Cisplatin

Name	Cisplatin
CAS Type 1 Name	Platinum, diamminedichloro-, (SP-4-2)-
Equivalent Terms	Biocisplatinum \| cis Diamminedichloroplatinum \| cis-Diamminedichloroplatinum \| cis-Diamminedichloroplatinum(II) \| cis-Dichlorodiammineplatinum(II) \| cis Platinum \| cis-Platinum \| Diamminodichloride, Platinum \| Dichlorodiammineplatinum \| NSC-119875 \| Platidiam \| Platino \| Platinol \| Platinum Diamminodichloride
CAS Registry Number	15663-27-1
Definition	An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Structure
Top Interacting Genes
MeSH^® ID	D002945
External Links	CCRIS 15663-27-1 ChEBI 15663-27-1 ChemIDplus^® 15663-27-1 DrugBank DB00515 GENE-TOX 15663-27-1 Household Products Database 15663-27-1 HSDB^® 15663-27-1 PubChem D002945 TOXLINE^® Query

Top ↑ Ancestors

1.	Chemicals ← Inorganic Chemicals ← Chlorine Compounds ← Cisplatin
2.	Chemicals ← Inorganic Chemicals ← Nitrogen Compounds ← Cisplatin
3.	Chemicals ← Inorganic Chemicals ← Platinum Compounds ← Cisplatin

Top ↑ Descendants

Cisplatin
	5-FU-CDDP protocol
	ACV protocol
	ADOC protocol
	APEL protocol
	APO protocol 2
	AP protocol 1
	aquahydroxydiamminoplatinum
	ASHAP protocol
	B 85-0040
	BAPP protocol
	BAP protocol 2
	BAP regimen
	BBVDD protocol
	BCMV protocol
	BEMP protocol 2
	BEP protocol
	BEPV protocol
	BIP protocol
	bis(6-aminoquinoline)dichloroplatinum(II)
	BOMP protocol
	BOP-CISCA-POMB-ACE regimen
	BOPP protocol
	BV-CAP protocol
	CAB protocol
	CAE-P protocol
	CAF-PH protocol
	CAP-1 protocol
	CAPABLE protocol
	CAPF protocol
	CAP-M protocol
	CAP protocol 1
	CAP therapy protocol
	CBC protocol
	CCC protocol
	CCE protocol
	CCP protocol
	CE-AVN protocol
	CEBA combination
	CE-CAP protocol
	CECA protocol
	CEP combination
	CEVP protocol
	CFB protocol
	CF regimen
	CGV protocol
	CHAMP-5 protocol
	chlorodiethylenetriamine platinum
	chlorodiethylenetriamine platinum(II)-glutathione complex
	chlorodiethylenetriamine platinum(II)-S-methyl-glutathione complex
	CIF protocol
	CIP protocol
	CISCA(II)-VB(IV) protocol
	CISCA protocol
	cis-diammineplatinum(II)-polyglutamic acid complex
	CisEBP protocol
	cisplatin-4-methylpyridine
	cisplatin-deoxy(adenosine monophosphate guanosine) adduct
	cisplatin-deoxy(guanosine monophosphate guanosine) adduct
	cisplatin-DNA adduct
	cisplatin-guanosine adduct
	cisplatin, methionine drug combination
	cisplatin-procaine complex
	cis-platinum dichloride bis(diethyl 4-pyridylmethylphosphonate)
	Cis-VACD protocol
	CMF protocol
	CNR-NEO 2 protocol
	COBDP regimen
	COB protocol
	COMPA regimen
	COMPE protocol
	COPAC protocol
	COPE regimen
	COPU protocol
	COSS-86 protocol
	CPDD protocol
	CP protocol
	CPT protocol
	CPVP protocol
	CVACE protocol
	CVB protocol
	D 17872
	DBCT protocol
	DBPT protocol
	DBPT regimen
	DCEP protocol
	DCM-Dex-CDDP
	DDP-BLM protocol
	DEB-M protocol
	DECAV protocol
	deoxyadenylyl-thymidyl-deoxyguanylyl-deoxyguanosine-cisplatin complex
	DHAP protocol
	diaminneplatinum(II)-chlorocholylglycinate
	diamminediaqua platinum(II)
	diamminedichlorodihydroxyplatinum IV
	diammine-diiodoplatin
	diamminemonoaquamonochloroplatinum(II)
	diamminetetrachloroplatinum(II)
	DICE protocol
	dichlorbis(benzothiazole)platinum(II)
	dichloro(4,5-dimethyl-2-phenylenediamine-N,N')platinum(II)
	dichlorobis(glycylglycine ethyl ester)platinum II
	dichlorobis(tranylcypromine)platinum(II)
	disodium hexachloroplatinate
	DOP protocol
	DT-PACE protocol
	DT PACE regimen
	DVP (cisplatin)
	DVP protocol
	EAP protocol
	ECBC protocol
	ECP regimen
	ECT chemotherapy protocol
	EDAP regimen
	EDP protocol
	EEPFL protocol
	EEP protocol
	EFP protocol
	ELETOP protocol
	ENSG 3C protocol
	EP-OMB protocol
	EPO protocol
	EpPt-OMB protocol
	ESAP protocol
	ESHAP regimen
	ESHAP regimen, modified
	EVAC-G-CSF protocol
	EVAP regimen
	FACP protocol
	FADIP protocol
	FAMP protocol
	FAP2 protocol
	FAPEL protocol
	FAP protocol
	FAP regimen
	FCT protocol
	FEMTX-P protocol
	FEPA protocol
	FEP protocol
	FLAP protocol
	FLAP regimen
	FLEP protocol
	FLEP regimen
	FLMP protocol
	FLUDAP protocol
	FMP protocol
	FPEPIR regimen
	FP protocol
	FTP protocol
	FVP protocol
	GAP protocol
	GDP protocol
	GIP protocol
	HAC protocol
	HD-CEP regimen
	HFAP protocol
	HLFP regimen
	HOP protocol
	IAP protocol
	ICE protocol 1
	IMAP protocol
	K1 protocol
	lipoplatin
	MAC-VD protocol
	MADDOC protocol
	MAP protocol
	MBCF protocol
	MBD protocol
	m-BOP protocol
	MCF protocol
	MC protocol
	MECCA protocol
	MEC protocol 1
	MEC protocol 2
	MEPH protocol
	MEPP protocol
	MEP regimen
	M-FLP protocol
	MICE regimen
	MIFAP regimen
	MINE-ESHAP protocol
	MiPE protocol
	MIP protocol
	mito-MBD protocol
	modified M-VAC protocol
	MPEMi protocol
	MPEpiE protocol
	MPEpiV protocol
	MP regimen
	M-VAC protocol
	M-VEC protocol
	MVP-CAB protocol
	MVP protocol 2
	NaPIM protocol
	NIACF regimen
	NIP regimen
	NOV 002
	OC-HDP protocol
	OPEC-D protocol
	OPEC OJEC protocol
	OPEC protocol 1
	opTPFL regimen
	OS 87 protocol
	PAB-CAP protocol
	PADIC protocol
	PAE protocol
	PAMP protocol
	PAVE protocol 2
	PAVI protocol
	PAV-M protocol
	PBMF protocol
	PBML protocol
	PCMF protocol
	PCV regimen
	PDN-1
	PEA-M regimen
	PEA regimen
	PELF protocol 2
	PEM protocol
	PEP protocol
	PE regimen
	PET protocol
	PET regimen
	PEV-B protocol
	PFAP protocol
	PFLI-alpha protocol
	PFL-MP protocol
	PFL protocol
	PIAF regimen
	PIN protocol
	plachitin
	PMFV protocol
	PMUE protocol
	PMUE protocol 2
	PMU protocol
	poly(ethylene glycol)-poly(cisplatin-aspartic acid)
	POMACE protocol
	POMB-ACE-PAV regimen
	POMB-ACE regimen
	POMP regimen
	PPA protocol
	PPM protocol
	PP regimen
	(PtCl2(4,7-H-5-methyl-7-oxo(1,2,4)triazolo(1,5-a)pyrimidine)2)
	PTP protocol
	PVA protocol
	PVB protocol
	PVC protocol
	PVeBV protocol
	PVP protocol 3
	PVP protocol 4
	Rizzoli IOR protocol
	selenium-cisplatin conjugate
	silaplatin
	SPI-077 B103
	SPI-77, liposomal
	SSG IX protocol
	STAMP-I protocol
	T10 A protocol
	TAP protocol
	TCAP protocol
	TCF protocol
	TEMP protocol
	THP-FLPM protocol
	TIP regimen
	TPFL4 regimen
	TPFL5 protocol
	TPF protocol
	TP protocol
	transplatin
	VAB-6 regimen
	VAB-III protocol
	VAB II protocol
	VAB-IV protocol
	VCH protocol
	VCPC protocol
	VDA-P protocol
	VDD protocol
	VeIP protocol
	VEP combination
	ViFuP protocol
	VIP-B protocol
	VIP-E protocol
	VIP protocol 2
	VIP protocol 3
	VIP-VB protocol
	VlhP protocol
	VMBP protocol
	VMP-CIsCF protocol
	VMP protocol
	VPCBAE protocol
	VPCP protocol
	VPC regimen
	VP-P protocol