Chlorine Compounds - Diseases

These diseases are associated with Chlorine Compounds or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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1–50 of 23,756 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Potassium Chloride	Hypertension	M	41 genes: AHR \| ANXA1 \| APOE \| AQP1 \| CACNA1C \| CACNA2D1 \| CALCA \| CAT \| CAV1 \| EDN1 \| EDNRA \| FOS \| FXYD2 \| GCG \| GCLC \| GLP1R \| GNAS \| GNRH1 \| GSTA5 \| GSTT1 \| GSTT2 \| HMOX1 \| IGF1 \| IL1B \| INS \| ITM2B \| KCNJ1 \| KNG1 \| LPL \| MDH1 \| NOS2 \| NOS3 \| NPTN \| NR3C1 \| PLAT \| SERPINE1 \| SLC9A3R2 \| SOD1 \| TP53 \| TPM1 \| UMOD	93.53	49
2.	Sodium Chloride	Hypertension	M	37 genes: ABCC1 \| ACE \| AGT \| AGTR2 \| AVP \| BCL2 \| CALCA \| CCL2 \| COL1A1 \| CYBA \| EDN1 \| EDNRA \| FOS \| GJA5 \| GPX1 \| HIF1A \| HMOX1 \| HSD11B2 \| ICAM1 \| IL1B \| IL6 \| JUN \| KCNJ1 \| MMP2 \| NOS3 \| NPPA \| POMC \| PTGS2 \| RELA \| REN \| SCNN1A \| SOD1 \| SOD2 \| TGFB1 \| TH \| TNF \| TP53	74.75	217
3.	Cadmium Chloride	Neoplasm Invasiveness	M	97 genes: ACO1 \| ACTB \| ADAMTS1 \| AHR \| ALDOA \| ALOX5 \| AMBP \| ANGPTL4 \| ANXA1 \| ANXA2 \| AXL \| CALR \| CALU \| CAT \| CCL2 \| CCL5 \| CDH1 \| CDKN2A \| CFL1 \| CHI3L1 \| CSTB \| CTNNB1 \| CTSB \| CTSD \| CTSS \| CXCL12 \| CXCR4 \| CYP2E1 \| DEK \| EGF \| EGFR \| ENO1 \| EPO \| EPS8 \| ESR1 \| FN1 \| FTH1 \| HGF \| HIF1A \| HMOX1 \| HPSE \| HRAS \| ID4 \| IGF1 \| IL1B \| IL1RN \| IL6 \| ITGA5 \| ITGB1 \| KRT19 \| LDHB \| MALAT1 \| MAPK1 \| MAPK3 \| MET \| MMP1 \| MMP14 \| MMP2 \| MMP9 \| MT2A \| MT3 \| MYD88 \| MYLK \| NCAM1 \| NME1 \| NRG1 \| NUAK1 \| PAX6 \| PDCD4 \| PKM \| PLAU \| PRDX2 \| PTEN \| RELA \| RHOA \| RPS6KA3 \| RPSA \| SET \| SLC39A10 \| SMPD1 \| SNAI1 \| SOD2 \| SP1 \| SRC \| SUMO1 \| TF \| TGFB1 \| TIMP1 \| TIMP3 \| TKT \| TLN1 \| TLR4 \| TNF \| TWIST1 \| TXN \| ZBTB16 \| ZFP36	54.39	84
4.	Cisplatin	Nausea	M	4 genes: ABCB1 \| IFNG \| TNF \| TNFRSF10A	50.14	37
5.	Cisplatin	Myocardial Ischemia	M	112 genes: ACTB \| ADM2 \| ADRB2 \| AGT \| AK1 \| ALDOA \| APLP2 \| AREG \| ARNTL \| ATP1A1 \| BHLHE40 \| CALR \| CAMK2D \| CANX \| CCL2 \| CCL4 \| CCND1 \| CCND2 \| CD38 \| CDH2 \| CEBPD \| CES3 \| COX5B \| CRK \| CTSC \| CTTNBP2 \| CXCL10 \| CXCL2 \| DCN \| DLAT \| DNM1L \| DUSP1 \| DUSP6 \| EDN1 \| EGR2 \| EIF2A \| ENSA \| F2RL1 \| F3 \| FABP5 \| FGF1 \| FGF2 \| GAS5 \| GATM \| GCH1 \| GCLC \| GDF15 \| GHR \| GK \| GSTA1 \| GSTM2 \| GSTP1 \| HIVEP2 \| HK1 \| HMGB1 \| HMOX1 \| HSPA1A \| HSPA2 \| HSPA9 \| ICAM1 \| ID1 \| ID3 \| IGFBP3 \| IL1A \| IL1B \| IL6 \| IL6ST \| IRF1 \| JAK2 \| JUNB \| KCNJ8 \| KITLG \| KLF4 \| MAP3K8 \| MAPK14 \| MSN \| MX1 \| NCL \| NEDD4 \| NFKBIA \| NOS3 \| NR4A1 \| P4HB \| PDE4B \| PDK4 \| PDLIM5 \| PLA2G2A \| PPM1B \| PRDX6 \| PRKCE \| PTPRA \| RAB7A \| RALBP1 \| RGCC \| RHOC \| RSAD2 \| SLC6A6 \| SOCS3 \| SOD2 \| SPARC \| STAT5A \| SULT1A1 \| TAP1 \| TFRC \| TLE4 \| TMPO \| TNF \| TUBA1A \| TXNRD1 \| VCAM1 \| VEGFA \| ZFP36	48.17	17
6.	Cisplatin	Seizures	M	46 genes: ABAT \| ABCC2 \| ACAT1 \| ACHE \| ADORA2A \| ADRA1B \| AGT \| ALAD \| APEX1 \| APOE \| ATP7A \| BCHE \| BDNF \| CAT \| CDKL5 \| CHRNA7 \| CLU \| CNR1 \| FGF2 \| FOS \| GAMT \| IL1B \| IL6 \| KCNJ11 \| LEP \| MPDZ \| MT3 \| NGF \| NGFR \| NOS1 \| NOS2 \| NRP2 \| PAM \| PDYN \| PNKP \| PRKCD \| PTGS2 \| SIGMAR1 \| SLC17A7 \| SLC1A1 \| SLC2A1 \| SLC30A1 \| SOD2 \| SYN2 \| TCF4 \| TSC2	48.17	62
7.	Sodium Chloride	Stomach Neoplasms	M	21 genes: ACE \| AGTR2 \| ALOX5 \| CASP8 \| CDKN1A \| CXCL8 \| DES \| EGFR \| HBEGF \| HMOX1 \| IL1B \| IL6 \| JUN \| MAPK1 \| MAPK3 \| MAPK8 \| NOS3 \| PTGS2 \| SOD2 \| TNF \| TP53	47.55	30
8.	Cisplatin	Vomiting	M	3 genes: ABCB1 \| ASPG \| IFNG	45.55	61
9.	Hydrochloric Acid	Inflammation	M	23 genes: CALCA \| CCL2 \| CCL4 \| CXCL2 \| CXCL8 \| EDN1 \| FGF2 \| HMOX1 \| ICAM1 \| IL1B \| IL6 \| MIF \| MMP2 \| MMP9 \| MPO \| NOS2 \| PTGS2 \| SCGB1A1 \| SOD1 \| TAC1 \| TGFA \| TNF \| TRPV1	44.54	53
10.	Sodium Chloride	Hyperalgesia	M	21 genes: AGT \| ALOX5 \| AVP \| CALCA \| CCL2 \| CXCL8 \| EDN1 \| FOS \| GFAP \| IL1A \| IL1B \| IL6 \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| NOS1 \| PTGS2 \| TNF \| TRPA1 \| TRPV1	43.80	31
11.	Cisplatin	Pain	M	20 genes: ADM \| AKT1 \| ALB \| BDKRB2 \| CACNA2D1 \| CNR1 \| COMT \| CSF2 \| CSF3 \| EDN1 \| GCH1 \| HRH1 \| IL1RN \| PDYN \| PLCB1 \| TAC1 \| TNF \| TRPA1 \| TRPV1 \| VIP	41.84	31
12.	aluminum chloride	Alzheimer Disease	M	14 genes: ACHE \| APP \| BACE1 \| BAX \| BCL2 \| BDNF \| CASP3 \| CRH \| IGF1 \| IL1B \| INS \| SOD2 \| TF \| TNF	41.64	46
13.	Sodium Chloride	Adenocarcinoma	M	16 genes: ACE \| BCL2 \| CASP8 \| CXCL8 \| EGFR \| IL1B \| NOS3 \| NPPA \| PGR \| PTGS2 \| SOD2 \| TGFB1 \| TNF \| TP53 \| TRP53 \| VEGFA	38.10	23
14.	Cisplatin	Cell Transformation, Neoplastic	M	87 genes: ACTG1 \| AKR1C1 \| AKR1C2 \| AKR1C3 \| APC \| BCL2 \| BRCA1 \| CAT \| CCND1 \| CDH1 \| CDKL2 \| CLDN1 \| CXCL8 \| CXCR4 \| EBF1 \| EDN1 \| EGF \| ENO2 \| ESR1 \| FN1 \| FOS \| HMGN1 \| HRAS \| IGF1R \| IL6 \| IRS1 \| JUN \| KCNH2 \| KRAS \| KRT15 \| KRT19 \| LGALS3 \| LOXL2 \| MAPK8 \| MDM2 \| MIR143 \| MIR146A \| MIR15B \| MIR185 \| MIR191 \| MIR200B \| MIR205 \| MIR21 \| MIR221 \| MIR25 \| MIR29A \| MIR30D \| MIR320A \| MIR34B \| MIR34C \| MIR638 \| MIR99B \| MITF \| MMP9 \| MUC1 \| MYC \| MYD88 \| NFKB1 \| NOS2 \| OCLN \| PARG \| PHGDH \| PHLPP1 \| PIM1 \| POR \| PTK2 \| RAC1 \| RELA \| SATB2 \| SLC16A1 \| SLC2A1 \| SLC40A1 \| SNAI1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TFRC \| TGFB1 \| TNFAIP3 \| TP53 \| TP63 \| TRP53 \| TSC22D1 \| VIM \| WNT5A \| ZEB2	37.89	62
15.	arsenic trichloride	Cell Transformation, Neoplastic	M	11 genes: CAT \| IL6 \| MAPK8 \| MIR106A \| MIR190A \| MIR21 \| MYC \| NCF1 \| PHLPP1 \| STAT3 \| TRP53	37.78	12
16.	Cadmium Chloride	Cell Transformation, Neoplastic	M	74 genes: AKR1C1 \| AKR1C2 \| BCL2 \| BRCA1 \| CAT \| CCL18 \| CCND1 \| CDH1 \| CLDN1 \| CXCL8 \| CXCR4 \| EDN1 \| EGF \| EIF3I \| ENO2 \| EPAS1 \| ESR1 \| FN1 \| FOS \| HRAS \| IGBP1 \| IGF1R \| IL6 \| IRS1 \| JUN \| KCNH2 \| KRAS \| KRT14 \| KRT15 \| KRT19 \| KRT5 \| LGALS3 \| LIN28A \| MAPK8 \| MDM2 \| MIR15B \| MIR205 \| MIR21 \| MIR221 \| MIR638 \| MIRLET7C \| MITF \| MMP14 \| MMP9 \| MYC \| MYCN \| MYD88 \| NCF1 \| NFKB1 \| NOS2 \| NOTCH1 \| NRG1 \| OCLN \| PDCD4 \| PHGDH \| PIM1 \| POR \| RAC1 \| RELA \| SLC2A1 \| SLC40A1 \| SNAI1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TFRC \| TGFB1 \| TNFAIP3 \| TP53 \| TP63 \| TRP53 \| TSC22D1 \| VIM	35.45	59
17.	Sodium Chloride	Cardiomegaly	M	14 genes: AGT \| ATP2A2 \| EDN1 \| FGF2 \| HIF1A \| HMOX1 \| IL1B \| NOS3 \| NPPA \| POMC \| PRKCA \| REN \| SOD2 \| TNF	33.52	42
18.	Calcium Chloride	Calcinosis	M	9 genes: ALPL \| BGLAP \| CCL2 \| COL1A1 \| IL1B \| MMP2 \| MMP9 \| TGFB1 \| TIMP1	33.21	5
19.	Cisplatin	Arrhythmias, Cardiac	M	8 genes: AGT \| CACNA1C \| EDN1 \| ESR2 \| GJA1 \| KCNH2 \| OPRL1 \| PTGS2	28.76	15
20.	aluminum chloride	Disease Models, Animal	M	11 genes: APP \| FOS \| GFAP \| GRIN1 \| IL1B \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| SNCA \| TNF	28.12	7
21.	Cisplatin	Hypotension	M	29 genes: ADORA2A \| ADRA1B \| AGT \| ALB \| BDKRB2 \| CAT \| CNR1 \| EDN1 \| EDN2 \| FGF1 \| HRH1 \| IFNG \| IL1A \| IL1B \| IL6 \| LTF \| MAOA \| NISCH \| NPPB \| PDYN \| PLAT \| PLAU \| PRL \| SCNN1G \| SLC9A3 \| SOD1 \| TAC1 \| TNF \| VIP	27.91	47
22.	Mercuric Chloride	Autoimmune Diseases	M	20 genes: B2M \| CD28 \| COL1A1 \| COPA \| CXCR3 \| EGR1 \| FAS \| FBL \| FCGR2B \| HMGCR \| HP \| HPX \| HSPA9 \| IFNG \| IL4 \| IL6 \| SOD2 \| STAT3 \| TIMP1 \| TNFRSF4	26.61	60
23.	Lithium Chloride	Disease Models, Animal	M	16 genes: AKT1 \| APP \| ESR1 \| FOS \| GFAP \| GRIN1 \| IFNG \| IL1B \| MAPK1 \| MAPK3 \| MAPT \| SNCA \| STAT3 \| TNF \| TRP53 \| VIM	26.53	16
24.	Cisplatin	Diarrhea	M	7 genes: CSF3 \| IL1A \| IL1RN \| LTF \| MYO5B \| PYY \| SLC9A3	26.23	16
25.	Cisplatin	Necrosis	M	43 genes: AGT \| AHR \| AIFM1 \| ARG2 \| ATF4 \| ATG5 \| ATG7 \| BCL2 \| CAST \| CAT \| CD40LG \| CDC42 \| CTSB \| CYP2E1 \| DPP7 \| FABP3 \| FAS \| FASL \| GAPDH \| GATM \| GSTP1 \| HAVCR1 \| HMGB1 \| IFNG \| IL1B \| IL1RN \| IL6 \| LGALS3 \| LPL \| MGMT \| MIR192 \| NFE2L2 \| NOS2 \| PRNP \| PUF60 \| RBP4 \| SET \| SLC31A1 \| SOD1 \| SOD2 \| SOD3 \| SPARC \| TNF	25.62	64
26.	Cisplatin	Neurodevelopmental Disorders	M	31 genes: ANK2 \| ANKRD11 \| ARID1B \| CASK \| COL4A3BP \| CTNNB1 \| DLG4 \| DOCK8 \| FOXP1 \| HIVEP3 \| KMT2A \| KMT2C \| NCKAP1 \| PARD3B \| PLXNB1 \| PPM1D \| PTEN \| PTK7 \| PTPN11 \| SCN2A \| SETBP1 \| SMC3 \| SRGAP3 \| TANC2 \| TBL1XR1 \| TCF4 \| TCF7L2 \| TNRC6B \| TRIO \| WDFY3 \| ZC3H4	23.01	2
27.	aluminum chloride	Brain Injuries	M	9 genes: BDNF \| EPO \| FOS \| IL1B \| IL2 \| IL6 \| JUN \| SOD2 \| TNF	21.90	9
28.	Mercuric Chloride	Brain Injuries	M	28 genes: ALB \| BDNF \| CCL2 \| CEBPB \| CFB \| CHRM2 \| CSF3 \| CXCL10 \| EPO \| FOS \| GABRB3 \| GSK3B \| HSPA1A \| IL10 \| IL12RB2 \| IL17RD \| IL1A \| IL1B \| IL1RN \| IL2 \| IL6 \| JUN \| NPPB \| PARP1 \| PTGS2 \| SOD2 \| TNF \| UCP2	21.69	19
29.	Cisplatin	Weight Loss	M	12 genes: ADORA2A \| ATG5 \| ATG7 \| EPO \| IL10 \| IL4 \| LEP \| LIF \| LTF \| MT1 \| SOD1 \| TSC22D3	21.60	15
30.	Hydrochloric Acid	Stomach Ulcer	M	9 genes: CAT \| IL1B \| MMP9 \| NOS2 \| NOS3 \| PTGS1 \| PTGS2 \| TNF \| VGF	21.23	24
31.	Mercuric Chloride	Dermatitis, Contact	M	24 genes: BCL2 \| CASP8 \| CCR1 \| CD86 \| CTGF \| CXCR3 \| CYP1A1 \| CYP1B1 \| DDIT3 \| G6PD \| GCLC \| GSR \| GSTP1 \| HMOX1 \| HSPB1 \| LCN2 \| NQO1 \| PIR \| PRDX6 \| SAA1 \| SOD1 \| SOD3 \| TXN \| TXNRD1	21.06	4
32.	Cisplatin	Prenatal Exposure Delayed Effects	M	8 genes: ATM \| CTGF \| FGF2 \| FOSB \| MAOA \| OGG1 \| PON1 \| SIGMAR1	21.05	9
33.	ferric chloride	Brain Injuries	M	7 genes: ALB \| APEX1 \| IL1B \| IL6 \| JUN \| SOD2 \| TNF	20.77	8
34.	Cadmium Chloride	Hepatomegaly	M	3 genes: CYP1A2 \| PEPD \| PPARA	19.77	7
35.	Cisplatin	Renal Insufficiency	M	11 genes: AGT \| APOE \| CYBA \| CYP24A1 \| EDN1 \| EPO \| IFNG \| MME \| NOX4 \| PPARG \| TLR4	19.56	26
36.	Cisplatin	Poisoning	M	13 genes: ABCB1 \| ACHE \| ALB \| BCHE \| CDKN2A \| CDKN2B \| CSF3 \| CST3 \| CYP4F3 \| EPO \| GSK3B \| PRKDC \| SLC22A2	19.34	13
37.	Cisplatin	Fatigue	M	3 genes: EPO \| TGFBR2 \| TNFRSF10A	19.14	8
38.	Mercuric Chloride	Glomerulonephritis	M	20 genes: ADM \| AGT \| ALB \| CCL1 \| CCL2 \| CCL3 \| CCL5 \| CFD \| CXCL8 \| CXCR3 \| ESR1 \| IFNG \| IL10 \| IL1B \| IL2 \| IL2RA \| IL6 \| NPHS1 \| PPARG \| TNF	19.14	25
39.	Cisplatin	Memory Disorders	M	14 genes: ACHE \| BCL2 \| CHRNA7 \| GIT1 \| IGF2 \| IL1B \| MDK \| NQO2 \| REL \| SIGMAR1 \| SLC17A7 \| STAT3 \| SYP \| VEGFA	19.13	14
40.	Hydrochloric Acid	Bronchial Hyperreactivity	M	6 genes: CALCA \| CCL2 \| CXCL1 \| ICAM1 \| PTGS1 \| TAC1	19.11	6
41.	Cadmium Chloride	Prenatal Exposure Delayed Effects	M	5 genes: ADORA1 \| ATM \| CTGF \| FOSB \| OGG1	18.96	8
42.	Hydrochloric Acid	Liver Cirrhosis	M	9 genes: ALB \| CCL2 \| CHRM3 \| FGF2 \| FGF7 \| FGFR2 \| IL6 \| MMP2 \| NFE2L2	18.83	11
43.	Mercuric Chloride	Hepatitis, Autoimmune	M	11 genes: CCL2 \| CCL5 \| IFNG \| IL10 \| IL13 \| IL2 \| IL4 \| IL5 \| IL6 \| LEP \| TGFB1	18.82	2
44.	Mercuric Chloride	Arthritis, Experimental	M	20 genes: ABCB1 \| ALB \| CAT \| CP \| CRP \| DNMT1 \| EGFR \| GSK3B \| IFNG \| IL10 \| IL13 \| IL1B \| IL4 \| IL6 \| LEP \| SAA1 \| STAT1 \| STAT3 \| TAC1 \| TNF	18.76	19
45.	Hydrochloric Acid	Myocardial Infarction	M	11 genes: CASP3 \| CAT \| ICAM1 \| IL1B \| IL6 \| MMP2 \| MMP9 \| NOS2 \| NOS3 \| SOD1 \| TNF	18.72	12
46.	Lithium Chloride	Status Epilepticus	M	13 genes: CASP3 \| CD40 \| CDH2 \| FOS \| HMOX1 \| JUN \| NOS1 \| NOS2 \| PDXK \| PTGS2 \| SRC \| TNF \| VEGFA	18.51	35
47.	Cisplatin	Ventricular Fibrillation	M	3 genes: EPO \| KCNJ8 \| PLAU	18.33	4
48.	Cadmium Chloride	Edema	M	19 genes: AMN \| APOA1 \| CASP3 \| CASP8 \| CASP9 \| CAT \| COL2A1 \| CXCL8 \| CYP1A \| GSR \| IL6 \| KNG1 \| MAP2K6 \| POMC \| PTGS2 \| PTHLH \| SLC9A1 \| SLC9A3 \| TNF	18.17	18
49.	Potassium Chloride	Hypotension	M	12 genes: CAT \| CNR1 \| EDN1 \| FGF1 \| GCG \| IL1B \| INS \| KNG1 \| PLAT \| PRL \| SOD1 \| TAC1	17.52	28
50.	Cisplatin	Brain Ischemia	M	49 genes: ADD3 \| ALB \| ASIC1 \| BBC3 \| BDNF \| CASP3 \| CASP9 \| CAT \| CCL2 \| CCL4 \| CCL9 \| CEBPB \| CXCL10 \| CYCS \| DIABLO \| EGR1 \| GPX1 \| HIF1A \| ICAM1 \| IL10RB \| IL12RB1 \| IL18 \| IL1A \| IL1B \| IL1RN \| IL6 \| JUN \| MAP2K1 \| MAPK1 \| MAPK3 \| MMP9 \| MPO \| NFKB1 \| NFKBIA \| NOS2 \| PARP1 \| PLAT \| PLAU \| PTGS2 \| RB1 \| RELA \| SOD1 \| SOD2 \| STAT3 \| TNF \| TNFRSF1A \| TNFRSF1B \| TP53 \| UCP2	17.48	49

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