKIL \| SLC13A4 \| SLC17A1 \| SLC1A2 \| SLC25A15 \| SLC25A22 \| SLC25A4 \| SLC26A1 \| SLC27A5 \| SLC30A10 \| SLC34A1 \| SLC35B1 \| SLC39A11 \| SLC44A4 \| SLC6A6 \| SLCO1A4 \| SMAD7 \| SMAGP \| SMIM26 \| SMPD3 \| SMS \| SMYD2 \| SNAP23 \| SORBS1 \| SORD \| SORT1 \| SPA17 \| SPARC \| SPATA1 \| SPATA24 \| SPDL1 \| SPG7 \| SPNS1 \| SPP2 \| SRPRB \| SRSF1 \| SRSF10 \| SRSF2 \| SSB \| SSU72 \| ST3GAL6 \| ST6GAL1 \| ST7L \| STARD10 \| STARD13 \| STOML2 \| STRBP \| SUB1 \| SUCLA2 \| SULT1C3 \| SYNC \| SYNCRIP \| SYNJ2BP \| SZRD1 \| TAB1 \| TAF10 \| TAF12 \| TAF5L \| TANGO2 \| TANK \| TARDBP \| TCEA3 \| TCEB2 \| TCP11L2 \| TFRC \| TIMM8B \| TM2D3 \| TM9SF3 \| TMA7 \| TMED2 \| TMEM116 \| TMEM14A \| TMEM161B \| TMEM194B \| TMEM218 \| TMEM242 \| TMEM30A \| TMEM37 \| TMEM56 \| TMEM82 \| TMEM98 \| TMSB4X \| TNFRSF1A \| TNFRSF9 \| TOMM20 \| TOMM6 \| TOPBP1 \| TOR1A \| TOR1AIP2 \| TPI1 \| TPM3 \| TRAPPC5 \| TRIM36 \| TRIM54 \| TRIO \| TRMT6 \| TRNAU1AP \| TRRAP \| TSC22D1 \| TSC22D3 \| TSFM \| TSPYL1 \| TSR2 \| TST \| TTC28 \| TTC39A \| TTLL9 \| TUBA4A \| TUBB2A \| TXN1 \| TXNRD1 \| TXNRD2 \| U2AF1 \| UBE2B \| UBE2F \| UBE2H \| UBE2T \| UBL3 \| UFD1 \| UGDH \| UGT2A1 \| UGT2B1 \| UGT2B10 \| UGT2B7 \| UHRF1BP1L \| URAD \| USP7 \| VDAC1 \| VEGFC \| VGLL4 \| VIPR1 \| VPS35 \| VRK1 \| WASHC2C \| WBP5 \| WDR6 \| WDR74 \| WTAP \| WWC3 \| XPNPEP2 \| YAF2 \| YBX1 \| ZBED4 \| ZBTB39 \| ZC3H7B \| ZCRB1 \| ZEB2 \| ZFP36L1 \| ZFP697 \| ZFP956 \| ZKSCAN1 \| ZNF106 \| ZNF655 \| ZNF703 \| ZNRD1 \| ZWINT	Drug-Induced Liver Injury \| Liver Neoplasms \| Methemoglobinemia \| Nose Neoplasms
8.	Duval C, et al. Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model. Environ Health Perspect. 2017 Mar;125(3):428-436.	Dietary Fats \| Tetrachlorodibenzodioxin	ACACA \| CCL2 \| CD36 \| CD68 \| COL1A1 \| COL3A1 \| CPT1A \| DGAT1 \| DGAT2 \| FASN \| G6PC \| GYS2 \| IL1B \| ITGAM \| LEP \| MLXIPL \| MOGAT1 \| MTTP \| PCK1 \| PKLR \| PPARA \| PPARG \| SCD1 \| SLC2A2 \| SREBF1 \| TGFB1	Drug-Induced Liver Injury \| Hepatomegaly \| Liver Cirrhosis \| Non-alcoholic Fatty Liver Disease \| Obesity
9.	Efferth T, et al. Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature. Arch Toxicol. 2017 Apr;91(4):1833-1846.	artesunate \| Drugs, Chinese Herbal \| temozolomide		Drug-Induced Liver Injury \| Glioblastoma
10.	El-Shitany NA, et al. Proanthocyanidin protects against cisplatin-induced oxidative liver damage through inhibition of inflammation and NF-κβ/TLR-4 pathway. Environ Toxicol. 2017 Mar 29.	Cisplatin \| Grape Seed Proanthocyanidins	BAX \| BCL2 \| CAT \| GPT \| IL1B \| IL6 \| NOS2 \| PTGS2 \| TLR4 \| TNF	Drug-Induced Liver Injury
11.	Fang ZZ, et al. Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury. Arch Toxicol. 2017 May;91(5):2235-2244.	1-Naphthylisothiocyanate \| pirinixic acid	ABCB11 \| CHKA \| CXCL1 \| CXCL2 \| CYP7A1 \| EGR1 \| GPT \| IL6 \| LCN2 \| MT1 \| MT2 \| PPARA \| RELA \| SAA1 \| SAA2 \| SCD1 \| SLC51B \| SMPD3 \| STAT3	Disease Models, Animal \| Drug-Induced Liver Injury \| Necrosis
12.	Ganai AA, et al. Genistein attenuates D-GalN induced liver fibrosis/chronic liver damage in rats by blocking the TGF-β/Smad signaling pathways. Chem Biol Interact. 2017 Jan 5;261:80-85.	Galactosamine \| Genistein	ACTA2 \| COL1A1 \| COL3A1 \| GPT \| SMAD2 \| SMAD3 \| SMAD7 \| TGFB1	Drug-Induced Liver Injury \| Liver Cirrhosis \| Liver Failure
13.	Gunasekaran V, et al. Targeting hepatocellular carcinoma with piperine by radical-mediated mitochondrial pathway of apoptosis: An in vitro and in vivo study. Food Chem Toxicol. 2017 Jul;105:106-118.	Diethylnitrosamine \| piperine	BAX \| BCL2 \| CASP3 \| CASP9 \| CAT \| CYCS \| FGFR1 \| IGF1R \| MET \| TGFBR1	Drug-Induced Liver Injury \| Hepatomegaly \| Weight Loss
14.	Guo HL, et al. Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2α-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75.	4-phenylbutyric acid \| Pyrazinamide	ATF4 \| ATF6 \| CASP3 \| DDIT3 \| EIF2AK3 \| EIF2S1 \| ERN1 \| GPT \| HSPA5 \| XBP1	Drug-Induced Liver Injury \| Tuberculosis
15.	Jiao J, et al. iTRAQ-based quantitative proteomics discovering potential serum biomarkers in locoweed poisoned rabbits. Chem Biol Interact. 2017 Apr 25;268:111-118.	Plant Preparations	A1BG \| ATP5B \| C5 \| CFB \| CFH \| CFI \| CP \| EEF1A2 \| F2 \| FETUB \| GC \| GSN \| HBB2 \| HP \| HPX \| KNG1 \| KRT10 \| KRT2 \| LGALS3BP \| RPS5 \| SERPINA3 \| SERPINC1 \| SERPIND1 \| TF \| THBS4	Brain Injuries \| Drug-Induced Liver Injury \| Kidney Diseases
16.	Joshi N, et al. Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis. Toxicology. 2017 Feb 15;377:73-80.	1-Naphthylisothiocyanate	ALPL \| COL1A1 \| ITGB6 \| RAG1 \| TGFB2	Drug-Induced Liver Injury \| Hyperplasia \| Liver Cirrhosis, Biliary
17.	Kang L, et al. Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes. Toxicol In Vitro. 2017 Apr;40:313-323.	chrysophanic acid \| Emodin \| physcione	ABCB11 \| ABCB4 \| ABCC2 \| ABCC3 \| ABCC4 \| CYP27A1 \| CYP7A1 \| CYP8B1 \| SLC10A1	Drug-Induced Liver Injury
18.	Kemelo MK, et al. The involvement of sirtuin 1 and heme oxygenase 1 in the hepatoprotective effects of quercetin against carbon tetrachloride-induced sub-chronic liver toxicity in rats. Chem Biol Interact. 2017 May 1;269:1-8.	Carbon Tetrachloride \| Quercetin	ALT \| CAT \| HMOX1 \| SIRT1	Drug-Induced Liver Injury
19.	Kim SJ, et al. Sestrin2 protects against acetaminophen-induced liver injury. Chem Biol Interact. 2017 May 1;269:50-58.	Acetaminophen	CASP3 \| GPT \| IL1B \| IL6 \| MAPK1 \| MAPK3 \| SESN2 \| TNF	Drug-Induced Liver Injury \| Hepatomegaly
20.	Marx-Stoelting P, et al. Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice. Arch Toxicol. 2017 Jan 6.	cyproconazole \| Phenobarbital \| prochloraz \| Tetrachlorodibenzodioxin	ABCC2 \| ABCC3 \| AHR \| CD36 \| CDKN1A \| CYP1A1 \| CYP2B10 \| CYP2B6 \| GADD45 \| NR1I2 \| NR1I3	Drug-Induced Liver Injury \| Liver Neoplasms
21.	Mosedale M, et al. Editor''s Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach. Toxicol Sci. 2017 Apr 1;156(2):438-454.	tolvaptan	SLPI	Drug-Induced Liver Injury
22.	Poon KL, et al. Editor''s Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models. Toxicol Sci. 2017 Mar 1;156(1):133-148.	Acetaminophen \| Amiodarone \| Diclofenac \| Flutamide \| rosiglitazone \| troglitazone	CYP2K18 \| GSR \| GSTT1B	Drug-Induced Liver Injury
23.	Poon KL, et al. Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates. Arch Toxicol. 2017 Mar;91(3):1187-1197.	1-hydroxymethylmidazolam \| 1-hydroxymethylmidazolam glucuronide \| 4-hydroxymidazolam \| Acetaminophen \| Amiodarone \| Aspirin \| Carbamazepine \| Chlorpromazine \| Clotrimazole \| Desipramine \| Diclofenac \| Flutamide \| Glutathione \| hydroxynefazodone \| Imipramine \| Indomethacin \| Ketoconazole \| Midazolam \| mono-N-desethylamiodarone \| nefazodone \| pioglitazone \| Propafenone \| rosiglitazone \| Tacrine \| troglitazone \| Verapamil	CYP3A4	Drug-Induced Liver Injury \| Drug-Related Side Effects and Adverse Reactions
24.	Seo HL, et al. Liqustri lucidi Fructus inhibits hepatic injury and functions as an antioxidant by activation of AMP-activated protein kinase in vivo and in vitro. Chem Biol Interact. 2017 Jan 25;262:57-68.	Arachidonic Acid \| Carbon Tetrachloride \| Drugs, Chinese Herbal \| Iron \| Plant Extracts	ACACA \| ALT \| BCL2L1 \| CASP3 \| GPT \| STK11	Disease Models, Animal \| Drug-Induced Liver Injury
25.	Shirato T, et al. Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis. Arch Toxicol. 2017 Mar;91(3):1319-1333.	Glutathione \| Thioacetamide	ACTA2 \| APOB \| ATF6 \| CYP2E1 \| DDIT3 \| NFE2L2 \| PLIN2 \| PRDX2 \| SCD1 \| SOD1 \| SOD2	Drug-Induced Liver Injury \| Fatty Liver \| Hepatomegaly
26.	Vispute SG, et al. Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction. Toxicology. 2017 Mar 1;378:95-106.	Acetaminophen \| Dexamethasone \| Mifepristone	CYP3A11 \| FGF21 \| GPT \| NR1I2	Drug-Induced Liver Injury
27.	Wang D, et al. Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice. Chem Biol Interact. 2017 Apr 25;268:47-52.	canadine \| tetrahydropalmatine	CYP1A2 \| CYP2E1 \| CYP3A11	Drug-Induced Liver Injury \| Edema
28.	Wang JX, et al. Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases. Toxicol Lett. 2017 Jan 4;265:38-46.	Acetaminophen \| rosiglitazone	CRP \| CXCL1 \| CYBB \| GSR \| MAPK1 \| MAPK3 \| NOX4 \| TNF	Drug-Induced Liver Injury \| Hepatomegaly \| Necrosis
29.	Wang P, et al. Hepatoprotective effect of 2''-O-galloylhyperin against oxidative stress-induced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway. Food Chem Toxicol. 2017 Apr;102:129-142.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one \| 2''-galloylhyperin \| Carbon Tetrachloride \| Hydrogen Peroxide \| Silymarin	BAX \| BCL2 \| CASP3 \| HMOX1 \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| NFE2L2	Drug-Induced Liver Injury
30.	Wang Q, et al. Methamphetamine induces hepatotoxicity via inhibiting cell division, arresting cell cycle and activating apoptosis: In vivo and in vitro studies. Food Chem Toxicol. 2017 Jul;105:61-72.	Methamphetamine	ABO2 \| BARD1 \| BUB1B \| CASP3 \| CCL12 \| CCNA2 \| CCNB1 \| CCNB2 \| CCNE1 \| CDCA3 \| CDK1 \| CENPH \| CENPQ \| CENPW \| CEP72 \| CIDEA \| CKAP2 \| COL10A1 \| CSN1S1 \| DEPDC1 \| DIAPH3 \| DYDC2 \| ECT2 \| EVC2 \| FAM154A \| FAM64A \| FOXE1 \| GBGT1 \| KIF20A \| KNSTRN \| KNTC1 \| KRT80 \| MAGEB3 \| MCC \| NCAPG \| NDC80 \| NUF2 \| OLR288 \| OLR75 \| OVCH2 \| PAIP1 \| PARP1 \| PBK \| PGBD5 \| PPP1R1B \| PRL5A2 \| PRR14L \| PSAT1 \| RGD1305928 \| RRM2 \| RTN4RL1 \| SHCBP1 \| SHISA2 \| SKA1 \| SPC25 \| SULT2A2 \| TEX13B \| TFAP2A \| TOP2A \| TRNP1 \| UBE2C \| UBE2T	Drug-Induced Liver Injury
31.	Wolenski FS, et al. Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury. Toxicol Sci. 2017 May 1;157(1):50-61.	Bile Acids and Salts \| TAK-875	ABCB11 \| ABCC2 \| ABCC3 \| ABCC4 \| FFAR1 \| SLC10A1 \| SLCO1B1 \| SLCO1B3	Drug-Induced Liver Injury
32.	Zhang DG, et al. Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation. Toxicol Appl Pharmacol. 2017 Jan 1;314:39-47.	6-ethylchenodeoxycholic acid \| Carbon Tetrachloride	AKT1 \| CCL2 \| CXCL1 \| CXCL2 \| IL1B \| IL4 \| MAPK1 \| MAPK3 \| NR1H4 \| TNF	Drug-Induced Liver Injury \| Hepatomegaly \| Necrosis
33.	Zhang N, et al. Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats. Toxicol Lett. 2017 Feb 5;267:1-10.	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide \| Ethanol \| salvianolic acid B	CRP \| CYP2E1 \| GPT \| HNF1A \| IL6 \| MLXIPL \| SIRT1 \| TNF	Drug-Induced Liver Injury \| Hepatomegaly \| Weight Gain
34.	Zhang W, et al. Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ. Toxicol Appl Pharmacol. 2017 Feb 1;316:17-26.	2-chloro-5-nitrobenzanilide \| Diethylhexyl Phthalate	GPT \| INS1 \| INSR \| PPARG \| SLC2A4	Drug-Induced Liver Injury \| Hepatomegaly \| Insulin Resistance
35.	Ahn M, et al. Hepatoprotective effects of allyl isothiocyanate against carbon tetrachloride-induced hepatotoxicity in rat. Chem Biol Interact. 2016 Jul 25;254:102-8.	allyl isothiocyanate \| Carbon Tetrachloride	AIF1 \| CAT \| GPT \| HMOX1 \| TNF	Drug-Induced Liver Injury
36.	Ajiboye TO. Lophirones B and C Attenuate Acetaminophen-Induced Liver Damage in Mice: Studies on Hepatic, Oxidative Stress and Inflammatory Biomarkers. J Biochem Mol Toxicol. 2016 Oct;30(10):497-505.	Acetaminophen \| Biflavonoids	ALB \| CAT \| CXCL8 \| GSR \| IL6 \| TNF	Drug-Induced Liver Injury
37.	Al-Attrache H, et al. Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α. Toxicol Lett. 2016 Sep 6;258:71-86.	Acetylcysteine \| benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone \| Diclofenac	ATF4 \| CASP3 \| CASP8 \| CASP9 \| CRP \| CXCL8 \| DDIT3 \| EIF2S1 \| HMOX1 \| HSPA5 \| SOD2 \| TNF	Acute Pain \| Arthritis, Rheumatoid \| Cholestasis \| Drug-Induced Liver Injury \| Osteoarthritis
38.	Alotaibi SA, et al. Prophylactic and Therapeutic Potential of Acetyl-l-carnitine against Acetaminophen-Induced Hepatotoxicity in Mice. J Biochem Mol Toxicol. 2016 Jan;30(1):5-11.	Acetaminophen \| Acetylcarnitine \| Acetylcysteine	GSR	Drug-Induced Liver Injury
39.	Alp H, et al. Protective Effects of Intralipid and Caffeic Acid Phenethyl Ester (CAPE) on Hepatotoxicity and Pancreatic Injury Caused by Dichlorvos in Rats. Biochem Genet. 2016 Dec;54(6):803-815.	Dichlorvos		Drug-Induced Liver Injury \| Necrosis \| Pancreatic Diseases
40.	Arab HH, et al. Tangeretin attenuates cisplatin-induced renal injury in rats: Impact on the inflammatory cascade and oxidative perturbations. Chem Biol Interact. 2016 Oct 25;258:205-13.	Cisplatin \| 9,10-Dimethyl-1,2-benzanthracene \| Galactosamine \| Silymarin \| Streptozocin \| tangeretin	CASP3 \| IL10 \| NFE2L2 \| NOS2 \| RELA \| TNF	Breast Neoplasms \| Diabetes Mellitus, Experimental \| Drug-Induced Liver Injury \| Drug-Related Side Effects and Adverse Reactions \| Kidney Diseases
41.	Atawia RT, et al. Telmisartan ameliorates carbon tetrachloride-induced acute hepatotoxicity in rats. Environ Toxicol. 2016 Mar 1.	Carbon Tetrachloride \| telmisartan	CAT \| GPT \| MPO \| NOS2 \| PTGS2 \| RELA \| TNF	Drug-Induced Liver Injury
42.	Caballero-Gallardo K, et al. Mice housed on coal dust-contaminated sand: A model to evaluate the impacts of coal mining on health. Toxicol Appl Pharmacol. 2016 Mar 1;294:11-20.	Coal \| Dust	CYP1A1 \| NQO1 \| SCD1 \| SOD1	Chromosome Breakage \| Drug-Induced Liver Injury \| Micronuclei, Chromosome-Defective \| Non-alcoholic Fatty Liver Disease \| Pneumonia
43.	Calvano J, et al. Serum microRNAs-217 and -375 as biomarkers of acute pancreatic injury in rats. Toxicology. 2016 Aug 10;368-369:1-9.	Acetaminophen \| Ceruletide \| Streptozocin	MIR216A \| MIR216B \| MIR217 \| MIR375	Drug-Induced Liver Injury \| Hemorrhage \| Necrosis \| Pancreatic Diseases
44.	Darrow LA, et al. Modeled Perfluorooctanoic Acid (PFOA) Exposure and Liver Function in a Mid-Ohio Valley Community. Environ Health Perspect. 2016 Mar 15.	perfluorooctanoic acid	GPT	Drug-Induced Liver Injury \| Liver Diseases
45.	den Braver MW, et al. Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines. Toxicol Lett. 2016 Jun 24;253:46-54.	4'-hydroxydiclofenac \| Diclofenac	CYP2C9 \| CYP3A4	Drug-Induced Liver Injury
46.	den Braver MW, et al. Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. Toxicol Lett. 2016 Jul 25;255:52-62.	Diclofenac	GSTA1 \| GSTA3 \| GSTA4 \| GSTM1 \| GSTM2 \| GSTM4 \| GSTP1 \| GSTT1	Drug-Induced Liver Injury
47.	Donato MT, et al. Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development. Toxicol Lett. 2016 Nov 30;263:58-67.	Amikacin \| Amiodarone \| Amitriptyline \| Azathioprine \| bosentan \| Chlorpromazine \| Cyclosporine \| Doxycycline \| Ethinyl Estradiol \| Fenofibrate \| Glyburide \| Maprotiline \| Metformin \| 1-Naphthylisothiocyanate \| Perhexiline \| Simvastatin \| sodium citrate \| Tamoxifen \| Tetracycline \| tianeptine \| Ticlopidine \| troglitazone \| Valproic Acid \| Zidovudine	ABCB11 \| ABCB4 \| ABCC2 \| ABCC3 \| ABCC4 \| ABCG2 \| ABCG5 \| ABCG8 \| NR1H4 \| NR1I2 \| SLC10A1 \| SLCO1A1	Drug-Induced Liver Injury
48.	Duan L, et al. Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. Food Chem Toxicol. 2016 Dec;98(Pt B):107-118.	Acetaminophen	AIFM1 \| BAX \| DIABLO \| GPT \| SH3BP5	Drug-Induced Liver Injury
49.	Du K, et al. Editor''s Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction. Toxicol Sci. 2016 Dec;154(2):214-226.	Acetaminophen \| Metformin	AIFM1 \| BAX \| DIABLO \| GPT	Drug-Induced Liver Injury
50.	Du Z, et al. TPhP exposure disturbs carbohydrate metabolism, lipid metabolism, and the DNA damage repair system in zebrafish liver. Sci Rep. 2016 Feb 22;6:21827.	triphenyl phosphate	ABCC8 \| ANGPTL4 \| ANPEPB \| AOC1 \| ASH1L \| BDH1 \| CCNB1 \| CCNE1 \| CD36 \| CD82B \| CHEK2 \| CHIA.4 \| CHS1 \| CYP11A1 \| CYP17A1 \| CYP1A1 \| CYP7A1 \| DNMT1 \| ELOVL6 \| ELOVL7B \| FAAH2B \| FABP1A \| FEN1 \| FMO5 \| FUK \| GADD45A \| GBGT1L4 \| INS \| LPL \| PPT1 \| RRM1 \| RRM2B \| SDHDA \| ST3GAL1 \| TPI1A \| TPI1B	Drug-Induced Liver Injury

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