| Interacting Gene | Interactions | Organisms | |
|---|---|---|---|
| 1. | CASP3 | 243 | 6 |
| 2. | TNF | 195 | 4 |
| 3. | TP53 | 166 | 4 |
| 4. | BAX | 120 | 5 |
| 5. | BCL2 | 106 | 3 |
| 6. | RELB | 90 | 2 |
| 7. | CASP9 | 87 | 4 |
| 8. | CDKN1A | 76 | 3 |
| 9. | TRP53 | 69 | 3 |
| 10. | CAT | 66 | 3 |
| 11. | SLC31A1 | 62 | 3 |
| 12. | PARP1 | 59 | 3 |
| 13. | IL6 | 54 | 3 |
| 14. | TP73 | 52 | 1 |
| 15. | CASP8 | 50 | 4 |
| 16. | BCL2L1 | 48 | 3 |
| 17. | H2AFX | 46 | 4 |
| 18. | MAPK1 | 44 | 4 |
| 19. | MAPK3 | 44 | 4 |
| 20. | TP63 | 41 | 1 |
| 21. | RELA | 39 | 3 |
| 22. | BBC3 | 34 | 3 |
| 23. | NFE2L2 | 34 | 3 |
| 24. | ABCC2 | 33 | 3 |
| 25. | NOS2 | 32 | 3 |
| 26. | JUN | 31 | 4 |
| 27. | TNFSF10 | 31 | 1 |
| 28. | ABCB1 | 30 | 4 |
| 29. | FAS | 30 | 4 |
| 30. | HMOX1 | 30 | 3 |
| 31. | PMAIP1 | 30 | 2 |
| 32. | BIRC5 | 29 | 3 |
| 33. | ERCC1 | 29 | 4 |
| 34. | FASLG | 28 | 3 |
| 35. | HAVCR1 | 28 | 3 |
| 36. | IL1B | 28 | 3 |
| 37. | PTGS2 | 28 | 3 |
| 38. | AKT1 | 27 | 3 |
| 39. | HIF1A | 24 | 2 |
| 40. | ATP7B | 23 | 2 |
| 41. | NQO1 | 23 | 4 |
| 42. | CHEK1 | 22 | 3 |
| 43. | FOS | 21 | 3 |
| 44. | CTNNA1 | 19 | 1 |
| 45. | GSR | 19 | 3 |
| 46. | MYC | 19 | 2 |
| 47. | TNFRSF10B | 19 | 2 |
| 48. | XIAP | 19 | 1 |
| 49. | CITED2 | 18 | 2 |
| 50. | GADD45A | 18 | 3 |