| Interacting Gene | Interactions | Organisms | |
|---|---|---|---|
| 1. | MAPK3 | 486 | 11 |
| 2. | MAPK1 | 482 | 11 |
| 3. | TNF | 434 | 7 |
| 4. | TRPV1 | 374 | 12 |
| 5. | CASP3 | 362 | 12 |
| 6. | HMOX1 | 262 | 7 |
| 7. | BCL2 | 222 | 3 |
| 8. | IL6 | 205 | 7 |
| 9. | PTGS2 | 200 | 5 |
| 10. | RARA | 190 | 5 |
| 11. | IL1B | 187 | 8 |
| 12. | RARB | 187 | 7 |
| 13. | TP53 | 169 | 6 |
| 14. | ABCB11 | 165 | 6 |
| 15. | BAX | 164 | 6 |
| 16. | CYP26A1 | 162 | 9 |
| 17. | RXRA | 158 | 7 |
| 18. | AKT1 | 149 | 3 |
| 19. | RELA | 147 | 5 |
| 20. | CYP2E1 | 146 | 4 |
| 21. | NFE2L2 | 140 | 5 |
| 22. | CCND1 | 136 | 5 |
| 23. | MMP9 | 136 | 6 |
| 24. | CDKN1A | 135 | 3 |
| 25. | CAT | 120 | 8 |
| 26. | CXCL8 | 120 | 5 |
| 27. | CYP1A1 | 119 | 5 |
| 28. | PPARA | 116 | 6 |
| 29. | NOS2 | 115 | 5 |
| 30. | PARP1 | 112 | 4 |
| 31. | VEGFA | 112 | 5 |
| 32. | IFNG | 104 | 4 |
| 33. | CALCA | 100 | 5 |
| 34. | PPARG | 99 | 5 |
| 35. | FOS | 97 | 6 |
| 36. | TAC1 | 97 | 6 |
| 37. | NQO1 | 96 | 4 |
| 38. | CASP9 | 93 | 5 |
| 39. | JUN | 92 | 7 |
| 40. | TGFB1 | 90 | 4 |
| 41. | MMP2 | 80 | 5 |
| 42. | CCL2 | 79 | 4 |
| 43. | DDIT3 | 78 | 4 |
| 44. | CYP3A4 | 75 | 1 |
| 45. | SOD2 | 73 | 5 |
| 46. | EGFR | 72 | 3 |
| 47. | NFKBIA | 72 | 3 |
| 48. | ITGAM | 71 | 2 |
| 49. | TNFSF10 | 71 | 3 |
| 50. | ESR1 | 70 | 8 |