| Interacting Gene | Interactions | Organisms | |
|---|---|---|---|
| 1. | TNF | 1,119 | 12 |
| 2. | CASP3 | 858 | 12 |
| 3. | CYP1A1 | 831 | 22 |
| 4. | MAPK1 | 821 | 16 |
| 5. | MAPK3 | 802 | 14 |
| 6. | ESR1 | 580 | 12 |
| 7. | IL1B | 552 | 8 |
| 8. | AHR | 518 | 12 |
| 9. | AKT1 | 509 | 12 |
| 10. | PTGS2 | 493 | 7 |
| 11. | BCL2 | 487 | 8 |
| 12. | NOS2 | 466 | 6 |
| 13. | HMOX1 | 454 | 8 |
| 14. | ESR2 | 445 | 7 |
| 15. | IL6 | 400 | 6 |
| 16. | BAX | 384 | 10 |
| 17. | PPARG | 373 | 6 |
| 18. | CAT | 364 | 13 |
| 19. | NFE2L2 | 336 | 8 |
| 20. | TP53 | 328 | 6 |
| 21. | RELA | 321 | 6 |
| 22. | CASP9 | 291 | 7 |
| 23. | CDKN1A | 287 | 4 |
| 24. | PARP1 | 287 | 6 |
| 25. | CYP2C9 | 271 | 2 |
| 26. | CYP3A4 | 270 | 4 |
| 27. | CYP1A2 | 256 | 8 |
| 28. | VEGFA | 248 | 6 |
| 29. | MMP9 | 233 | 4 |
| 30. | CCND1 | 210 | 5 |
| 31. | IFNG | 210 | 5 |
| 32. | TGFB1 | 210 | 6 |
| 33. | CYP1B1 | 209 | 8 |
| 34. | NQO1 | 203 | 5 |
| 35. | CXCL8 | 200 | 5 |
| 36. | VKORC1 | 191 | 6 |
| 37. | FOS | 188 | 5 |
| 38. | NFKBIA | 186 | 6 |
| 39. | JUN | 184 | 6 |
| 40. | SOD2 | 176 | 8 |
| 41. | CCL2 | 173 | 6 |
| 42. | HIF1A | 172 | 6 |
| 43. | CASP8 | 170 | 5 |
| 44. | INS1 | 158 | 4 |
| 45. | BCL2L1 | 137 | 5 |
| 46. | AR | 133 | 3 |
| 47. | MMP2 | 131 | 4 |
| 48. | EGF | 129 | 5 |
| 49. | AGT | 121 | 4 |
| 50. | UGT1A1 | 119 | 4 |