Pyrans - Diseases

These diseases are associated with Pyrans or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

Disease categories [Show chart]

1–50 of 120,597 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	ochratoxin A	Breast Neoplasms	M	94 genes: ABCB1B \| ACTA2 \| AHR \| AKAP12 \| AKT1 \| AR \| ARRDC3 \| AURKA \| BARD1 \| BAX \| BCL2 \| BCL2A1 \| BIRC5 \| BRIP1 \| CASP7 \| CASP8 \| CAT \| CCND1 \| CCNE1 \| CD74 \| CDH1 \| CDKN2A \| CHEK1 \| CLDN4 \| CTNNB1 \| CXCL8 \| CXCR4 \| CYP19A1 \| CYP1A1 \| CYP3A4 \| DDIT3 \| EEF2 \| EGFR \| EXO1 \| F3 \| FOS \| GPI \| GPX1 \| GPX2 \| GSTP1 \| H2AFX \| HADHB \| HES1 \| HIF1A \| HMOX1 \| HNRNPK \| HRAS \| HSP90AA1 \| IFNG \| IGF1 \| IGF1R \| IL1B \| IL24 \| IL6 \| JUN \| MDM2 \| MIF \| MKI67 \| MME \| MMP9 \| NAT2 \| NFKBIA \| NOS2 \| NQO1 \| NQO2 \| NRG1 \| OCLN \| PARP1 \| PDPK1 \| PHB \| PIK3CA \| PPM1D \| PTEN \| PTGS2 \| RAD51 \| RARA \| RB1 \| RBM3 \| RELA \| RGS2 \| RPS6 \| SERPINB2 \| SFRP2 \| SLC2A2 \| SLC2A5 \| SOD2 \| SPP1 \| SRC \| TNF \| TOP2A \| TP53 \| TRP53 \| UBE2C \| VIM	112.87	121
2.	alpha-naphthoflavone	Carcinoma, Hepatocellular	M	33 genes: AR \| CASP8 \| CDH13 \| CDKN1B \| CTSD \| CXCL8 \| CYP17A1 \| CYP1A1 \| EGFR \| ENO1 \| ESR1 \| FOS \| GSTP1 \| HMGCR \| IL6 \| JUN \| MMP2 \| MMP9 \| MTOR \| MYC \| NFE2L2 \| PGK1 \| PKM \| PTGS2 \| PTK2 \| RB1 \| SLC2A1 \| SLC5A5 \| SOD2 \| TGFB1 \| TNF \| TP53 \| TRP53	84.77	42
3.	Quercetin	Mammary Neoplasms, Animal	M	74 genes: ACTB \| ANXA1 \| ANXA2 \| ANXA4 \| APC \| AQP1 \| BRCA1 \| CCND1 \| CDC42 \| CDH1 \| CDK4 \| CDS1 \| COMT \| COX1 \| CSN2 \| DUSP6 \| EFEMP1 \| EGFR \| ENO1 \| EPHX1 \| ERBB2 \| ESR1 \| ESR2 \| FN1 \| G0S2 \| GATM \| GDA \| GGT1 \| GNAI2 \| GSS \| HBA1 \| HNRNPA1 \| HRAS \| ID3 \| IL6ST \| INS1 \| KITLG \| KNG1 \| LSR \| MGP \| MIF \| MIR10A \| MIR205 \| NSMF \| PEBP1 \| PGAM1 \| PGR \| PIK3R1 \| PKM \| PLK2 \| PPARA \| PRDX2 \| PRL \| PTBP1 \| RAN \| RASA1 \| RASSF1 \| RB1 \| RBP1 \| RBP4 \| RPL3 \| S100A6 \| SCD \| SGK1 \| SLC12A2 \| SNRPD3 \| STAT3 \| STMN1 \| TF \| TKT \| TP53I3 \| TUBB2B \| UCP2 \| XDH	83.07	20
4.	ochratoxin A	Carcinoma	M	46 genes: ACSL1 \| ANXA1 \| AQP1 \| BCL2 \| BCL2L1 \| CCND1 \| CDH1 \| CNN3 \| EEF1A1 \| EGFR \| EZR \| FABP4 \| GGT1 \| GSS \| GSTP1 \| GSTT1 \| HIF1A \| HRAS \| ID3 \| ID4 \| KITLG \| LPL \| MET \| MIF \| MYC \| PHB \| PLAUR \| PLK2 \| PRLR \| PTEN \| PTGS2 \| RB1 \| RBP4 \| RPL6 \| S1PR1 \| SCD \| SELENOP \| SGK1 \| SOD2 \| TF \| TGFB1 \| TMEM37 \| TP53 \| TPM3 \| UCP2 \| XDH	71.87	25
5.	Genistein	Abortion, Spontaneous	M	48 genes: AHR \| ALPPL2 \| APOE \| ARNT \| CD68 \| CD82 \| CEACAM1 \| COL1A1 \| COL1A2 \| COL5A1 \| COL6A1 \| COL6A3 \| CXCL10 \| CYP1A1 \| CYP24A1 \| DHFR \| FETUB \| FN1 \| FST \| GLS \| HSD17B1 \| IGF1 \| IGF2 \| IGFBP1 \| IGFBP3 \| IGFBP6 \| IL12B \| IL1B \| IL6 \| ITGB6 \| JAK2 \| LGALS3 \| LIF \| MGP \| MMP15 \| MMP7 \| NCAM1 \| PGF \| PRLR \| PTGIS \| RBP4 \| SPAG5 \| TFRC \| TGFB1 \| TGFBI \| TIMP2 \| TIMP3 \| TNFSF10	68.12	7
6.	ochratoxin A	Mammary Neoplasms, Experimental	M	44 genes: ABCB1B \| ACSL1 \| ANXA1 \| AQP1 \| AURKA \| CCND1 \| CD44 \| CDH1 \| CNN3 \| EEF1A1 \| EGFR \| EZR \| FABP4 \| GGT1 \| GSS \| HMOX1 \| HRAS \| ID1 \| ID3 \| ID4 \| IGF1 \| IL10 \| KITLG \| LPL \| MIF \| MMP9 \| PHB \| PLK2 \| PRLR \| PTK2 \| RB1 \| RBP4 \| RPL6 \| S1PR1 \| SCD \| SELENOP \| SGK1 \| SOD2 \| SPP1 \| TF \| TPM3 \| TRP53 \| UCP2 \| XDH	66.60	21
7.	alpha-Tocopherol	Diabetes Mellitus, Type 2	M	25 genes: BCL2 \| BCL2L1 \| CASP3 \| CASP8 \| CAT \| CCND2 \| CPT1A \| CYP1A2 \| CYP3A2 \| GSTM1 \| HMOX1 \| HP \| ICAM1 \| INS1 \| NFKB1 \| NOS2 \| NOS3 \| PPARA \| PPARG \| PPARGC1A \| RELA \| SOD1 \| SOD2 \| TGFB1 \| TNF	62.87	20
8.	Aflatoxin B1	Necrosis	M	37 genes: AGT \| AHR \| APP \| ARG2 \| ATG5 \| ATG7 \| BCL2 \| CAST \| CAT \| CDC42 \| CTSB \| CYP2B1 \| CYP2E1 \| DMD \| FAS \| GAPDH \| GATM \| GSTP1 \| HAVCR1 \| HMGB1 \| IL17A \| IL1RN \| IL6 \| LGALS3 \| LPL \| MGMT \| MIR192 \| MTHFR \| NFE2L2 \| POMC \| PRNP \| RBP4 \| RDH13 \| SET \| SLC31A1 \| SOD1 \| TNF	59.58	43
9.	alpha-naphthoflavone	Neoplasm Invasiveness	M	23 genes: AHR \| CAT \| CCL2 \| CTSD \| EGFR \| ENO1 \| ESR1 \| IL1B \| IL1RN \| IL6 \| MAPK1 \| MAPK3 \| MMP1 \| MMP2 \| MMP3 \| MMP9 \| PKM \| PTK2 \| RELA \| SOD2 \| SRC \| TGFB1 \| TNF	58.58	37
10.	Aflatoxin B1	Carcinoma, Hepatocellular	M	162 genes: A2M \| ABCB1 \| ABCB4 \| ACACA \| ACLY \| ACOX1 \| ACSL4 \| ACTB \| ADAMTS1 \| AFP \| AKR1B10 \| AKR1C2 \| ANXA4 \| APC \| APCS \| APEX1 \| APOA1 \| AR \| ARID1A \| ARID2 \| BCL2L1 \| BID \| BIRC5 \| BTG2 \| C9 \| CA2 \| CASP8 \| CCNA1 \| CCND1 \| CCNE1 \| CD274 \| CD276 \| CDH13 \| CDK14 \| CDK4 \| CDKN1B \| CDKN2A \| CEBPA \| CP \| CRP \| CTSD \| CXCL12 \| CXCL8 \| CYLD \| CYP17A1 \| CYP1A1 \| CYP2E1 \| CYR61 \| DEPDC5 \| DPYD \| E2F1 \| EAF2 \| EGF \| ENO1 \| EPHX1 \| ESR1 \| F2 \| FABP5 \| FASN \| FATE1 \| FBP1 \| FDFT1 \| FGF19 \| FOS \| FOXM1 \| FST \| GAPDH \| GDF15 \| GJB1 \| GLI1 \| GNMT \| GPC3 \| GSTM1 \| GSTP1 \| HGFAC \| HHIP \| HMGB2 \| HMGCR \| HOTAIR \| HRAS \| HSPA5 \| HSPA9 \| HSPB1 \| HTATIP2 \| IDH1 \| IGF1R \| IGF2 \| IGF2R \| IL6 \| IQGAP1 \| IQGAP2 \| IRF2 \| IRS1 \| IRS2 \| ITIH3 \| JDP2 \| JUN \| KMT2A \| KMT2B \| KMT2C \| MAT1A \| MBTPS2 \| ME1 \| MECP2 \| MET \| MIR122 \| MLXIPL \| MMP2 \| MMP9 \| MT1A \| MT2A \| MVK \| MYC \| NFE2L2 \| NFKBIA \| NME1 \| NR0B2 \| NR1H4 \| PCK1 \| PDGFB \| PGD \| PGK1 \| PHB \| PKM \| PNPT1 \| PPARG \| PPP1R1A \| PRDX6 \| PTEN \| PTGS2 \| PTK2 \| RB1 \| RPS6KA3 \| RRM1 \| RRM2 \| SCD \| SERPINA4 \| SFN \| SKP2 \| SLC2A2 \| SLIT2 \| SPRTN \| SREBF1 \| STAT1 \| TAGLN2 \| TATDN1 \| TERT \| TFPI2 \| TLR4 \| TNF \| TNFSF10 \| TP53 \| TRIM24 \| TRP53 \| TSC1 \| TST \| TYMS \| UBD \| UBE2E2 \| UCHL1 \| USP2 \| VCAM1	50.10	126
11.	Rotenone	Parkinson Disease	M	35 genes: ABCB1 \| AIF1 \| ATP13A2 \| BDNF \| CP \| DDIT4 \| DRD1 \| DRD2 \| EDN1 \| GDNF \| GFAP \| GPX1 \| GSTA4 \| GSTM1 \| HMOX1 \| HSPA1A \| HSPA9 \| IGF2 \| IL6 \| KCNJ4 \| LRRK2 \| MAP3K5 \| MAPT \| NGF \| NQO1 \| PARK2 \| PARK7 \| PINK1 \| PRKN \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TNF	49.31	89
12.	Rotenone	Nerve Degeneration	M	40 genes: APP \| ATP13A2 \| ATXN3 \| BAX \| BCL2 \| BDNF \| CASP3 \| CD9 \| CDH1 \| CNTF \| CP \| CTNNB1 \| DDIT4 \| EIF2S1 \| GRM4 \| GST-1 \| IFNG \| IGF1 \| IGF2 \| KCNJ4 \| LEP \| LRRK2 \| MAPK1 \| MAPK3 \| MT1 \| MT2 \| NGF \| PINK1 \| PPARG \| PRKN \| SIRT1 \| SKN-1 \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TH \| TNF \| XDH	41.85	66
13.	epicatechin gallate	Breast Neoplasms	M	15 genes: AKT1 \| BCL2 \| CAT \| CYP1A1 \| DHFR \| HRAS \| IL1B \| IL6 \| NOS2 \| PTGS1 \| RELA \| SOD2 \| TNF \| TOP2A \| TRP53	41.19	29
14.	Isoflavones	Mammary Neoplasms, Animal	M	17 genes: ANXA1 \| ANXA2 \| CCND1 \| DES \| ENO1 \| ESR1 \| ESR2 \| EZR \| FN1 \| INS1 \| INSIG1 \| KNG1 \| KRT5 \| PGR \| PTBP1 \| S100A8 \| SCD	40.58	7
15.	Quercetin	Pancreatic Neoplasms	M	53 genes: AHR \| ATM \| AXL \| BCAR1 \| BCL2L1 \| BRCA1 \| BRCA2 \| CDH1 \| CDKN2A \| CFLAR \| CTNNB1 \| CXCL8 \| DPYD \| EFEMP1 \| EGFR \| FOXP1 \| GADD45A \| HIF1A \| KDR \| KLF5 \| KRAS \| MEN1 \| MMP9 \| MYC \| NFKBIA \| NRP1 \| PALLD \| PDX1 \| PLAU \| PPARG \| PTCH1 \| PTEN \| PTGS2 \| PTHLH \| RB1 \| SLC29A1 \| SMAD4 \| SOD2 \| SPINK1 \| STAT3 \| STK11 \| TERT \| TFPI2 \| TGFB1 \| TNF \| TNFRSF10B \| TNFSF10 \| TP53 \| TP63 \| TRP53 \| TSC2 \| TYMS \| ZNRF3	40.41	56
16.	Vitamin E	Myocardial Ischemia	M	47 genes: ACOT2 \| ACTB \| ADIPOQ \| AK1 \| ALDH6A1 \| ALDOA \| APLP2 \| CALR \| CCL2 \| CCND1 \| CCND2 \| CIRBP \| CRP \| DCN \| DNM1L \| F3 \| FGF2 \| GCLC \| GSTP1 \| HADHA \| HMGB1 \| HMOX1 \| HSPA1A \| HSPA9 \| ICAM1 \| IL1B \| IL6 \| KCNJ8 \| MAP3K8 \| MSN \| MX1 \| NFKBIA \| NOS3 \| PEBP1 \| PPAT \| PSMB5 \| PYGB \| RALBP1 \| SELE \| SOD2 \| STAT5A \| TNF \| UGCG \| VCAM1 \| VEGFA \| ZEB1 \| ZFP36	39.87	13
17.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	Cardiomyopathies	M	22 genes: AGT \| AKT1 \| ATF3 \| CAT \| CYP2C9 \| EDN1 \| FAS \| FASLG \| HGF \| IL1A \| IL1B \| IL6 \| MAPK1 \| MAPK14 \| MAPK3 \| PARP1 \| PTGS2 \| SOD2 \| STAT3 \| TLR2 \| TNF \| TRP53	35.72	20
18.	Aflatoxin B1	Weight Loss	M	13 genes: ATG5 \| ATG7 \| CRH \| EPO \| IL10 \| LEP \| LIF \| LTF \| MAPT \| NPY \| POMC \| SOD1 \| TSC22D3	35.58	14
19.	ochratoxin A	Liver Cirrhosis	M	28 genes: A2M \| ACTA2 \| AGT \| ALAD \| ALB \| C1QB \| CP \| CTGF \| CTNNB1 \| CYBA \| CYP1A2 \| DHCR7 \| F2 \| F3 \| F5 \| GC \| HGF \| IGFBP1 \| IGFBP2 \| IL6 \| NFE2L2 \| RGN \| SLC22A8 \| SPP1 \| TAGLN2 \| TGFB1 \| VEGFA \| VIM	35.01	21
20.	Rotenone	Brain Injuries	M	26 genes: ALB \| BDNF \| CCL2 \| CD14 \| CEBPB \| FOS \| GRM8 \| GSK3B \| HSPA1A \| IL10 \| IL1A \| IL1B \| IL6 \| JUN \| LSG1 \| MMP9 \| MPO \| NPPB \| PARP1 \| PTGS2 \| SOD2 \| TNF \| TNFRSF1A \| TRAF4 \| UCP2 \| VEGFA	32.39	31
21.	ochratoxin A	Precancerous Conditions	M	27 genes: AKT1 \| ATP5B \| CAT \| CCND1 \| CDH1 \| CDKN2A \| CEBPA \| CPS1 \| EIF4EBP1 \| GJB1 \| GSTA4 \| GSTO1 \| GSTP1 \| HRAS \| IGF2 \| IGFBP1 \| IL6 \| MAPK8 \| MAPK9 \| MDM2 \| MGMT \| PHB \| PTGS2 \| SOD2 \| TRP53 \| TSC2 \| VEGFA	32.10	22
22.	Rotenone	Disease Models, Animal	M	26 genes: AIF1 \| AKT1 \| ALB \| APP \| CLDN11 \| ESR1 \| FAS \| FOS \| GFAP \| HBB \| IFNG \| IL1B \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| MAPT \| MMP9 \| PARK2 \| RHOA \| SERPINE1 \| SNCA \| SOD1 \| STAT3 \| TNF \| TRP53	31.15	40
23.	troglitazone	Liver Cirrhosis	M	31 genes: ABCB4 \| ACTA2 \| AGT \| ALAD \| ALB \| CCL2 \| CD14 \| CD9 \| COL1A1 \| COL1A2 \| CP \| CTGF \| CTNNB1 \| CYBA \| CYP1A2 \| FBN1 \| FGF2 \| FLT1 \| IGFBP1 \| IGFBP2 \| IL6 \| KRT8 \| MMP2 \| NFE2L2 \| PLAU \| SMAD3 \| SPP1 \| STAT1 \| TGFB1 \| VEGFA \| VTN	30.56	28
24.	aluminum maltolate	Nerve Degeneration	M	9 genes: APP \| BAX \| BCL2 \| BDNF \| CASP3 \| MAPK1 \| MAPK3 \| NGF \| TNF	28.44	26
25.	Isoflavones	Adenocarcinoma	M	15 genes: BCL2 \| CASP8 \| CCND1 \| CKB \| CXCL8 \| ENO1 \| ESR1 \| ESR2 \| KRT8 \| MKI67 \| PCNA \| PGR \| SELENBP1 \| TNF \| TP53	28.38	14
26.	troglitazone	Drug-Induced Liver Injury	M	76 genes: ABCB1B \| ABCC2 \| ADIPOQ \| AHR \| ALB \| ALDOB \| APOA1 \| APOE \| ARG1 \| ATOH8 \| BAX \| BDH1 \| C3 \| CAT \| CCL2 \| CLU \| CP \| CTNNB1 \| CXCL1 \| CXCL10 \| CYP2C19 \| CYP2C9 \| CYP2E1 \| CYP2K18 \| CYP3A23/3A1 \| CYP8B1 \| DNAJB9 \| DNAJC12 \| ENO1 \| FADS1 \| FADS2 \| FASN \| FCMR \| FLT1 \| GADD45A \| GCLC \| GOT1 \| GPT \| GSN \| GSR \| GSTM1 \| GSTM3 \| GSTP1 \| GSTT1 \| HACL1 \| HADHA \| HMGB1 \| HMOX1 \| HPX \| IFNG \| IGF1 \| IL11 \| IL1A \| IL1B \| IL1R2 \| IL6 \| LCN2 \| LRAT \| MAP3K5 \| MMP2 \| NFE2L2 \| NR1H3 \| NR1I2 \| NR1I3 \| PDK4 \| PEX11A \| PPARA \| PTGS2 \| SELENBP1 \| SESN2 \| SOD1 \| SOD2 \| SPP1 \| TALDO1 \| TBXA2R \| TNF	27.89	92
27.	Genistein	Infertility, Female	M	21 genes: AR \| CEBPA \| CEBPB \| CTGF \| CYP17A1 \| CYP19A1 \| DHFR \| ESR1 \| ESR2 \| FSHB \| LEP \| LEPR \| LHB \| LIF \| MAPK1 \| MAPK3 \| NR1I2 \| NR2F2 \| NR5A2 \| PRL \| TP53	26.90	15
28.	troglitazone	Hemangiosarcoma	M	14 genes: ANGPT2 \| CCND1 \| COL18A1 \| CTNNB1 \| FLT1 \| GJA4 \| HRAS \| JUN \| KDR \| MYC \| TEK \| TP53 \| VEGFA \| VEGFC	26.75	8
29.	Aflatoxin B1	Lung Neoplasms	M	141 genes: A2M \| ACSM1 \| ACTB \| ADAM28 \| AKT1 \| ANXA2 \| APC \| APOA1 \| APOC3 \| APOE \| ATOX1 \| AZGP1 \| BAP1 \| BCL2L1 \| BIRC5 \| BRCA2 \| CASC1 \| CASP8 \| CCND1 \| CCNG1 \| CDH13 \| CDKN1A \| CDKN1B \| CDKN1C \| CDKN2A \| CEACAM1 \| CES1 \| CES1F \| CHRNA3 \| CHRNA5 \| CHRNA7 \| CRP \| CTGF \| CXCL14 \| CYP1A2 \| CYP1B1 \| CYP24A1 \| CYP2A6 \| CYP2E1 \| DAB2IP \| DDR1 \| DLEC1 \| DNASE1L3 \| DNMT3A \| DOK2 \| DPYD \| EAF2 \| EEF2 \| EHMT2 \| EMX2 \| EPHX1 \| ERBB3 \| ERCC6 \| ESR1 \| FAS \| FGF9 \| FGFR2 \| FHIT \| FOS \| FOXM1 \| GAST \| GATA6 \| GC \| GJA1 \| GJB1 \| GPX1 \| GSTM1 \| GSTP1 \| GSTT1 \| HES1 \| HEY1 \| HMOX1 \| HRAS \| ID3 \| IKBKG \| IL10 \| IL6 \| JAG1 \| JUN \| JUNB \| MAP3K8 \| MAPK1 \| MAPK3 \| MCL1 \| MET \| MIR146A \| MIR193A \| MIR222 \| MIR30A \| MIR31 \| MIR34C \| MIR370 \| MIR410 \| MIR432 \| MIR494 \| MMP10 \| MTHFR \| MYC \| NFYA \| NOTCH2 \| NOTCH3 \| OGG1 \| PCNA \| PON1 \| PPP2R1B \| PRDX6 \| PRKN \| PTEN \| PTGIS \| RARB \| RASSF1 \| RIOX2 \| ROBO1 \| RUNX3 \| SELENBP1 \| SELENOP \| SFTPD \| SLC22A18 \| SLC3A2 \| SLC7A5 \| SLCO1B3 \| SND1 \| SOX2 \| SPP1 \| STAT5A \| TEP1 \| TERT \| TFRC \| TLR4 \| TNF \| TP53 \| TP63 \| TRP53 \| TSHR \| TTR \| TYMS \| TYRP1 \| UGT2B17 \| VHL \| WNT5A \| XPC	26.57	131
30.	Rotenone	Lewy Body Disease	M	10 genes: AIF1 \| BECN1 \| EDN1 \| GFAP \| IGF2 \| NGF \| NTRK1 \| NTRK2 \| SNCA \| SOD2	26.37	5
31.	alpha-naphthoflavone	Drug-Induced Liver Injury	M	22 genes: ABCC1 \| AHR \| ARNT \| BAX \| CAT \| CCL2 \| CYP2C11 \| CYP2C9 \| ENO1 \| GCLC \| GSR \| GSTP1 \| IL1B \| IL6 \| MMP2 \| NFE2L2 \| NR1I3 \| PPARA \| PTGS2 \| SOD1 \| SOD2 \| TNF	26.29	29
32.	aflatoxin G1	Adenocarcinoma	M	8 genes: IL1B \| NR1I2 \| PTGS2 \| SOD2 \| STAT3 \| TNF \| TP53 \| VEGFA	26.16	11
33.	ochratoxin A	Liver Neoplasms	M	31 genes: ABCB1B \| AHR \| ANXA2 \| ASNS \| CCND1 \| CDKN2A \| CTNNB1 \| CYP2E1 \| GJB1 \| GNMT \| GPX2 \| GPX3 \| GSTM1 \| HGF \| HMOX1 \| HRAS \| IGF2 \| IL2 \| JUN \| MAPK14 \| MYC \| NAT2 \| NFE2L2 \| OAT \| PPARG \| SCD \| SERPINE1 \| SLC11A2 \| TNF \| TP53 \| XPA	25.88	34
34.	epicatechin gallate	Disease Progression	M	7 genes: BCL2 \| CAT \| HRAS \| MYC \| PREP \| SOD2 \| TOP2A	25.54	13
35.	troglitazone	Fatty Liver	M	32 genes: ATPIF1 \| BIRC3 \| CAT \| CEBPB \| CXCL8 \| CYCS \| CYP19A1 \| CYP2E1 \| FGF21 \| GPT \| GPX1 \| HADHB \| INS \| LDLR \| LEP \| MAT1A \| MTTP \| MYC \| NR1H3 \| NR1I2 \| PLIN2 \| PNPLA3 \| PPARA \| SCD1 \| SERPINE1 \| SLC2A2 \| SOD1 \| SOD2 \| SREBF1 \| TNF \| UCP2 \| XBP1	24.98	30
36.	epigallocatechin gallate	Disease Progression	M	27 genes: ABCB1 \| ABCC1 \| ATP7B \| BCL2 \| CAT \| CDH1 \| CTSB \| DDX58 \| EGF \| EGFR \| ERBB2 \| FGF2 \| GSTP1 \| HIKESHI \| HRAS \| MMP2 \| MRPS11 \| MYC \| NBAS \| PLPP1 \| RAD23A \| RPL13 \| SOD2 \| SOD3 \| STAT1 \| TERT \| TOP2A	24.80	28
37.	Apigenin	Drug-Induced Liver Injury	M	24 genes: ABCC1 \| AHR \| ARNT \| BAX \| CAT \| CCL2 \| CYP2C9 \| GCLC \| HMOX1 \| IFNG \| IL1B \| IL4 \| IL6 \| LTF \| MMP2 \| NFE2L2 \| NR1H4 \| NR1I2 \| PTGS2 \| SOD1 \| SOD2 \| SULT1E1 \| TNF \| UGT1A9	23.72	33
38.	troglitazone	Cholestasis	M	33 genes: ABCB11 \| ABCC2 \| ABCC3 \| AGT \| CAT \| CCL7 \| CXCL2 \| CXCL8 \| CYP1A2 \| CYP7A1 \| CYP8B1 \| DNAJB9 \| DNAJC12 \| EGR1 \| FAM129A \| HACL1 \| HOGA1 \| ICAM1 \| ID4 \| IGF1 \| IL6 \| LY96 \| MAPK14 \| NFE2L2 \| NOS2 \| NR1H3 \| RELA \| SERPINE1 \| SLCO1A1 \| SLCO1A4 \| TNF \| VCAM1 \| VIL1	23.54	18
39.	Aflatoxin B1	Drug-Related Side Effects and Adverse Reactions	M	46 genes: ABCB1 \| ABCB1A \| ABCC2 \| ABCC4 \| ABCG2 \| ADORA1 \| ALB \| BCHE \| CES2 \| CLU \| COMMD1 \| CSF2 \| CYP1A2 \| CYP2C9 \| CYP2D6 \| CYP2E1 \| DHFR \| EPHX2 \| FGA \| HAVCR1 \| HMGB1 \| HMOX1 \| HOMER1 \| IGF1 \| IGFBP1 \| IL3 \| KITLG \| MTHFR \| MTRR \| NAT1 \| NAT2 \| NFE2L2 \| PLK2 \| PPARA \| PTGS2 \| REN \| SHMT1 \| SLCO1B1 \| SLCO2A1 \| SPP1 \| THBD \| TLR1 \| TLR2 \| TRP53 \| TYMS \| UGT1A1	22.91	48
40.	Rotenone	Neurodegenerative Diseases	M	17 genes: APP \| FTH1 \| FTL1 \| GDNF \| GSR \| GSTM1 \| GSTM2 \| GSTM6 \| GSTO1 \| HMOX1 \| IL6 \| MAPT \| MGST1 \| NGF \| SIRT1 \| SNCA \| SOD2	22.82	16
41.	ochratoxin A	Drug-Induced Liver Injury	M	54 genes: ABCB1A \| ABCB1B \| ABCC2 \| AHR \| AIFM1 \| ALB \| ANXA2 \| APOE \| BAX \| CAT \| CLU \| CP \| CTNNB1 \| CYP2A6 \| CYP2C9 \| CYP2E1 \| DSC2 \| FADS1 \| GADD45A \| GC \| GCLC \| GSTM1 \| GSTM2 \| GSTP1 \| GSTT1 \| HAVCR1 \| HMOX1 \| IFNG \| IGF1 \| IL1A \| IL1B \| IL1R2 \| IL4 \| IL6 \| LCN2 \| MIR148A \| NAT2 \| NFE2L2 \| NR1I2 \| PON1 \| PRKDC \| PTGS2 \| RGN \| SESN2 \| SLC22A8 \| SOD1 \| SOD2 \| SOD3 \| SORD \| SPP1 \| TAGLN2 \| TF \| TNF \| VIM	22.54	56
42.	aflatoxin G1	Lung Neoplasms	M	8 genes: CHEK2 \| CYP1A2 \| HMOX1 \| IL10 \| IL1B \| IL6 \| TNF \| TP53	21.98	13
43.	cladosporin	Inflammation	M	10 genes: CCL3 \| CCL4 \| CXCL2 \| CXCR3 \| IFNG \| IL10 \| IL1B \| IL6 \| MIF \| TNF	21.28	32
44.	splitomicin	Thrombosis	M	5 genes: F2 \| F3 \| KLKB1 \| SIRT1 \| TNF	19.87	8
45.	ochratoxin A	Acute Kidney Injury	M	31 genes: A2M \| ALB \| ATP5B \| BAX \| CD44 \| CLU \| CST3 \| CYP2C9 \| EGFR \| GSK3B \| GSTM2 \| GSTP1 \| HAVCR1 \| HMOX1 \| HSPA1A \| IGF1 \| IGFBP1 \| IL10 \| IL6 \| LCN2 \| NFE2L2 \| NOS2 \| NQO1 \| OCLN \| PPARG \| SLC22A12 \| SPP1 \| TGFB1 \| TNF \| TP53 \| VEGFA	19.48	35
46.	troglitazone	Hepatitis, Autoimmune	M	10 genes: ALDOB \| C1S \| CCL2 \| CCL5 \| CXCL1 \| IFNG \| IL5 \| IL6 \| LEP \| TGFB1	19.22	3
47.	beta-Naphthoflavone	Liver Neoplasms	M	26 genes: ACOT1 \| AHR \| ANXA4 \| APCS \| ASNS \| CCND1 \| CTNNB1 \| CYP2E1 \| EGLN3 \| ESM1 \| ESR1 \| GPX2 \| GPX3 \| GSTM1 \| HMOX1 \| IL12A \| JUN \| NFE2L2 \| NR1H4 \| NR1I3 \| PPARA \| PQLC3 \| SERPINE1 \| TNF \| TP53 \| ZDHHC2	19.01	28
48.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	Retinal Diseases	M	9 genes: HMOX1 \| ICAM1 \| MMP9 \| NOS2 \| OCLN \| PDGFB \| TNF \| VEGFA \| VIM	18.90	4
49.	ochratoxin A	Craniofacial Abnormalities	M	18 genes: ANXA1 \| APAF1 \| B4GALT7 \| CNTN4 \| COL2A1 \| CTNNB1 \| DLL3 \| DLX5 \| EGFR \| FADD \| FGD1 \| FGF8 \| PDGFRA \| PTEN \| STRA6 \| TGFB2 \| THRB \| TRP53	18.17	28
50.	Warfarin	Calcinosis	M	7 genes: ALPL \| BGLAP \| CASP3 \| COL1A1 \| IL1B \| PDGFB \| SPP1	16.67	6

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