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Chemical Paraquat

1–50 of 499 results.
  Curated. Reference Cited Chemicals Cited Genes Cited Diseases
1. Curated.
Alizadeh-Tabrizi N, et al.
Atorvastatin protected from paraquat-induced cytotoxicity in alveolar macrophages via down-regulation of TLR-4.
Environ Toxicol Pharmacol. 2017 Jan;49:8-13.
 Atorvastatin Calcium | Paraquat MPO | TLR4  
2. Curated.
Hou L, et al.
Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation.
Toxicology. 2017 Apr 1;380:1-10.
 acetovanillone | Maneb | Paraquat AIF1 | ITGAM | NCF1 | NFKBIA | NOS2 | RELA | TNF Nerve Degeneration
3. Curated.
Lei Y, et al.
Toll-like receptor 4 ablation rescues against paraquat-triggered myocardial dysfunction: Role of ER stress and apoptosis.
Environ Toxicol. 2017 Feb;32(2):656-668.
 Paraquat BAD | BAX | CASP3 | CASP9 | DDIT3 | EIF2AK3 | EIF2S1 | HSPA5 | IL1B | MAPK1 | MAPK3 | NFKBIA | TLR4 Ventricular Dysfunction, Left
4. Curated.
Ortega-Arellano HF, et al.
Minocycline protects, rescues and prevents knockdown transgenic parkin Drosophila against paraquat/iron toxicity: Implications for autosomic recessive juvenile parkinsonism.
Neurotoxicology. 2017 May;60:42-53.
 ferrous sulfate | Paraquat PARK | PRKN Parkinson Disease
5. Curated.
Shen H, et al.
Epigallocatechin-3-gallate alleviates paraquat-induced acute lung injury and inhibits upregulation of toll-like receptors.
Life Sci. 2017 Feb 1;170:25-32.
 epigallocatechin gallate | ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate | Paraquat IL1B | IL6 | MYD88 | TLR2 | TLR4 | TLR9 | TNF | TRAF6 Acute Lung Injury | Edema | Hemorrhage
6. Curated.
Shen H, et al.
MyD88 gene knockout attenuates paraquat-induced acute lung injury.
Toxicol Lett. 2017 Mar 5;269:41-46.
 Paraquat IL1B | MYD88 | RELA | TLR4 | TLR9 | TNF Acute Lung Injury
7. Curated.
Wang S, et al.
Ablation of Akt2 prevents paraquat-induced myocardial mitochondrial injury and contractile dysfunction: Role of Nrf2.
Toxicol Lett. 2017 Mar 5;269:1-14.
 Paraquat AKT1 | AKT2 | BAX | BCL2 | CASP3 | NFE2L2 | PPARGC1A  
8. Curated.
Wu M, et al.
Regulator of G protein signaling-1 modulates paraquat-induced oxidative stress and longevity via the insulin like signaling pathway in Caenorhabditis elegans.
Toxicol Lett. 2017 May 5;273:97-105.
 Cadmium Chloride | Paraquat AGE-1 | DAF-16 | DAF-2 | PDK-1 | RGS-1 | RGS20  
9. Curated.
Anandhan A, et al.
Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions.
Mol Neurobiol. 2016 Jun 20.
 Iron | Maneb | Paraquat | Sirolimus ACACA | ATG5 | MTOR | PRKAA1 | PRKAA2 | SLC2A4 | SLC5A1 | SNCA | ULK1 Parkinsonian Disorders
10. Curated.
de Oliveira MR, et al.
Protective effect of carnosic acid against paraquat-induced redox impairment and mitochondrial dysfunction in SH-SY5Y cells: Role for PI3K/Akt/Nrf2 pathway.
Toxicol In Vitro. 2016 Apr;32:41-54.
 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | Paraquat | salvin BAX | BCL2 | CASP3 | CASP9 | GCLC | GCLM | GSR | HMOX1 | NFE2L2 | NQO1 | SOD2  
11. Curated.
Ding YW, et al.
SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro.
Int J Mol Med. 2016 Apr;37(4):1049-58.
 Paraquat CAT | HMOX1 | NFE2L2 | SIRT1  
12. Curated.
Dou T, et al.
Nrf2/ARE Pathway Involved in Oxidative Stress Induced by Paraquat in Human Neural Progenitor Cells.
Oxid Med Cell Longev. 2016;2016:8923860.
 Paraquat CASP9 | CAT | CSNK2A2 | CYCS | HMOX1 | NFE2L2 | NQO1  
13. Curated.
Gu SY, et al.
Unfractionated bone marrow cells attenuate paraquat-induced glomerular injury and acute renal failure by modulating the inflammatory response.
Sci Rep. 2016 Mar 18;6:23287.
 Paraquat CSF3 | CXCL1 | IFNG | IL1B | IL6 | MMP2 | MMP3 | MMP9 | NPHS2 | TIMP1 | TIMP2 | TNF Acute Kidney Injury | Disease Models, Animal
14. Curated.
Hong GL, et al.
Cycloartenyl Ferulate Inhibits Paraquat-Induced Apoptosis in HK-2 Cells With the Involvement of ABCC1.
J Cell Biochem. 2016 Apr;117(4):872-80.
 cycloartenyl ferulate | Paraquat ABCC1  
15. Curated.
Huang CL, et al.
Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability.
Mol Neurobiol. 2016 May;53(4):2169-88.
 Acetylcysteine | calpeptin | Cyclosporine | Dibucaine | diphenyleneiodonium | Paraquat | phenylmethylpyrazolone | U 74389F BAK1 | BAX | CASP3 | DIABLO | HTR2A | PARP1 | TH Movement Disorders | Weight Loss
16. Curated.
Huang M, et al.
MAPK pathway mediates epithelial-mesenchymal transition induced by paraquat in alveolar epithelial cells.
Environ Toxicol. 2016 Nov;31(11):1407-1414.
 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | Paraquat | SB 203580 ACTA2 | CDH1 | COL1A1 | COL3A1 | FN1 | MAPK1 | MAPK3 | MMP2 | MMP9 | SMAD2 | TJP1  
17. Curated.
Lebov JF, et al.
Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study.
Occup Environ Med. 2016 Jan;73(1):3-12.
 alachlor | Aldicarb | Atrazine | Chlordan | Coumaphos | imazethapyr | metalaxyl | metolachlor | Paraquat | Parathion | pendimethalin | Permethrin | Petroleum | Phorate   Kidney Failure, Chronic
18. Curated.
Li S, et al.
Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways.
Mol Med Rep. 2016 Feb;13(2):1833-8.
 Paraquat | resveratrol CAT | HMOX1 | NFE2L2 | SIRT1 Acute Lung Injury
19. Curated.
Liu H, et al.
[The protective effect of bone marrow mesenchymal stem cells carrying antioxidant gene superoxide dismutase on paraquat lung injury in mice].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016 Jan;34(1):1-7.
 Paraquat TGFB1 | TNF Acute Lung Injury
20. Curated.
Liu MW, et al.
Radix puerariae extracts ameliorate paraquat-induced pulmonary fibrosis by attenuating follistatin-like 1 and nuclear factor erythroid 2p45-related factor-2 signalling pathways through downregulation of miRNA-21 expression.
BMC Complement Altern Med. 2016 Jan 12;16:11.
 Paraquat | plant extract, Puerariae Radix ACTA2 | COL3A1 | CTGF | FSTL1 | HMOX1 | MIR21 | MMP9 | NFE2L2 | RELA | TGFB1 Pulmonary Fibrosis
21. Curated.
Pourgholamhossein F, et al.
Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress.
Environ Toxicol Pharmacol. 2016 Jul;45:340-5.
 Paraquat | thymoquinone ACTA2 | COL1A1 | COL4A1 | TGFB1 Disease Models, Animal | Hemorrhage | Inflammation | Pulmonary Fibrosis
22. Curated.
Qiaoli S, et al.
KLF2 and caveolin-1 as early indicators of acute lung injury induced by paraquat.
Eur Rev Med Pharmacol Sci. 2016;20(1):138-45.
 Paraquat CAV1 | KLF2 | KLF4 Acute Lung Injury
23. Curated.
Sheremet NL, et al.
Previously Unclassified Mutation of mtDNA m.3472T>C: Evidence of Pathogenicity in Leber''s Hereditary Optic Neuropathy.
Biochemistry (Mosc). 2016 Jul;81(7):748-54.
 Paraquat ND1 Optic Atrophy, Hereditary, Leber
24. Curated.
Wang Q, et al.
Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model.
Life Sci. 2016 Jul 15;157:116-24.
 Paraquat | vatalanib BADB | BAXA | BAXB | BBC3 | CASP3A | CASP8 | CASPA | CAT | CDC42L | FASLG | FOSAB | GCLC | GCLM | HMOX1A | JUN | KEAP1B | MAPK8B | MMP13A | MPX | NFE2L2A | NGEF | NOS2A | PMAIP1 | RAC1A | RELA | RHOAB | ROCK2A | SOD1 | SOD2 | TNFRSFA | TNFSF10L3 | TP53 Edema
25. Curated.
Wang S, et al.
Toll-like receptor 4 knockout alleviates paraquat-induced cardiomyocyte contractile dysfunction through an autophagy-dependent mechanism.
Toxicol Lett. 2016 Aug 22;257:11-22.
 bafilomycin A | ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate | Paraquat ATG5 | ATG7 | MAP1LC3B | MTOR | SQSTM1 | TLR4 | ULK1 Cardiotoxicity
26. Curated.
Xu J, et al.
Tumor necrosis factor-α induced protein 6 attenuates acute lung injury following paraquat exposure.
Toxicol Mech Methods. 2016;26(1):32-5.
 Paraquat IL1B | IL6 | TNF | TNFAIP6 Acute Lung Injury
27. Curated.
Zhu Y, et al.
HIF-1α regulates EMT via the Snail and β-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis.
J Cell Mol Med. 2016 Apr;20(4):688-97.
 Paraquat ACTA2 | HIF1A | TJP1  
28. Curated.
Akcılar R, et al.
Hyperbaric oxygen treatment ameliorates lung injury in paraquat intoxicated rats.
Int J Clin Exp Pathol. 2015;8(10):13034-42.
 Oxygen | Paraquat FGF2 | IL6 | NOS2 | TGFB1 | TNF Acute Lung Injury
29. Curated.
Berto MD, et al.
The effect of superoxide anion and hydrogen peroxide imbalance on prostate cancer: an integrative in vivo and in vitro analysis.
Med Oncol. 2015 Nov;32(11):251.
 Paraquat | Porphyrins BAX | BCL2 | CASP3 | CASP8 | CAT | GPX1 | SOD1 | SOD2 Prostatic Neoplasms
30. Curated.
Cao Y, et al.
[Inhibition of pulmonary nuclear factor -ΚB and tumor necrosis factor -α expression by diallyl sulfide in rats with paraquat poisoning].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Apr;27(4):274-9.
 allyl sulfide | Dexamethasone | Paraquat RELA | TNF Acute Lung Injury | Pulmonary Edema
31. Curated.
Caputi FF, et al.
Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells.
Environ Toxicol Pharmacol. 2015 Nov;40(3):895-900.
 Maneb | Paraquat OPRD1 | OPRM1 | PSMB1 | PSMC4 | SNCA | TH  
32. Curated.
Cassar M, et al.
A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
Hum Mol Genet. 2015 Jan 1;24(1):197-212.
 Dopamine | Paraquat DOP1R2 | RYR | TH | TRPA1 Parkinsonian Disorders
33. Curated.
Chen JL, et al.
Methylene blue attenuates acute liver injury induced by paraquat in rats.
Int Immunopharmacol. 2015 Sep;28(1):808-12.
 Methylene Blue | Paraquat HMOX1 | MPO Drug-Induced Liver Injury | Weight Loss
34. Curated.
Dong J, et al.
Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents.
Arch Toxicol. 2015 Sep 7.
 Bleomycin | Paraquat | Silicon Dioxide ANKRD1 | ARG1 | AURKA | BIRC5 | C1QB | CAPN6 | CCL17 | CCL2 | CCL3 | CCL4 | CCL6 | CCNG1 | CCR5 | CDC20 | CDKN1A | CLDN4 | COL1A1 | COL6A1 | CSF2 | CTSA | CTSB | CTSH | CTSK | CXCL1 | CXCL10 | CXCL13 | DBP | EGR1 | EGR2 | ELN | FN1 | GPNMB | HIST1H2AD | HIST1H2AH | HIST1H2AK | IFIT3 | IL1RN | IL4I1 | LCN2 | MCM2 | MMP12 | MMP14 | MMP2 | MMP3 | NOXO1 | OAS1G | OAS2 | PTN | SFRP1 | SLC26A4 | SLPI | SPP1 | TIMP1 | TNC Pulmonary Fibrosis
35. Curated.
Furlong M, et al.
Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson''s disease.
Environ Int. 2015 Feb;75:144-50.
 Paraquat | Permethrin | Rotenone | Trifluralin   Parkinson Disease
36. Curated.
Guo F, et al.
Losartan attenuates paraquat-induced pulmonary fibrosis in rats.
Hum Exp Toxicol. 2015 May;34(5):497-505.
 Losartan | Paraquat COL3A1 | MMP9 | TGFB1 | TIMP1 Pulmonary Fibrosis
37. Curated.
Heredia L, et al.
Neurobehavioral effects of concurrent exposure to cesium-137 and paraquat during neonatal development in mice.
Toxicology. 2015 Mar 2;329:73-9.
 Cesium | Paraquat   Anxiety Disorders | Memory Disorders
38. Curated.
Hong GL, et al.
Mifepristone-inducible recombinant adenovirus attenuates paraquat-induced lung injury in rats.
Hum Exp Toxicol. 2015 Jan;34(1):32-43.
 Mifepristone | Paraquat CAT | HMOX1 | IL1B | IL6 | NFE2L2 | NQO1 | RELA | TNF Acute Lung Injury
39. Curated.
Huang M, et al.
Inhibition of connective tissue growth factor attenuates paraquat-induced lung fibrosis in a human MRC-5 cell line.
Environ Toxicol. 2015 Jun 30.
 Paraquat CTGF | MMP2 | MMP9 | TGFB1 | TIMP1  
40. Curated.
Izumi Y, et al.
Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity.
J Pharmacol Sci. 2015 Nov;129(3):150-9.
 benzyloxycarbonylleucyl-leucyl-leucine aldehyde | lactacystin | Paraquat CAT | GCLC | HMOX1 | NFE2L2  
41. Curated.
Koike M, et al.
Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration.
Sci Rep. 2015 Jun 25;5:11722.
 6-O-palmitol-ascorbate-2-O-phosphate | Paraquat | Proteoglycans | Superoxides ACAN | COL2A1 | GPX1 | MMP13 | MMP3 | SOD2 | SOD3 | SOX9 Cartilage Diseases
42. Curated.
Kumar A, et al.
The manganese-salen compound EUK-134 and N-acetyl cysteine rescue from zinc- and paraquat-induced toxicity in rat polymorphonuclear leukocytes.
Chem Biol Interact. 2015 Apr 25;231:18-26.
 Acetylcysteine | EUK-134 | Paraquat | Zinc Sulfate GSR | GSTA4 | MPO | MT1A | MT2A  
43. Curated.
Li D, et al.
Protective effects of thalidomide on pulmonary injuries in a rat model of paraquat intoxication.
J Inflamm (Lond). 2015;12:46.
 Paraquat | Thalidomide COL1A1 | IL6 | TGFB1 | TNF Pulmonary Edema
44. Curated.
Lim JH, et al.
Paraquat reduces natural killer cell activity via metallothionein induction.
J Immunotoxicol. 2015;12(4):342-9.
 Paraquat GATA3 | MT1  
45. Curated.
Li T, et al.
Superantigen staphylococcal enterotoxin C1 mutant can reduce paraquat pulmonary fibrosis.
Toxicol Mech Methods. 2015;25(7):574-80.
 enterotoxin C, staphylococcal | Paraquat ACTA2 | COL1A1 | COL3A1 | IL1B | TGFB1 | TNF Cyanosis | Diarrhea | Fever | Gastrointestinal Diseases | Hemorrhage | Inflammation | Muscle Weakness | Poisoning | Pulmonary Edema | Pulmonary Fibrosis | Respiratory Insufficiency
46. Curated.
Liu Z, et al.
NLRP3 inflammasome activation is essential for paraquat-induced acute lung injury.
Inflammation. 2015 Feb;38(1):433-44.
 Glyburide | Paraquat CASP1 | IL18 | IL1B | MPO | NLRP3 | PYCARD Acute Lung Injury | Hemorrhage | Pulmonary Edema
47. Curated.
Navarro-Yepes J, et al.
Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.
Mol Neurobiol. 2015 Sep 26.
 4-(4-(5-nitrofuran-2-ylmethylene)-3, 5-dioxopyrazolidin-1-yl)benzoic acid ethyl ester | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | Chloroquine | 1-Methyl-4-phenylpyridinium | Oxidopamine | Paraquat MAP1LC3B | PARK7 | SNCA | SQSTM1 | UBB  
48. Curated.
Pandey A, et al.
Efficacy of methuselah gene mutation toward tolerance of dichlorvos exposure in Drosophila melanogaster.
Free Radic Biol Med. 2015 Jun;83:54-65.
 Dichlorvos | Paraquat ACHE | CAT | MTH Organophosphate Poisoning
49. Curated.
Qian J, et al.
Increased toll-like receptor 9 expression is associated with the severity of paraquat-induced lung injury in mice.
Hum Exp Toxicol. 2015 Apr;34(4):430-8.
 Paraquat ACTA2 | COL1A1 | COL3A1 | IL1B | IL6 | TLR9 | TNF Acute Lung Injury | Hemorrhage | Pulmonary Edema | Pulmonary Fibrosis
50. Curated.
Rao SV, et al.
Evidence of neuroprotective effects of saffron and crocin in a Drosophila model of parkinsonism.
Neurotoxicology. 2015 Dec 17;52:230-242.
 crocin | Paraquat | Plant Extracts | Rotenone ACHE | CAT Parkinsonian Disorders
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