Chemically-Induced Disorders - Chemicals

These chemicals are associated with Chemically-Induced Disorders or its descendants. A chemical has either a curated association to the disease (M marker/mechanism and/or T therapeutic) or an inferred association via a curated gene interaction.

1–50 of 76,636 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Methamphetamine	Amphetamine-Related Disorders	M	72 genes: ACSL6 \| ADORA2A \| AK5 \| AKT1 \| AOAH \| ARRB2 \| ASTN2 \| BDNF \| CCHCR1 \| CD55 \| CDH13 \| CENPCP1 \| COL28A1 \| COMT \| CSMD1 \| CUBN \| CYP2D6 \| DCSTAMP \| DRD1 \| DRD2 \| DRD3 \| DRD4 \| EPHX1 \| FHIT \| FKBP15 \| FOS \| GABRG2 \| GDNF \| GRM2 \| GSTM1 \| GSTP1 \| GSTT1 \| HS3ST4 \| HTR3A \| HTR6 \| LARGE1 \| LINGO2 \| MAP2K5 \| MARC1 \| MARC2 \| MYO5B \| NOS1 \| NPY1R \| NRG1 \| OPRM1 \| PCOLCE2 \| PDE4B \| PDE4D \| PDE6C \| PDYN \| PICK1 \| PLAT \| POU5F1 \| PRDM2 \| PRKG1 \| PROKR2 \| PSD3 \| RALY \| RAPGEF5 \| RELA \| RGS17 \| SERPINA5 \| SGCZ \| SH3RF3 \| SLC6A3 \| SLC6A4 \| SLC6A9 \| SMYD3 \| SNCA \| TRPM3 \| USP48 \| ZNF385D	172.98	76
2.	Arsenic	Arsenic Poisoning	M	60 genes: AKAP9 \| AQP9 \| AS3MT \| ATXN7 \| CCL20 \| CCL3L3 \| CCL4 \| CCRL2 \| CD44 \| CD83 \| CRP \| CXCL2 \| CXCL3 \| ERCC1 \| ERCC3 \| ERCC4 \| GADD45B \| GOLGA4 \| HSPA1B \| ID2 \| IER3 \| IL1A \| IL1B \| IL1RN \| INPP5A \| KCNJ2 \| MINPP1 \| MT1A \| MTHFR \| N4BP2L2 \| NDUFB8 \| NR4A2 \| PDE4B \| PELI1 \| PFKFB3 \| PIAS1 \| PNP \| PTX3 \| RFX3 \| RGS1 \| RUFY3 \| SFPQ \| SKIL \| SOD2 \| SOX18 \| SRP68 \| SSBP1 \| TAF1D \| TNF \| TNFAIP6 \| TNIK \| TP53 \| TRA2A \| TRAPPC10 \| UBE2E1 \| USO1 \| USP13 \| ZFAND6 \| ZNF267 \| ZNF331	115.21	30
3.	bisphenol A	Drug-Induced Liver Injury	M	188 genes: ABCB1 \| ABCB1A \| ABCB1B \| ABCC1 \| ABCC2 \| ADAM8 \| ADIPOQ \| AHR \| AIFM1 \| ALB \| ALDOB \| AMBP \| ANXA2 \| APOA1 \| APOE \| APOH \| ARG1 \| ARNT \| ATG5 \| ATOH8 \| ATP6V1D \| BAX \| BDH1 \| BTD \| C3 \| CADPS2 \| CAT \| CCDC80 \| CCL2 \| CCR2 \| CDC25B \| CDS1 \| CELA1 \| CHRM3 \| CLU \| COL14A1 \| COL3A1 \| CP \| CSF3 \| CTNNB1 \| CTSE \| CXCL1 \| CXCL10 \| CYP2A6 \| CYP2C19 \| CYP2C9 \| CYP2E1 \| CYP3A23/3A1 \| DGAT2 \| DHRS7 \| DNAJB9 \| DNAJC12 \| DSC2 \| ECHDC1 \| EIF2AK1 \| ENO1 \| EPHX1 \| ERLEC1 \| FADS1 \| FADS2 \| FASN \| FCMR \| FGA \| FLT1 \| FMO3 \| GADD45A \| GC \| GCLC \| GGH \| GOT1 \| GPT \| GSN \| GSR \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| GSTT1B \| GULO \| HACL1 \| HADHA \| HAO2 \| HAVCR1 \| HLA-DRB1 \| HMGB1 \| HMOX1 \| HPX \| HRH2 \| IFNG \| IGF1 \| IL11 \| IL17A \| IL18 \| IL1A \| IL1B \| IL22 \| IL4 \| IL6 \| ITPR1 \| KNG1 \| KRT18 \| LBP \| LCN2 \| LGALS3 \| LRAT \| LTF \| MAP1LC3B \| MAP3K5 \| MDH1 \| MED1 \| MIR107 \| MIR141 \| MIR149 \| MIR192 \| MIR19A \| MIR200C \| MIR27B \| MMP2 \| MST1R \| MTHFR \| NAT2 \| NFE2L2 \| NOX4 \| NR1H3 \| NR1H4 \| NR1I2 \| NR1I3 \| NREP \| OAS1A \| PAN2 \| PCOLCE \| PCYT1A \| PDK4 \| PEX11A \| PLAT \| PLG \| PNP \| POLG \| PON1 \| PPARA \| PPTC7 \| PRKDC \| PTF1A \| PTGS2 \| PZP \| RBP1 \| RDH13 \| REEP5 \| RGN \| S100A11 \| SELENBP1 \| SERPINA6 \| SERPING1 \| SESN2 \| SGF29 \| SLC13A4 \| SLC22A8 \| SLC25A29 \| SLPI \| SNX18 \| SOD1 \| SOD2 \| SOD3 \| SORD \| SORL1 \| SPP1 \| SRP72 \| SULT1C3 \| SULT1E1 \| TAGLN2 \| TALDO1 \| TBXA2R \| TCTN1 \| TF \| TMED7 \| TMEM117 \| TMEM164 \| TMEM38B \| TNF \| TTR \| UBA5 \| UGT1A9 \| UNC93B1 \| VIM \| WASL \| ZDHHC23	104.52	108
4.	bisphenol A	Poisoning	M	16 genes: ABCB1 \| ACHE \| ALB \| BCHE \| CDKN2A \| CDKN2B \| CSF3 \| CST3 \| CYP4F3 \| EPO \| GCG \| GSK3B \| HAND1 \| PRKDC \| SLC22A2 \| XIRP1	86.53	15
5.	Tetrachlorodibenzodioxin	Poisoning	M	10 genes: ABCB1 \| ACHE \| ALB \| CDKN2A \| CDKN2B \| CSF3 \| CST3 \| GSK3B \| HAND1 \| XIRP1	67.33	11
6.	Amphetamine	Cocaine-Related Disorders	M	32 genes: ARC \| BDNF \| CALM1 \| CALM2 \| CARTPT \| CCKBR \| CHRM5 \| COMT \| CREB1 \| CRH \| CRHR2 \| DRD1 \| DRD2 \| DRD3 \| EGR1 \| FGF2 \| FOS \| FOSB \| GABRG2 \| GAD1 \| GDNF \| GRIA2 \| GRIN1 \| GRM5 \| HCRTR1 \| HTR1B \| JUND \| MAPK1 \| MAPK3 \| NPY \| PDYN \| SLC6A3	63.78	69
7.	Methapyrilene	Drug-Induced Liver Injury	M	53 genes: ABCB1B \| ABCC2 \| ALDOB \| ANXA2 \| BAX \| BDH1 \| CCL2 \| CXCL1 \| CXCL10 \| CYP2C11 \| CYP3A23/3A1 \| EPHX1 \| FGA \| GADD45A \| GCLC \| GPT \| GSR \| GSTM2 \| GULO \| HMOX1 \| IL1A \| IL1B \| IL6 \| LGALS3 \| MIR10B \| MIR122 \| MIR149 \| MIR181C \| MIR192 \| MIR19A \| MIR200C \| MIR22 \| MIR27B \| MIR30A \| MIR30C-1 \| MIR327 \| MIR337 \| MIR34C \| MIR351 \| MIR410 \| MIR503 \| MIR687 \| MIR697 \| MIR704 \| MIR744 \| MIR877 \| MIR879 \| NR1H4 \| NR1I2 \| NR1I3 \| OBP3 \| PPARA \| SPP1	62.83	35
8.	Valproic Acid	Poisoning	M	12 genes: ABCB1 \| ACHE \| ALB \| BCHE \| CDKN2A \| CDKN2B \| CSF3 \| CST3 \| GSK3B \| HAND1 \| PRKDC \| SLC22A2	59.68	14
9.	1-Naphthylisothiocyanate	Drug-Induced Liver Injury	M	80 genes: ABCB1 \| ABCC1 \| ABCC2 \| AHR \| ANXA2 \| ATP6V1D \| BAX \| BDH1 \| C3 \| CAR3 \| CAT \| CCL2 \| CLU \| COL3A1 \| CP \| CTSE \| CXCL1 \| CXCL10 \| CYP2C11 \| CYP2C9 \| CYP2E1 \| CYP3A23/3A1 \| CYP8B1 \| DHRS7 \| DNAJB9 \| F2RL3 \| FASN \| FGA \| FMO3 \| GADD45A \| GC \| GCLC \| GPT \| GSR \| GSTM2 \| GSTM3 \| GSTP1 \| GSTT1 \| HAO2 \| HAVCR1 \| HMOX1 \| IFNG \| IL17A \| IL1B \| IL6 \| KNG1 \| KRT18 \| LBP \| LCN2 \| LGALS3 \| LRAT \| MDH1 \| MIR218-1 \| MIR337 \| MIR351 \| MIR704 \| NFE2L2 \| NOX4 \| NR1H3 \| NR1H4 \| NR1I2 \| NR1I3 \| NREP \| OLR59 \| PLAT \| PON1 \| PPARA \| PTGS2 \| REEP5 \| RGN \| S100A11 \| SERPINA6 \| SLC22A8 \| SOD2 \| SPP1 \| TAGLN2 \| TNF \| TTR \| UST5R \| VIM	56.72	83
10.	Streptozocin	Drug-Induced Liver Injury	M	80 genes: ABCB1B \| ABCC1 \| ABCC2 \| ADIPOQ \| AHR \| AIFM1 \| ALB \| ALDOB \| APOA1 \| APOE \| ATG5 \| BAX \| BDH1 \| CAR3 \| CAT \| CCL2 \| CHRM3 \| CLU \| COL3A1 \| CP \| CYP2C11 \| CYP2E1 \| CYP8B1 \| DHRS7 \| EDEM1 \| ENO1 \| EPHX1 \| FADS1 \| FASN \| FLT1 \| GCLC \| GOT1 \| GPT \| GSR \| GSTM2 \| GSTM3 \| GSTP1 \| GULO \| HAO2 \| HAVCR1 \| HMGB1 \| HMOX1 \| IFNG \| IGF1 \| IL17A \| IL18 \| IL1A \| IL1B \| IL22 \| IL4 \| IL6 \| KNG1 \| LCN2 \| LGALS3 \| MAP3K5 \| MDH1 \| MIR10A \| MIR132 \| MIR217 \| MIR697 \| MIR744 \| MIR879 \| MMP2 \| NFE2L2 \| NOX4 \| NR1H3 \| OLR59 \| POLG \| PPARA \| PTGS2 \| SERPINA6 \| SOD1 \| SOD2 \| SOD3 \| SORD \| SPP1 \| TNF \| TTR \| VIM \| ZDHHC23	52.11	66
11.	2-Acetylaminofluorene	Drug-Induced Liver Injury	M	50 genes: ABCB1 \| ABCB1A \| ABCB1B \| ABCC1 \| ABCC2 \| AHR \| ALB \| ATP6V1D \| BAX \| CAT \| CCL2 \| CLU \| CXCL1 \| CXCL10 \| CYP2E1 \| CYP3A23/3A1 \| ENO1 \| EPHX1 \| GCLC \| GSR \| GSTM1 \| GSTP1 \| HADHA \| HMOX1 \| IFNA2 \| IFNG \| IL1B \| IL6 \| MIR132 \| MIR181C \| MIR200C \| MIR22 \| MIR410 \| MMP2 \| MTHFR \| NAT2 \| NFE2L2 \| NR1I2 \| PTGS2 \| RGN \| S100A11 \| SESN2 \| SOD1 \| SOD2 \| SULT1E1 \| TALDO1 \| TF \| TNF \| TTR \| UGT1A9	46.88	52
12.	Valproic Acid	Drug-Induced Liver Injury	M	169 genes: ABCB1 \| ABCB1A \| ABCC1 \| ABCC2 \| ADIPOQ \| AHR \| AIFM1 \| ALB \| ANXA2 \| APOA1 \| APOE \| ARG1 \| ARNT \| ATG5 \| ATOH8 \| ATP6V1D \| BAX \| BDH1 \| BTD \| C3 \| CADPS2 \| CAR3 \| CAT \| CCDC80 \| CCL2 \| CCR2 \| CDC25B \| CDS1 \| CELA1 \| CHRM3 \| CLU \| COL14A1 \| COL3A1 \| CP \| CSF3 \| CTNNB1 \| CXCL1 \| CXCL10 \| CYP2A5 \| CYP2A6 \| CYP2C19 \| CYP2C9 \| CYP2E1 \| CYP3A23/3A1 \| CYP8B1 \| DGAT2 \| DHFR \| DHRS7 \| DNAJB9 \| DNAJC12 \| DSC2 \| ECHDC1 \| EDEM1 \| EIF2AK1 \| ENO1 \| EPHX1 \| ERLEC1 \| FADS1 \| FADS2 \| FASN \| FGA \| FLT1 \| FMO3 \| GADD45A \| GCLC \| GGH \| GOT1 \| GPT \| GSN \| GSR \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| GSTT1B \| HACL1 \| HADHA \| HAO2 \| HBA-A1 \| HLA-A \| HLA-B \| HLA-DQB1 \| HLA-DRB1 \| HMGB1 \| HMOX1 \| HPX \| IFNG \| IGF1 \| IL11 \| IL18 \| IL1A \| IL1R2 \| IL6 \| ITPR1 \| KITL \| KNG1 \| KRT18 \| LGALS3 \| LRAT \| MAP1LC3B \| MAP3K5 \| MDH1 \| MIR10A \| MIR10B \| MIR181C \| MIR217 \| MIR351 \| MIR592 \| MMP2 \| MTHFR \| NAT2 \| NFE2L2 \| NFXL1 \| NOX4 \| NR1H3 \| NR1H4 \| NR1I2 \| NREP \| PAN2 \| PCOLCE \| PCYT1A \| PDK4 \| PEX11A \| PLAT \| PLG \| PNP \| POLG \| PON1 \| PPARA \| PRKDC \| PTGS2 \| RBP1 \| RDH13 \| REEP5 \| RGN \| S100A11 \| SELENBP1 \| SERPINA6 \| SERPING1 \| SESN2 \| SGF29 \| SLC10A7 \| SLC13A4 \| SLC25A29 \| SNX18 \| SOD1 \| SOD2 \| SORD \| SORL1 \| SPP1 \| SRP72 \| TAGLN2 \| TALDO1 \| TBXA2R \| TCTN1 \| TF \| TMED7 \| TMEM117 \| TMEM164 \| TMEM38B \| TNF \| TTR \| UBA5 \| UNC93B1 \| VIM \| WASL \| ZDHHC23	46.57	129
13.	Valproic Acid	Drug-Related Side Effects and Adverse Reactions	M	53 genes: ABCB1 \| ABCB1A \| ABCC1 \| ABCC12 \| ABCC2 \| ABCC4 \| ABCG2 \| ACHE \| ADORA1 \| ADORA2A \| ALB \| ARID5B \| ATIC \| BCHE \| CES2 \| CLU \| COMMD1 \| CSF3 \| CYP1A2 \| CYP2C9 \| CYP2E1 \| DHFR \| EPHX2 \| FGA \| HLA-B \| HLA-C \| HMGB1 \| HMOX1 \| HSPB6 \| IGF1 \| IGFBP1 \| IL3 \| KITLG \| MTHFR \| MTR \| MTRR \| NAT1 \| NAT2 \| NFE2L2 \| PLK2 \| PPARA \| PTGS2 \| SHMT1 \| SLC34A2 \| SLCO1B1 \| SPP1 \| TCN2 \| TOP1 \| TRP53 \| TXN1 \| TYMS \| UGT1A1 \| VKORC1	44.50	63
14.	Cannabinoids	Marijuana Abuse	M	7 genes: APOL2 \| CALM1 \| CALM2 \| CAMK2B \| FDFT1 \| GCC1 \| SCARB1	44.18	2
15.	Phencyclidine	Phencyclidine Abuse	M	7 genes: APOL2 \| CALM1 \| CALM2 \| CAMK2B \| FDFT1 \| GCC1 \| SCARB1	43.74	1
16.	Tetrachlorodibenzodioxin	Drug-Related Side Effects and Adverse Reactions	M	57 genes: ABCB1 \| ABCB1A \| ABCC1 \| ABCC12 \| ABCC2 \| ABCC4 \| ABCG2 \| ACHE \| ADORA1 \| ADORA2A \| ALB \| ARID5B \| ATIC \| CES2 \| CLU \| COMMD1 \| CSF2 \| CSF3 \| CYP1A2 \| CYP2C9 \| CYP2E1 \| DHFR \| EPHX2 \| FGA \| HLA-B \| HLA-C \| HMGB1 \| HMOX1 \| HOMER1 \| HSPB6 \| IGF1 \| IGFBP1 \| IL3 \| KITLG \| MTRR \| NAT1 \| NAT2 \| NFE2L2 \| PLK2 \| PPARA \| PTGS2 \| SHMT1 \| SLC19A1 \| SLC34A2 \| SLCO1B1 \| SLCO2A1 \| SPP1 \| TCN2 \| THBD \| TLR1 \| TLR2 \| TOP1 \| TRP53 \| TXN1 \| TYMS \| UGT1A1 \| VKORC1	43.71	53
17.	Manganese	Manganese Poisoning	M	13 genes: ATP13A2 \| BLI-3 \| BNIP3 \| CYP2D6 \| DAT-1 \| HTT \| IFNG \| IL1B \| NOS2 \| PRKN \| SKN-1 \| SNCA \| TNF	42.76	34
18.	Diclofenac	Drug-Induced Liver Injury	M	60 genes: ABCB1A \| ABCB1B \| ABCC1 \| ABCC2 \| AIFM1 \| ALB \| ARNT \| BAX \| CAT \| CCL2 \| CLU \| CTNNB1 \| CXCL1 \| CYP2C19 \| CYP2C9 \| CYP2K18 \| CYP3A23/3A1 \| DHFR \| DNAJB9 \| EIF2AK1 \| EPHX1 \| FASN \| GADD45A \| GC \| GCLC \| GOT1 \| GPT \| GSR \| GSTM1 \| GSTM2 \| GSTM4 \| GSTP1 \| GSTT1 \| GSTT1B \| HAVCR1 \| HLA-DRB1 \| HMGB1 \| HMOX1 \| IFNG \| IL17A \| IL1A \| IL1B \| IL4 \| IL6 \| KNG1 \| LCN2 \| MIR122 \| NFE2L2 \| NR1I2 \| NR1I3 \| POLG \| PTGS2 \| RGN \| SLC22A8 \| SOD2 \| SORD \| TNF \| TTR \| UGT1A9 \| VIM	41.28	112
19.	Amphetamine	Amphetamine-Related Disorders	M	16 genes: ACHE \| ADORA2A \| AKT1 \| BDNF \| COMT \| CYP2D6 \| DRD1 \| DRD2 \| DRD3 \| FOS \| GABRG2 \| GDNF \| HTR1B \| PDYN \| SLC6A3 \| SLC6A9	39.47	38
20.	fumonisin B1	Drug-Induced Liver Injury	M	41 genes: ABCB1 \| AHR \| ALDOB \| ANXA2 \| BAX \| CAR3 \| CAT \| CCL2 \| CLU \| CP \| CTNNB1 \| CXCL1 \| CYP2E1 \| CYP8B1 \| EPHX1 \| FMO3 \| GSTM1 \| GSTM2 \| GSTM3 \| HMOX1 \| HPX \| IFNG \| IGF1 \| IL1A \| IL1B \| IL6 \| KRT18 \| MIR27B \| NFE2L2 \| NR1I3 \| PON1 \| PPARA \| PZP \| RGN \| S100A11 \| SERPINA6 \| SERPING1 \| SOD1 \| TAGLN2 \| TNF \| TTR	39.20	43
21.	Chenodeoxycholic Acid	Drug-Induced Liver Injury	M	25 genes: ABCC1 \| ABCC2 \| APOA1 \| BAX \| CCL2 \| CSF3 \| CXCL1 \| CXCL10 \| CYP2C11 \| CYP3A23/3A1 \| CYP8B1 \| GCLC \| GPT \| GSTM1 \| GSTM2 \| HMOX1 \| IFNG \| MAP1LC3B \| NFE2L2 \| NR1H4 \| NR1I2 \| NR1I3 \| PON1 \| PPARA \| PTGS2	38.30	38
22.	arsenic trioxide	Arsenic Poisoning	M	30 genes: AKAP9 \| AQP9 \| CCL20 \| CCL4 \| CD44 \| CRP \| CXCL2 \| ERCC4 \| GADD45B \| HSPA1B \| ID2 \| IL1A \| IL1B \| IL1RN \| KCNJ2 \| MT1A \| NR4A2 \| PDE4B \| PELI1 \| PIAS1 \| PNP \| SFPQ \| SOD2 \| SOX18 \| SSBP1 \| TAF1D \| TNF \| TNFAIP6 \| TP53 \| TRA2A	37.95	11
23.	Tetrachlorodibenzodioxin	Drug-Induced Liver Injury	M	192 genes: ABCB1 \| ABCB1A \| ABCB1B \| ABCC1 \| ABCC2 \| ADAM8 \| ADIPOQ \| AHR \| AIFM1 \| ALB \| ALDOB \| AMBP \| ANXA2 \| APOA1 \| APOE \| APOH \| ARG1 \| ARNT \| ATG5 \| ATOH8 \| ATP6V1D \| BAX \| BDH1 \| BTD \| C3 \| CADPS2 \| CAR3 \| CAT \| CCDC80 \| CCL2 \| CCR2 \| CDC25B \| CDS1 \| CELA1 \| CLU \| COL14A1 \| COL3A1 \| CP \| CSF3 \| CTNNB1 \| CTSE \| CXCL1 \| CXCL10 \| CYP2A5 \| CYP2A6 \| CYP2C11 \| CYP2C19 \| CYP2C9 \| CYP2E1 \| CYP3A23/3A1 \| CYP8B1 \| DGAT2 \| DHFR \| DHRS7 \| DNAJB9 \| DNAJC12 \| DSC2 \| ECHDC1 \| EDEM1 \| EIF2AK1 \| ENO1 \| EPHX1 \| ERLEC1 \| FADS1 \| FADS2 \| FASN \| FGA \| FLT1 \| FMO3 \| GADD45A \| GC \| GCLC \| GGH \| GOT1 \| GPT \| GSN \| GSR \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| GSTT1B \| GULO \| HACL1 \| HADHA \| HAO2 \| HBA-A1 \| HLA-A \| HLA-B \| HLA-DRB1 \| HMGB1 \| HMOX1 \| HPD \| HPX \| HRH2 \| IFNA2 \| IFNG \| IGF1 \| IL11 \| IL17A \| IL18 \| IL1A \| IL1B \| IL1R2 \| IL22 \| IL4 \| IL6 \| ITPR1 \| KITL \| KNG1 \| KRT18 \| LBP \| LCN2 \| LGALS3 \| LRAT \| LTF \| MAP1LC3B \| MAP3K5 \| MDH1 \| MED1 \| MIR122 \| MIR141 \| MMP2 \| MST1R \| NAT2 \| NFE2L2 \| NFXL1 \| NOX4 \| NR1H3 \| NR1H4 \| NR1I2 \| NR1I3 \| NREP \| OAS1A \| OBP3 \| OLR59 \| PAN2 \| PCOLCE \| PCYT1A \| PDK4 \| PEX11A \| PLAT \| PLG \| POLG \| PON1 \| PPARA \| PPTC7 \| PTGS2 \| PZP \| RBP1 \| RDH13 \| REEP5 \| RGN \| S100A11 \| SELENBP1 \| SERPINA6 \| SERPING1 \| SESN2 \| SGF29 \| SLC10A7 \| SLC13A4 \| SLC22A8 \| SLC25A29 \| SLPI \| SNX18 \| SOD1 \| SOD2 \| SOD3 \| SORD \| SORL1 \| SPP1 \| SRP72 \| SULT1C3 \| SULT1E1 \| TAGLN2 \| TALDO1 \| TBXA2R \| TF \| TMED7 \| TMEM164 \| TMEM38B \| TNF \| TTR \| UBA5 \| UGT1A9 \| UNC93B1 \| UST5R \| VIM \| WASL \| ZDHHC23	37.00	118
24.	Lithocholic Acid	Drug-Induced Liver Injury	M	35 genes: ABCB1 \| ABCB1B \| ABCC1 \| ABCC2 \| ALB \| ANXA2 \| BAX \| CTNNB1 \| CYP2C11 \| CYP2C9 \| CYP2E1 \| CYP3A23/3A1 \| CYP8B1 \| EPHX1 \| FADS1 \| FADS2 \| FASN \| GCLC \| GPT \| GSTM1 \| GSTM2 \| HLA-B \| HMOX1 \| IL1B \| IL6 \| MMP2 \| NFE2L2 \| NR1H3 \| NR1H4 \| NR1I2 \| NR1I3 \| PPARA \| PTGS2 \| SOD1 \| TNF	36.44	53
25.	Cyclosporine	Poisoning	M	9 genes: ABCB1 \| ACHE \| ALB \| BCHE \| CDKN2B \| CST3 \| EPO \| GSK3B \| SLC22A2	36.10	12
26.	Malathion	Neurotoxicity Syndromes	M	15 genes: ADD3 \| BCHE \| CASP3 \| CCK \| CRISPLD2 \| CYP3A5 \| LAT \| MTOR \| NQO1 \| P2RX1 \| PLAT \| RNASE6 \| SRSF5 \| ST8SIA1 \| TIMP3	36.05	8
27.	Deoxycholic Acid	Drug-Induced Liver Injury	M	27 genes: ABCB1 \| ABCC1 \| ABCC2 \| ADIPOQ \| BAX \| CCL2 \| CSF3 \| CXCL1 \| CXCL10 \| CYP2C11 \| CYP2E1 \| CYP8B1 \| GCLC \| GSTP1 \| HMOX1 \| IFNG \| IL1B \| IL6 \| MDH1 \| NFE2L2 \| NR1H4 \| NR1I2 \| NR1I3 \| PTGS2 \| SLC22A8 \| SOD2 \| TNF	35.97	40
28.	sodium arsenite	Arsenic Poisoning	M	30 genes: AKAP9 \| AQP9 \| AS3MT \| CCL20 \| CCL4 \| CD44 \| CRP \| CXCL2 \| CXCL3 \| ERCC1 \| ERCC4 \| GADD45B \| HSPA1B \| ID2 \| IER3 \| IL1A \| IL1B \| IL1RN \| KCNJ2 \| KRT10 \| MT1A \| MTHFR \| NR4A2 \| SOD2 \| TAF1D \| TNF \| TNFAIP6 \| TP53 \| UBE2E1 \| ZNF267	35.92	24
29.	Pentobarbital	Substance Withdrawal Syndrome	M	18 genes: BDNF \| CNR1 \| CRH \| DRD2 \| FOS \| GNAI1 \| GNAO1 \| GNAS \| GRIA2 \| GRIN2A \| HCRTR1 \| MAPK1 \| MAPK3 \| NPY \| PBW1 \| POMC \| PRL \| REN	35.83	25
30.	bromobenzene	Drug-Induced Liver Injury	M	29 genes: ABCB1A \| ALB \| AMBP \| APOH \| ARG1 \| CYP2C11 \| CYP2E1 \| EPHX1 \| GC \| GCLC \| GOT1 \| GPT \| GSTM1 \| GSTM2 \| GSTP1 \| GSTT1 \| HBA-A1 \| HMOX1 \| IGF1 \| NFE2L2 \| NOX4 \| PTGS2 \| PZP \| RGN \| SELENBP1 \| SOD1 \| SORD \| TF \| TTR	35.48	34
31.	Dopamine	Substance Withdrawal Syndrome	M	22 genes: ADORA1 \| BDNF \| CHRM5 \| CHRNA6 \| CHRNB2 \| CHRNB4 \| CREB1 \| DRD2 \| FOS \| GRIA1 \| GRIA2 \| HCRTR1 \| HRH1 \| HTR2C \| MAPK1 \| MAPK3 \| NOS2 \| NPY \| OPRK1 \| POMC \| PRL \| SLC6A4	35.37	29
32.	Aspirin	Asthma, Aspirin-Induced	M	11 genes: CCR3 \| CYSLTR1 \| CYSLTR2 \| LTC4S \| MS4A2 \| PTGDR2 \| PTGER2 \| PTGIR \| PTGS2 \| TBX21 \| TBXA2R	34.74	19
33.	hexachlorobutadiene	Drug-Induced Liver Injury	M	16 genes: ALB \| CCL2 \| CLU \| EPHX1 \| GCLC \| GSR \| GSTM1 \| GSTM4 \| HAVCR1 \| HMOX1 \| IL1B \| KNG1 \| LCN2 \| MMP2 \| RGN \| SPP1	34.74	17
34.	Taurocholic Acid	Drug-Induced Liver Injury	M	22 genes: ABCB1 \| ABCC1 \| ABCC2 \| APOA1 \| CCL2 \| CSF3 \| CXCL1 \| CXCL10 \| CYP2C11 \| IL1B \| IL6 \| MAP1LC3B \| MMP2 \| NR1H4 \| NR1I2 \| NR1I3 \| PON1 \| PTGS2 \| SLC22A8 \| SOD1 \| SOD2 \| TNF	34.50	24
35.	ciprofibrate	Drug-Induced Liver Injury	M	25 genes: ABCB1A \| ABCB1B \| ANXA2 \| APOA1 \| BDH1 \| CAT \| CYP2E1 \| CYP3A23/3A1 \| GCLC \| GSTM1 \| IL1B \| LCN2 \| MED1 \| NR1H3 \| NR1I3 \| PDK4 \| PEX11A \| PON1 \| PPARA \| PTGS2 \| SOD1 \| SOD2 \| TAGLN2 \| TNF \| UGT1A9	33.39	29
36.	Emodin	Drug-Induced Liver Injury	M	27 genes: ABCB1 \| ABCB1A \| ABCB1B \| ABCC2 \| AHR \| BAX \| CAT \| COL3A1 \| CXCL1 \| CYP2C19 \| CYP2C9 \| CYP8B1 \| DHFR \| GSTM3 \| GSTP1 \| HMOX1 \| IFNA2 \| IL1B \| IL4 \| IL6 \| ITPR1 \| NFE2L2 \| NR1H3 \| SOD1 \| SOD2 \| TNF \| UGT1A9	33.34	35
37.	Dimethylnitrosamine	Drug-Induced Liver Injury	M	63 genes: ABCB1 \| ABCB1A \| ABCB1B \| ALB \| ANXA2 \| ATP6V1D \| BAX \| BDH1 \| CAR3 \| CAT \| CCL2 \| CELA1 \| COL3A1 \| CSF3 \| CTSE \| CXCL1 \| CXCL10 \| CYP2A6 \| CYP2C11 \| CYP2E1 \| CYP3A23/3A1 \| DHRS7 \| EPHX1 \| GADD45A \| GC \| GCLC \| GGH \| GOT1 \| GPT \| GSN \| GSR \| GULO \| HAO2 \| HMOX1 \| HPD \| IL18 \| IL1A \| IL1B \| IL6 \| KRT18 \| LBP \| LCN2 \| LGALS3 \| LRAT \| MDH1 \| MMP2 \| NOX4 \| NREP \| OBP3 \| OLR59 \| PLAT \| RGN \| S100A11 \| SERPINA6 \| SLC22A8 \| SOD1 \| SPIN2A \| SPP1 \| SULT1E1 \| TAGLN2 \| TNF \| UST5R \| VIM	33.28	43
38.	Galactosamine	Drug-Induced Liver Injury	M	20 genes: ALB \| AMBP \| BAX \| CAT \| CCL2 \| COL3A1 \| CXCL1 \| GPT \| HMOX1 \| IFNG \| IL18 \| IL1B \| IL6 \| NFE2L2 \| PPARA \| PTGS2 \| SESN2 \| SOD1 \| SPP1 \| TNF	32.84	48
39.	methylmercuric chloride	Poisoning	M	8 genes: ABCB1 \| ACHE \| ALB \| BCHE \| CDKN2A \| GSK3B \| HAND1 \| XIRP1	32.82	14
40.	Chloroform	Drug-Induced Liver Injury	M	22 genes: ABCB1 \| ABCB1B \| ANXA2 \| CAT \| CCL2 \| CLU \| CYP2E1 \| CYP3A23/3A1 \| FADS1 \| FGA \| GADD45A \| GPT \| GSR \| GSTM3 \| HAVCR1 \| HMOX1 \| IFNG \| IL4 \| KRT18 \| LBP \| LGALS3 \| TTR	32.74	32
41.	Simvastatin	Drug-Induced Liver Injury	M	53 genes: ABCB1 \| ABCC2 \| ADIPOQ \| APOA1 \| APOE \| ARG1 \| BAX \| CAT \| CCL2 \| CCR2 \| CDC25B \| COL3A1 \| CTNNB1 \| CXCL1 \| CXCL10 \| CYP2C9 \| ENO1 \| FASN \| FLT1 \| GSTP1 \| HLA-DQB1 \| HMGB1 \| HMOX1 \| IFNG \| IGF1 \| IL17A \| IL18 \| IL1A \| IL1B \| IL1R2 \| IL22 \| IL4 \| IL6 \| LBP \| MAP1LC3B \| MDH1 \| MMP2 \| MTHFR \| NFE2L2 \| NR1H3 \| NR1I2 \| NR1I3 \| PDK4 \| PLAT \| PON1 \| PPARA \| PTGS2 \| SESN2 \| SOD2 \| SPP1 \| TF \| TNF \| VIM	32.44	62
42.	Nanotubes, Carbon	Poisoning	M	8 genes: ABCB1 \| ALB \| BCHE \| CDKN2A \| CDKN2B \| CSF3 \| CST3 \| GSK3B	31.90	11
43.	Dactinomycin	Drug-Induced Liver Injury	M	36 genes: ABCB1 \| ABCB1A \| ABCB1B \| ABCC1 \| ABCC2 \| AHR \| AIFM1 \| ALB \| ARNT \| BAX \| CCL2 \| CYP2A5 \| CYP3A23/3A1 \| GADD45A \| GCLC \| GSTP1 \| HMOX1 \| IFNG \| IGF1 \| IL11 \| IL17A \| IL1A \| IL1B \| IL6 \| ITPR1 \| LGALS3 \| MAP1LC3B \| MIR22 \| NFE2L2 \| NR1H4 \| NR1I2 \| PLAT \| PTGS2 \| SOD2 \| TNF \| VIM	31.73	43
44.	perfluorooctanoic acid	Drug-Induced Liver Injury	M	99 genes: ABCB1 \| ABCB1A \| ABCB1B \| ABCC1 \| ABCC2 \| ADIPOQ \| AHR \| ALB \| ALDOB \| AMBP \| APOA1 \| APOE \| ARG1 \| ARNT \| ATP6V1D \| BAX \| BTD \| C3 \| CADPS2 \| CAR3 \| CAT \| CCL2 \| CLU \| COL3A1 \| CP \| CTNNB1 \| CXCL1 \| CXCL10 \| CYP2A5 \| CYP2E1 \| CYP3A23/3A1 \| CYP8B1 \| DGAT2 \| DHFR \| DNAJB9 \| ENO1 \| EPHX1 \| FADS1 \| FASN \| FGA \| GADD45A \| GCLC \| GPT \| GSR \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| GULO \| HACL1 \| HADHA \| HMOX1 \| HPX \| IGF1 \| IL1B \| IL4 \| IL6 \| KNG1 \| KRT18 \| LTF \| MDH1 \| MIR30A \| MIR337 \| MIR410 \| MIR503 \| MMP2 \| NAT2 \| NFE2L2 \| NR1H3 \| NR1H4 \| NR1I2 \| NR1I3 \| NREP \| OLR59 \| PDK4 \| PEX11A \| PLG \| PNP \| PON1 \| PPARA \| PTGS2 \| PZP \| RBP1 \| REEP5 \| RGN \| SELENBP1 \| SERPING1 \| SLC22A8 \| SLPI \| SOD1 \| SORD \| SORL1 \| SULT1E1 \| TMED7 \| TNF \| TTR \| UGT1A9	31.25	78
45.	Styrene	Drug-Induced Liver Injury	M	17 genes: ALB \| BAX \| CAT \| CCL2 \| CLU \| CYP2C11 \| CYP2E1 \| EPHX1 \| GCLC \| GSTM1 \| GSTP1 \| GSTT1 \| IL1B \| IL4 \| IL6 \| PTGS2 \| TNF	31.17	26
46.	Norepinephrine	Cocaine-Related Disorders	M	19 genes: COMT \| CRH \| CRHR1 \| DRD1 \| DRD2 \| EGR1 \| FGF2 \| FOS \| FOSB \| MAPK1 \| MAPK3 \| NGF \| NPY \| OPRK1 \| OPRM1 \| PDYN \| POMC \| SLC6A3 \| SLC6A4	30.71	51
47.	Particulate Matter	Drug-Induced Liver Injury	M	82 genes: ABCC2 \| ADIPOQ \| AHR \| ALB \| ANXA2 \| APOE \| ARG1 \| ARNT \| ATG5 \| ATOH8 \| BAX \| C3 \| CAT \| CCL2 \| CCR2 \| CHRM3 \| CLU \| COL14A1 \| CP \| CSF3 \| CTNNB1 \| CXCL1 \| CXCL10 \| CYP2C11 \| CYP2E1 \| DGAT2 \| DHRS7 \| DNAJB9 \| DNAJC12 \| ENO1 \| FGA \| GADD45A \| GCLC \| GOT1 \| GSN \| GSR \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTP1 \| GSTT1 \| HMOX1 \| IFNG \| IGF1 \| IL11 \| IL17A \| IL18 \| IL1A \| IL1B \| IL1R2 \| IL22 \| IL4 \| IL6 \| LBP \| LCN2 \| MAP3K5 \| MIR107 \| MIR10A \| MIR10B \| MIR132 \| MIR181C \| MIR30A \| MIR744 \| MIR877 \| MMP2 \| NFE2L2 \| NOX4 \| NR1I2 \| PAN2 \| PLAT \| PLG \| PPARA \| PTGS2 \| SLPI \| SOD1 \| SOD2 \| SOD3 \| SPP1 \| TF \| TNF \| TTR	30.21	67
48.	methylmercuric chloride	Drug-Induced Liver Injury	M	97 genes: ABCB1 \| ABCC2 \| ADAM8 \| ALB \| ANXA2 \| APOA1 \| APOE \| APOH \| ATG5 \| ATP6V1D \| BAX \| C3 \| CADPS2 \| CAT \| CCL2 \| CDC25B \| CHRM3 \| CLU \| COL14A1 \| CP \| CTNNB1 \| CXCL1 \| CXCL10 \| CYP2A5 \| DGAT2 \| DHFR \| DNAJB9 \| DNAJC12 \| DSC2 \| EDEM1 \| EIF2AK1 \| FADS1 \| FADS2 \| FASN \| FGA \| FLT1 \| GADD45A \| GCLC \| GGH \| GOT1 \| GPT \| GSN \| GSR \| GSTM1 \| GSTM2 \| GSTM3 \| GSTP1 \| GSTT1 \| HACL1 \| HADHA \| HAVCR1 \| HLA-B \| HLA-DQB1 \| HMOX1 \| HPD \| HPX \| IGF1 \| IL11 \| IL1B \| IL6 \| ITPR1 \| KRT18 \| LCN2 \| LGALS3 \| MAP1LC3B \| MIR141 \| MIR367 \| MMP2 \| NFE2L2 \| NR1H3 \| NR1H4 \| NREP \| PAN2 \| PCYT1A \| PDK4 \| PEX11A \| PNP \| PON1 \| PTGS2 \| RBP1 \| RGN \| S100A11 \| SELENBP1 \| SESN2 \| SLC10A7 \| SLC22A8 \| SOD1 \| SOD2 \| SORL1 \| SPP1 \| TAGLN2 \| TALDO1 \| TCTN1 \| TMEM38B \| UBA5 \| VIM \| WASL	30.13	55
49.	Methyl Parathion	Neurotoxicity Syndromes	M	11 genes: ABCB1 \| ADD3 \| BCHE \| CCK \| FOS \| GABRR2 \| P2RX1 \| PON1 \| SRSF5 \| TGM1 \| TIMP3	29.86	5
50.	Ethanol	Amphetamine-Related Disorders	M	32 genes: ACHE \| ADORA2A \| AK5 \| AKT1 \| ARRB2 \| BDNF \| CCHCR1 \| CUBN \| DRD1 \| DRD2 \| DRD3 \| EPHX1 \| FOS \| GABRG2 \| GDNF \| GSTM1 \| GSTP1 \| GSTT1 \| HTR3A \| MYO5B \| NOS1 \| OPRM1 \| PDE4B \| PDE4D \| PDYN \| PLAT \| POU5F1 \| RELA \| SLC6A3 \| SLC6A4 \| SLC6A9 \| SNCA	29.39	25

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