| 1. |
Asbestos
|
Mesothelioma, Malignant
|
M |
|
36 genes: ANXA2 | BAP1 | BCL2 | CALB2 | CCL3 | CCL5 | CDKN1A | CDKN2A | CLEC11A | CSF1 | CXCL12 | CXCL8 | EGFR | ENOX2 | EPHX1 | FN1 | FTH1 | GSTM1 | HEPH | HGF | IFNG | IGF2BP3 | IL1A | IL2RA | IL4 | IL6 | LTA | MIF | MSLN | NAT2 | NF2 | PARP1 | PYCARD | TF | TP53 | TXN
|
131.68 |
26
 |
| 2. |
Urethane
|
Lung Neoplasms
|
M |
|
42 genes: CCND1 | CCNG1 | CDKN1A | CDKN1B | CDKN1C | CDKN2A | CYP2E1 | EGFR | EHMT2 | FOS | FOXM1 | GAST | GJA1 | GJB1 | HRAS | IFNG | IL10 | IL1B | IL2 | IL6 | JUN | JUNB | KRAS | MAPK1 | MAPK3 | MIR127 | MIR193A | MIR1A-1 | MIR34C | MMP10 | MPO | MYC | NOS2 | PAS1 | PCNA | RAF1 | SPP1 | TEP1 | TERT | TGFB1 | TNF | TRP53
|
103.21 |
105
 |
| 3. |
sodium arsenite
|
Lung Neoplasms
|
M |
|
124 genes: A2M | ACTB | ADA | AKT1 | ANXA2 | APOA1 | APOE | BCL2L1 | BECN1 | BIRC5 | BRAF | BRCA2 | CASP8 | CCND1 | CCNG1 | CDH13 | CDKN1A | CDKN1B | CDKN1C | CDKN2A | CHEK2 | CRP | CTGF | CTNNB1 | CXCL14 | CYP1A2 | CYP1B1 | CYP2E1 | DAB2IP | DAPK1 | DDR1 | DNMT3A | DOK2 | EEF2 | EGFR | EHMT2 | EPHX1 | ERBB2 | ERBB3 | ERCC6 | ESR1 | FAS | FASLG | FGFR1 | FHIT | FOS | GATA6 | GC | GJA1 | GPX1 | GPX3 | GSTM1 | GSTP1 | GSTT1 | HES1 | HMOX1 | HRAS | ID3 | IFNG | IKBKG | IL10 | IL1B | IL2 | IL6 | JUN | JUNB | KRAS | MAP2K7 | MAP3K8 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MET | MIR127 | MIR154 | MIR155 | MIR222 | MIR34B | MIR34C | MMP1 | MMP10 | MPO | MTHFR | MYC | NOS2 | NOTCH2 | OGG1 | PCNA | PIK3CA | PON1 | PRDX1 | PRDX6 | PTEN | PTGIS | PTMA | PYCARD | RAF1 | RAMP2 | RARB | RASSF1 | ROBO1 | SELENBP1 | SELENOP | SERPINA1 | SLC7A5 | SOX2 | SPP1 | SPRY2 | STAT5A | TERT | TFRC | TGFB1 | TGFBR2 | TLR4 | TNF | TP53 | TP63 | TRP53 | TTR | VHL | WNT5A | WT1 | XPC
|
99.29 |
146
 |
| 4. |
Asbestos, Serpentine
|
Pulmonary Fibrosis
|
M |
|
37 genes: ADIPOQ | AREG | CCL11 | CCL2 | CCL3 | CCL4 | CCL5 | CCR2 | COL3A1 | CSF2 | CSF3 | CTGF | CXCL2 | CXCL8 | ELN | FGF2 | FN1 | HMGB1 | HMOX1 | IL12B | IL13 | IL1B | IL1RN | IL4 | IL5 | IL6 | MMP2 | MMP9 | PDGFA | PDGFB | PTX3 | SMAD7 | SOD3 | SPP1 | TGFB1 | TIMP1 | TNF
|
97.27 |
40 |
| 5. |
Particulate Matter
|
Lung Neoplasms
|
M |
|
83 genes: ACE | AKT1 | ANXA2 | APOE | BECN1 | BRAF | CASP8 | CCL18 | CCND1 | CDKN1A | CDKN1B | CHEK2 | CRP | CTGF | CTNNB1 | CXCL14 | CYP1A2 | CYP1B1 | CYP2E1 | EEF2 | EFEMP1 | EGFR | FAS | FGF9 | FGFR2 | FOS | GJA1 | GPX1 | GSTM1 | GSTP1 | GSTP2 | GSTT1 | HMOX1 | ID3 | IFNG | IL10 | IL1B | IL2 | IL24 | IL6 | IRF1 | JAG1 | JUN | JUNB | KRAS | MAP3K8 | MAPK1 | MAPK3 | MIR10A | MIR127 | MIR136 | MIR222 | MIR224 | MIR30A | MIR31 | MIR34B | MIR487B | MIR494 | MMP1 | MMP10 | MPO | MYC | NOS2 | OGG1 | PCNA | PRDX1 | PRDX6 | PTEN | PTGIS | RAMP2 | SELENOP | SFTPB | SFTPD | SLCO1B3 | SPP1 | TFRC | TGFB1 | TLR4 | TNF | TP53 | TRP53 | TTR | TYRP1
|
97.13 |
116
 |
| 6. |
2-Acetylaminofluorene
|
Lung Neoplasms
|
M |
|
49 genes: AKT1 | APOC3 | BCL2L1 | BIRC5 | CCND1 | CCNG1 | CDH13 | CDKN1A | CDKN1B | CDKN2A | CTGF | CYP1A2 | CYP1B1 | CYP2E1 | DDR1 | EGFR | EPHX1 | ERBB2 | ESR1 | FAS | FHIT | FOS | GJA1 | GJB1 | GSTM1 | GSTP1 | HMOX1 | HRAS | IFNG | IL10 | IL1B | IL6 | JUN | MIR155 | MIR31 | MIR410 | MTHFR | MYC | NOS2 | PCNA | PTEN | RASSF1 | TFRC | TGFB1 | TNF | TP53 | TRP53 | TTR | XPC
|
89.27 |
68
 |
| 7. |
Bleomycin
|
Pulmonary Fibrosis
|
M |
|
35 genes: AREG | CAT | CCL11 | CCL2 | CCL3 | CCR2 | CCR3 | CEBPB | COL3A1 | CSF2 | CSF3 | CTGF | CXCL2 | CXCL8 | EDN1 | ELN | FGF2 | FN1 | HGF | HMGB1 | HMOX1 | IL12B | IL13 | IL1B | IL4 | IL6 | MECP2 | MMP2 | MMP9 | NFE2L2 | SMAD7 | SPP1 | TGFB1 | TIMP1 | TNF
|
86.39 |
70 |
| 8. |
Carbon Tetrachloride
|
Lung Neoplasms
|
M |
|
114 genes: ACE | ACSM1 | ACTB | ADA | AKT1 | ANXA2 | APOA1 | APOC3 | APOE | BCL2L1 | BIRC5 | CASP8 | CCND1 | CCNG1 | CDH13 | CDKN1A | CDKN1B | CDKN2A | CEACAM1 | CES1F | CHEK2 | CLPTM1L | CTGF | CTNNB1 | CXCL14 | CYP1A2 | CYP1B1 | CYP2E1 | DAB2IP | DAPK1 | DDR1 | DNMT3A | DPYD | EFEMP1 | EGFR | EPHX1 | ESR1 | FAS | FASLG | FGF9 | FGFR1 | FGFR2 | FHIT | FOS | FOXM1 | GAST | GC | GJA1 | GJB1 | GPX1 | GRB7 | GSTM1 | GSTP1 | GSTT1 | HES1 | HMOX1 | HRAS | ID3 | IFNG | IL10 | IL1B | IL2 | IL6 | IRF1 | JUN | JUNB | KRAS | MAPK1 | MAPK14 | MAPK3 | MCL1 | MET | MIR127 | MIR155 | MIR30A | MIR31 | MIR34C | MIR370 | MIR410 | MMP1 | MMP10 | MPO | MYC | NOS2 | NOTCH2 | NPPA | OGG1 | PCNA | PON1 | PRDX1 | PRDX6 | PTEN | PTGIS | PTMA | RAMP2 | RARB | ROBO1 | SELENBP1 | SERPINA1 | SLC3A2 | SPP1 | TFRC | TGFB1 | TGFBR2 | TLR4 | TNF | TP53 | TRP53 | TSHR | TTR | TYMS | WNT5A | WT1 | XPC
|
86.12 |
135
 |
| 9. |
chromium hexavalent ion
|
Lung Neoplasms
|
M |
|
43 genes: AKT1 | BCL2L1 | BRCA2 | CASP8 | CCND1 | CDKN1A | CDKN1B | CDKN2A | CTNNB1 | CYP1B1 | EEF2 | EGFR | ERBB2 | ERBB3 | ESR1 | FGF9 | FOS | GPX1 | GSTP1 | HMOX1 | HRAS | IFNG | IL1B | IL2 | IL6 | JUN | MAP2K7 | MAPK1 | MAPK14 | MAPK3 | MYC | NOS2 | OGG1 | PCNA | PRDX1 | PRDX6 | SFTPB | SOX2 | TERT | TFRC | TNF | TP53 | TRP53
|
85.95 |
67
 |
| 10. |
Lipopolysaccharides
|
Lung Neoplasms
|
M |
|
94 genes: A2M | ACTB | AKT1 | ANXA2 | APOA1 | APOE | ATOX1 | BCL2L1 | BECN1 | BRAF | CASP8 | CCL18 | CCND1 | CCNG1 | CDH13 | CDKN1A | CDKN1B | CDKN1C | CDKN2A | CES1 | CES1F | COL6A1 | COX17 | CRP | CTGF | CTNNB1 | CXCL14 | CYP1A2 | CYP2E1 | DPYD | EGFR | ESR1 | FAS | FASLG | FGF9 | FOS | FOXM1 | GJA1 | GPX1 | GPX3 | GSTM1 | GSTP1 | GSTT1 | HMOX1 | HRAS | IFNG | IKBKG | IL10 | IL1B | IL2 | IL6 | IRF1 | JAG1 | JUN | JUNB | KRAS | MAP3K8 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MIR146A | MIR155 | MMP1 | MPO | MPP1 | MYC | NOS2 | NOTCH3 | NPPA | PCNA | PPP2R1B | PRDX1 | PRDX6 | PTEN | PYCARD | RAF1 | RARB | SELENBP1 | SELENOP | SFTPB | SFTPD | SLC7A5 | SPP1 | STAT5A | STK11 | TFRC | TGFB1 | TGFBR2 | TLR4 | TNF | TP53 | TRP53 | TTR
|
84.86 |
118
 |
| 11. |
Diethylnitrosamine
|
Lung Neoplasms
|
M |
|
109 genes: A2M | ACE | ACSM1 | AKT1 | ANXA2 | APC | APOA1 | APOC3 | APOE | ATOX1 | AZGP1 | BCL2L1 | BIRC5 | BRAF | BRCA2 | CASP8 | CCND1 | CCNG1 | CDH13 | CDKN1A | CDKN1B | CDKN1C | CDKN2A | CEACAM1 | CES1 | CES1F | CHEK2 | CHRNA7 | COL6A1 | CRP | CTGF | CTNNB1 | CXCL14 | CYP1A2 | CYP1B1 | CYP2A6 | CYP2E1 | DAPK1 | DDR1 | DNMT3A | DOK1 | DPYD | EFEMP1 | EGFR | EPHX1 | FAS | FGFR1 | FGFR2 | FHIT | FOS | FOXM1 | GAST | GC | GJA1 | GJB1 | GPX1 | GPX3 | GSTM1 | GSTP1 | GSTP2 | HMOX1 | HRAS | ID3 | IFNG | IGBP1 | IKBKG | IL10 | IL1B | IL2 | IL6 | IRF1 | JUN | KRAS | MAP2K7 | MAPK1 | MAPK14 | MAPK3 | MET | MTHFR | MYC | NFYA | NOS2 | NOTCH2 | OGG1 | PCNA | PON1 | PRDX1 | PTEN | PTMA | RAF1 | RARB | RASSF1 | ROBO1 | RUNX3 | SLC22A18 | SLC3A2 | SND1 | SPP1 | SPRY2 | STAT5A | TERT | TFRC | TGFB1 | TGFBR2 | TNF | TP53 | TRP53 | TYMS | UGT2B17
|
82.57 |
142
 |
| 12. |
Methylnitrosourea
|
Lung Neoplasms
|
M |
|
44 genes: ACTB | AKT1 | APC | BIRC5 | CASP8 | CCND1 | CDKN1A | CHEK2 | CTGF | CTNNB1 | DAPK1 | EGFR | EPHX1 | ESR1 | FGFR1 | FGFR2 | FHIT | FOS | GJB1 | HMOX1 | HRAS | ID3 | IFNG | IL10 | IL1B | IL2 | IRF1 | JUN | JUNB | KRAS | MAPK1 | MAPK14 | MAPK3 | MYC | NOS2 | PCNA | PTEN | SPP1 | SPRY2 | TNF | TP53 | TRP53 | TYRP1 | WNT5A
|
81.29 |
83 |
| 13. |
Azoxymethane
|
Lung Neoplasms
|
M |
|
29 genes: AKT1 | APC | BIRC5 | CCND1 | CDKN1A | CDKN1B | CDKN2A | CYP1A2 | CYP2E1 | FAS | FASLG | HMOX1 | HRAS | IFNG | IL10 | IL1B | IL2 | IL6 | KRAS | MAPK1 | MAPK3 | MYC | NOS2 | PCNA | TGFB1 | TNF | TP53 | TRP53 | TYMS
|
80.06 |
71
 |
| 14. |
Asbestos
|
Lung Neoplasms
|
M |
|
37 genes: ANXA2 | BAP1 | CDKN1A | CDKN2A | CES1 | CTGF | EGFR | EPHX1 | FAS | FASLG | FOS | GSTM1 | GSTP1 | GSTT1 | HMOX1 | IFNG | IL10 | IL6 | JUN | KRAS | MAPK1 | MAPK14 | MIRLET7BHG | MPO | NOS2 | PRDX1 | PTGIS | PYCARD | RASSF1 | SERPINA1 | SPP1 | TFRC | TGFB1 | TGFBR2 | TNF | TP53 | TRP53
|
79.51 |
80
 |
| 15. |
lipopolysaccharide, E. coli O26-B6
|
Pneumonia
|
M |
|
25 genes: CASP1 | CCL19 | CCL2 | CCL20 | CCL24 | CCL4 | CCL7 | CCL8 | CCR2 | CCR6 | CD40LG | CSF2 | CXCL1 | CXCL9 | CXCR2 | HMOX1 | IFNG | IL1B | IL1R1 | IL6 | MYD88 | TGFB1 | TLR4 | TNF | TNFRSF1A
|
77.59 |
5 |
| 16. |
Nicotine
|
Lung Neoplasms
|
M |
|
66 genes: ACE | ACTB | AKT1 | APOE | BAP1 | BCL2L1 | BIRC5 | BRAF | CASP8 | CCND1 | CDKN1A | CDKN1B | CEACAM1 | CHEK2 | CHRNA3 | CHRNA5 | CHRNA7 | CHRNB4 | COL6A1 | CRP | CYP1A2 | CYP2A6 | CYP2E1 | EEF2 | EGFR | FAS | FASLG | FOS | GATA6 | GPX1 | GPX3 | HEY1 | HMOX1 | HRAS | ID3 | IFNG | IL10 | IL1B | IL2 | IL6 | JUN | JUNB | MAP2K7 | MAPK1 | MAPK3 | MCL1 | MMP1 | MPO | MYC | NOS2 | PCNA | PIK3CA | PON1 | PRKN | PTEN | PYCARD | RAF1 | RAMP2 | SLC7A5 | SPP1 | TFRC | TGFB1 | TNF | TP53 | TRP53 | TSHR
|
76.43 |
85
 |
| 17. |
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
|
Lung Neoplasms
|
M |
|
39 genes: AKT1 | ANXA2 | BIRC5 | CASP8 | CCND1 | CCNG1 | CDKN1A | CDKN1B | CDKN2A | CHRNA7 | COL6A1 | COX17 | CTNNB1 | CYP1A2 | CYP1B1 | CYP2A6 | CYP2E1 | DAPK1 | DPYD | EEF2 | EGFR | EPHX1 | FOS | HES1 | HMOX1 | IL6 | IRF1 | JUN | KRAS | MAPK1 | MAPK3 | MYC | PCNA | PRDX6 | RAF1 | RARB | TP53 | TRP53 | TYMS
|
76.22 |
104
 |
| 18. |
Cacodylic Acid
|
Lung Neoplasms
|
M |
|
37 genes: AKT1 | BCL2L1 | CASP8 | CCND1 | CDH13 | CDKN1A | CDKN2A | CHEK2 | CYP1A2 | EGFR | ESR1 | FASLG | FGF9 | FOS | GJB1 | GPX1 | GSTM1 | GSTP1 | GSTP2 | GSTT1 | HMOX1 | IL1B | IL24 | IRF1 | JAG1 | JUN | MAPK1 | MYC | NOTCH3 | OGG1 | PCNA | RAF1 | TGFB1 | TGFBR2 | TNF | TP53 | TSHR
|
73.80 |
51 |
| 19. |
Particulate Matter
|
Pulmonary Fibrosis
|
M |
|
44 genes: ADIPOQ | AREG | CAT | CCL11 | CCL2 | CCL3 | CCL4 | CCL5 | CCR2 | CEBPB | CFD | CSF2 | CSF3 | CTGF | CXCL2 | CXCL8 | EDN1 | EGF | FGF2 | FN1 | GREM1 | HGF | HMOX1 | IGF1 | IL12B | IL13 | IL1B | IL1RN | IL4 | IL5 | IL6 | MECP2 | MMP2 | MMP9 | MT2 | NFE2L2 | PDGFB | SMAD7 | SOD3 | SPP1 | TGFA | TGFB1 | TIMP1 | TNF
|
73.77 |
41
 |
| 20. |
nitrofen
|
Lung Diseases
|
M |
|
25 genes: CRISPLD2 | CTGF | FOXA2 | IGF1R | IGF2R | INSR | IRX1 | IRX2 | IRX3 | IRX5 | KLF2 | NKX2-1 | PDGFA | PDGFRA | PTGS2 | PTH1R | PTHLH | SCGB1A1 | SCNN1A | SFTPB | SOD2 | SPRY2 | TGFB1 | TNF | VEGFA
|
73.65 |
32 |
| 21. |
Mustard Gas
|
Lung Neoplasms
|
M |
|
67 genes: ACE | ALX4 | BIRC5 | BRCA2 | CASP8 | CCND1 | CCNG1 | CDKN1A | CDKN1B | CEACAM1 | CHEK2 | CTGF | CYP1B1 | DNMT3A | FAS | FASLG | FGF9 | FGFR2 | FOS | FOXM1 | GAST | GJA1 | GJB1 | GPX1 | GSTM1 | HES1 | HEY1 | HMOX1 | ID3 | IFNG | IKBKG | IL10 | IL1B | IL24 | IL6 | JUN | MAP2K7 | MAP3K8 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MIR155 | MIR222 | MIR30A | MIR31 | MIR494 | MPO | MYC | NOS2 | NOTCH2 | NOTCH3 | PCNA | PRDX1 | PTGIS | RAF1 | RARB | RUNX3 | SFTPD | SMARCC1 | SND1 | SPP1 | TGFB1 | TLR4 | TNF | TP53 | TRP53
|
70.66 |
64
 |
| 22. |
Cobalt
|
Pneumonia
|
M |
|
28 genes: AHR | CASP1 | CCL17 | CCL19 | CCL2 | CCL20 | CCL24 | CCL4 | CCL7 | CCL8 | CCL9 | CSF2 | CX3CL1 | CXCL1 | CXCL5 | CXCL9 | HMOX1 | IFNG | IL18 | IL1B | IL4 | IL6 | PARP1 | PF4 | SIRT1 | SPP1 | TGFB1 | TNF
|
69.04 |
7 |
| 23. |
Acrolein
|
Lung Neoplasms
|
M |
|
36 genes: ACTB | AKT1 | APOA1 | APOE | CASP8 | CDKN1B | CTNNB1 | EGFR | ESR1 | FAS | FASLG | GSTP1 | GSTP2 | HMOX1 | IFNG | IL10 | IL1B | IL2 | IL6 | IRF1 | JUN | KRAS | MAPK1 | MAPK14 | MAPK3 | MIR224 | MIR370 | MMP1 | MYC | NOS2 | OGG1 | PON1 | PRDX1 | PTGIS | TNF | TP53
|
68.45 |
72
 |
| 24. |
9,10-Dimethyl-1,2-benzanthracene
|
Lung Neoplasms
|
M |
|
58 genes: ACTB | AKT1 | ANXA2 | APOE | BCL2L1 | BECN1 | BIRC5 | BRAF | CASP8 | CCND1 | CCNG1 | CDH13 | CDKN1A | CDKN1C | CDKN2A | CES1F | CTGF | CXCL14 | CYP1A2 | CYP1B1 | CYP2E1 | EEF2 | EFEMP1 | EPHX1 | ESR1 | FAS | FASLG | FHIT | FOS | GJA1 | GSTP1 | HMOX1 | HRAS | ID3 | IGBP1 | IL1B | IL2 | IL24 | IL6 | JUN | MCL1 | MPO | MYC | NOS2 | OGG1 | PCNA | PPP2R1B | SELENOP | SPP1 | SPRY2 | STAT5A | TFRC | TGFB1 | TGFBR2 | TNF | TP53 | TRP53 | TYMS
|
65.28 |
75
 |
| 25. |
Oxygen
|
Lung Neoplasms
|
M |
|
84 genes: ACE | ACTB | ADAM28 | AKT1 | ANXA2 | APC | APOA1 | BCL2L1 | BIRC5 | BRCA2 | CASP8 | CCND1 | CDH13 | CDKN1A | CDKN1B | CDKN1C | CHRNA3 | CHRNA7 | CTGF | CTNNB1 | CYP1A2 | CYP1B1 | CYP2E1 | DNASE1L3 | EGFR | ESR1 | FAS | FASLG | FOS | GAST | GJA1 | GPX1 | GPX3 | GSTM1 | GSTP1 | HES1 | HMOX1 | IFNG | IKBKG | IL10 | IL1B | IL6 | JUN | JUNB | MAP3K8 | MAPK1 | MAPK3 | MMP1 | MMP10 | MPO | MYC | NOS2 | NOTCH3 | NPPA | OGG1 | PCNA | PIK3CA | PON1 | PRDX1 | PRDX6 | PTEN | PTGIS | PTMA | RAMP2 | SELENBP1 | SFTPB | SFTPD | SLC3A2 | SLC7A5 | SOX2 | SPP1 | SPRY2 | TFRC | TGFB1 | TGFBR2 | TLR4 | TNF | TP53 | TRP53 | TYMS | TYRP1 | VHL | WT1 | XPC
|
65.01 |
93
 |
| 26. |
Asbestos
|
Pulmonary Fibrosis
|
M |
|
23 genes: CCL11 | CCL2 | CCL3 | CCL5 | CCR2 | CFD | CSF2 | CSF3 | CTGF | CXCL2 | CXCL8 | EDN1 | FN1 | HGF | HMOX1 | IL4 | IL5 | IL6 | SERPINA1 | SOD3 | SPP1 | TGFB1 | TNF
|
64.73 |
30
 |
| 27. |
Cadmium
|
Lung Neoplasms
|
M |
|
85 genes: A2M | ACE | AKT1 | ANXA2 | APOA1 | APOE | AZGP1 | BCL2L1 | BECN1 | BRAF | CASP8 | CBR2 | CCND1 | CDKN1A | CDKN1B | CDKN2A | CES1 | CES1F | COX17 | CRP | CTGF | CTNNB1 | CXCL14 | CYP24A1 | CYP2E1 | DNMT3A | EEF2 | EGFR | EHMT2 | EPHX1 | ESR1 | FAS | FGFR1 | FGFR2 | FOS | GAST | GC | GJA1 | GPX1 | GPX3 | GSTM1 | GSTP1 | GSTT1 | HMOX1 | IFNG | IL10 | IL1B | IL6 | JUN | JUNB | KRAS | MAPK1 | MAPK14 | MAPK3 | MET | MIR146A | MIR222 | MMP1 | MYC | NOS2 | OGG1 | PON1 | PPP2R1B | PRDX1 | PRDX6 | PTEN | RAF1 | RASSF1 | SELENBP1 | SELENOP | SERPINA1 | SLC3A2 | SPP1 | STK11 | TFRC | TGFB1 | TGFBR2 | TLR4 | TNF | TP53 | TP63 | TRP53 | TTR | TYMS | VHL
|
64.65 |
115
 |
| 28. |
Benzene
|
Lung Neoplasms
|
M |
|
54 genes: ACSM1 | ACTB | ADA | BAP1 | BCL2L1 | BRCA2 | CASP8 | CCND1 | CCNG1 | CDKN1A | CDKN1B | CDKN1C | CDKN2A | CES1 | CRP | CYP1A2 | CYP1B1 | CYP2E1 | DNMT3A | EEF2 | EGFR | EPHX1 | FGFR2 | FOS | GATA6 | GJA1 | GJB1 | GSTM1 | GSTP1 | GSTT1 | HMOX1 | IFNG | IL10 | IL2 | IL6 | IRF1 | JUN | KRAS | MAP3K8 | MIR34B | MIR34C | MPO | MYC | NFYA | NOS2 | OGG1 | PCNA | PTEN | SLC7A5 | TERT | TNF | TP53 | TRP53 | XPC
|
63.84 |
88
 |
| 29. |
Asbestos, Crocidolite
|
Lung Neoplasms
|
M |
|
60 genes: AKT1 | BAP1 | BCL2L1 | CASP8 | CCND1 | CDH13 | CDKN1A | CDKN1C | CDKN2A | CEACAM1 | CTGF | CTNNB1 | CYP24A1 | DAPK1 | EGFR | ERBB2 | FAS | FGFR1 | FGFR2 | FOS | GATA6 | HEY1 | HMOX1 | HRAS | IFNG | IL10 | IL1B | IL24 | IL6 | JUN | JUNB | MAPK1 | MAPK14 | MAPK3 | MCL1 | MET | MMP1 | MPO | MYC | NOS2 | NOTCH2 | OGG1 | PCNA | PTEN | PYCARD | RAF1 | RASSF1 | ROBO1 | SELENOP | SLC3A2 | SLC7A5 | SPP1 | SPRY2 | TFRC | TGFB1 | TNF | TP53 | TP63 | TRP53 | WT1
|
63.09 |
73
 |
| 30. |
Tobacco Smoke Pollution
|
Carcinoma, Non-Small-Cell Lung
|
M |
|
66 genes: ABCB1 | AKR1C1 | APC | AREG | ATF3 | AXL | BIRC5 | CASP8 | CAT | CD74 | CD9 | CDH13 | CDKN2A | CHGA | CSF3 | CST6 | CXCL8 | CYP2E1 | EGFR | ENO1 | ENO2 | FGF9 | FGFR1 | FHIT | FOXO3 | GCLC | GSTP1 | HES1 | IL10 | IL6R | ITGB1 | KIF5B | KRAS | LGALS1 | MDM2 | MET | MIR1246 | MIR638 | MMP1 | MMP9 | MS4A1 | MT3 | MYC | NDRG1 | NFE2L2 | NNAT | NQO1 | PGAM1 | PHGDH | PLBD1 | PPIA | PRDX1 | PSAT1 | PTHLH | PYCARD | RAF1 | RASSF1 | RECK | RHEB | RRAD | SOD2 | STAT3 | TGFA | TP53 | UCHL1 | VEGFA
|
63.04 |
60
 |
| 31. |
Asbestos, Amphibole
|
Lung Neoplasms
|
M |
|
27 genes: APOE | BCL2L1 | CASP8 | CCND1 | CCNG1 | CDKN1A | CDKN1C | CHEK2 | CYP24A1 | CYP2E1 | EGFR | FASLG | GPX1 | HMOX1 | IFNG | IL1B | IL6 | MAP3K8 | MAPK1 | MAPK3 | NOS2 | PCNA | PRDX1 | TGFB1 | TNF | TP53 | WT1
|
63.01 |
42
 |
| 32. |
arsenite
|
Lung Neoplasms
|
M |
|
70 genes: AKT1 | ALX4 | BIRC5 | CASP8 | CCND1 | CCNG1 | CDKN1A | CDKN1B | CDKN1C | CDKN2A | CLPTM1L | CTNNB1 | CXCL14 | CYP1A2 | CYP1B1 | CYP24A1 | DAPK1 | DDR1 | DNMT3A | EGFR | EHMT2 | EPHX1 | ESR1 | FGFR2 | FOS | GATA6 | GC | GJA1 | GPX1 | GPX3 | GSTM1 | GSTP1 | GSTT1 | HES1 | HMOX1 | ID3 | IFNG | IL1B | IL2 | IL6 | IRF1 | JAG1 | JUN | KRAS | MAP3K8 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MPO | MYC | NOS2 | NOTCH2 | OGG1 | PCNA | PTEN | RUNX3 | SLC3A2 | SOX2 | SPRY2 | STAT5A | TGFB1 | TLR4 | TNF | TP53 | TP63 | TRP53 | TYMS | WNT5A | WT1
|
62.55 |
107
 |
| 33. |
Tobacco Smoke Pollution
|
Lung Neoplasms
|
M |
|
113 genes: A2M | ACTB | AKT1 | ANXA2 | APC | APOA1 | APOE | BCL2L1 | BECN1 | BIRC5 | BRCA2 | CASP8 | CCND1 | CDH13 | CDKN1A | CDKN1B | CDKN1C | CDKN2A | CES1 | CES1F | CHRNA3 | CHRNA5 | CHRNA7 | COL6A1 | CRP | CTGF | CTNNB1 | CXCL14 | CYP1A2 | CYP1B1 | CYP2A6 | CYP2E1 | DNASE1L3 | DPYD | EEF2 | EFEMP1 | EGFR | FAS | FGF9 | FGFR1 | FHIT | FOS | GAST | GATA6 | GJA1 | GPX1 | GPX3 | GSTM1 | GSTP1 | GSTP2 | GSTT1 | HES1 | HEY1 | HMOX1 | ID3 | IFNG | IKBKG | IL10 | IL1B | IL24 | IL6 | JUN | KRAS | MAP3K8 | MAPK1 | MAPK14 | MAPK3 | MET | MIR146A | MIR222 | MIR224 | MIR30A | MIR34B | MIR34C | MIR370 | MIR4435-2HG | MIRLET7BHG | MMP1 | MMP10 | MPO | MTHFR | MYC | NOS2 | NOTCH2 | NPPA | OGG1 | PCNA | PIK3CA | PRDX1 | PRDX6 | PYCARD | RAF1 | RASSF1 | RUNX3 | SELENBP1 | SERPINA1 | SFTPB | SFTPD | SLC22A18 | SLC3A2 | SLC7A5 | SLCO1B3 | SPP1 | TFRC | TGFB1 | TGFBR2 | TLR4 | TNF | TP53 | TP63 | TYMS | WNT5A | XPC
|
62.49 |
151
 |
| 34. |
Diazinon
|
Lung Neoplasms
|
M |
|
65 genes: ACSM1 | AKT1 | ALX4 | APOE | AZGP1 | BCL2L1 | BIRC5 | CASP8 | CCND1 | CCNG1 | CDKN1A | CDKN1C | CHRNA3 | CHRNA5 | CHRNA7 | CYP1A2 | DDR1 | DOK1 | EGFR | EPHX1 | ERBB3 | ESR1 | FAS | FASLG | FGF9 | FGFR1 | FOXM1 | GATA6 | GPX1 | GPX3 | GSTM1 | GSTP2 | GSTT1 | HMOX1 | IFNG | IL10 | IL2 | IL6 | JUN | JUNB | MAP2K7 | MAPK1 | MAPK3 | MCL1 | MET | MYC | NFYA | NOS2 | PCNA | PON1 | PRKN | PTEN | PTMA | PYCARD | RASSF1 | RUNX3 | SERPINA1 | SLC22A18 | TGFB1 | TLR4 | TNF | TP53 | VHL | WNT5A | WT1
|
61.04 |
78
 |
| 35. |
Phenobarbital
|
Lung Neoplasms
|
M |
|
117 genes: A2M | ADA | AKT1 | ANXA2 | APC | APOA1 | APOC3 | APOE | ATOX1 | AZGP1 | BCL2L1 | BIRC5 | BRAF | BRCA2 | CASP8 | CCND1 | CDKN1A | CDKN1B | CDKN2A | CEACAM1 | CES1 | CES1F | CRP | CTGF | CTNNB1 | CXCL14 | CYP1A2 | CYP1B1 | CYP24A1 | CYP2A6 | CYP2E1 | DDR1 | DNASE1L3 | DNMT3A | DPYD | EFEMP1 | EGFR | EPHX1 | ESR1 | FAS | FASLG | FGFR2 | FHIT | FOS | FOXM1 | GATA6 | GJA1 | GJB1 | GPX1 | GPX3 | GSTM1 | GSTP1 | GSTP2 | GSTT1 | HES1 | HMOX1 | HRAS | ID3 | IKBKG | IL10 | IL1B | IL2 | IL6 | IRF1 | JAG1 | JUN | JUNB | MAPK1 | MAPK14 | MAPK3 | MCL1 | MET | MIR127 | MIR136 | MIR154 | MIR369 | MIR370 | MIR409 | MIR410 | MIR494 | MMP1 | MMP10 | MPP1 | MYC | OGG1 | PCNA | PON1 | PRDX1 | PRDX6 | PTEN | PTGIS | RAF1 | RAMP2 | RARB | RASSF1 | RIOX2 | ROBO1 | SELENBP1 | SELENOP | SLC22A18 | SLC3A2 | SLC7A5 | SLCO1B3 | SND1 | SPP1 | SPRY2 | TEP1 | TFRC | TGFB1 | TGFBR2 | TNF | TP53 | TRP53 | TTR | TYMS | UGT2B17 | WNT5A
|
60.44 |
117
 |
| 36. |
Ozone
|
Lung Neoplasms
|
M |
|
60 genes: ACTB | AKT1 | ANXA2 | APC | APOE | BECN1 | BIRC5 | CCND1 | CCNG1 | CDH13 | CDKN1A | CEACAM1 | CHRNA7 | CXCL14 | CYP1A2 | CYP1B1 | CYP2E1 | EEF2 | EGFR | EHMT2 | EPHX1 | ERCC6 | ESR1 | FAS | FGF9 | FOS | GPX3 | GSTM1 | GSTP1 | GSTP2 | GSTT1 | HEY1 | HMOX1 | HRAS | IFNG | IL10 | IL1B | IL2 | IL24 | IL6 | JUN | JUNB | KRAS | MAPK1 | MAPK3 | MIR222 | MYC | NOS2 | NOTCH3 | PCNA | PON1 | RAMP2 | SFTPD | SPP1 | TFRC | TGFB1 | TLR4 | TNF | TYMS | VHL
|
59.53 |
98
 |
| 37. |
Dieldrin
|
Lung Neoplasms
|
M |
|
54 genes: ACTB | APOA1 | APOE | BCL2L1 | BIRC5 | CASP8 | CCND1 | CDKN1A | CDKN1C | CHEK2 | CHRNA3 | CHRNA5 | CHRNA7 | CHRNB4 | CYP1A2 | CYP1B1 | DNASE1L3 | EGFR | EPHX1 | ERBB3 | ESR1 | FGF9 | FGFR1 | FOS | GJA1 | GPX1 | GPX3 | GSTP2 | HMOX1 | IL10 | IL1B | IL6 | JAG1 | JUN | JUNB | MAP2K7 | MAPK1 | MAPK3 | MET | MYC | NOTCH2 | PCNA | PON1 | PRDX6 | PYCARD | RAF1 | RARB | TGFB1 | TNF | TP53 | TRP53 | VHL | WNT5A | WT1
|
57.73 |
65
 |
| 38. |
Dust
|
Pulmonary Fibrosis
|
M |
|
21 genes: CALCA | CAT | CCL11 | CCL2 | CCL3 | CCL4 | CCL5 | CSF2 | CSF3 | CTGF | CXCL2 | CXCL8 | FGF7 | IL12B | IL13 | IL1B | IL4 | IL5 | IL6 | MMP9 | TNF
|
56.12 |
22 |
| 39. |
Cobalt
|
Pulmonary Fibrosis
|
M |
|
22 genes: CALCA | CAT | CCL2 | CCL3 | CCL4 | CCL5 | CSF2 | CTGF | CXCL2 | CXCL8 | FN1 | HMOX1 | IGF1 | IL1B | IL4 | IL6 | MMP9 | NFE2L2 | SPP1 | TGFB1 | TIMP1 | TNF
|
55.96 |
27 |
| 40. |
Antigens, Dermatophagoides
|
Pneumonia
|
M |
|
14 genes: CASP1 | CCL11 | CCL2 | CCL24 | CSF2 | CXCL1 | IFNG | IL13 | IL17A | IL1B | IL33 | IL4 | TGFB1 | TNF
|
55.77 |
3 |
| 41. |
Asbestos, Crocidolite
|
Pulmonary Fibrosis
|
M |
|
34 genes: AREG | CALCA | CAT | CCL2 | CCL3 | CCR2 | COL3A1 | CSF2 | CSF3 | CTGF | CXCL2 | CXCL8 | EDN1 | EGF | FGF2 | FN1 | GREM1 | HMGB1 | HMOX1 | IGF1 | IL1B | IL1RN | IL5 | IL6 | MMP2 | MMP9 | PTX3 | SKIL | SMAD7 | SOD3 | SPP1 | TGFB1 | TIMP1 | TNF
|
54.57 |
39 |
| 42. |
Asbestos, Crocidolite
|
Mesothelioma, Malignant
|
M |
|
30 genes: BAP1 | BCL10 | BCL2 | CALB2 | CCL3 | CDKN1A | CDKN2A | COL12A1 | CTNNB1 | CXCL8 | EGFR | FN1 | IFNG | IL1A | IL6 | ILK | LIMCH1 | MET | MLANA | NF2 | OSMR | PARP1 | PYCARD | RAF1 | RXRA | SOD2 | TP53 | TXN | VIM | WT1
|
54.50 |
22
 |
| 43. |
Metformin
|
Lung Neoplasms
|
M |
|
37 genes: AKT1 | BCL2L1 | CASP8 | CCNG1 | CDKN1A | CRP | CYP1A2 | CYP1B1 | CYP2E1 | ESR1 | FAS | FOS | GSTP1 | HMOX1 | IFNG | IL1B | IL6 | JUN | MAPK1 | MAPK3 | MMP10 | MPO | MYC | NOS2 | OGG1 | PON1 | PTEN | RAF1 | SELENOP | SLC3A2 | SLC7A5 | STK11 | TGFB1 | TLR4 | TNF | TP53 | XPC
|
54.36 |
47
 |
| 44. |
Polycyclic Hydrocarbons, Aromatic
|
Lung Neoplasms
|
M |
|
24 genes: CDKN1A | CYP1A2 | CYP1B1 | DNMT3A | EGFR | EPHX1 | FAS | FGF9 | GJA1 | GSTM1 | GSTP1 | GSTT1 | HMOX1 | IFNG | IL10 | IL1B | IL6 | JUN | MAPK1 | MAPK3 | PON1 | SPP1 | TNF | TP53
|
53.87 |
37
 |
| 45. |
Mustard Gas
|
Pulmonary Fibrosis
|
M |
|
35 genes: CAT | CCL11 | CCL2 | CCL3 | CCL4 | CCL5 | CCR2 | CSF2 | CSF3 | CTGF | CXCL2 | CXCL8 | EDN1 | EGF | FGF2 | FGF7 | FN1 | HMOX1 | IGF1 | IL12B | IL13 | IL1B | IL1RN | IL4 | IL5 | IL6 | MMP2 | MMP9 | NFE2L2 | PDGFA | SPP1 | TGFA | TGFB1 | TIMP1 | TNF
|
53.64 |
35 |
| 46. |
Smoke
|
Pulmonary Fibrosis
|
M |
|
31 genes: ADIPOQ | AREG | CAT | CCL2 | CCL5 | CFD | CSF2 | CTGF | CXCL2 | CXCL8 | DSP | EGF | FGF2 | FN1 | GREM1 | HGF | HMOX1 | IGF1 | IL1B | IL1RN | IL6 | MMP2 | MMP9 | NFE2L2 | PDGFA | SERPINA1 | SPP1 | TGFA | TGFB1 | TIMP1 | TNF
|
53.45 |
32
 |
| 47. |
vinyl carbamate
|
Lung Neoplasms
|
M |
|
17 genes: BIRC5 | CCND1 | CDKN1A | CDKN1B | CTNNB1 | CYP2E1 | DAPK1 | DNMT3A | ESR1 | FHIT | HRAS | KRAS | MYC | PCNA | PTEN | RARB | RASSF1
|
53.22 |
68 |
| 48. |
Dust
|
Pneumonia
|
M |
|
22 genes: AHR | CASP1 | CCL11 | CCL19 | CCL2 | CCL20 | CCL24 | CCL4 | CCL7 | CSF2 | CXCL1 | IFNG | IL13 | IL17A | IL1B | IL4 | IL6 | MYD88 | TLR4 | TNF | TNFRSF1A | TNFRSF1B
|
52.88 |
6 |
| 49. |
Ethylnitrosourea
|
Lung Neoplasms
|
M |
|
31 genes: APC | CCND1 | CCNG1 | CDKN1A | CDKN2A | EGFR | EMX2 | EPHX1 | ERBB2 | FOS | GATA6 | GJA1 | GJB1 | GSTT1 | HMOX1 | HRAS | ID3 | JAG1 | JUN | KRAS | MYC | NFYA | PCNA | PRKN | PTEN | SPP1 | TFRC | TNF | TP53 | TRP53 | TYRP1
|
52.66 |
74 |
| 50. |
Toluene 2,4-Diisocyanate
|
Asthma
|
M |
|
21 genes: CCL11 | CCL2 | CCL5 | GSTM1 | GSTP1 | HLA-DQB1 | ICAM1 | IL13 | IL1B | IL1RL1 | IL4 | IL5 | KRT19 | MMP9 | NOS2 | PHF11 | PTEN | TGFB1 | TNF | TSLP | VEGFA
|
52.61 |
60
 |