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Disease Neoplasm Invasiveness

1–50 of 234 results.
  Curated. Reference Cited Chemicals Cited Genes Cited Diseases
1. Curated.
Bhowmik T, et al.
Down-regulation of cyclin-dependent kinase-4 and MAPK through estrogen receptor mediated cell cycle arrest in human breast cancer induced by gold nanoparticle tagged toxin protein NKCT1.
Chem Biol Interact. 2017 Apr 25;268:119-128.
 NKCT1 protein, Naja kaouthia AKT1 | CCND1 | CDK4 | CDKN1A | MAPK1 | MAPK3 | RELA Neoplasm Invasiveness
2. Curated.
Chen MC, et al.
Inhibition of NF-κB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38.
Environ Toxicol. 2017 Feb;32(2):669-678.
 anthra(1,9-cd)pyrazol-6(2H)-one | SB 203580 | thymoquinone MAPK1 | MAPK3 | MMP2 | MMP9 | SNAI1 | TIMP1 | TIMP2 | TWIST1 | VIM Neoplasm Invasiveness
3. Curated.
Chen YF, et al.
Estrogen and ERα enhanced β-catenin degradation and suppressed its downstream target genes to block the metastatic function of HA22T hepatocellular carcinoma cells via modulating GSK-3β and β-TrCP expression.
Environ Toxicol. 2017 Feb;32(2):519-529.
 benzyloxycarbonylleucyl-leucyl-leucine aldehyde | Estradiol | Lithium Chloride | Melatonin BTRC | CTNNB1 | ESR1 | GSK3B Neoplasm Invasiveness
4. Curated.
Ho HY, et al.
Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase-plasminogen activator through modulation of the Akt signaling pathway.
Environ Toxicol. 2017 Feb;32(2):645-655.
 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | hispolon AKT1 | PLAU Neoplasm Invasiveness
5. Curated.
Kim CW, et al.
Cigarette smoke extracts induced the colon cancer migration via regulating epithelial mesenchymal transition and metastatic genes in human colon cancer cells.
Environ Toxicol. 2017 Feb;32(2):690-704.
 Tobacco Smoke Pollution BAX | CCND1 | CCNE1 | CDH1 | CDH2 | CDKN1A | CDKN1B | CTSD | SNAI1 | SNAI2 Neoplasm Invasiveness
6. Curated.
Kim YW, et al.
Sauchinone exerts anticancer effects by targeting AMPK signaling in hepatocellular carcinoma cells.
Chem Biol Interact. 2017 Jan 5;261:108-117.
 cobaltous chloride | sauchinone ACACA | BCL2 | CASP3 | CCND1 | CDKN1A | CDKN1B | EIF4EBP1 | HIF1A | MAPK1 | MAPK3 | MTOR | PARP1 | RPS6KB1 | SERPINE1 | STK11 | VEGFA Neoplasm Invasiveness
7. Curated.
Li CH, et al.
Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial-mesenchymal transition in non-small cell lung cancer cells.
Arch Toxicol. 2017 May;91(5):2165-2178.
 Benzo(a)pyrene | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | Chir 99021 AHR | CYP1A1 | CYP1B1 | GSK3B | VIM Neoplasm Invasiveness
8. Curated.
Lisiak N, et al.
Semisynthetic oleanane triterpenoids inhibit migration and invasion of human breast cancer cells through downregulated expression of the ITGB1/PTK2/PXN pathway.
Chem Biol Interact. 2017 Apr 25;268:136-147.
 methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate ITGB1 | PTK2 | PXN Neoplasm Invasiveness
9. Curated.
Shen KH, et al.
Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression.
Chem Biol Interact. 2017 Apr 25;268:129-135.
 solasodine AKT1 | BSG | MIR21 | MMP2 | MMP9 | RECK | TIMP1 | TIMP2 Neoplasm Invasiveness
10. Curated.
Aroui S, et al.
Naringin suppresses cell metastasis and the expression of matrix metalloproteinases (MMP-2 and MMP-9) via the inhibition of ERK-P38-JNK signaling pathway in human glioblastoma.
Chem Biol Interact. 2016 Jan 25;244:195-203.
 naringin MAPK1 | MAPK3 | MMP2 | MMP9 Neoplasm Invasiveness
11. Curated.
Baek SH, et al.
Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells.
Phytomedicine. 2016 May 15;23(5):566-77.
 resveratrol | Vanadates BCL2 | BCL2L1 | BIRC3 | BIRC5 | CASP3 | CASP9 | CCND1 | JAK2 | MMP2 | MMP9 | PARP1 | SOCS1 | STAT3 | VEGFA Carcinoma, squamous cell of head and neck | Neoplasm Invasiveness
12. Curated.
Chang PY, et al.
Tricetin inhibits human osteosarcoma cells metastasis by transcriptionally repressing MMP-9 via p38 and Akt pathways.
Environ Toxicol. 2016 Nov 8.
 tricetin MMP9 Neoplasm Invasiveness
13. Curated.
Chen YJ, et al.
Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFκB/c-Jun activation in breast cancer MDA-MB-231 cells.
Toxicol Appl Pharmacol. 2016 Nov 1;310:98-107.
 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | Gallic Acid | Gold | U 0126 EGF | EGFR | EP300 | JUN | MAP2K1 | MMP9 | RELA Neoplasm Invasiveness
14. Curated.
Han M, et al.
Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway.
Pharmacogn Mag. 2016 May;12(Suppl 2):S237-44.
 prolinedithiocarbamate | Quercetin CDH1 | IL6 | MMP2 | MMP9 | PTGS2 | RELA | TLR4 | TNF Neoplasm Invasiveness
15. Curated.
Inagaki Y, et al.
Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity.
Int J Oncol. 2016 Feb;48(2):533-40.
 C646 compound LAMA3 | MMP15 | SPP1 Neoplasm Invasiveness
16. Curated.
Jeon M, et al.
Elevated IL-1β expression induces invasiveness of triple negative breast cancer cells and is suppressed by zerumbone.
Chem Biol Interact. 2016 Oct 25;258:126-33.
 BAY 11-7085 | zerumbone IL1B | IL1RN | RELA Neoplasm Invasiveness
17. Curated.
Kim B, et al.
Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling.
Phytother Res. 2016 Nov;30(11):1833-1840.
 Apigenin | naringenin | Quercetin MAPK1 | MAPK3 | MET | NANOG | PROM1 | SOX2 | STAT3 Neoplasm Invasiveness
18. Curated.
Liu J, et al.
Niclosamide inhibits epithelial-mesenchymal transition and tumor growth in lapatinib-resistant human epidermal growth factor receptor 2-positive breast cancer.
Int J Biochem Cell Biol. 2016 Feb;71:12-23.
 lapatinib | Niclosamide ACTA2 | ALDH1A1 | CD24 | CD44 | CDH1 | CDH2 | ERBB2 | MTOR | RELA | SNAI1 | SOX2 | SRC | TGFB1 | VIM Breast Neoplasms | Neoplasm Invasiveness | Neoplasms, Experimental
19. Curated.
Lu KH, et al.
3-Hydroxyflavone inhibits human osteosarcoma U2OS and 143B cells metastasis by affecting EMT and repressing u-PA/MMP-2 via FAK-Src to MEK/ERK and RhoA/MLC2 pathways and reduces 143B tumor growth in vivo.
Food Chem Toxicol. 2016 Nov;97:177-186.
 3-hydroxyflavone EPCAM | FN1 | MAPK1 | MAPK3 | MMP2 | PLAU | PTK2 | RHOA | SNAI2 | SRC | VIM Neoplasm Invasiveness | Neoplasm Metastasis
20. Curated.
Miret N, et al.
Hexachlorobenzene modulates the crosstalk between the aryl hydrocarbon receptor and transforming growth factor-β1 signaling, enhancing human breast cancer cell migration and invasion.
Toxicology. 2016 Jul 29;366-367:20-31.
 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | AG 1879 | alpha-naphthoflavone | anthra(1,9-cd)pyrazol-6(2H)-one | Hexachlorobenzene | SB 203580 | Tetrachlorodibenzodioxin AHR | CYP1A1 | SMAD3 | TGFB1 Neoplasm Invasiveness
21. Curated.
Perumal D, et al.
Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma.
Cancer Res. 2016 Mar 1;76(5):1225-36.
 ON123300 | palbociclib | SRT1720 APAF1 | CASP9 | CCND1 | CCNE1 | CDC25A | CDK4 | CDKN1C | CDKN2A | FADD | MYC | NUAK1 | RB1 | RELA | RPS6KB1 | SIRT1 Multiple Myeloma | Neoplasm Invasiveness
22. Curated.
Piperigkou Z, et al.
Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules.
Toxicol Lett. 2016 Jan 5;240(1):32-42.
 Heparin CXCL8 | IL6 | MMP14 | NFE2L2 | PLAU | PSMB5 | PSMB6 | PSMB7 | SDC1 | SDC2 | SDC4 Neoplasm Invasiveness
23. Curated.
Verrando P, et al.
Trans-nonachlor decreases miR-141-3p levels in human melanocytes in vitro promoting melanoma cell characteristics and shows a multigenerational impact on miR-8 levels in Drosophila.
Toxicology. 2016 Aug 10;368-369:129-141.
 nonachlor CDH5 | MIR106B | MIR125A | MIR130A | MIR140 | MIR141 | MIR155 | MIR15A | MIR185 | MIR186 | MIR18A | MIR19A | MIR20A | MIR21 | MIR22 | MIR222 | MIR23A | MIR25 | MIR26B | MIR27A | MIR28 | MIR29C | MIR320A | MIR8 | MIR93 Neoplasm Invasiveness | Weight Loss
24. Curated.
Yang F, et al.
Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo.
Oncol Rep. 2016 Mar;35(3):1602-10.
 Quercetin THBS1 Neoplasm Invasiveness | Neoplasms, Experimental | Prostatic Neoplasms
25. Curated.
Yan HL, et al.
miR-346 promotes migration and invasion of nasopharyngeal carcinoma cells via targeting BRMS1.
J Biochem Mol Toxicol. 2016 Dec;30(12):602-607.
   BRMS1 | MIR346 Nasopharyngeal carcinoma | Neoplasm Invasiveness | Neoplasm Metastasis
26. Curated.
Yu MH, et al.
Hydroquinone stimulates cell invasion through activator protein-1-dependent induction of MMP-9 in HepG2 human hepatoma cells.
Food Chem Toxicol. 2016 Mar;89:120-5.
 anthra(1,9-cd)pyrazol-6(2H)-one | hydroquinone | SB 203580 | Tetradecanoylphorbol Acetate | U 0126 JUN | MMP9 Neoplasm Invasiveness
27. Curated.
Zhang C, et al.
Salinomycin suppresses TGF-β1-induced epithelial-to-mesenchymal transition in MCF-7 human breast cancer cells.
Chem Biol Interact. 2016 Mar 25;248:74-81.
 salinomycin CDH1 | CTNNB1 | MMP2 | SNAI1 | TGFB1 | VIM Neoplasm Invasiveness | Neoplasm Metastasis
28. Curated.
Chang TC, et al.
4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype.
Toxicol Appl Pharmacol. 2015 Oct 15;288(2):258-68.
 4-acetylantroquinonol B | Folfox protocol CTNNB1 | EZH2 | JAK2 | LGR5 | NANOG | SMO | SOX2 | SRC | STAT3 | SUZ12 | TYK2 Colorectal Neoplasms | Neoplasm Invasiveness | Weight Loss
29. Curated.
Chen YY, et al.
Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways.
Environ Toxicol. 2015 Jan;30(1):74-82.
 bufalin AKT1 | EIF2AK3 | GRB2 | JUN | MAP2K7 | MAP3K3 | MMP1 | MMP2 | MMP9 | NOS2 | PTGS2 | PTK2 | RELA | RHOA | ROCK1 | SOS1 | VEGFA Neoplasm Invasiveness
30. Curated.
Gandhy SU, et al.
Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC.
Oncotarget. 2015 Sep 22;6(28):26359-72.
 Metformin HULC | SP1 | SP3 | SP4 Neoplasm Invasiveness
31. Curated.
George AL, et al.
PLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived Primary Melanoma Cells.
J Cancer. 2015;6(12):1320-30.
 PLX4032 BRAF | MAGEA1 | MAPK1 | MAPK3 | MITF | MLANA | PMEL | TYR | TYRP1 Melanoma | Neoplasm Invasiveness
32. Curated.
Guo J, et al.
Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling.
Toxicol Lett. 2015 May 5;234(3):201-10.
 Acetylcysteine | Benzo(a)pyrene | U 0126 MAPK1 | MAPK3 | MMP9 Neoplasm Invasiveness | Neoplasm Metastasis
33. Curated.
Jao HY, et al.
Suppression of the migration and invasion is mediated by triptolide in B16F10 mouse melanoma cells through the NF-kappaB-dependent pathway.
Environ Toxicol. 2015 Sep 29.
 triptolide CXCR4 | GRB2 | MMP2 | MMP9 | PTGS2 | PTK2 | RHOA | ROCK1 | SOS1 Neoplasm Invasiveness
34. Curated.
Jayaram S, et al.
Pectic polysaccharide from corn (Zea mays L.) effectively inhibited multi-step mediated cancer cell growth and metastasis.
Chem Biol Interact. 2015 Jun 25;235:63-75.
 Plant Extracts | Polysaccharides LGALS3 | MMP2 | MMP9 | VEGFA Neoplasm Invasiveness | Neoplasm Metastasis
35. Curated.
Jin UH, et al.
Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway.
Chem Res Toxicol. 2015 May 18;28(5):907-18.
 cobaltous chloride | Omeprazole | Tetrachlorodibenzodioxin | tranilast AHR | ARNT | CXCR4 | CYP1A1 | CYP1B1 | HIF1A Neoplasm Invasiveness | Pancreatic Neoplasms
36. Curated.
Ji Q, et al.
Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression.
BMC Cancer. 2015;15:97.
 LY2109761 | resveratrol CDH1 | MMP2 | MMP9 | SNAI1 | SNAI2 | TGFB1 | VIM Neoplasm Invasiveness | Neoplasm Metastasis
37. Curated.
Johnson KC, et al.
DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer.
Clin Epigenetics. 2015;7(1):75.
   CYP2E1 | DLX4 | EDNRB | EN1 | GLYCAM1 | HOXB13 | ITPK1 | NUAK1 | PAGE4 | PAX6 | RNF207 | RPL3L | SLC6A12 | SORL1 | SOX11 | TBX15 | TMEM139 | ZBTB16 Neoplasm Invasiveness
38. Curated.
Kim ES, et al.
A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells.
Chem Biol Interact. 2015 Jul 25;237:58-65.
 Fingolimod Hydrochloride | Phytochemicals | sphingosine 1-phosphate CDH1 | GNAQ | MMP9 | PLCB4 | S1PR3 | VIM Neoplasm Invasiveness
39. Curated.
Kim JH, et al.
Emetine inhibits migration and invasion of human non-small-cell lung cancer cells via regulation of ERK and p38 signaling pathways.
Chem Biol Interact. 2015 Aug 30;242:25-33.
 Emetine MAPK1 | MAPK14 | MAPK3 | MMP2 | MMP9 | RECK Neoplasm Invasiveness
40. Curated.
Kirane A, et al.
Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis.
Cancer Res. 2015 Sep 15;75(18):3699-705.
 gemcitabine | R428 compound | Vitamin K | Warfarin AXL | CASP3 | CDH1 | CTNNB1 | EMCN | GAS6 | PARP1 | VIM | ZEB1 Neoplasm Invasiveness | Neoplasm Metastasis | Neoplasms, Experimental | Pancreatic Neoplasms
41. Curated.
Lee MM, et al.
Pipoxolan inhibits CL1-5 lung cancer cells migration and invasion through inhibition of MMP-9 and MMP-2.
Chem Biol Interact. 2015 Apr 18;236:19-30.
 pipoxolan MMP2 | MMP9 Neoplasm Invasiveness
42. Curated.
Lee WT, et al.
Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions.
Food Chem Toxicol. 2015 Apr;78:33-41.
 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 3-(4-methylphenylsulfonyl)-2-propenenitrile | antroquinonol | Curcumin | Tetradecanoylphorbol Acetate CDH1 | CDH2 | FOS | JUN | MAPK1 | MAPK3 | MMP9 | NFKBIA | RELA | SNAI1 | VIM Neoplasm Invasiveness
43. Curated.
Lian S, et al.
Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells.
Toxicology. 2015 Dec 2;338:104-16.
 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 3-(4-methylphenylsulfonyl)-2-propenenitrile | acetovanillone | Acetylcysteine | anthra(1,9-cd)pyrazol-6(2H)-one | Cadmium | Cadmium Chloride | Curcumin | diphenyleneiodonium | Hydrogen Peroxide | tyrphostin AG 1478 AKT1 | EGFR | FOS | IKBKB | JUN | MAP2K1 | MAPK1 | MAPK3 | MAPK8 | MAPK9 | MMP9 | NCF1 | NFKBIA | RELA Neoplasm Invasiveness
44. Curated.
Liao CL, et al.
The crude extract of Corni Fructus inhibits the migration and invasion of U-2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling.
Environ Toxicol. 2015 Jan;30(1):53-63.
 Plant Extracts EIF2AK3 | ERN1 | GRB2 | HIF1A | MAP2K7 | MAP3K3 | MAPK1 | MAPK3 | MMP2 | MMP9 | PTGS2 | PTK2 | RELA | RHOA | ROCK1 | SOS1 | VEGFA Neoplasm Invasiveness
45. Curated.
Liu R, et al.
Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line.
J Biol Chem. 2015 Dec 25;290(52):30988-1002.
 Celecoxib | JTE 013 | MK 2206 | sphingosine 1-phosphate | Taurocholic Acid | U 0126 EGFR | IL6 | MAPK1 | MAPK3 | MMP2 | MMP9 | PTGS2 | RELA | S1PR2 | TNF Neoplasm Invasiveness
46. Curated.
Liu W, et al.
Dehydroeffusol effectively inhibits human gastric cancer cell-mediated vasculogenic mimicry with low toxicity.
Toxicol Appl Pharmacol. 2015 Sep 1;287(2):98-110.
 dehydroeffusol CDH5 | CTNNB1 | MAPK1 | MAPK3 | MMP2 Anxiety Disorders | Neoplasm Invasiveness
47. Curated.
Liu ZM, et al.
TG-interacting factor transcriptionally induced by AKT/FOXO3A is a negative regulator that antagonizes arsenic trioxide-induced cancer cell apoptosis.
Toxicol Appl Pharmacol. 2015 May 15;285(1):41-50.
 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline | 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine | arsenic trioxide | U 0126 AKT1 | CDKN1A | FOS | MAPK1 | MAPK3 | PARP1 | TGIF1 Leukemia, Promyelocytic, Acute | Neoplasm Invasiveness
48. Curated.
Lu Y, et al.
Salinomycin exerts anticancer effects on human breast carcinoma MCF-7 cancer stem cells via modulation of Hedgehog signaling.
Chem Biol Interact. 2015 Feb 25;228:100-7.
 salinomycin ALDH1A1 | GLI1 | SMO Neoplasm Invasiveness
49. Curated.
Mazur PK, et al.
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
Nat Med. 2015 Oct;21(10):1163-71.
 Ceruletide | gemcitabine | (+)-JQ1 compound | vorinostat AKT1 | BCL2L1 | BRD4 | CASP3 | CDKN1C | CSF2 | CSF3 | EGF | IL1A | IL1B | IL2 | IL4 | IL6 | KRAS | MCL1 | MYC | PARP1 | STAT3 | TRP53 Disease Models, Animal | Lung Neoplasms | Metaplasia | Neoplasm Invasiveness | Neoplasms, Experimental | Pancreatic Neoplasms | Precancerous Conditions
50. Curated.
Mikuła-Pietrasik J, et al.
Colorectal cancer-promoting activity of the senescent peritoneal mesothelium.
Oncotarget. 2015 Oct 6;6(30):29178-95.
   IL6 | MMP3 | PLAU Neoplasm Invasiveness
1–50 of 234 results.
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