Neoplasm Invasiveness - Pathways

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	Disease	Pathway	Pathway ID	Association inferred via
1.	Neoplasm Invasiveness	Immune System	REACT:R-HSA-168256	65 genes: ACTB \| ALDOA \| ALOX5 \| ANXA1 \| ANXA2 \| CALR \| CAT \| CCL2 \| CCL5 \| CDH1 \| CFL1 \| CHI3L1 \| CSTB \| CTNNB1 \| CTSB \| CTSD \| CTSS \| EEF2 \| EGF \| EGFR \| FGF16 \| FN1 \| FTH1 \| FTL \| GAB2 \| GLYCAM1 \| HGF \| HIF1A \| HMOX1 \| HPSE \| HRAS \| IL1B \| IL1RN \| IL6 \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| MMP1 \| MMP2 \| MMP3 \| MMP9 \| MT2A \| MYD88 \| NCAM1 \| NRG1 \| PKM \| PLAU \| PLAUR \| PTEN \| PTK2 \| RELA \| RHOA \| RPS6KA3 \| SRC \| SUMO1 \| TGFB1 \| TIMP1 \| TLN1 \| TLR4 \| TNF \| TWIST1 \| TXN \| ZBTB16 \| ZEB1
2.	Neoplasm Invasiveness	Signal Transduction	REACT:R-HSA-162582	45 genes: ACTB \| AKR1B10 \| ANXA1 \| AXL \| BCAR1 \| CCL5 \| CDH1 \| CTNNB1 \| CXCL12 \| CXCR4 \| EDNRB \| EGF \| EGFR \| ESR1 \| FGF16 \| FN1 \| GAB2 \| HGF \| HIF1A \| HRAS \| IGF1 \| IL6 \| ITGB1 \| KDM1A \| MAPK1 \| MAPK3 \| MET \| MMP3 \| MMP9 \| MYD88 \| MYLK \| NCAM1 \| NRG1 \| PTEN \| PTK2 \| RELA \| RHOA \| RPS6KA3 \| S1PR2 \| SP1 \| SRC \| TGFB1 \| TGIF1 \| TLN1 \| TNF
3.	Neoplasm Invasiveness	Innate Immune System	REACT:R-HSA-168249	43 genes: ACTB \| ALDOA \| ALOX5 \| ANXA2 \| CAT \| CFL1 \| CHI3L1 \| CSTB \| CTNNB1 \| CTSB \| CTSD \| CTSS \| EEF2 \| EGF \| EGFR \| FGF16 \| FN1 \| FTH1 \| FTL \| GAB2 \| HGF \| HPSE \| HRAS \| IL1B \| MAPK1 \| MAPK3 \| MET \| MMP9 \| MYD88 \| NCAM1 \| NRG1 \| PKM \| PLAU \| PLAUR \| PTEN \| PTK2 \| RELA \| RHOA \| RPS6KA3 \| SRC \| TLN1 \| TLR4 \| TXN
4.	Neoplasm Invasiveness	Cytokine Signaling in Immune system	REACT:R-HSA-1280215	38 genes: ALOX5 \| ANXA1 \| CCL2 \| CCL5 \| EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HIF1A \| HMOX1 \| HRAS \| IL1B \| IL1RN \| IL6 \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| MMP1 \| MMP2 \| MMP3 \| MMP9 \| MT2A \| MYD88 \| NCAM1 \| NRG1 \| PTK2 \| RELA \| SRC \| SUMO1 \| TGFB1 \| TIMP1 \| TLN1 \| TNF \| TWIST1 \| ZEB1
5.	Neoplasm Invasiveness	Signaling by Interleukins	REACT:R-HSA-449147	36 genes: ALOX5 \| ANXA1 \| CCL2 \| CCL5 \| EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HIF1A \| HMOX1 \| HRAS \| IL1B \| IL1RN \| IL6 \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| MMP1 \| MMP2 \| MMP3 \| MMP9 \| MYD88 \| NCAM1 \| NRG1 \| PTK2 \| RELA \| SRC \| TGFB1 \| TIMP1 \| TLN1 \| TNF \| TWIST1 \| ZEB1
6.	Neoplasm Invasiveness	Developmental Biology	REACT:R-HSA-1266738	32 genes: ACTB \| ANGPTL4 \| CFL1 \| CTNNB1 \| EGF \| EGFR \| FGF16 \| FN1 \| FOXP1 \| GAB2 \| HGF \| HRAS \| ITGA5 \| ITGB1 \| KRT19 \| KRT7 \| MAPK1 \| MAPK3 \| MET \| MMP2 \| MMP9 \| NCAM1 \| NRG1 \| PAX6 \| PTK2 \| RELA \| RHOA \| RPS6KA3 \| SRC \| TGFB1 \| TLN1 \| TNF
7.	Neoplasm Invasiveness	Hemostasis	REACT:R-HSA-109582	29 genes: ALDOA \| ANXA2 \| BCAR1 \| BSG \| CALU \| CFL1 \| EGF \| FN1 \| GAB2 \| HGF \| HRAS \| IGF1 \| ITGA5 \| ITGB1 \| ITPK1 \| KDM1A \| MAPK1 \| MAPK3 \| MMP1 \| PLAU \| PLAUR \| PTK2 \| RHOA \| SRC \| TF \| TGFB1 \| TIMP1 \| TIMP3 \| TLN1
8.	Neoplasm Invasiveness	Pathways in cancer	KEGG:hsa05200	28 genes: CDH1 \| CDKN2A \| CTNNB1 \| CXCL12 \| CXCR4 \| EDNRB \| EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HIF1A \| HRAS \| IGF1 \| IL6 \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| MMP1 \| MMP2 \| MMP9 \| PTEN \| PTK2 \| RELA \| RHOA \| TGFB1 \| ZBTB16
9.	Neoplasm Invasiveness	Proteoglycans in cancer	KEGG:hsa05205	28 genes: ACTB \| CTNNB1 \| EGFR \| ESR1 \| FN1 \| HGF \| HIF1A \| HPSE \| HRAS \| IGF1 \| ITGA5 \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| MMP2 \| MMP9 \| PDCD4 \| PLAU \| PLAUR \| PTK2 \| RHOA \| SRC \| TGFB1 \| TIMP3 \| TLR4 \| TNF \| TWIST1
10.	Neoplasm Invasiveness	Disease	REACT:R-HSA-1643685	27 genes: ADAMTS1 \| CALR \| CDH1 \| CTNNB1 \| CXCR4 \| EEF2 \| EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| MYD88 \| NRG1 \| PRDX2 \| RELA \| RPL3L \| RPSA \| SOD2 \| SRC \| TGFB1 \| TLN1 \| TLR4
11.	Neoplasm Invasiveness	Metabolism	REACT:R-HSA-1430728	25 genes: AHR \| AKR1B10 \| ALDOA \| ALOX5 \| ANGPTL4 \| BSG \| CAT \| CYP2E1 \| ENO1 \| HMOX1 \| HPSE \| ITPK1 \| LDHB \| MT2A \| MT3 \| NME1 \| PKM \| PTEN \| RPL3L \| RPSA \| SLC6A12 \| SMPD1 \| SP1 \| TKT \| TXN
12.	Neoplasm Invasiveness	Metabolism of proteins	REACT:R-HSA-392499	25 genes: ACTB \| ADAMTS1 \| CALR \| CCL2 \| CDKN2A \| CTNNB1 \| CTSD \| EEF2 \| ESR1 \| HIF1A \| IGF1 \| MMP1 \| MMP2 \| PAX6 \| PLAUR \| PTEN \| RECK \| RHOA \| RPL3L \| RPSA \| SORL1 \| SUMO1 \| TGFB1 \| TLN1 \| TXN
13.	Neoplasm Invasiveness	Signaling by GPCR	REACT:R-HSA-372790	24 genes: ANXA1 \| CCL5 \| CXCL12 \| CXCR4 \| EDNRB \| EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| MMP3 \| NCAM1 \| NRG1 \| PTK2 \| RHOA \| RPS6KA3 \| S1PR2 \| SRC \| TLN1
14.	Neoplasm Invasiveness	Axon guidance	REACT:R-HSA-422475	23 genes: ACTB \| CFL1 \| EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HRAS \| ITGA5 \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| MMP2 \| MMP9 \| NCAM1 \| NRG1 \| PTK2 \| RHOA \| RPS6KA3 \| SRC \| TLN1
15.	Neoplasm Invasiveness	Adaptive Immune System	REACT:R-HSA-1280218	22 genes: CALR \| CDH1 \| CTSB \| CTSD \| CTSS \| EGF \| EGFR \| FGF16 \| GLYCAM1 \| HGF \| HRAS \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| MYD88 \| NRG1 \| PTEN \| RELA \| SRC \| TLR4 \| ZBTB16
16.	Neoplasm Invasiveness	Focal adhesion	KEGG:hsa04510	20 genes: ACTB \| BCAR1 \| CTNNB1 \| EGF \| EGFR \| FN1 \| HGF \| HRAS \| IGF1 \| ITGA5 \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| MYLK \| PTEN \| PTK2 \| RHOA \| SRC \| TLN1
17.	Neoplasm Invasiveness	MicroRNAs in cancer	KEGG:hsa05206	20 genes: CDKN2A \| EGFR \| FOXP1 \| HMOX1 \| HRAS \| ITGA5 \| MAPK1 \| MET \| MIR141 \| MIR200B \| MIR200C \| MMP9 \| PDCD4 \| PLAU \| PTEN \| RECK \| RHOA \| TIMP3 \| ZEB1 \| ZEB2
18.	Neoplasm Invasiveness	Extracellular matrix organization	REACT:R-HSA-1474244	19 genes: ADAMTS1 \| BSG \| CDH1 \| CTSB \| CTSD \| CTSS \| DMD \| FN1 \| ITGA5 \| ITGB1 \| LOXL2 \| MMP1 \| MMP14 \| MMP2 \| MMP3 \| MMP9 \| NCAM1 \| TGFB1 \| TIMP1
19.	Neoplasm Invasiveness	Interleukin-4 and 13 signaling	REACT:R-HSA-6785807	19 genes: ALOX5 \| ANXA1 \| CCL2 \| FN1 \| HGF \| HIF1A \| HMOX1 \| IL1B \| IL6 \| ITGB1 \| MMP1 \| MMP2 \| MMP3 \| MMP9 \| TGFB1 \| TIMP1 \| TNF \| TWIST1 \| ZEB1
20.	Neoplasm Invasiveness	Neutrophil degranulation	REACT:R-HSA-6798695	19 genes: ALDOA \| ALOX5 \| ANXA2 \| CAT \| CHI3L1 \| CSTB \| CTSB \| CTSD \| CTSS \| EEF2 \| FTH1 \| FTL \| HPSE \| MAPK1 \| MMP9 \| PKM \| PLAU \| PLAUR \| RHOA
21.	Neoplasm Invasiveness	PI3K-Akt signaling pathway	KEGG:hsa04151	19 genes: EGF \| EGFR \| EPO \| EPOR \| FGF16 \| FN1 \| HGF \| HRAS \| IGF1 \| IL6 \| ITGA5 \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| PTEN \| PTK2 \| RELA \| TLR4
22.	Neoplasm Invasiveness	Platelet activation, signaling and aggregation	REACT:R-HSA-76002	19 genes: ALDOA \| BCAR1 \| CALU \| CFL1 \| EGF \| FN1 \| GAB2 \| HGF \| IGF1 \| MAPK1 \| MAPK3 \| PTK2 \| RHOA \| SRC \| TF \| TGFB1 \| TIMP1 \| TIMP3 \| TLN1
23.	Neoplasm Invasiveness	Signalling by NGF	REACT:R-HSA-166520	19 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| MYD88 \| NCAM1 \| NRG1 \| PTEN \| PTK2 \| RELA \| RHOA \| RPS6KA3 \| SRC \| TLN1
24.	Neoplasm Invasiveness	Gastrin-CREB signalling pathway via PKC and MAPK	REACT:R-HSA-881907	18 genes: ANXA1 \| EDNRB \| EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| MMP3 \| NCAM1 \| NRG1 \| PTK2 \| RPS6KA3 \| SRC \| TLN1
25.	Neoplasm Invasiveness	Gene Expression	REACT:R-HSA-74160	18 genes: ACTB \| CDKN2A \| DEK \| EEF2 \| EGFR \| ESR1 \| MAPK3 \| NUAK1 \| PRDX2 \| PTEN \| RPL3L \| RPSA \| SET \| SP1 \| SUMO1 \| TGIF1 \| TXN \| ZFP36
26.	Neoplasm Invasiveness	Signaling by VEGF	REACT:R-HSA-194138	18 genes: AXL \| BCAR1 \| CTNNB1 \| EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| RHOA \| SRC \| TLN1
27.	Neoplasm Invasiveness	VEGFA-VEGFR2 Pathway	REACT:R-HSA-4420097	18 genes: AXL \| BCAR1 \| CTNNB1 \| EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| RHOA \| SRC \| TLN1
28.	Neoplasm Invasiveness	Fc epsilon receptor (FCERI) signaling	REACT:R-HSA-2454202	17 genes: EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTEN \| PTK2 \| RELA \| SRC \| TLN1
29.	Neoplasm Invasiveness	NGF signalling via TRKA from the plasma membrane	REACT:R-HSA-187037	17 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTEN \| PTK2 \| RHOA \| RPS6KA3 \| SRC \| TLN1
30.	Neoplasm Invasiveness	Rap1 signaling pathway	KEGG:hsa04015	17 genes: ACTB \| BCAR1 \| CDH1 \| CTNNB1 \| EGF \| EGFR \| FGF16 \| HGF \| HRAS \| IGF1 \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| RHOA \| SRC \| TLN1
31.	Neoplasm Invasiveness	Signaling by SCF-KIT	REACT:R-HSA-1433557	17 genes: EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| MMP9 \| NCAM1 \| NRG1 \| PTEN \| PTK2 \| SRC \| TLN1
32.	Neoplasm Invasiveness	Downstream signal transduction	REACT:R-HSA-186763	16 genes: BCAR1 \| EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTEN \| PTK2 \| SRC \| TLN1
33.	Neoplasm Invasiveness	Regulation of actin cytoskeleton	KEGG:hsa04810	16 genes: ACTB \| BCAR1 \| CFL1 \| EGF \| EGFR \| FGF16 \| FN1 \| HRAS \| ITGA5 \| ITGB1 \| MAPK1 \| MAPK3 \| MYLK \| PTK2 \| RHOA \| SRC
34.	Neoplasm Invasiveness	Signaling by PDGF	REACT:R-HSA-186797	16 genes: BCAR1 \| EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTEN \| PTK2 \| SRC \| TLN1
35.	Neoplasm Invasiveness	DAP12 interactions	REACT:R-HSA-2172127	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTEN \| PTK2 \| SRC \| TLN1
36.	Neoplasm Invasiveness	DAP12 signaling	REACT:R-HSA-2424491	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTEN \| PTK2 \| SRC \| TLN1
37.	Neoplasm Invasiveness	Diseases of signal transduction	REACT:R-HSA-5663202	15 genes: CTNNB1 \| EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NRG1 \| SRC \| TGFB1 \| TLN1
38.	Neoplasm Invasiveness	HIF-1 signaling pathway	KEGG:hsa04066	15 genes: ALDOA \| EGF \| EGFR \| ENO1 \| EPO \| HIF1A \| HMOX1 \| IGF1 \| IL6 \| MAPK1 \| MAPK3 \| RELA \| TF \| TIMP1 \| TLR4
39.	Neoplasm Invasiveness	IGF1R signaling cascade	REACT:R-HSA-2428924	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| IGF1 \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| SRC \| TLN1
40.	Neoplasm Invasiveness	Interleukin-2 signaling	REACT:R-HSA-451927	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| SRC \| TLN1
41.	Neoplasm Invasiveness	Interleukin-3, 5 and GM-CSF signaling	REACT:R-HSA-512988	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| SRC \| TLN1
42.	Neoplasm Invasiveness	Interleukin receptor SHC signaling	REACT:R-HSA-912526	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| SRC \| TLN1
43.	Neoplasm Invasiveness	IRS-related events triggered by IGF1R	REACT:R-HSA-2428928	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| IGF1 \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| SRC \| TLN1
44.	Neoplasm Invasiveness	MAPK1/MAPK3 signaling	REACT:R-HSA-5684996	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| IL6 \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| SRC \| TLN1
45.	Neoplasm Invasiveness	MAPK family signaling cascades	REACT:R-HSA-5683057	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| IL6 \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| SRC \| TLN1
46.	Neoplasm Invasiveness	RET signaling	REACT:R-HSA-8853659	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| GAB2 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| SRC \| TLN1
47.	Neoplasm Invasiveness	Signaling by EGFR	REACT:R-HSA-177929	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTEN \| PTK2 \| SRC \| TLN1
48.	Neoplasm Invasiveness	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACT:R-HSA-2404192	15 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| IGF1 \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| SRC \| TLN1
49.	Neoplasm Invasiveness	ARMS-mediated activation	REACT:R-HSA-170984	14 genes: EGF \| EGFR \| FGF16 \| FN1 \| HGF \| HRAS \| MAPK1 \| MAPK3 \| MET \| NCAM1 \| NRG1 \| PTK2 \| SRC \| TLN1
50.	Neoplasm Invasiveness	Cytokine-cytokine receptor interaction	KEGG:hsa04060	14 genes: CCL2 \| CCL5 \| CXCL12 \| CXCR4 \| EGF \| EGFR \| EPO \| EPOR \| HGF \| IL1B \| IL6 \| MET \| TGFB1 \| TNF

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