Cisplatin - Diseases

These diseases are associated with Cisplatin or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

Disease categories [Show chart]

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Cisplatin	Nausea	M	4 genes: ABCB1 \| IFNG \| TNF \| TNFRSF10A	50.14	37
2.	Cisplatin	Myocardial Ischemia	M	112 genes: ACTB \| ADM2 \| ADRB2 \| AGT \| AK1 \| ALDOA \| APLP2 \| AREG \| ARNTL \| ATP1A1 \| BHLHE40 \| CALR \| CAMK2D \| CANX \| CCL2 \| CCL4 \| CCND1 \| CCND2 \| CD38 \| CDH2 \| CEBPD \| CES3 \| COX5B \| CRK \| CTSC \| CTTNBP2 \| CXCL10 \| CXCL2 \| DCN \| DLAT \| DNM1L \| DUSP1 \| DUSP6 \| EDN1 \| EGR2 \| EIF2A \| ENSA \| F2RL1 \| F3 \| FABP5 \| FGF1 \| FGF2 \| GAS5 \| GATM \| GCH1 \| GCLC \| GDF15 \| GHR \| GK \| GSTA1 \| GSTM2 \| GSTP1 \| HIVEP2 \| HK1 \| HMGB1 \| HMOX1 \| HSPA1A \| HSPA2 \| HSPA9 \| ICAM1 \| ID1 \| ID3 \| IGFBP3 \| IL1A \| IL1B \| IL6 \| IL6ST \| IRF1 \| JAK2 \| JUNB \| KCNJ8 \| KITLG \| KLF4 \| MAP3K8 \| MAPK14 \| MSN \| MX1 \| NCL \| NEDD4 \| NFKBIA \| NOS3 \| NR4A1 \| P4HB \| PDE4B \| PDK4 \| PDLIM5 \| PLA2G2A \| PPM1B \| PRDX6 \| PRKCE \| PTPRA \| RAB7A \| RALBP1 \| RGCC \| RHOC \| RSAD2 \| SLC6A6 \| SOCS3 \| SOD2 \| SPARC \| STAT5A \| SULT1A1 \| TAP1 \| TFRC \| TLE4 \| TMPO \| TNF \| TUBA1A \| TXNRD1 \| VCAM1 \| VEGFA \| ZFP36	48.17	17
3.	Cisplatin	Seizures	M	46 genes: ABAT \| ABCC2 \| ACAT1 \| ACHE \| ADORA2A \| ADRA1B \| AGT \| ALAD \| APEX1 \| APOE \| ATP7A \| BCHE \| BDNF \| CAT \| CDKL5 \| CHRNA7 \| CLU \| CNR1 \| FGF2 \| FOS \| GAMT \| IL1B \| IL6 \| KCNJ11 \| LEP \| MPDZ \| MT3 \| NGF \| NGFR \| NOS1 \| NOS2 \| NRP2 \| PAM \| PDYN \| PNKP \| PRKCD \| PTGS2 \| SIGMAR1 \| SLC17A7 \| SLC1A1 \| SLC2A1 \| SLC30A1 \| SOD2 \| SYN2 \| TCF4 \| TSC2	48.17	62
4.	Cisplatin	Vomiting	M	3 genes: ABCB1 \| ASPG \| IFNG	45.55	61
5.	Cisplatin	Pain	M	20 genes: ADM \| AKT1 \| ALB \| BDKRB2 \| CACNA2D1 \| CNR1 \| COMT \| CSF2 \| CSF3 \| EDN1 \| GCH1 \| HRH1 \| IL1RN \| PDYN \| PLCB1 \| TAC1 \| TNF \| TRPA1 \| TRPV1 \| VIP	41.84	31
6.	Cisplatin	Cell Transformation, Neoplastic	M	87 genes: ACTG1 \| AKR1C1 \| AKR1C2 \| AKR1C3 \| APC \| BCL2 \| BRCA1 \| CAT \| CCND1 \| CDH1 \| CDKL2 \| CLDN1 \| CXCL8 \| CXCR4 \| EBF1 \| EDN1 \| EGF \| ENO2 \| ESR1 \| FN1 \| FOS \| HMGN1 \| HRAS \| IGF1R \| IL6 \| IRS1 \| JUN \| KCNH2 \| KRAS \| KRT15 \| KRT19 \| LGALS3 \| LOXL2 \| MAPK8 \| MDM2 \| MIR143 \| MIR146A \| MIR15B \| MIR185 \| MIR191 \| MIR200B \| MIR205 \| MIR21 \| MIR221 \| MIR25 \| MIR29A \| MIR30D \| MIR320A \| MIR34B \| MIR34C \| MIR638 \| MIR99B \| MITF \| MMP9 \| MUC1 \| MYC \| MYD88 \| NFKB1 \| NOS2 \| OCLN \| PARG \| PHGDH \| PHLPP1 \| PIM1 \| POR \| PTK2 \| RAC1 \| RELA \| SATB2 \| SLC16A1 \| SLC2A1 \| SLC40A1 \| SNAI1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TFRC \| TGFB1 \| TNFAIP3 \| TP53 \| TP63 \| TRP53 \| TSC22D1 \| VIM \| WNT5A \| ZEB2	37.89	62
7.	Cisplatin	Arrhythmias, Cardiac	M	8 genes: AGT \| CACNA1C \| EDN1 \| ESR2 \| GJA1 \| KCNH2 \| OPRL1 \| PTGS2	28.76	15
8.	Cisplatin	Hypotension	M	29 genes: ADORA2A \| ADRA1B \| AGT \| ALB \| BDKRB2 \| CAT \| CNR1 \| EDN1 \| EDN2 \| FGF1 \| HRH1 \| IFNG \| IL1A \| IL1B \| IL6 \| LTF \| MAOA \| NISCH \| NPPB \| PDYN \| PLAT \| PLAU \| PRL \| SCNN1G \| SLC9A3 \| SOD1 \| TAC1 \| TNF \| VIP	27.91	47
9.	Cisplatin	Diarrhea	M	7 genes: CSF3 \| IL1A \| IL1RN \| LTF \| MYO5B \| PYY \| SLC9A3	26.23	16
10.	Cisplatin	Necrosis	M	43 genes: AGT \| AHR \| AIFM1 \| ARG2 \| ATF4 \| ATG5 \| ATG7 \| BCL2 \| CAST \| CAT \| CD40LG \| CDC42 \| CTSB \| CYP2E1 \| DPP7 \| FABP3 \| FAS \| FASL \| GAPDH \| GATM \| GSTP1 \| HAVCR1 \| HMGB1 \| IFNG \| IL1B \| IL1RN \| IL6 \| LGALS3 \| LPL \| MGMT \| MIR192 \| NFE2L2 \| NOS2 \| PRNP \| PUF60 \| RBP4 \| SET \| SLC31A1 \| SOD1 \| SOD2 \| SOD3 \| SPARC \| TNF	25.62	64
11.	Cisplatin	Neurodevelopmental Disorders	M	31 genes: ANK2 \| ANKRD11 \| ARID1B \| CASK \| COL4A3BP \| CTNNB1 \| DLG4 \| DOCK8 \| FOXP1 \| HIVEP3 \| KMT2A \| KMT2C \| NCKAP1 \| PARD3B \| PLXNB1 \| PPM1D \| PTEN \| PTK7 \| PTPN11 \| SCN2A \| SETBP1 \| SMC3 \| SRGAP3 \| TANC2 \| TBL1XR1 \| TCF4 \| TCF7L2 \| TNRC6B \| TRIO \| WDFY3 \| ZC3H4	23.01	2
12.	Cisplatin	Weight Loss	M	12 genes: ADORA2A \| ATG5 \| ATG7 \| EPO \| IL10 \| IL4 \| LEP \| LIF \| LTF \| MT1 \| SOD1 \| TSC22D3	21.60	15
13.	Cisplatin	Prenatal Exposure Delayed Effects	M	8 genes: ATM \| CTGF \| FGF2 \| FOSB \| MAOA \| OGG1 \| PON1 \| SIGMAR1	21.05	9
14.	Cisplatin	Renal Insufficiency	M	11 genes: AGT \| APOE \| CYBA \| CYP24A1 \| EDN1 \| EPO \| IFNG \| MME \| NOX4 \| PPARG \| TLR4	19.56	26
15.	Cisplatin	Poisoning	M	13 genes: ABCB1 \| ACHE \| ALB \| BCHE \| CDKN2A \| CDKN2B \| CSF3 \| CST3 \| CYP4F3 \| EPO \| GSK3B \| PRKDC \| SLC22A2	19.34	13
16.	Cisplatin	Fatigue	M	3 genes: EPO \| TGFBR2 \| TNFRSF10A	19.14	8
17.	Cisplatin	Memory Disorders	M	14 genes: ACHE \| BCL2 \| CHRNA7 \| GIT1 \| IGF2 \| IL1B \| MDK \| NQO2 \| REL \| SIGMAR1 \| SLC17A7 \| STAT3 \| SYP \| VEGFA	19.13	14
18.	Cisplatin	Ventricular Fibrillation	M	3 genes: EPO \| KCNJ8 \| PLAU	18.33	4
19.	Cisplatin	Brain Ischemia	M	49 genes: ADD3 \| ALB \| ASIC1 \| BBC3 \| BDNF \| CASP3 \| CASP9 \| CAT \| CCL2 \| CCL4 \| CCL9 \| CEBPB \| CXCL10 \| CYCS \| DIABLO \| EGR1 \| GPX1 \| HIF1A \| ICAM1 \| IL10RB \| IL12RB1 \| IL18 \| IL1A \| IL1B \| IL1RN \| IL6 \| JUN \| MAP2K1 \| MAPK1 \| MAPK3 \| MMP9 \| MPO \| NFKB1 \| NFKBIA \| NOS2 \| PARP1 \| PLAT \| PLAU \| PTGS2 \| RB1 \| RELA \| SOD1 \| SOD2 \| STAT3 \| TNF \| TNFRSF1A \| TNFRSF1B \| TP53 \| UCP2	17.48	49
20.	Cisplatin	Ataxia	M	5 genes: ABCB7 \| ATP7A \| CACNA1A \| CP \| SLC2A1	17.37	6
21.	Cisplatin	Abnormalities, Drug-Induced	M	4 genes: CAT \| EPHX1 \| RHOA \| WNT11	16.63	5
22.	Cisplatin	Fever	M	16 genes: ASPG \| CSF3 \| CXCL8 \| HMGB1 \| IFNG \| IL1A \| IL1B \| IL6 \| NOS1 \| PRL \| PTGES \| PTGS2 \| SOD2 \| STAT3 \| TNF \| TNFRSF1A	16.03	20
23.	Cisplatin	Leukopenia	M	3 genes: ASPG \| CSF3 \| TPMT	14.89	25
24.	Cisplatin	Exanthema	M	1 gene: C1QA	14.29	2
25.	Cisplatin	Paralysis	M	3 genes: ATP7A \| BCHE \| SIRT1	13.84	14
26.	Cisplatin	Anorexia	M	6 genes: IL1B \| IL1RN \| PYY \| TNF \| TNFRSF10A \| TNFRSF1A	13.54	10
27.	Cisplatin	Hypokalemia	M	4 genes: ADRB2 \| AGT \| NPPB \| NR3C1	13.48	9
28.	Cisplatin	Coma	M	1 gene: CPS1	13.38	2
29.	Cisplatin	Gastrointestinal Diseases	M	8 genes: ABCC2 \| CSF3 \| EDN1 \| GAST \| KEAP1 \| MTR \| MYLK \| NFE2L2	12.72	16
30.	Cisplatin	Postoperative Complications	M	2 genes: BCHE \| NPPB	12.68	3
31.	Cisplatin	Kidney Tubular Necrosis, Acute	M	3 genes: FABP1 \| PPARA \| SOD2	12.35	13
32.	Cisplatin	Hematuria	M	2 genes: ASPG \| PLAU	12.28	3
33.	Cisplatin	Muscle Weakness	M	4 genes: CAMKMT \| CSF2 \| CSF3 \| PMP22	12.19	4
34.	Cisplatin	Paresthesia	M	1 gene: PMP22	11.20	10
35.	Cisplatin	Dyspnea	M	1 gene: NPPB	11.08	2
36.	Cisplatin	Coronary Artery Disease	M	36 genes: ADAMTS7 \| ANGPTL4 \| APOC3 \| ATP2B1 \| CCL2 \| CD40LG \| CDKN2B \| CXCL12 \| DDAH2 \| EPO \| ESR1 \| ESR2 \| GDF15 \| HMOX1 \| IRS1 \| JCAD \| LDLR \| LIPA \| LTA \| MIR146A \| MIR146B \| MMP3 \| MRAS \| MRPS6 \| NOS3 \| NPPB \| PAPPA \| PCSK9 \| PDGFD \| PON1 \| PTGS2 \| SH2B3 \| TERT \| TLR4 \| TRIB1 \| VEGFA	10.99	33
37.	Cisplatin	Hypotension, Orthostatic	M	1 gene: ABCB1	10.00	2
38.	Cisplatin	Angina Pectoris	M	1 gene: PLAU	9.87	6
39.	Cisplatin	Nephritis, Interstitial	M	8 genes: ALB \| CCL1 \| CCL2 \| CCL7 \| CYP2C9 \| DCN \| NGF \| THBS1	9.68	9
40.	Cisplatin	Kidney Diseases	M	60 genes: ACKR3 \| ACTA2 \| ADRA1B \| AGT \| ALAD \| ALB \| ANXA1 \| B2M \| CALB1 \| CASP1 \| CDKN1A \| CLU \| CSF3 \| CST3 \| CTSD \| CYBB \| CYP3A5 \| EDN1 \| EGF \| EPO \| FGA \| FGF2 \| GATM \| GSTP1 \| HAVCR1 \| HOXD11 \| IL1RN \| IL33 \| LCN2 \| LEPR \| LRP2 \| MIR192 \| MIR21 \| MPO \| MXI1 \| NFE2L2 \| NOS2 \| NPR1 \| NQO1 \| NR4A1 \| PARP1 \| PPARA \| PTGS2 \| PYCARD \| RASAL1 \| RBP4 \| RGN \| RRM2B \| SLC22A2 \| SLC47A1 \| SLC7A9 \| SOD2 \| SPARC \| SPP1 \| TERT \| TFAP2A \| TGFB1 \| THG1L \| TINAG \| WNT4	9.13	158
41.	Cisplatin	Anemia, Hemolytic	M	7 genes: EPO \| G6PD \| GCLC \| GSR \| HMOX1 \| ITPA \| TPI1	8.80	13
42.	CMF protocol	Thrombosis	M	2 genes: PROC \| PROS1	8.65	5
43.	Cisplatin	Anemia	M	20 genes: AGT \| ASPG \| ATG5 \| ATG7 \| ATP7A \| CSF2 \| CSF3 \| EPO \| GSR \| HAMP \| IGF2 \| KRAS \| PARP1 \| PRL \| SLC40A1 \| SLC46A1 \| SOD2 \| TNF \| TNFRSF10A \| TYMS	8.11	112
44.	Cisplatin	Bone Marrow Diseases	M	2 genes: NQO2 \| TINF2	7.95	10
45.	Cisplatin	Drug Hypersensitivity	M	18 genes: ABCC2 \| ADORA2A \| CYP2C9 \| FASLG \| FCER1G \| GSTM1 \| GSTP1 \| HSPA1A \| IL10 \| IL4 \| NLRP3 \| POSTN \| PTGER3 \| PTGS1 \| TAC1 \| TBXAS1 \| TNF \| TNFRSF10A	7.90	18
46.	Cisplatin	Sleep Wake Disorders	M	1 gene: IL1B	7.86	2
47.	Cisplatin	Testicular Diseases	M	3 genes: FASLG \| PPP3CA \| TSC22D3	7.83	5
48.	Cisplatin	Weight Gain	M	51 genes: ABCG1 \| AHR \| AKAP2 \| AKR1C2 \| ANXA5 \| APBB2 \| BCAT1 \| CAV1 \| CAVIN1 \| CLIC4 \| CNR1 \| CTSD \| FAM126B \| FBLN2 \| FGF1 \| FSTL1 \| FTO \| GDF15 \| GSN \| IDO1 \| IGFBP5 \| LARGE1 \| LEP \| MAP4 \| ME1 \| MEST \| MMP12 \| MMP2 \| MPRIP \| MYO10 \| NEK7 \| NID1 \| OSBPL8 \| PALLD \| PCYOX1 \| PIK3CA \| PYCARD \| RFNG \| RYK \| SCD1 \| SCD2 \| SETBP1 \| SIPA1L1 \| SORBS2 \| SPARC \| SPTBN1 \| STS \| TNF \| TPM4 \| VIM \| ZDHHC2	7.74	15
49.	Cisplatin	Constipation	M	1 gene: PON1	7.63	3
50.	Cisplatin	Learning Disorders	M	17 genes: ACHE \| APOD \| BCL2 \| CAMKMT \| HMOX1 \| IL1B \| IL1RN \| MICU1 \| MT1 \| MT2 \| POR \| RNF135 \| SIGMAR1 \| SLC17A7 \| SYP \| TH \| VEGFA	7.37	17

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