Rotenone - Diseases

These diseases are associated with Rotenone or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

Disease categories [Show chart]

1–50 of 2,525 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Rotenone	Parkinson Disease	M	35 genes: ABCB1 \| AIF1 \| ATP13A2 \| BDNF \| CP \| DDIT4 \| DRD1 \| DRD2 \| EDN1 \| GDNF \| GFAP \| GPX1 \| GSTA4 \| GSTM1 \| HMOX1 \| HSPA1A \| HSPA9 \| IGF2 \| IL6 \| KCNJ4 \| LRRK2 \| MAP3K5 \| MAPT \| NGF \| NQO1 \| PARK2 \| PARK7 \| PINK1 \| PRKN \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TNF	49.31	89
2.	Rotenone	Nerve Degeneration	M	40 genes: APP \| ATP13A2 \| ATXN3 \| BAX \| BCL2 \| BDNF \| CASP3 \| CD9 \| CDH1 \| CNTF \| CP \| CTNNB1 \| DDIT4 \| EIF2S1 \| GRM4 \| GST-1 \| IFNG \| IGF1 \| IGF2 \| KCNJ4 \| LEP \| LRRK2 \| MAPK1 \| MAPK3 \| MT1 \| MT2 \| NGF \| PINK1 \| PPARG \| PRKN \| SIRT1 \| SKN-1 \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TH \| TNF \| XDH	41.85	66
3.	Rotenone	Brain Injuries	M	26 genes: ALB \| BDNF \| CCL2 \| CD14 \| CEBPB \| FOS \| GRM8 \| GSK3B \| HSPA1A \| IL10 \| IL1A \| IL1B \| IL6 \| JUN \| LSG1 \| MMP9 \| MPO \| NPPB \| PARP1 \| PTGS2 \| SOD2 \| TNF \| TNFRSF1A \| TRAF4 \| UCP2 \| VEGFA	32.39	31
4.	Rotenone	Disease Models, Animal	M	26 genes: AIF1 \| AKT1 \| ALB \| APP \| CLDN11 \| ESR1 \| FAS \| FOS \| GFAP \| HBB \| IFNG \| IL1B \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| MAPT \| MMP9 \| PARK2 \| RHOA \| SERPINE1 \| SNCA \| SOD1 \| STAT3 \| TNF \| TRP53	31.15	40
5.	Rotenone	Lewy Body Disease	M	10 genes: AIF1 \| BECN1 \| EDN1 \| GFAP \| IGF2 \| NGF \| NTRK1 \| NTRK2 \| SNCA \| SOD2	26.37	5
6.	Rotenone	Neurodegenerative Diseases	M	17 genes: APP \| FTH1 \| FTL1 \| GDNF \| GSR \| GSTM1 \| GSTM2 \| GSTM6 \| GSTO1 \| HMOX1 \| IL6 \| MAPT \| MGST1 \| NGF \| SIRT1 \| SNCA \| SOD2	22.82	16
7.	Rotenone	Parkinsonian Disorders	M	16 genes: ATP13A2 \| DRD2 \| GDNF \| GSR \| HTRA2 \| LRRK2 \| MAPT \| NGF \| PARK7 \| PARP1 \| PINK1 \| PRKCD \| PRKN \| SLC18A2 \| SNCA \| TH	16.06	59
8.	Rotenone	Drug-Induced Liver Injury	M	49 genes: ABCB1 \| AIFM1 \| ALB \| ALDOB \| ANXA2 \| ATG5 \| BAX \| CAT \| CCL2 \| CLU \| CP \| CTNNB1 \| CXCL1 \| DHRS7 \| EPHX1 \| FASN \| FGA \| FLT1 \| GADD45A \| GCLC \| GPT \| GSR \| GSTM1 \| GSTM2 \| HBA-A1 \| HMOX1 \| IFNG \| IGF1 \| IL1A \| IL1B \| IL6 \| LGALS3 \| MAP1LC3B \| MAP3K5 \| MIR34C \| MMP2 \| NFE2L2 \| NOX4 \| PDK4 \| PEX11A \| PTGS2 \| S100A11 \| SESN2 \| SOD1 \| SOD2 \| SPP1 \| SULT1E1 \| TNF \| WASL	14.96	42
9.	Rotenone	Retinal Degeneration	M	6 genes: BCL2 \| CCL2 \| CP \| GDNF \| NMNAT1 \| SOD1	9.58	8
10.	Rotenone	Gliosis	M	5 genes: BDNF \| GFAP \| GRM8 \| MAPK1 \| MAPK3	7.05	6
11.	Rotenone	Optic Atrophy, Hereditary, Leber	M	3 genes: IL1A \| IL1B \| ND6	6.92	5
12.	Rotenone	Attention Deficit Disorder with Hyperactivity	M	6 genes: DRD2 \| GRM5 \| GRM7 \| GRM8 \| PTPRD \| SLC6A3	5.90	8
13.	Rotenone	Tauopathies	M	2 genes: GSK3B \| MAPT	5.14	7
14.	Rotenone	Chromosome Breakage	M	5 genes: BRCA1 \| CAT \| H2AFX \| MYC \| NFE2L2	4.35	6
15.	Rotenone	Motor Neuron Disease	M	2 genes: PRDX3 \| SOD1	4.23	2
16.	Rotenone	Neurotoxicity Syndromes	M	9 genes: ABCB1 \| BCL2L1 \| CASP3 \| FOS \| MTOR \| NFE2L2 \| NQO1 \| PRKCD \| TIMP3	4.16	12
17.	Rotenone	Neuromuscular Manifestations	M	1 gene: SKN-1	4.05	2
18.	Rotenone	Hypokinesia	M	1 gene: GCH1	3.40	10
19.	deguelin	Poisoning	M	2 genes: GSK3B \| PRKDC	3.33	3
20.	Rotenone	Cataract	M	3 genes: ATM \| ERCC6 \| PITX3	3.26	5
21.	Rotenone	Hemorrhage	M	2 genes: FOS \| NQO1	3.26	3
22.	Rotenone	Parkinson Disease, Secondary	M	5 genes: ABCB1 \| ATP13A2 \| GDNF \| NOS2 \| PARK2	3.10	9
23.	Rotenone	Neurobehavioral Manifestations	M	2 genes: FKBP5 \| NGF	2.93	4
24.	Rotenone	Motor Skills Disorders	M	1 gene: PTEN	2.85	2
25.	Rotenone	Dyskinesias	M	2 genes: CP \| DRD2	2.84	3
26.	Rotenone	Cerebrovascular Disorders	M	1 gene: EDN1	2.65	2
27.	Rotenone	Mitochondrial Diseases	M	2 genes: NOS2 \| SOD2	2.65	4
28.	Rotenone	Sleep Wake Disorders	M	2 genes: IL1B \| SLC6A3	2.62	3
29.	Rotenone	Hyperkinesis	M	10 genes: ADORA2A \| DRD1 \| DRD2 \| FOS \| NGF \| NPY \| NTRK2 \| NTS \| SLC6A3 \| TH	2.56	14
30.	Rotenone	Dystonia	M	3 genes: GCH1 \| TH \| TOR1A	2.49	7
31.	Rotenone	Poisoning	M	4 genes: ABCB1 \| ACHE \| ALB \| GSK3B	2.49	5
32.	Rotenone	Muscle Rigidity	M	3 genes: GCH1 \| NPY \| NTS	2.47	7
33.	Rotenone	Gastrointestinal Diseases	M	3 genes: EDN1 \| KEAP1 \| NFE2L2	2.40	3
34.	Rotenone	Weight Loss	M	9 genes: ADORA2A \| ATG5 \| ATG7 \| IL10 \| LEP \| MAPT \| MT1 \| NPY \| SOD1	2.40	11
35.	Rotenone	Movement Disorders	M	7 genes: ACHE \| ADORA2A \| DRD1 \| DRD2 \| MT1 \| MT2 \| UTS2	2.39	11
36.	Rotenone	Catalepsy	M	5 genes: AGT \| DRD1 \| DRD2 \| NTS \| TH	2.32	17
37.	Rotenone	Agricultural Workers' Diseases	M			2
38.	Rotenone	Blindness	M			1
39.	Rotenone	Death	M			1
40.	Rotenone	Motor Disorders	M			2
41.	Rotenone	Optic Nerve Diseases	M			1
42.	Rotenone	Sialorrhea	M			1
43.	Rotenone	Signs and Symptoms, Respiratory	M			1
44.	Rotenone	Striatonigral Degeneration	M			2
45.	Rotenone	Vision Disorders	M			1
46.	Rotenone	Vision, Low	M			1
47.	Rotenone	Necrosis	M T	26 genes: AGT \| AIFM1 \| APP \| ATF4 \| ATG5 \| ATG7 \| BCL2 \| CAT \| CDC42 \| CTSB \| DPP7 \| FAS \| GAPDH \| IFNG \| IL1B \| IL6 \| LGALS3 \| LPL \| NFE2L2 \| NOS2 \| RBP4 \| SET \| SOD1 \| SOD2 \| TNF \| TNNT2	6.61	33
48.	deguelin	Breast Neoplasms	T	47 genes: AKT1 \| ANGPTL4 \| ATM \| BAX \| BCL2 \| BIRC5 \| BRCA1 \| CASP7 \| CASP8 \| CCND1 \| CDH1 \| CTNNB1 \| CXCL8 \| CXCR4 \| CYP1A1 \| EGFR \| FOS \| HIF1A \| IFNG \| IGF1 \| IGF1R \| IL6 \| JUN \| KDR \| KRT18 \| MAP2K7 \| MKI67 \| MMP1 \| MMP2 \| MMP9 \| NCOA3 \| NFKBIA \| NOS2 \| NOS3 \| PARP1 \| PIK3CA \| PTGS2 \| RB1 \| RELA \| RPS6 \| SFRP2 \| SNAI1 \| SRC \| STAT3 \| TNF \| TP53 \| VIM	113.54	90
49.	Rotenone	Reperfusion Injury	T	45 genes: AGT \| BCL2 \| CASP3 \| CASP8 \| CAT \| CCL2 \| CD36 \| CDKN1A \| CXCL1 \| CXCL2 \| CXCL8 \| CYBB \| EDN1 \| EGR1 \| ETS1 \| FOS \| GPT \| GPX1 \| HMOX1 \| HSPA1A \| HSPA8 \| HSPB1 \| ICAM1 \| IL10 \| IL1A \| IL1B \| IL6 \| JUN \| KDR \| MAPK8 \| MAPK9 \| MMP9 \| MPO \| NOS2 \| NOS3 \| PPARG \| PTEN \| PTGS2 \| RELA \| SOD1 \| SOD2 \| STAT3 \| SULT1E1 \| TNF \| XDH	78.78	51
50.	deguelin	Prostatic Neoplasms	T	34 genes: AKT1 \| ATM \| ATR \| BAX \| BCL2 \| BRCA1 \| CCND1 \| CDH1 \| CDKN1A \| CTNNB1 \| CXCL8 \| CYP1A1 \| EGFR \| GSK3B \| HIF1A \| ICAM1 \| IGF1 \| IL10 \| IL6 \| MAPK3 \| MMP13 \| MMP9 \| MYC \| NCOA3 \| NOS3 \| PARP1 \| PIK3CA \| PRKDC \| PTGS2 \| STAT3 \| TGFB1 \| TP53 \| VEGFA \| VIM	76.13	66

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