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Illuminating how chemicals affect human health.
CisplatinThese pathways are enriched significantly among genes that interact with Cisplatin or its descendants. We show only terms with a corrected p-value <0.01.
| Pathway | Pathway ID | P-value | Corrected P-value | Annotated Genes | Genome Frequency | |
|---|---|---|---|---|---|---|
| 1. | Metabolism | REACT:111217 | 0 | 0 | 685 | 1497/42469 genes: 3.52% |
| 2. | Signal Transduction | REACT:111102 | 3.69e-292 | 1.06e-289 | 708 | 1921/42469 genes: 4.52% |
| 3. | Disease | REACT:116125 | 1.63e-281 | 4.69e-279 | 557 | 1229/42469 genes: 2.89% |
| 4. | Immune System | REACT:6900 | 9.04e-247 | 2.59e-244 | 504 | 1142/42469 genes: 2.69% |
| 5. | Metabolic pathways | KEGG:01100 | 2.66e-230 | 7.64e-228 | 502 | 1211/42469 genes: 2.85% |
| 6. | Pathways in cancer | KEGG:05200 | 1.03e-162 | 2.95e-160 | 225 | 333/42469 genes: 0.78% |
| 7. | Developmental Biology | REACT:111045 | 2.57e-152 | 7.36e-150 | 258 | 475/42469 genes: 1.12% |
| 8. | Hemostasis | REACT:604 | 6.48e-144 | 1.86e-141 | 255 | 492/42469 genes: 1.16% |
| 9. | Gene Expression | REACT:71 | 3.99e-126 | 1.15e-123 | 360 | 1091/42469 genes: 2.57% |
| 10. | Cell Cycle | REACT:115566 | 2.34e-122 | 6.72e-120 | 248 | 548/42469 genes: 1.29% |
| 11. | MAPK signaling pathway | KEGG:04010 | 4.23e-114 | 1.21e-111 | 174 | 286/42469 genes: 0.67% |
| 12. | Metabolism of proteins | REACT:17015 | 4.34e-97 | 1.24e-94 | 240 | 639/42469 genes: 1.50% |
| 13. | Cellular responses to stress | REACT:120956 | 1.80e-93 | 5.15e-91 | 149 | 257/42469 genes: 0.61% |
| 14. | Transmembrane transport of small molecules | REACT:15518 | 1.78e-91 | 5.09e-89 | 212 | 532/42469 genes: 1.25% |
| 15. | Focal adhesion | KEGG:04510 | 1.20e-90 | 3.43e-88 | 133 | 210/42469 genes: 0.49% |
| 16. | Extracellular matrix organization | REACT:118779 | 2.49e-89 | 7.16e-87 | 148 | 266/42469 genes: 0.63% |
| 17. | Cytokine-cytokine receptor interaction | KEGG:04060 | 7.35e-77 | 2.11e-74 | 140 | 278/42469 genes: 0.65% |
| 18. | Tuberculosis | KEGG:05152 | 4.93e-66 | 1.41e-63 | 106 | 185/42469 genes: 0.44% |
| 19. | Apoptosis | KEGG:04210 | 3.50e-63 | 1.01e-60 | 73 | 90/42469 genes: 0.21% |
| 20. | Mitotic M-M/G1 phases | REACT:21300 | 1.56e-60 | 4.48e-58 | 138 | 342/42469 genes: 0.81% |
| 21. | Toxoplasmosis | KEGG:05145 | 3.25e-60 | 9.33e-58 | 87 | 136/42469 genes: 0.32% |
| 22. | Regulation of actin cytoskeleton | KEGG:04810 | 6.36e-60 | 1.83e-57 | 110 | 221/42469 genes: 0.52% |
| 23. | Neurotrophin signaling pathway | KEGG:04722 | 2.63e-58 | 7.54e-56 | 84 | 131/42469 genes: 0.31% |
| 24. | Cell cycle | KEGG:04110 | 5.39e-56 | 1.55e-53 | 81 | 127/42469 genes: 0.30% |
| 25. | Prostate cancer | KEGG:05215 | 1.58e-55 | 4.53e-53 | 69 | 92/42469 genes: 0.22% |
| 26. | Small cell lung cancer | KEGG:05222 | 2.67e-55 | 7.66e-53 | 67 | 87/42469 genes: 0.20% |
| 27. | Pancreatic cancer | KEGG:05212 | 4.80e-55 | 1.38e-52 | 60 | 70/42469 genes: 0.16% |
| 28. | Insulin signaling pathway | KEGG:04910 | 1.65e-54 | 4.74e-52 | 86 | 148/42469 genes: 0.35% |
| 29. | p53 signaling pathway | KEGG:04115 | 5.14e-54 | 1.47e-51 | 59 | 69/42469 genes: 0.16% |
| 30. | Chemokine signaling pathway | KEGG:04062 | 5.94e-53 | 1.71e-50 | 97 | 195/42469 genes: 0.46% |
| 31. | Apoptosis | REACT:578 | 1.85e-50 | 5.32e-48 | 85 | 157/42469 genes: 0.37% |
| 32. | Osteoclast differentiation | KEGG:04380 | 2.50e-50 | 7.16e-48 | 78 | 132/42469 genes: 0.31% |
| 33. | Wnt signaling pathway | KEGG:04310 | 1.59e-49 | 4.57e-47 | 86 | 164/42469 genes: 0.39% |
| 34. | Endocytosis | KEGG:04144 | 2.14e-49 | 6.15e-47 | 99 | 218/42469 genes: 0.51% |
| 35. | Hepatitis C | KEGG:05160 | 5.50e-48 | 1.58e-45 | 78 | 139/42469 genes: 0.33% |
| 36. | Chagas disease (American trypanosomiasis) | KEGG:05142 | 7.05e-48 | 2.02e-45 | 68 | 105/42469 genes: 0.25% |
| 37. | Colorectal cancer | KEGG:05210 | 3.88e-47 | 1.11e-44 | 53 | 64/42469 genes: 0.15% |
| 38. | Tight junction | KEGG:04530 | 3.32e-46 | 9.52e-44 | 77 | 141/42469 genes: 0.33% |
| 39. | Axon guidance | KEGG:04360 | 1.49e-45 | 4.27e-43 | 74 | 132/42469 genes: 0.31% |
| 40. | Measles | KEGG:05162 | 2.27e-45 | 6.51e-43 | 76 | 140/42469 genes: 0.33% |
| 41. | DNA Repair | REACT:216 | 3.75e-45 | 1.08e-42 | 68 | 112/42469 genes: 0.26% |
| 42. | Amoebiasis | KEGG:05146 | 9.34e-44 | 2.68e-41 | 66 | 109/42469 genes: 0.26% |
| 43. | Mus musculus biological processes | REACT:200794 | 1.80e-43 | 5.17e-41 | 87 | 192/42469 genes: 0.45% |
| 44. | GnRH signaling pathway | KEGG:04912 | 8.07e-42 | 2.32e-39 | 65 | 111/42469 genes: 0.26% |
| 45. | Cell-Cell communication | REACT:111155 | 1.75e-41 | 5.01e-39 | 72 | 138/42469 genes: 0.32% |
| 46. | Toll-like receptor signaling pathway | KEGG:04620 | 2.68e-41 | 7.69e-39 | 64 | 109/42469 genes: 0.26% |
| 47. | VEGF signaling pathway | KEGG:04370 | 3.88e-41 | 1.11e-38 | 55 | 80/42469 genes: 0.19% |
| 48. | T cell receptor signaling pathway | KEGG:04660 | 5.90e-41 | 1.69e-38 | 64 | 110/42469 genes: 0.26% |
| 49. | Calcium signaling pathway | KEGG:04020 | 8.09e-41 | 2.32e-38 | 82 | 182/42469 genes: 0.43% |
| 50. | ErbB signaling pathway | KEGG:04012 | 4.71e-40 | 1.35e-37 | 58 | 92/42469 genes: 0.22% |