Flavonoids - Diseases

These diseases are associated with Flavonoids or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

Disease categories [Show chart]

1–50 of 74,287 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	alpha-naphthoflavone	Carcinoma, Hepatocellular	M	33 genes: AR \| CASP8 \| CDH13 \| CDKN1B \| CTSD \| CXCL8 \| CYP17A1 \| CYP1A1 \| EGFR \| ENO1 \| ESR1 \| FOS \| GSTP1 \| HMGCR \| IL6 \| JUN \| MMP2 \| MMP9 \| MTOR \| MYC \| NFE2L2 \| PGK1 \| PKM \| PTGS2 \| PTK2 \| RB1 \| SLC2A1 \| SLC5A5 \| SOD2 \| TGFB1 \| TNF \| TP53 \| TRP53	84.77	42
2.	Quercetin	Mammary Neoplasms, Animal	M	74 genes: ACTB \| ANXA1 \| ANXA2 \| ANXA4 \| APC \| AQP1 \| BRCA1 \| CCND1 \| CDC42 \| CDH1 \| CDK4 \| CDS1 \| COMT \| COX1 \| CSN2 \| DUSP6 \| EFEMP1 \| EGFR \| ENO1 \| EPHX1 \| ERBB2 \| ESR1 \| ESR2 \| FN1 \| G0S2 \| GATM \| GDA \| GGT1 \| GNAI2 \| GSS \| HBA1 \| HNRNPA1 \| HRAS \| ID3 \| IL6ST \| INS1 \| KITLG \| KNG1 \| LSR \| MGP \| MIF \| MIR10A \| MIR205 \| NSMF \| PEBP1 \| PGAM1 \| PGR \| PIK3R1 \| PKM \| PLK2 \| PPARA \| PRDX2 \| PRL \| PTBP1 \| RAN \| RASA1 \| RASSF1 \| RB1 \| RBP1 \| RBP4 \| RPL3 \| S100A6 \| SCD \| SGK1 \| SLC12A2 \| SNRPD3 \| STAT3 \| STMN1 \| TF \| TKT \| TP53I3 \| TUBB2B \| UCP2 \| XDH	83.07	20
3.	Genistein	Abortion, Spontaneous	M	48 genes: AHR \| ALPPL2 \| APOE \| ARNT \| CD68 \| CD82 \| CEACAM1 \| COL1A1 \| COL1A2 \| COL5A1 \| COL6A1 \| COL6A3 \| CXCL10 \| CYP1A1 \| CYP24A1 \| DHFR \| FETUB \| FN1 \| FST \| GLS \| HSD17B1 \| IGF1 \| IGF2 \| IGFBP1 \| IGFBP3 \| IGFBP6 \| IL12B \| IL1B \| IL6 \| ITGB6 \| JAK2 \| LGALS3 \| LIF \| MGP \| MMP15 \| MMP7 \| NCAM1 \| PGF \| PRLR \| PTGIS \| RBP4 \| SPAG5 \| TFRC \| TGFB1 \| TGFBI \| TIMP2 \| TIMP3 \| TNFSF10	68.12	7
4.	alpha-naphthoflavone	Neoplasm Invasiveness	M	23 genes: AHR \| CAT \| CCL2 \| CTSD \| EGFR \| ENO1 \| ESR1 \| IL1B \| IL1RN \| IL6 \| MAPK1 \| MAPK3 \| MMP1 \| MMP2 \| MMP3 \| MMP9 \| PKM \| PTK2 \| RELA \| SOD2 \| SRC \| TGFB1 \| TNF	58.58	37
5.	Rotenone	Parkinson Disease	M	35 genes: ABCB1 \| AIF1 \| ATP13A2 \| BDNF \| CP \| DDIT4 \| DRD1 \| DRD2 \| EDN1 \| GDNF \| GFAP \| GPX1 \| GSTA4 \| GSTM1 \| HMOX1 \| HSPA1A \| HSPA9 \| IGF2 \| IL6 \| KCNJ4 \| LRRK2 \| MAP3K5 \| MAPT \| NGF \| NQO1 \| PARK2 \| PARK7 \| PINK1 \| PRKN \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TNF	49.31	89
6.	Rotenone	Nerve Degeneration	M	40 genes: APP \| ATP13A2 \| ATXN3 \| BAX \| BCL2 \| BDNF \| CASP3 \| CD9 \| CDH1 \| CNTF \| CP \| CTNNB1 \| DDIT4 \| EIF2S1 \| GRM4 \| GST-1 \| IFNG \| IGF1 \| IGF2 \| KCNJ4 \| LEP \| LRRK2 \| MAPK1 \| MAPK3 \| MT1 \| MT2 \| NGF \| PINK1 \| PPARG \| PRKN \| SIRT1 \| SKN-1 \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TH \| TNF \| XDH	41.85	66
7.	epicatechin gallate	Breast Neoplasms	M	15 genes: AKT1 \| BCL2 \| CAT \| CYP1A1 \| DHFR \| HRAS \| IL1B \| IL6 \| NOS2 \| PTGS1 \| RELA \| SOD2 \| TNF \| TOP2A \| TRP53	41.19	29
8.	Isoflavones	Mammary Neoplasms, Animal	M	17 genes: ANXA1 \| ANXA2 \| CCND1 \| DES \| ENO1 \| ESR1 \| ESR2 \| EZR \| FN1 \| INS1 \| INSIG1 \| KNG1 \| KRT5 \| PGR \| PTBP1 \| S100A8 \| SCD	40.58	7
9.	Quercetin	Pancreatic Neoplasms	M	53 genes: AHR \| ATM \| AXL \| BCAR1 \| BCL2L1 \| BRCA1 \| BRCA2 \| CDH1 \| CDKN2A \| CFLAR \| CTNNB1 \| CXCL8 \| DPYD \| EFEMP1 \| EGFR \| FOXP1 \| GADD45A \| HIF1A \| KDR \| KLF5 \| KRAS \| MEN1 \| MMP9 \| MYC \| NFKBIA \| NRP1 \| PALLD \| PDX1 \| PLAU \| PPARG \| PTCH1 \| PTEN \| PTGS2 \| PTHLH \| RB1 \| SLC29A1 \| SMAD4 \| SOD2 \| SPINK1 \| STAT3 \| STK11 \| TERT \| TFPI2 \| TGFB1 \| TNF \| TNFRSF10B \| TNFSF10 \| TP53 \| TP63 \| TRP53 \| TSC2 \| TYMS \| ZNRF3	40.41	56
10.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	Cardiomyopathies	M	22 genes: AGT \| AKT1 \| ATF3 \| CAT \| CYP2C9 \| EDN1 \| FAS \| FASLG \| HGF \| IL1A \| IL1B \| IL6 \| MAPK1 \| MAPK14 \| MAPK3 \| PARP1 \| PTGS2 \| SOD2 \| STAT3 \| TLR2 \| TNF \| TRP53	35.72	20
11.	Rotenone	Brain Injuries	M	26 genes: ALB \| BDNF \| CCL2 \| CD14 \| CEBPB \| FOS \| GRM8 \| GSK3B \| HSPA1A \| IL10 \| IL1A \| IL1B \| IL6 \| JUN \| LSG1 \| MMP9 \| MPO \| NPPB \| PARP1 \| PTGS2 \| SOD2 \| TNF \| TNFRSF1A \| TRAF4 \| UCP2 \| VEGFA	32.39	31
12.	Rotenone	Disease Models, Animal	M	26 genes: AIF1 \| AKT1 \| ALB \| APP \| CLDN11 \| ESR1 \| FAS \| FOS \| GFAP \| HBB \| IFNG \| IL1B \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| MAPT \| MMP9 \| PARK2 \| RHOA \| SERPINE1 \| SNCA \| SOD1 \| STAT3 \| TNF \| TRP53	31.15	40
13.	Isoflavones	Adenocarcinoma	M	15 genes: BCL2 \| CASP8 \| CCND1 \| CKB \| CXCL8 \| ENO1 \| ESR1 \| ESR2 \| KRT8 \| MKI67 \| PCNA \| PGR \| SELENBP1 \| TNF \| TP53	28.38	14
14.	Genistein	Infertility, Female	M	21 genes: AR \| CEBPA \| CEBPB \| CTGF \| CYP17A1 \| CYP19A1 \| DHFR \| ESR1 \| ESR2 \| FSHB \| LEP \| LEPR \| LHB \| LIF \| MAPK1 \| MAPK3 \| NR1I2 \| NR2F2 \| NR5A2 \| PRL \| TP53	26.90	15
15.	Rotenone	Lewy Body Disease	M	10 genes: AIF1 \| BECN1 \| EDN1 \| GFAP \| IGF2 \| NGF \| NTRK1 \| NTRK2 \| SNCA \| SOD2	26.37	5
16.	alpha-naphthoflavone	Drug-Induced Liver Injury	M	22 genes: ABCC1 \| AHR \| ARNT \| BAX \| CAT \| CCL2 \| CYP2C11 \| CYP2C9 \| ENO1 \| GCLC \| GSR \| GSTP1 \| IL1B \| IL6 \| MMP2 \| NFE2L2 \| NR1I3 \| PPARA \| PTGS2 \| SOD1 \| SOD2 \| TNF	26.29	29
17.	epicatechin gallate	Disease Progression	M	7 genes: BCL2 \| CAT \| HRAS \| MYC \| PREP \| SOD2 \| TOP2A	25.54	13
18.	epigallocatechin gallate	Disease Progression	M	27 genes: ABCB1 \| ABCC1 \| ATP7B \| BCL2 \| CAT \| CDH1 \| CTSB \| DDX58 \| EGF \| EGFR \| ERBB2 \| FGF2 \| GSTP1 \| HIKESHI \| HRAS \| MMP2 \| MRPS11 \| MYC \| NBAS \| PLPP1 \| RAD23A \| RPL13 \| SOD2 \| SOD3 \| STAT1 \| TERT \| TOP2A	24.80	28
19.	Apigenin	Drug-Induced Liver Injury	M	24 genes: ABCC1 \| AHR \| ARNT \| BAX \| CAT \| CCL2 \| CYP2C9 \| GCLC \| HMOX1 \| IFNG \| IL1B \| IL4 \| IL6 \| LTF \| MMP2 \| NFE2L2 \| NR1H4 \| NR1I2 \| PTGS2 \| SOD1 \| SOD2 \| SULT1E1 \| TNF \| UGT1A9	23.72	33
20.	Rotenone	Neurodegenerative Diseases	M	17 genes: APP \| FTH1 \| FTL1 \| GDNF \| GSR \| GSTM1 \| GSTM2 \| GSTM6 \| GSTO1 \| HMOX1 \| IL6 \| MAPT \| MGST1 \| NGF \| SIRT1 \| SNCA \| SOD2	22.82	16
21.	beta-Naphthoflavone	Liver Neoplasms	M	26 genes: ACOT1 \| AHR \| ANXA4 \| APCS \| ASNS \| CCND1 \| CTNNB1 \| CYP2E1 \| EGLN3 \| ESM1 \| ESR1 \| GPX2 \| GPX3 \| GSTM1 \| HMOX1 \| IL12A \| JUN \| NFE2L2 \| NR1H4 \| NR1I3 \| PPARA \| PQLC3 \| SERPINE1 \| TNF \| TP53 \| ZDHHC2	19.01	28
22.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	Retinal Diseases	M	9 genes: HMOX1 \| ICAM1 \| MMP9 \| NOS2 \| OCLN \| PDGFB \| TNF \| VEGFA \| VIM	18.90	4
23.	Chalcones	Necrosis	M	7 genes: BCL2 \| CAT \| IFNG \| IL6 \| NFE2L2 \| NOS2 \| TNF	16.55	13
24.	beta-Naphthoflavone	Lipidoses	M	9 genes: AP1S1 \| ASNS \| C10ORF10 \| FNDC4 \| INHBE \| LSS \| NUPR1 \| SERPINA3 \| TAGLN	16.39	3
25.	Rotenone	Parkinsonian Disorders	M	16 genes: ATP13A2 \| DRD2 \| GDNF \| GSR \| HTRA2 \| LRRK2 \| MAPT \| NGF \| PARK7 \| PARP1 \| PINK1 \| PRKCD \| PRKN \| SLC18A2 \| SNCA \| TH	16.06	59
26.	alpha-naphthoflavone	Edema	M	11 genes: CASP3 \| CASP8 \| CASP9 \| CAT \| CXCL8 \| CYP1A \| GSR \| IL6 \| POMC \| PTGS2 \| TNF	15.30	7
27.	Rotenone	Drug-Induced Liver Injury	M	49 genes: ABCB1 \| AIFM1 \| ALB \| ALDOB \| ANXA2 \| ATG5 \| BAX \| CAT \| CCL2 \| CLU \| CP \| CTNNB1 \| CXCL1 \| DHRS7 \| EPHX1 \| FASN \| FGA \| FLT1 \| GADD45A \| GCLC \| GPT \| GSR \| GSTM1 \| GSTM2 \| HBA-A1 \| HMOX1 \| IFNG \| IGF1 \| IL1A \| IL1B \| IL6 \| LGALS3 \| MAP1LC3B \| MAP3K5 \| MIR34C \| MMP2 \| NFE2L2 \| NOX4 \| PDK4 \| PEX11A \| PTGS2 \| S100A11 \| SESN2 \| SOD1 \| SOD2 \| SPP1 \| SULT1E1 \| TNF \| WASL	14.96	42
28.	Diosmin	Necrosis	M	6 genes: AHR \| BCL2 \| CAT \| CYP2E1 \| NOS2 \| TNF	14.38	13
29.	Isoflavones	Endometrial Neoplasms	M	6 genes: CXCL8 \| DCN \| ESR1 \| ESR2 \| PGR \| SOCS3	12.60	6
30.	beta-Naphthoflavone	Inflammation	M	27 genes: AHR \| CASP1 \| CCL2 \| CYP2B1 \| CYP2B2 \| CYP3A2 \| CYP3A23/3A1 \| EGR1 \| GATA3 \| HMOX1 \| IL13 \| IL17A \| IL1A \| IL1B \| IL6 \| IRF7 \| KYNU \| MMP2 \| NOS2 \| NPPB \| PPARA \| PTGS2 \| SOD1 \| TGFB1 \| TIMP1 \| TLR2 \| TNF	11.65	50
31.	beta-Naphthoflavone	Liver Neoplasms, Experimental	M	18 genes: ALAS2 \| APOA4 \| BCL2 \| CAR3 \| CD63 \| CTNNB1 \| CYP1A2 \| CYP2A4 \| CYP2E1 \| GLUL \| GSTP1 \| IL6 \| NR1I3 \| RB1 \| RGN \| SPP1 \| SQLE \| TP53	11.57	21
32.	Isoflavones	Endometrial Hyperplasia	M	3 genes: CELSR2 \| CSRP1 \| DDX1	10.76	1
33.	beta-Naphthoflavone	Precancerous Conditions	M	14 genes: ACY1 \| ANXA4 \| CAT \| CCND1 \| CEBPA \| CISH \| GSTP1 \| IGFBP1 \| IL6 \| MDM2 \| NR1I3 \| PTGS2 \| SOD2 \| STAT5A	10.20	18
34.	Rotenone	Retinal Degeneration	M	6 genes: BCL2 \| CCL2 \| CP \| GDNF \| NMNAT1 \| SOD1	9.58	8
35.	Quercetin	Prenatal Exposure Delayed Effects	M	7 genes: ATM \| CTGF \| CYP2D6 \| FGF2 \| MAOA \| OGG1 \| PON1	8.35	10
36.	galangin	Chromosome Aberrations	M	3 genes: CDK6 \| EPAS1 \| GSTP1	8.22	4
37.	Silymarin	Weight Gain	M	6 genes: ADIPOQ \| AHR \| CALM1 \| LBP \| TNF \| VIM	7.88	5
38.	kaempferol	Leukemia	M	4 genes: CCND1 \| ESR1 \| KMT2A \| NCOA3	7.65	7
39.	beta-Naphthoflavone	Adenoma	M	9 genes: ABCG2 \| ALOX5 \| BCL2 \| CTNNB1 \| CYP1B1 \| IGF1 \| PRL \| TP53 \| TXNRD1	7.42	12
40.	Rotenone	Gliosis	M	5 genes: BDNF \| GFAP \| GRM8 \| MAPK1 \| MAPK3	7.05	6
41.	beta-Naphthoflavone	Hepatomegaly	M	14 genes: A1BG \| ABCC3 \| ACOT1 \| AKR7A3 \| ALDH1B1 \| CYP1A1 \| CYP1A2 \| CYP2B1 \| HDC \| LEPR \| NR1H2 \| NR1I2 \| NR1I3 \| PPARA	7.02	9
42.	Rotenone	Optic Atrophy, Hereditary, Leber	M	3 genes: IL1A \| IL1B \| ND6	6.92	5
43.	kaempferol	Chromosome Breakage	M	3 genes: CAT \| H2AFX \| NFE2L2	6.85	4
44.	naringenin	Weight Gain	M	4 genes: AHR \| APP \| CTSD \| TNF	6.58	4
45.	Quercetin	Leukemia	M	20 genes: AR \| BAD \| BIRC2 \| BIRC3 \| CCND1 \| CFLAR \| DDIT4 \| ESR1 \| FOXM1 \| HP \| IL2 \| JAK2 \| KMT2A \| PLK1 \| PPP1R13L \| PRKCZ \| PTEN \| SETD2 \| TNFSF10 \| TOP2A	6.53	17
46.	Genistein	Premature Birth	M	8 genes: CAT \| EDN1 \| IL4 \| IL6 \| LTF \| MMP9 \| PTGS2 \| SOD2	6.52	5
47.	daidzein	Erectile Dysfunction	M	4 genes: BCL2 \| BCL2L1 \| NOS3 \| PRL	6.46	10
48.	Quercetin	Muscular Atrophy	M	11 genes: AKT1 \| CITED2 \| CTNNB1 \| FBXO32 \| GSK3B \| IGF1 \| MT1 \| SOD1 \| TNF \| TRIM63 \| WWTR1	6.26	7
49.	Rotenone	Attention Deficit Disorder with Hyperactivity	M	6 genes: DRD2 \| GRM5 \| GRM7 \| GRM8 \| PTPRD \| SLC6A3	5.90	8
50.	Genistein	Puberty, Precocious	M	5 genes: GNAS \| GNRH1 \| IGF1 \| LHB \| PTGS2	5.41	6

1–50 of 74,287 results.

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