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Disease Systemic Inflammatory Response Syndrome

These chemicals are associated with Systemic Inflammatory Response Syndrome or its descendants. A chemical has either a curated association to the disease (M marker/mechanism and/or T therapeutic) or an inferred association via a curated gene interaction.

1–50 of 8,594 results.
  Chemical Disease Direct Evidence Enrichment Analysis Inference Network Inference Score References
1. Zymosan Sepsis M
12 genes: CASP3 | CXCR2 | IFNG | IL10 | MAPK1 | MAPK3 | MIF | MMP9 | NOS2 | TGFB1 | TLR4 | TNF 		32.88 9
2. lipopolysaccharide, Escherichia coli O111 B4 Sepsis M
12 genes: CASP3 | HMGB1 | IFNG | IL10 | MAPK1 | MAPK3 | MMP9 | NOS2 | TGFB1 | TGFBI | TLR4 | TNF 		30.26 12
3. Nitric Oxide Sepsis M
14 genes: ADM | CASP3 | IFNG | IL10 | MAPK1 | MAPK3 | MMP9 | MT1 | MT2 | NOS2 | NOS3 | TGFB1 | TLR4 | TNF 		28.50 11
4. Mechlorethamine Sepsis M
8 genes: CASP3 | CXCR2 | IL10 | MAPK1 | MAPK3 | MMP9 | NOS2 | TNF 		22.93 8
5. Peptidoglycan Sepsis M
6 genes: IFNG | IL10 | MAPK1 | MAPK3 | NOS2 | TNF 		21.54 7
6. Lipopolysaccharides Sepsis M
23 genes: ADM | CASP3 | CSF3 | CXCR2 | HMGB1 | IFNA2 | IFNG | IL10 | LBP | LTA | MAPK1 | MAPK3 | MIF | MMP9 | MT1 | MT2 | NOS2 | NOS3 | PROC | TGFB1 | TGFBI | TLR4 | TNF 		21.49 29
7. Glycosides Sepsis M
4 genes: IL10 | NOS2 | TGFB1 | TNF 		19.42 8
8. Doxorubicin Sepsis M
20 genes: ANGPT1 | CASP3 | CSF3 | HMGB1 | IFNG | IL10 | LBP | MAPK1 | MAPK3 | MIF | MMP9 | MT1 | MT2 | NOS2 | NOS3 | PROC | TGFB1 | TGFBI | TLR4 | TNF 		18.71 22
9. Bleomycin Sepsis M
11 genes: CASP3 | CSF3 | HMGB1 | IFNG | MAPK1 | MAPK3 | MIF | MMP9 | NOS2 | TGFB1 | TNF 		18.09 11
10. Paclitaxel Sepsis M
13 genes: ANGPT1 | CASP3 | CSF3 | HMGB1 | IL10 | LBP | MAPK1 | MAPK3 | MMP9 | NOS3 | TGFBI | TLR4 | TNF 		16.23 18
11. Sulfasalazine Sepsis M
8 genes: CASP3 | HMGB1 | IFNG | IL10 | MMP9 | NOS2 | TLR4 | TNF 		15.53 11
12. Dexamethasone Sepsis M
20 genes: ADM | ANGPT1 | CASP3 | CSF3 | HMGB1 | IFNG | IL10 | LBP | MAPK1 | MAPK3 | MIF | MMP9 | MT1 | MT2 | NOS2 | NOS3 | TGFB1 | TGFBI | TLR4 | TNF 		14.61 18
13. lipopolysaccharide, E coli O55-B5 Sepsis M
16 genes: CASP3 | CSF3 | HMGB1 | IFNG | IL10 | LBP | MAPK1 | MAPK3 | MMP9 | MT1 | MT2 | NOS2 | NOS3 | TGFB1 | TLR4 | TNF 		14.37 16
14. Cyclophosphamide Sepsis M
12 genes: ADM | ANGPT1 | CASP3 | IFNG | IL10 | MAPK1 | MAPK3 | MIF | NOS2 | NOS3 | TGFB1 | TNF 		14.05 12
15. Epoprostenol Sepsis M
4 genes: IL10 | MAPK1 | MAPK3 | TNF 		11.63 5
16. Fluorouracil Sepsis M
13 genes: ADM | ANGPT1 | CASP3 | IFNA2 | IFNG | MAPK1 | MAPK3 | MMP9 | NOS2 | PROC | TGFB1 | TGFBI | TNF 		10.79 13
17. Lipopolysaccharides Endotoxemia M
9 genes: ABCB1B | ALOX5 | ATP5A1 | CPS1 | HSPA9 | HSPD1 | NOS2 | OTC | SOD2 		10.38 21
18. vinorelbine Sepsis M
4 genes: CASP3 | IL10 | PROC | TNF 		9.61 9
19. 2-(4-isobutylphenyl)propionylmethanesulfonamide Sepsis M
2 genes: CXCR2 | MMP9 		9.18 2
20. lipopolysaccharide, E. coli O26-B6 Endotoxemia M
3 genes: ABCB1B | ALOX5 | NOS2 		9.05 5
21. Melphalan Sepsis M
6 genes: CASP3 | MAPK1 | MAPK3 | TGFB1 | TLR4 | TNF 		9.03 7
22. Ifosfamide Sepsis M
6 genes: CASP3 | IFNA2 | MMP9 | NOS2 | TLR4 | TNF 		8.88 9
23. irinotecan Sepsis M
8 genes: CASP3 | IFNG | IL10 | MAPK1 | MAPK3 | MMP9 | TGFBI | TNF 		8.83 7
24. Methotrexate Sepsis M
16 genes: ADM | ANGPT1 | CASP3 | CXCR2 | IFNG | IL10 | LBP | MAPK1 | MAPK3 | MMP9 | NOS2 | NOS3 | TGFB1 | TGFBI | TLR4 | TNF 		8.52 14
25. Prednisolone Sepsis M
6 genes: CXCR2 | IFNG | IL10 | MMP9 | TGFB1 | TNF 		8.47 8
26. Ethanol Sepsis M
16 genes: CASP3 | HMGB1 | IFNG | IL10 | LBP | MAPK1 | MAPK3 | MIF | MMP9 | MT1 | MT2 | NOS2 | NOS3 | TGFB1 | TLR4 | TNF 		7.94 13
27. lipopolysaccharide, Escherichia coli O111 B4 Endotoxemia M
3 genes: ALOX5 | NOS2 | SOD2 		7.79 12
28. Colchicine Sepsis M
5 genes: CASP3 | IFNG | NOS2 | TGFB1 | TNF 		7.63 8
29. Methylprednisolone Sepsis M
5 genes: CASP3 | MAPK1 | NOS2 | TGFB1 | TNF 		7.27 7
30. lipoteichoic acid Shock, Septic M
2 genes: NOS2 | TNF 		6.95 3
31. Endotoxins Shock, Septic M
2 genes: NOS2 | TNF 		6.68 3
32. Indomethacin Sepsis M
12 genes: CASP3 | IFNG | IL10 | LTA | MAPK1 | MAPK3 | MMP9 | NOS2 | NOS3 | TGFB1 | TLR4 | TNF 		6.47 10
33. Epirubicin Sepsis M
3 genes: CASP3 | NOS3 | TNF 		6.29 7
34. endotoxin, Escherichia coli Shock, Septic M
2 genes: NOS2 | TNF 		6.28 5
35. Galactosamine Shock, Septic M
2 genes: NOS2 | TNF 		5.58 2
36. Calcium Chloride Shock, Septic M
2 genes: NOS2 | TNF 		5.26 3
37. Histamine Shock, Septic M
2 genes: NOS2 | TNF 		4.91 3
38. Etoposide Sepsis M
5 genes: CASP3 | MAPK1 | MAPK3 | NOS2 | TNF 		4.42 9
39. adefovir dipivoxil Sepsis M
2 genes: IFNG | NOS2 		4.37 4
40. endothelium-dependent hyperpolarization factor Sepsis M   1 gene: NOS2 4.33 2
41. lipopolysaccharide, Escherichia coli O111 B4 Shock, Septic M
2 genes: NOS2 | TNF 		4.18 5
42. Prednisone Sepsis M
3 genes: IFNG | TGFB1 | TNF 		4.05 5
43. lipopolysaccharide, E coli O55-B5 Endotoxemia M
4 genes: ABCB1B | ATP5A1 | NOS2 | SOD2 		3.94 7
44. enterotoxin F, Staphylococcal Shock, Septic M   1 gene: TNF 3.78 3
45. Cisplatin Sepsis M
21 genes: ADM | ANGPT1 | CASP3 | CSF3 | CXCR2 | HMGB1 | IFNG | IL10 | LTA | MAPK1 | MAPK3 | MMP9 | MT1 | MT2 | NOS2 | NOS3 | PROC | TGFB1 | TGFBI | TLR4 | TNF 		3.58 20
46. endotoxin, Escherichia coli Endotoxemia M   1 gene: NOS2 3.39 3
47. FEC protocol Sepsis M   1 gene: IFNG 3.35 2
48. Ethanol Endotoxemia M
5 genes: ALOX5 | ATP5A1 | CPS1 | NOS2 | SOD2 		3.32 4
49. Galactosamine Endotoxemia M   1 gene: NOS2 3.18 2
50. Vinblastine Sepsis M
2 genes: CASP3 | HMGB1 		3.16 4
1–50 of 8,594 results.
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