Skip navigation

Chemical Rotenone

1–50 of 391 results.
  Curated. Reference Cited Chemicals Cited Genes Cited Diseases
1. Curated.
Chambers TP, et al.
Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity.
Toxicology. 2017 May 1;382:24-35.
 Imatinib Mesylate | Oxygen | Rotenone | Thapsigargin CANX | CASP3 | CASP7 | CASP9 | DDIT3 | ERO1A | HSPA5 | SH3BP5  
2. Curated.
Das S, et al.
Harmonization of Mangiferin on methylmercury engendered mitochondrial dysfunction.
Environ Toxicol. 2017 Feb;32(2):630-644.
 mangiferin | Methylmercury Compounds | Rotenone DNM1L | GSR  
3. Curated.
Guan Q, et al.
RNA-Seq Expression Analysis of Enteric Neuron Cells with Rotenone Treatment and Prediction of Regulated Pathways.
Neurochem Res. 2017 Feb;42(2):572-582.
 Rotenone ADAMTS1 | ATP1A2 | BHLHE40 | CCL6 | CLDN11 | EFNB3 | ETS1 | FMOD | FTL1 | GAS7 | GDF15 | IGF2 | LARP7 | LGALS3 | LTBP2 | MAPK9 | MBP | MGLL | MGP | NNAT | NPY | ODC1 | ODF2 | OGN | PDE10A | PPP3R1 | PTX3 | RGD1311744 | RUFY2 | SERPINE1 | SERPINE2 | SGK1 | SPP1 | TLE4 | TNNT2 | UGT8 | WARS | WISP2 | XRCC6  
4. Curated.
Hsu YC, et al.
Antitumor effects of deguelin on H460 human lung cancer cells in vitro and in vivo: Roles of apoptotic cell death and H460 tumor xenografts model.
Environ Toxicol. 2017 Jan;32(1):84-98.
 deguelin AIFM1 | BAK1 | BAX | BCL2 | BCL2L1 | CASP3  
5. Curated.
Ishido M, et al.
Neonatal rotenone lesions cause onset of hyperactivity during juvenile and adulthood in the rat.
Toxicol Lett. 2017 Jan 15;266:42-48.
 Rotenone ABCG5 | ANAPC1 | BAZ1B | CALCRL | CCR3 | DHRS7 | DNAH7 | EML4 | GRIFIN | HSPA1A | IGFBP5 | KLF2 | LILRB3 | PRKCD | RNF138 | SSPN | SULT1E1 | TNN | TNNT2 | TP53INP1 | WISP2 Attention Deficit Disorder with Hyperactivity | Hyperkinesis
6. Curated.
Naughton C, et al.
Interaction between subclinical doses of the Parkinson''s disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats.
Behav Brain Res. 2017 Jan 1;316:160-168.
 Rotenone SNCA Nerve Degeneration
7. Curated.
Tak E, et al.
Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure.
Toxicol Appl Pharmacol. 2017 Jan 1;314:72-81.
 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin | cobaltous chloride | deguelin | Oxygen | Thioacetamide ENTPD1 | HIF1A | NT5E Disease Models, Animal | Liver Failure, Acute
8. Curated.
Wang Y, et al.
Ultrafine carbon particles promote rotenone-induced dopamine neuronal loss through activating microglial NADPH oxidase.
Toxicol Appl Pharmacol. 2017 May 1;322:51-59.
 Rotenone | Soot CYBB | ITGAM | NCF1 | NCF4  
9. Curated.
Zhang XL, et al.
DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult.
Toxicol Lett. 2017 Apr 5;271:74-83.
 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one | Bibenzyls | Rotenone AKT1 | GSK3B | HMOX1 | NFE2L2 | PARK7  
10. Curated.
Abdelkader NF, et al.
Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson''s Disease: Modulation of Mitochondrial Perturbations.
Mol Neurobiol. 2016 Mar;53(2):810-7.
 Rotenone | Ursodeoxycholic Acid BAX | BCL2 | CASP3 | CASP8 | CASP9 | IL10 | IL1B | NFKB1 | TNF Movement Disorders
11. Curated.
Chen YJ, et al.
Tracking micro-optical resonances for identifying and sensing novel procaspase-3 protein marker released from cell cultures in response to toxins.
Nanotechnology. 2016 Apr 22;27(16):164001.
 Rotenone | Staurosporine CASP3 | SNCA  
12. Curated.
El-Horany HE, et al.
Ameliorative Effect of Quercetin on Neurochemical and Behavioral Deficits in Rotenone Rat Model of Parkinson''s Disease: Modulating Autophagy (Quercetin on Experimental Parkinson''s Disease).
J Biochem Mol Toxicol. 2016 Jul;30(7):360-9.
 Apomorphine | Quercetin | Rotenone BECN1 | DDIT3 Catalepsy | Disease Models, Animal | Gliosis | Movement Disorders | Necrosis | Parkinsonian Disorders | Weight Loss
13. Curated.
Gaballah HH, et al.
Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson''s disease.
Chem Biol Interact. 2016 May 5;251:10-6.
 resveratrol | Rotenone CASP3 | DDIT3 | HSPA5 | IL1B | NFE2L2 | XDH Catalepsy | Motor Disorders | Parkinsonian Disorders
14. Curated.
Goswami P, et al.
Endoplasmic Reticulum Stress Plays a Key Role in Rotenone-Induced Apoptotic Death of Neurons.
Mol Neurobiol. 2016 Jan;53(1):285-298.
 Rotenone | salubrinal CASP12 | CASP3 | CASP9 | DDIT3 | EIF2S1 | HSPA5 Chromosome Breakage
15. Curated.
Huang JY, et al.
20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway.
Acta Pharmacol Sin. 2016 Jun;37(6):731-40.
 Bibenzyls | Rotenone BAX | BCL2 | CASP3 | HMOX1 | NFE2L2 | NQO1 Parkinsonian Disorders
16. Curated.
Liu J, et al.
Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis.
Sci Rep. 2016 Feb 5;6:20639.
 Chloroquine | Rotenone | wortmannin BECN1 | CASP1 | CASP3 | IL1RN | IRAK3 | MAP1LC3B  
17. Curated.
Pan PK, et al.
Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson''s disease through regulating Keap1/Nrf2 signaling pathway.
Cell Mol Biol (Noisy-le-grand). 2016 Dec 30;62(14):11-17.
 Rotenone | safranal GCLC | HMOX1 | KEAP1 | NFE2L2 | NQO1  
18. Curated.
Peng K, et al.
Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity.
Oxid Med Cell Longev. 2016;2016:6705621.
 resveratrol | Rotenone DNM1L | FIS1 | MFN2 | OPA1 | PPARGC1A | TFAM Motor Disorders
19. Curated.
Sala G, et al.
Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson''s disease.
Neurotoxicology. 2016 May;54:161-9.
 3-methyladenine | Rotenone HSPA8 | SNCA  
20. Curated.
Wise JP JR, et al.
From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson''s Disease Models.
Toxicol Sci. 2016 Oct;153(2):372-81.
 Rotenone OPTN Parkinson Disease
21. Curated.
Yalçınkaya N, et al.
Expression changes of genes associated with apoptosis and survival processes in Parkinson''s disease.
Neurosci Lett. 2016 Feb 26;615:72-7.
 Rotenone AIFM1 | AKT1 | BCL2 | PARK7 | PTEN Disease Models, Animal | Parkinsonian Disorders
22. Curated.
Zhang JY, et al.
SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model.
Neurochem Res. 2016 Jul;41(7):1761-73.
 Rotenone SIRT3 | SNCA  
23. Curated.
Zhang L, et al.
Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction.
PLoS One. 2016;11(4):e0152931.
 Lithium Chloride | Rotenone | SB 216763 CASP3 | CTNNB1 | NR4A2  
24. Curated.
Chiu CC, et al.
Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.
Exp Neurol. 2015 Jan;263:244-53.
 4-hydroxy-2-nonenal | N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide | Rotenone ALDH2 | BAX | CASP3 | CASP9  
25. Curated.
Choi WS, et al.
JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.
Toxicology. 2015 Feb 3;328:75-81.
 anthra(1,9-cd)pyrazol-6(2H)-one | Rotenone CASP3 | MAPK10 | SLC18A2  
26. Curated.
Fan F, et al.
Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.
Toxicol Sci. 2015 Jun;145(2):283-95.
 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine | adefovir dipivoxil | Amlodipine | Amsacrine | aprepitant | artesunate | Estradiol | Betamethasone | bexarotene | bicalutamide | Bortezomib | Budesonide | Camptothecin | ciclesonide | ciclopirox | Clomiphene | Clomipramine | Colchicine | Danazol | Digitoxin | Domperidone | Doxorubicin | dronedarone | Duloxetine Hydrochloride | Emetine | Epirubicin | Ethinyl Estradiol | etoposide phosphate | exemestane | Ezetimibe | flunisolide | Flutamide | Fluticasone | fulvestrant | gemcitabine | Gestodene | Itraconazole | latoconazole | Loteprednol Etabonate | Mebendazole | Medroxyprogesterone | Megestrol Acetate | Methotrexate | Methylprednisolone | Mifepristone | MK 2206 | mycophenolate mofetil | 1-Naphthylisothiocyanate | Nebivolol | nitazoxanide | Nitrazepam | Norethindrone | norethindrone acetate | Oseltamivir | oxaliplatin | Oxymetholone | Paroxetine | pazopanib | Pentamidine | Prednisolone | Prochlorperazine | rifapentine | Rotenone | rubitecan | Staurosporine | sunitinib | Tamoxifen | tegaserod | telithromycin | temsirolimus | Teniposide | Testosterone | TG101348 | Ticlopidine | tolcapone | Toremifene | Triamcinolone | Valinomycin | verlukast | Vincristine | vorinostat | wortmannin AR | ESR1 | ESR2 | PGR | THRA | THRB  
27. Curated.
Feng Y, et al.
Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells.
J Neurochem. 2015 Aug;134(4):668-76.
 resveratrol | Rotenone BAX | BCL2 | SIRT1 | TP53  
28. Curated.
Furlong M, et al.
Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson''s disease.
Environ Int. 2015 Feb;75:144-50.
 Paraquat | Permethrin | Rotenone | Trifluralin   Parkinson Disease
29. Curated.
Guo J, et al.
L10P mutation in DJ-1 gene induced oxidative stress and mitochondrial disfunction.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 Dec;40(12):1285-91.
 Rotenone PARK7  
30. Curated.
Hou YS, et al.
Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.
Mol Cell Biol. 2015 Aug;35(16):2740-51.
 bafilomycin A1 | Metformin | pifithrin | Rotenone BAX | CASP3 | RPS6KB1 | SESN2 | SNCA | SQSTM1 | TRP53  
31. Curated.
Khalil WK, et al.
Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.
Neurochem Int. 2015 Jan;80:79-86.
 Rotenone BAX | BCL2 | CASP3 | TNF Neurobehavioral Manifestations
32. Curated.
Kumar D, et al.
Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer.
Oncotarget. 2015 Feb 20;6(5):3280-91.
 Rotenone ATG7 | CD63 | CD81 | CD9 | PDCD6IP | TSG101  
33. Curated.
Liang S, et al.
GAPDH-knockdown reduce rotenone-induced H9C2 cells death via autophagy and anti-oxidative stress pathway.
Toxicol Lett. 2015 May 5;234(3):162-71.
 Rotenone ATG5 | BECN1 | CASP3 | GAPDH | SQSTM1 | TP53 Necrosis
34. Curated.
Liang Y, et al.
Rifampicin attenuates rotenone-induced inflammation via suppressing NLRP3 inflammasome activation in microglia.
Brain Res. 2015 Oct 5;1622:43-50.
 Acetylcysteine | Adenosine Triphosphate | L 709049 | Lipopolysaccharides | Rifampin | Rotenone CASP1 | IL1B | NLRP3  
35. Curated.
Lu J, et al.
Angiotensin AT2 receptor stimulation inhibits activation of NADPH oxidase and ameliorates oxidative stress in rotenone model of Parkinson''s disease in CATH.a cells.
Neurotoxicol Teratol. 2015;47:16-24.
 CGP 42112A | PD 123319 | Rotenone AGT | AGTR2 | AGTRAP | NOX1 | NOX2 | NOX4 Disease Models, Animal | Parkinsonian Disorders
36. Curated.
Mattam U, et al.
Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson''s disease male Wistar rat model and effect of melatonin administration.
Biogerontology. 2015 Feb;16(1):109-23.
 Melatonin | Rotenone ARNTL | CRY1 | CRY2 | PER1 | PER2 | SNCA | TH Disease Models, Animal | Parkinsonian Disorders
37. Curated.
Nassar NN, et al.
Saxagliptin: a novel antiparkinsonian approach.
Neuropharmacology. 2015 Feb;89:308-17.
 Rotenone | saxagliptin BCL2 | BDNF | CASP3 | CYCS | DPP4 | ICAM1 | MPO | NFE2L2 | NOS2 | RELA | TH | TNF Motor Skills Disorders | Muscle Rigidity | Parkinson Disease, Secondary | Weight Loss
38. Curated.
Qin J, et al.
Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson''s disease.
Toxicol Lett. 2015 Nov 4;238(3):70-82.
 PQQ Cofactor | Rotenone BAX | BCL2 | DIABLO | GCLC | HMOX1 | NDUFS1 | NDUFS2 | NDUFS3 | NDUFS4 | SLC18A2 | TH Parkinson Disease, Secondary
39. Curated.
Rao SV, et al.
Evidence of neuroprotective effects of saffron and crocin in a Drosophila model of parkinsonism.
Neurotoxicology. 2015 Dec 17;52:230-242.
 crocin | Paraquat | Plant Extracts | Rotenone ACHE | CAT Parkinsonian Disorders
40. Curated.
Rios FJ, et al.
Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes.
J Pharmacol Exp Ther. 2015 Apr;353(1):27-34.
 2-acetylphenothiazine | Acetylcysteine | Aldosterone | anacetrapib | dalcetrapib | GKT137831 | NSC 74859 | Rotenone | torcetrapib AGT | CETP | CREB1 | CYBB | CYP11B1 | CYP11B2 | NOX1 | NOX4 | NOX5 | NR3C1 | NR3C2 | NR4A2 | PPARG | RARRES2 | STAR | STAT3  
41. Curated.
Singh AK, et al.
Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats.
Exp Gerontol. 2015 Jun;66:1-9.
 PQQ Cofactor | Rotenone ACOX1 | CAT | FASN | PPARGC1A | SOD2 | TFAM  
42. Curated.
Yi S, et al.
Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation.
Ann Hematol. 2015 Feb;94(2):201-10.
 deguelin CASP3 | CASP6 | CASP8 | CD14 | CDKN1A | CEBPA | ITGAM | NPM1 | PARP1 | TP53  
43. Curated.
Yuan YH, et al.
The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway.
Toxicol Lett. 2015 Mar 4;233(2):163-71.
 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid | Lithium | Rotenone AKT1 | GSK3B | SNCA  
44. Curated.
Zhang Y, et al.
Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease.
Sci Rep. 2015 Jul 24;5:12480.
 Dinoprostone | Rotenone AGT | EDN1 | NOS2 | NOS3 | NPPA | NPPB | NPPC | SCNN1G Ureteral Obstruction
45. Curated.
Zhao H, et al.
Deguelin inhibits the migration and invasion of lung cancer A549 and H460 cells via regulating actin cytoskeleton rearrangement.
Int J Clin Exp Pathol. 2015;8(12):15582-90.
 deguelin CD44 | ENO2 | MMP2 | MMP9 | RAC1 | ROCK1 | SERPINB3 Neoplasm Invasiveness
46. Curated.
Zharikov AD, et al.
shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson''s disease model.
J Clin Invest. 2015 Jul 1;125(7):2721-35.
 Dopamine | Rotenone SNCA | TH Disease Models, Animal | Mitochondrial Diseases | Neurodegenerative Diseases | Parkinson Disease, Secondary | Parkinsonian Disorders
47. Curated.
Zhou Q, et al.
Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis.
Toxicol Sci. 2015 Jan;143(1):81-96.
 Hydrogen Peroxide | Rotenone CASP3 | CAT | EIF4EBP1 | MTOR | PARP1 | RPS6KB1  
48. Curated.
Ai Q, et al.
Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.
Int Immunopharmacol. 2014 Jul;21(1):200-7.
 Galactosamine | lipopolysaccharide, E coli O55-B5 | Rotenone CASP3 | CASP8 | CASP9 | GPT | IL6 | TNF Liver Failure, Acute
49. Curated.
Cheng SY, et al.
RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB.
J Biochem Mol Toxicol. 2014 Jul;28(7):302-11.
 Ditiocarb | mancozeb | Maneb | 1-Methyl-4-phenylpyridinium | Oxidopamine | Oxygen | Rotenone DDIT4  
50. Curated.
Cleaver JE, et al.
Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.
Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13487-92.
 Hydrogen Peroxide | potassium bromate | Rotenone | veliparib ERCC6 | H2AFX  
1–50 of 391 results.
Download: CSV| Excel| XML| TSV