| 1. |
 |
Akai S, et al.
Toxicology. 2017 May 1;382:1-9.
|
2,2-bis(4-glycidyloxyphenyl)propane | 2,4-thiazolidinedione | Buthionine Sulfoximine | pioglitazone |
CD36 | CXCL2 | HMOX1 | IL6 | MIR133B | MIR206 | S100A8 | S100A9 | TNF |
Muscular Diseases | Necrosis |
| 2. |
 |
Bandeira AC, et al.
Chem Biol Interact. 2017 Feb 1;263:7-17.
|
Acetaminophen | lycopene |
CAT | GPT | MMP2 |
Drug-Induced Liver Injury | Necrosis |
| 3. |
 |
Cui X, et al.
Toxicol Lett. 2017 Jan 4;265:17-22.
|
Carbon Tetrachloride |
ACTA2 | COL1A1 | RDH13 | TGFB1 | TIMP1 |
Drug-Induced Liver Injury | Liver Cirrhosis, Experimental | Necrosis |
| 4. |
 |
El-Ganainy SO, et al.
Toxicol Lett. 2017 Jan 4;265:23-29.
|
Atorvastatin Calcium | Rosuvastatin Calcium |
AKT1 | MB |
Muscular Diseases | Myalgia | Necrosis | Weight Loss |
| 5. |
 |
Fang ZZ, et al.
Arch Toxicol. 2017 May;91(5):2235-2244.
|
1-Naphthylisothiocyanate | pirinixic acid |
ABCB11 | CHKA | CXCL1 | CXCL2 | CYP7A1 | EGR1 | GPT | IL6 | LCN2 | MT1 | MT2 | PPARA | RELA | SAA1 | SAA2 | SCD1 | SLC51B | SMPD3 | STAT3 |
Disease Models, Animal | Drug-Induced Liver Injury | Necrosis |
| 6. |
 |
Matsumoto H, et al.
J Toxicol Sci. 2017;42(2):175-181.
|
1,2,3-trichloropropane | 1-amino-2,4-dibromoanthraquinone | 2,4-diaminophenol | 2-amino-4-nitrophenol | 2-anisidine | 2-nitroanisole | 4,4'-thiobis(6-tert-butyl-3-cresol) | Anthraquinones | bromodichloromethane | Cisplatin | Dimethylnitrosamine | dinitrosopentamethylenetetramine | ethylenediamine | monuron | Nitrilotriacetic Acid | ochratoxin A | Phenolphthalein | Phenylbutazone | potassium bromate | tert-Butyl Alcohol | tetrachloroisophthalonitrile | tris(chloroethyl)phosphate |
DNM3 | ESCO2 | FIGNL1 | HAMP | HPGDS | RANBP1 | TPH1 | TPT1 | UBE2T |
Acute Kidney Injury | Hemosiderosis | Hyperplasia | Kidney Cortex Necrosis | Kidney Neoplasms | Kidney Papillary Necrosis | Necrosis | Weight Loss |
| 7. |
 |
Ramamoorthy H, et al.
Food Chem Toxicol. 2017 Jan;99:103-118.
|
Melatonin | Tenofovir |
NFKBIA | NOS2 | PTGS2 | RELA | TNF |
Kidney Diseases | Necrosis |
| 8. |
 |
Reena K, et al.
Environ Toxicol. 2017 Jan;32(1):265-277.
|
4-phenylenediamine |
CASP3 | LRP6 | MLST8 | MTOR | NFKBIA | RICTOR | RPTOR |
Necrosis |
| 9. |
 |
Sisó S, et al.
Toxicol Sci. 2017 Jun 1;157(2):330-341.
|
Isoflurophate |
AIF1 |
Necrosis | Neurogenic Inflammation | Status Epilepticus | Seizures |
| 10. |
 |
Wang H, et al.
Environ Toxicol. 2017 May;32(5):1587-1595.
|
Fluorides |
CASP3 | CASP9 | IFNG | IL1B | IL2 | TNF |
Necrosis |
| 11. |
 |
Wang JX, et al.
Toxicol Lett. 2017 Jan 4;265:38-46.
|
Acetaminophen | rosiglitazone |
CRP | CXCL1 | CYBB | GSR | MAPK1 | MAPK3 | NOX4 | TNF |
Drug-Induced Liver Injury | Hepatomegaly | Necrosis |
| 12. |
 |
Zhang DG, et al.
Toxicol Appl Pharmacol. 2017 Jan 1;314:39-47.
|
6-ethylchenodeoxycholic acid | Carbon Tetrachloride |
AKT1 | CCL2 | CXCL1 | CXCL2 | IL1B | IL4 | MAPK1 | MAPK3 | NR1H4 | TNF |
Drug-Induced Liver Injury | Hepatomegaly | Necrosis |
| 13. |
 |
Zhang H, et al.
Toxicology. 2017 Apr 1;380:50-61.
|
cyanoginosin LR |
AR | CYP19A1 | ESR1 | IL6 | MKI67 | MMP9 | TNF |
Hyperplasia | Inflammation | Necrosis | Prenatal Exposure Delayed Effects | Prostatic Diseases | Weight Loss |
| 14. |
 |
Adil M, et al.
Chem Biol Interact. 2016 Jun 25;253:66-77.
|
coenzyme Q10 | naringin | sodium arsenite |
GPT | HMOX1 | NFE2L2 | SMAD3 | TGFB1 |
Atrophy | Cardiomegaly | Cardiotoxicity | Edema | Fibrosis | Inflammation | Necrosis | Ventricular Dysfunction, Left | Weight Loss |
| 15. |
 |
Alp H, et al.
Biochem Genet. 2016 Dec;54(6):803-815.
|
Dichlorvos |
|
Drug-Induced Liver Injury | Necrosis | Pancreatic Diseases |
| 16. |
 |
Alvarenga EM, et al.
Chem Biol Interact. 2016 Dec 25;260:129-140.
|
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide | carvacrol | irinotecan |
CXCL1 | IL1B | MPO | NFKB1 | PTGS2 | TNF |
Bacteremia | Leukocyte Disorders | Mucositis | Necrosis |
| 17. |
 |
Ben Saad H, et al.
Chem Biol Interact. 2016 May 25;252:102-13.
|
potassium bromate | vanillin |
CAT | MT1 | MT2 |
Kidney Diseases | Necrosis |
| 18. |
 |
Bittencourt LF, et al.
Chem Biol Interact. 2016 Mar 22;252:74-81.
|
Chalcones |
|
Necrosis |
| 19. |
 |
Brito VB, et al.
Toxicology. 2016 Aug 10;368-369:46-57.
|
Doxorubicin |
CAT |
Necrosis |
| 20. |
 |
Bugel SM, et al.
Toxicol Appl Pharmacol. 2016 Apr 1;296:31-41.
|
Estradiol | Edetic Acid | N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide | SR 11302 | Tamoxifen |
AIFM1 | AP1S1 | BAXA | CALM2A | CALM3A | CAPN3B | CAPN7 | CAPNS1A | CASP8 | CASP9 | CDH1 | CDH11 | CDK2 | CDKN1A | CYP19A1B | CYP1A | EPCAM | ESR2A | FGF7 | FOSAB | HIF1AA | HIF1AL | HIF1AL2 | IGF1 | IGF2B | IGFBP1A | IGFBP1B | JUN | MITFA | MMP11A | MMP13A | MMP13B | MMP15A | MMP17A | MMP2 | MMP9 | NFKB2 | PRKCBA | PRKCBB | TB | TGFB3 | TIMP2A | TIMP2B | TNFA | TNFB | TP53 | VEGFAA | VEGFAB | VTG1 |
Necrosis |
| 21. |
 |
Calvano J, et al.
Toxicology. 2016 Aug 10;368-369:1-9.
|
Acetaminophen | Ceruletide | Streptozocin |
MIR216A | MIR216B | MIR217 | MIR375 |
Drug-Induced Liver Injury | Hemorrhage | Necrosis | Pancreatic Diseases |
| 22. |
 |
Chen PJ, et al.
Toxicol Appl Pharmacol. 2016 Feb 1;292:8-18.
|
Carbon Tetrachloride | Dexamethasone | 1-Methyl-3-isobutylxanthine |
ACTA2 | COL1A1 | INS | PTPN1 | TGFB1 |
Fatty Liver | Liver Cirrhosis, Experimental | Necrosis |
| 23. |
 |
Duan P, et al.
Toxicology. 2016 Feb 3;341-343:28-40.
|
3-methyladenine | 4-nonylphenol | Acetylcysteine |
AKT1 | APAF1 | BAD | BAX | BCL2 | BCL2L11 | BECN1 | CASP3 | CCNA2 | CCNB1 | CCND1 | CDKN1A | CDKN1B | EIF4EBP1 | MCL1 | MTOR | RPS6KB1 | TSC2 |
Necrosis |
| 24. |
 |
El-Ganainy SO, et al.
Toxicology. 2016 Jun 1;359-360:29-38.
|
Atorvastatin Calcium | coenzyme Q10 |
AKT1 |
Motor Disorders | Muscular Diseases | Necrosis | Weight Gain | Weight Loss |
| 25. |
 |
El-Horany HE, et al.
J Biochem Mol Toxicol. 2016 Jul;30(7):360-9.
|
Apomorphine | Quercetin | Rotenone |
BECN1 | DDIT3 |
Catalepsy | Disease Models, Animal | Gliosis | Movement Disorders | Necrosis | Parkinsonian Disorders | Weight Loss |
| 26. |
 |
Faria J, et al.
Toxicology. 2016 Jun 1;359-360:1-10.
|
Hydrogen Peroxide | tapentadol | Tramadol |
ALDOC | CASP3 | CASP9 | CKB | LDHA | NDUFS1 | PDK3 |
Necrosis |
| 27. |
 |
Goto A, et al.
Toxicol Appl Pharmacol. 2016 Sep 1;306:8-16.
|
Clozapine | Tretinoin |
HRH4 | ITGAM |
Agranulocytosis | Necrosis | Schizophrenia |
| 28. |
 |
Hirata-Koizumi M, et al.
J Toxicol Sci. 2016;41(5):693-700.
|
2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole | Clofibrate | Fenofibrate | Gemfibrozil | pirinixic acid |
ACAA2 | ACADVL | ACOT1 | ACOT2 | ACOT4 | ANGPTL4 | COLQ | CPT1A | CPT2 | CRAT | CYP4A1 | CYP4A3 | DACT2 | DECR1 | DECR2 | ECH1 | ECI1 | EHHADH | ELOVL6 | HMGCS2 | MGLL | NCEH1 | PDK4 | PEX11A | PLIN2 | PPCS | QPCT | SCD | SLC22A5 | SLC27A2 | VNN1 |
Drug-Induced Liver Injury | Necrosis |
| 29. |
 |
Horiguchi H, et al.
Arch Toxicol. 2016 Jan 20.
|
Cadmium Chloride | Lipopolysaccharides | Polymyxin B |
CSF2 | CSF3 | GOT2 | GPT |
Drug-Induced Liver Injury | Necrosis |
| 30. |
 |
Hussein MM, et al.
J Biochem Mol Toxicol. 2016 Apr 25.
|
Quercetin | Zinc Oxide |
CAT | HSD17B3 | HSD3B6 | NR5A1 |
Asthenozoospermia | Atrophy | Necrosis | Oligospermia |
| 31. |
 |
Ippolito DL, et al.
Toxicol Sci. 2016 Jan;149(1):67-88.
|
4,4'-diaminodiphenylmethane | allyl alcohol | Carbon Tetrachloride |
A2M | ARRB1 | C1QB | CD9 | COL1A1 | COL1A2 | COL5A2 | CP | CTGF | FBN1 | IGFBP1 | IGFBP2 | LAMC2 | LGALS1 | LGALS3BP | LOX | LUM | MMP2 | PCOLCE | PLAU | PLOD2 | SERPING1 | VIM | VTN |
Bile Duct Diseases | Hyperplasia | Inflammation | Liver Cirrhosis | Liver Diseases | Necrosis |
| 32. |
 |
Jonsson M, et al.
Toxicol In Vitro. 2016 Aug;34:309-20.
|
enniatins |
AIFM1 | ATG12 | ATG3 | BCL2L11 | BNIP3L | CASP3 | CCNB2 | CCNG1 | CCNL2 | CISD2 | CLN8 | CXADR | DCTN6 | DNM1 | GABARAPL1 | GOLPH3 | MALSU1 | MAP3K1 | MEF2A | MIEF1 | MPV17L | MTERF4 | NDUFS4 | NRF1 | PAM16 | PPP2CB | RRM2B | SH3GLB1 | TFB2M | TIMM21 | TIMM8B | TMEM11 | TNFSF10 | TOMM5 | TRMT10C | TUBB5 | YWHAG |
Necrosis |
| 33. |
 |
Joshi N, et al.
Toxicology. 2016 Jul 15;365:9-16.
|
clopidogrel | 1-Naphthylisothiocyanate |
F2RL3 |
Bile Duct Diseases | Fibrosis | Hyperplasia | Necrosis |
| 34. |
 |
Jugg BJ, et al.
Chem Res Toxicol. 2016 Oct 17;29(10):1602-1610.
|
Mustard Gas |
CCL2 | CCR5 | CDKN1A | CTGF | CXCL8 | CYR61 | EGR1 | FBXO32 | FGF2 | FOS | HBEGF | IL23A | MYC | NPPB | OSGIN1 | PPRC1 | SERPINE1 |
Acute Lung Injury | Necrosis | Pulmonary Edema |
| 35. |
 |
Kumar RP, et al.
Chem Biol Interact. 2016 Sep 25;257:110-8.
|
naringenin | Silver |
CAT | IL6 | NFKB1 | TNF |
Cardiomegaly | Drug-Induced Liver Injury | Necrosis | Nephritis, Interstitial |
| 36. |
 |
Kupski L, et al.
Toxicology. 2016 Aug 10;368-369:91-102.
|
ochratoxin A |
|
Necrosis |
| 37. |
 |
Kuwata K, et al.
Toxicol Sci. 2016 Jun;151(2):271-85.
|
acifluorfen |
CYP2B10 | NR1I3 |
Drug-Induced Liver Injury | Inflammation | Liver Neoplasms | Necrosis |
| 38. |
 |
Kuwata K, et al.
Food Chem Toxicol. 2016 Feb;88:75-86.
|
oxadiazon | protoporphyrin IX |
CYP1A1 | CYP1A2 | CYP2B10 | CYP3A11 | GPT | NR1I3 | POR |
Adenoma, Acidophil | Hepatomegaly | Liver Neoplasms | Necrosis | Porphyrias |
| 39. |
 |
Låg M, et al.
Toxicol In Vitro. 2016 Oct;36:53-65.
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole | Acetylcysteine | anthra(1,9-cd)pyrazol-6(2H)-one | cadmium acetate | manganese chloride | nickel chloride | sodium arsenite | Thiourea | Vanadates | zinc chloride |
CCL20 | CSF2 | CXCL10 | CXCL8 | DUOX1 | HMOX1 | IL10 | IL13 | IL1B | IL6 | MAPK1 | MAPK3 | RELA |
Necrosis |
| 40. |
 |
Lamb CL, et al.
Toxicol Appl Pharmacol. 2016 Nov 15;311:42-51.
|
Carbon Tetrachloride | Tetrachlorodibenzodioxin |
ACTA2 | COL1A1 | DES | DLK1 | SERPINE1 | TGFB1 | TIMP1 |
Drug-Induced Liver Injury | Hepatomegaly | Inflammation | Liver Cirrhosis, Experimental | Necrosis |
| 41. |
 |
Liang S, et al.
Chem Biol Interact. 2016 Oct 25;258:40-51.
|
benzyloxycarbonyl-valyl-alanyl-aspartic acid | Cyclosporine | Thioctic Acid | Zinc Oxide |
BAX | BCL2 | CASP3 | CASP8 | CASP9 | FAS |
Necrosis |
| 42. |
 |
Li SG, et al.
Hum Exp Toxicol. 2016 May;35(5):491-500.
|
arsenic trioxide | Lutein |
HMOX1 | MGST1 | NFE2L2 | NQO1 |
Necrosis | Oligospermia | Weight Loss |
| 43. |
 |
Meeran MF, et al.
Chem Biol Interact. 2016 May 5;251:17-25.
|
Isoproterenol | Thymol |
BCL2L1 | CASP8 | CASP9 | FAS |
Cardiotoxicity | Edema | Necrosis |
| 44. |
 |
Ozcicek A, et al.
Med Princ Pract. 2016;25(2):181-6.
|
Methotrexate | resveratrol |
IL1B | MPO | TNF |
Inflammation | Necrosis |
| 45. |
 |
Ozkok A, et al.
Toxicol Lett. 2016 Jan 5;240(1):105-13.
|
4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine | Cisplatin |
AGT | BCL2A1A | BCL2L1 | BIRC3 | CARD10 | CARD11 | CASP1 | CASP8 | CCL2 | CD27 | CD40 | CSF1 | CSF2 | CSF3 | CXCL1 | EIF2AK2 | F2R | FADD | ICAM1 | IFNG | IL10 | IL1A | IL1B | IL1R1 | IL6 | IRF1 | LTA | LTBR | MAP3K1 | MPO | MYD88 | NFKB2 | NFKBIA | RAF1 | REL | RELA | RELB | RIPK1 | RIPK2 | RIPK3 | STAT1 | TBK1 | TLR2 | TLR3 | TLR4 | TLR6 | TNF | TNFAIP3 | TNFRSF10B | TNFRSF1A | TNFRSF1B | TNFSF14 | TRAF3 | ZAP70 |
Acute Kidney Injury | Necrosis |
| 46. |
 |
Pacheco-Rivera R, et al.
Toxicol Lett. 2016 Jan 22;241:19-31.
|
Diethylnitrosamine |
ACTA2 | CCND1 | CDK2 | CDK4 | H2AFX | PDGFRB |
Fibrosis | Liver Neoplasms | Necrosis | Neoplasms, Experimental |
| 47. |
 |
Pizarro M, et al.
Toxicology. 2016 Aug 31;370:41-48.
|
Doxorubicin |
AKT1 | BECN1 | CASP3 | RPS6KB1 | SQSTM1 |
Necrosis |
| 48. |
 |
Rathinam A, et al.
Chem Biol Interact. 2016 Aug 25;256:161-6.
|
myrtenal | Streptozocin |
AKT1 | INS1 | IRS2 | SLC2A2 | SLC2A4 |
Diabetes Mellitus, Experimental | Hyperglycemia | Necrosis |
| 49. |
 |
Rosolen D, et al.
Chem Biol Interact. 2016 Oct 25;258:10-20.
|
N-phenylmaleimide |
FASN |
Necrosis |
| 50. |
 |
Rungsung S, et al.
Chem Biol Interact. 2016 May 25;252:87-92.
|
enrofloxacin | Selenium |
CAT |
Necrosis | Oligospermia | Weight Loss |