Neoplastic Processes - Chemicals

These chemicals are associated with Neoplastic Processes or its descendants. A chemical has either a curated association to the disease (M marker/mechanism and/or T therapeutic) or an inferred association via a curated gene interaction.

1–50 of 23,013 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Hydrogen Peroxide	Neoplasm Metastasis	M	113 genes: ABCC4 \| ACE \| AHR \| ALK \| ALOX5 \| ANXA1 \| ANXA4 \| ARHGDIA \| AXL \| CAT \| CAV1 \| CD44 \| CDH1 \| CDH2 \| CFL1 \| CSF1R \| CXCL12 \| CXCR4 \| DAPK1 \| DIO3 \| DMD \| EEF2 \| EGF \| EGFR \| EIF1AX \| EIF4A2 \| EML4 \| EPO \| EPOR \| ERBB2 \| ERCC1 \| ERCC4 \| ERP29 \| ESR1 \| EZR \| FADD \| FTL \| GAB2 \| GDF15 \| GJB1 \| GPX2 \| HGF \| HSP90AA1 \| HSPA1A \| IBSP \| IGF1 \| IL18 \| IL6 \| ITGB1 \| KRAS \| MAPK1 \| MAPK3 \| MAPK9 \| MED28 \| MIR100 \| MIR125A \| MIR130A \| MIR130B \| MIR148B \| MIR155 \| MIR181C \| MIR181D \| MIR18B \| MIR20B \| MIR221 \| MIR222 \| MIR224 \| MIR30A \| MIR30E \| MIR31 \| MIR342 \| MIR370 \| MIR99A \| MIR99B \| MLH1 \| MMP1 \| MMP10 \| MMP2 \| MMP9 \| MYC \| MYLK \| NDRG1 \| NME1 \| NPPA \| PLAUR \| PPIA \| PRNP \| PROX1 \| PTEN \| PTGS2 \| RB1 \| RECK \| S100A4 \| SERPINA1 \| SERPINB5 \| SLC39A4 \| SLC7A11 \| SNAI1 \| SNAI2 \| SOD2 \| SP1 \| SPP1 \| SRSF1 \| STAT3 \| TGFB1 \| TGFBR2 \| TNF \| TNFAIP8 \| TP53 \| TRP53 \| VEGFA \| VIM \| YWHAE	106.31	88
2.	Oxygen	Neoplasm Invasiveness	M	86 genes: ACTB \| ADAMTS1 \| AHR \| ALDOA \| ALOX5 \| ANGPTL4 \| ANXA1 \| ANXA2 \| AXL \| CAT \| CCL2 \| CCL5 \| CDH1 \| CFL1 \| CHRNA7 \| CTNNB1 \| CTSB \| CXCL12 \| CXCR4 \| CYP2E1 \| EDNRB \| EGFR \| ENO1 \| EPO \| EPOR \| ESR1 \| FTH1 \| HGF \| HIF1A \| HMOX1 \| HPSE \| IGF1 \| IL1B \| IL1RN \| IL6 \| IREB2 \| ITGA5 \| ITGB1 \| KDM1A \| KRT19 \| LDHB \| MAPK1 \| MAPK3 \| MIR141 \| MIR200B \| MIR200C \| MMP1 \| MMP14 \| MMP2 \| MMP3 \| MMP9 \| MT2A \| MT3 \| MYD88 \| MYLK \| NCAM1 \| NME1 \| NUAK1 \| PAX6 \| PKM \| PLAU \| PLAUR \| PRDX2 \| PTEN \| RELA \| RHOA \| RPSA \| S100A4 \| SMPD1 \| SNAI1 \| SOD2 \| SORL1 \| SOX11 \| SP1 \| SRC \| TGFB1 \| TIMP1 \| TIMP3 \| TKT \| TLR4 \| TNF \| TWIST1 \| TXN \| XRCC3 \| ZBTB16 \| ZEB1	100.35	72
3.	chromium hexavalent ion	Cell Transformation, Neoplastic	M	38 genes: BCL2 \| CAT \| CCND1 \| CDH1 \| CXCL8 \| CXCR4 \| ENO2 \| ESR1 \| FN1 \| FOS \| HRAS \| IGF1R \| IL6 \| IRS1 \| JUN \| KRT5 \| MAPK8 \| MIR143 \| MIR21 \| MMP9 \| MYC \| NCF1 \| NOS2 \| NOTCH1 \| PDCD4 \| PTK2 \| RELA \| SLC40A1 \| SNAI1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TFRC \| TP53 \| TRP53 \| VIM \| ZEB1	92.77	38
4.	2-Acetylaminofluorene	Cell Transformation, Neoplastic	M	41 genes: BCL2 \| BRCA1 \| CAT \| CCND1 \| CXCR4 \| EGF \| ESR1 \| FN1 \| FOS \| HRAS \| IL6 \| JUN \| KRT15 \| KRT19 \| MAPK8 \| MDM2 \| MIR185 \| MIR200B \| MIR205 \| MIR21 \| MIR221 \| MMP9 \| MUC1 \| MYC \| NFKB1 \| NOS2 \| NOTCH1 \| POR \| RAC1 \| RELA \| SLC40A1 \| SOD1 \| SOD2 \| STAT3 \| TFRC \| TGFB1 \| TP53 \| TRP53 \| TSC22D1 \| ZEB1 \| ZEB2	90.54	37
5.	sodium arsenite	Neoplasm Invasiveness	M	93 genes: ACTB \| ADAMTS1 \| AHR \| AKR1B10 \| ALDOA \| ALOX5 \| AMBP \| ANGPTL4 \| ANXA1 \| ANXA2 \| BRMS1 \| BSG \| CALR \| CAT \| CCL2 \| CDH1 \| CDKN2A \| CTNNB1 \| CTSB \| CTSD \| CTSS \| CXCL12 \| CXCR4 \| CYP2E1 \| EDNRB \| EEF2 \| EGF \| EGFR \| ENO1 \| ESR1 \| FN1 \| FTH1 \| FTL \| HGF \| HIF1A \| HMOX1 \| HRAS \| ID4 \| IGF1 \| IL1B \| IL1RN \| IL6 \| ITGB1 \| ITPK1 \| KRT19 \| KRT7 \| LDHB \| MAPK1 \| MAPK3 \| MET \| MIR141 \| MIR200B \| MIR200C \| MMP1 \| MMP14 \| MMP2 \| MMP9 \| MT2A \| MT3 \| MYLK \| NCAM1 \| NME1 \| PAX6 \| PDCD4 \| PKM \| PLAU \| PLAUR \| PRDX2 \| PTEN \| PTK2 \| RECK \| RELA \| RPSA \| SHBG \| SNAI1 \| SNAI2 \| SOD2 \| SORL1 \| SP1 \| SRC \| TGFB1 \| TIMP1 \| TIMP3 \| TKT \| TLR4 \| TNF \| TWIST1 \| TXN \| XRCC3 \| ZBTB16 \| ZEB1 \| ZEB2 \| ZFP36	84.71	82
6.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	Neoplasm Invasiveness	M	44 genes: ACTB \| AHR \| ALDOA \| ALOX5 \| ANGPTL4 \| ANXA1 \| CAT \| CDH1 \| CDKN2A \| CTNNB1 \| CTSD \| EGF \| EGFR \| ENO1 \| ESR1 \| FN1 \| HIF1A \| HMOX1 \| HRAS \| ID4 \| IL1B \| IL6 \| KDM1A \| KRT19 \| MAPK1 \| MAPK3 \| MIR141 \| MIR200C \| MMP2 \| MMP9 \| MT2A \| PKM \| PRDX2 \| PTEN \| RELA \| RHOA \| RPSA \| SOD2 \| SP1 \| TF \| TIMP1 \| TIMP3 \| TKT \| TNF	82.16	52
7.	Particulate Matter	Cell Transformation, Neoplastic	M	57 genes: AKR1C1 \| AKR1C2 \| AKR1C3 \| BCL2 \| BRCA1 \| CAT \| CCL18 \| CCND1 \| CDH1 \| CLDN1 \| CXCL8 \| CXCR4 \| EDN1 \| EGF \| EPAS1 \| FN1 \| FOS \| IL6 \| JUN \| KRAS \| KRT15 \| LOXL2 \| MAPK8 \| MDM2 \| MIR1246 \| MIR1275 \| MIR143 \| MIR191 \| MIR1915 \| MIR21 \| MIR25 \| MIR30D \| MIR34B \| MIR638 \| MIR877 \| MIR92B \| MIR99B \| MMP9 \| MUC1 \| MYC \| MYD88 \| NCF1 \| NFKB1 \| NOS2 \| OCLN \| PHGDH \| RAC1 \| RELA \| SLC2A1 \| SOD1 \| SOD2 \| STAT3 \| TFRC \| TGFB1 \| TNFAIP3 \| TP53 \| TRP53	77.35	43
8.	Diethylstilbestrol	Neoplasm Metastasis	M	63 genes: ABCB1 \| AGTR2 \| AHR \| ALDOA \| ARHGDIA \| BSG \| CAV1 \| CD44 \| CD82 \| CDH1 \| CDH2 \| CSF1R \| CSTA \| CXCL12 \| CXCR4 \| CYP19A1 \| DPYD \| EEF2 \| EGF \| EGFR \| EPO \| ERBB2 \| ESR1 \| EZR \| FADD \| GDF15 \| HSP90AA1 \| HSPA1A \| IGF1 \| IL6 \| LCN2 \| LGALS3 \| MAPK1 \| MAPK3 \| MET \| MIR34B \| MLH1 \| MMP2 \| MYC \| NCOA1 \| NME1 \| NPPA \| PLAUR \| PTEN \| RAC1 \| RB1 \| SERPINB5 \| SLC39A4 \| SLC7A11 \| SOD2 \| SP1 \| SPP1 \| STAT3 \| TGFB1 \| TGFBR2 \| TNF \| TNFSF10 \| TP53 \| TP63 \| TRP53 \| VEGFA \| VIM \| VIP	75.24	67
9.	sodium arsenite	Cell Transformation, Neoplastic	M	79 genes: AKR1C1 \| AKR1C2 \| AKR1C3 \| ALK \| BCL2 \| BRCA1 \| CAT \| CCND1 \| CD34 \| CDH1 \| CLDN1 \| CXCL8 \| CXCR4 \| EGF \| ENO2 \| EPAS1 \| ESR1 \| FN1 \| FOS \| HRAS \| IGF1R \| IL6 \| IL7R \| IRS1 \| JUN \| KRAS \| KRT14 \| KRT15 \| KRT19 \| KRT5 \| LIN28A \| MAPK8 \| MDM2 \| MIR143 \| MIR1469 \| MIR200B \| MIR205 \| MIR21 \| MIR25 \| MIR34B \| MIR34C \| MIR99B \| MIRLET7C \| MMP14 \| MMP9 \| MYC \| MYCN \| NCF1 \| NFKB1 \| NOS2 \| NOTCH1 \| OCLN \| PDCD4 \| PHGDH \| PIM1 \| POR \| PTK2 \| RAC1 \| RELA \| SATB2 \| SLC16A1 \| SLC2A1 \| SLC40A1 \| SNAI1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TFRC \| TGFB1 \| TNFAIP3 \| TP53 \| TP63 \| TRP53 \| TSC22D1 \| VIM \| WNT5A \| ZEB1 \| ZEB2	72.03	72
10.	Hydrogen Peroxide	Neoplasm Invasiveness	M	87 genes: ACO1 \| ACTB \| AHR \| AKR1B10 \| ALOX5 \| ANXA1 \| ANXA2 \| AXL \| BCAR1 \| CALR \| CALU \| CAT \| CCL2 \| CCL5 \| CDH1 \| CDKN2A \| CFL1 \| CTNNB1 \| CTSB \| CTSD \| CTSS \| CXCL12 \| CXCR4 \| CYP2E1 \| DLX4 \| DMD \| EEF2 \| EGF \| EGFR \| ENO1 \| EPO \| EPOR \| EPS8 \| ESR1 \| FN1 \| FTL \| GAB2 \| HGF \| HIF1A \| HMOX1 \| HOXB13 \| HRAS \| IGF1 \| IL1B \| IL6 \| ITGA5 \| ITGB1 \| LDHB \| MAPK1 \| MAPK3 \| MIR200C \| MMP1 \| MMP2 \| MMP3 \| MMP9 \| MT2A \| MT3 \| MYD88 \| MYLK \| NME1 \| NRG1 \| NUAK1 \| PDCD4 \| PKM \| PLAUR \| PRDX2 \| PTEN \| PTK2 \| RECK \| RELA \| S100A4 \| SLC39A10 \| SMPD1 \| SNAI1 \| SNAI2 \| SOD2 \| SORL1 \| SP1 \| SRC \| TF \| TGFB1 \| TIMP1 \| TNF \| TXN \| UBQLN1 \| XRCC3 \| ZFP36	70.64	79
11.	Nicotine	Neoplasm Invasiveness	M	52 genes: ACTB \| ALOX5 \| ANXA1 \| CALR \| CAT \| CCL2 \| CCL5 \| CDH1 \| CHRNA7 \| CTSB \| CXCR4 \| CYP2E1 \| EDNRB \| EEF2 \| EGFR \| ENO1 \| EPO \| FN1 \| FOXP1 \| HIF1A \| HMOX1 \| HRAS \| IGF1 \| IL1B \| IL1RN \| IL6 \| ITGB1 \| MALAT1 \| MAPK1 \| MAPK3 \| MMP1 \| MMP2 \| MMP3 \| MMP9 \| MT3 \| NCAM1 \| PLAU \| PLAUR \| PTEN \| RELA \| SNAI1 \| SNAI2 \| SOD2 \| SP1 \| SRC \| TGFB1 \| TIMP1 \| TIMP3 \| TNF \| TWIST1 \| ZEB1 \| ZFP36	68.48	57
12.	Tetradecanoylphorbol Acetate	Neoplasm Metastasis	M	104 genes: ABCB1 \| ABCC4 \| ACE \| ACKR3 \| ADORA2B \| AGTR1 \| AHR \| ALOX5 \| ANGPTL4 \| ANXA1 \| ANXA4 \| BSG \| CAT \| CD44 \| CD82 \| CDH1 \| CDH2 \| CIC \| CLIC1 \| CSF1R \| CSF3 \| CXCL12 \| CXCR4 \| CYP19A1 \| DAPK1 \| DIO3 \| DPYD \| EGF \| EGFR \| EHMT2 \| EIF1AX \| EIF4A2 \| EML4 \| ENPP2 \| ERBB2 \| ERP29 \| ESR1 \| EZR \| FLT1 \| FTL \| GDF15 \| GPCPD1 \| HGF \| HPSE \| HRH2 \| HSP90AA1 \| HSPA1A \| IBSP \| IGF1 \| IL18 \| IL2 \| IL6 \| ITGB1 \| KRAS \| LGALS3 \| LY96 \| MAPK1 \| MAPK3 \| MAPK9 \| MMP1 \| MMP2 \| MMP24 \| MMP9 \| MTDH \| MTHFR \| MYC \| MYLK \| NAGK \| NCOA1 \| NDRG1 \| NPPA \| OSM \| PDE5A \| PIK3C2B \| PLAU \| PLAUR \| PTEN \| PTGS2 \| RAC1 \| RB1 \| RPS6KA3 \| S100A4 \| SLC39A6 \| SLC7A11 \| SNAI1 \| SOD2 \| SP1 \| SPP1 \| SRSF1 \| STAT3 \| TBCB \| TGFB1 \| TGFBR2 \| TLR4 \| TNF \| TNFSF10 \| TP53 \| TP63 \| TPM4 \| TYMP \| UCHL3 \| VEGFA \| VIM \| YWHAE	68.25	99
13.	Tobacco Smoke Pollution	Neoplasm Invasiveness	M	93 genes: ACTB \| AHR \| AKR1B10 \| ALDOA \| ANGPTL4 \| ANXA1 \| ANXA2 \| AXL \| CALR \| CAT \| CCL2 \| CCL5 \| CD82 \| CDH1 \| CDKN2A \| CFL1 \| CHI3L1 \| CHRNA7 \| CSTB \| CTNNB1 \| CTSB \| CTSD \| CTSS \| CXCL12 \| CXCR4 \| CYP2E1 \| DMD \| EDNRB \| EEF2 \| EGF \| EGFR \| ENO1 \| EPOR \| FOXP1 \| FTH1 \| FTL \| GLYCAM1 \| HGF \| HIF1A \| HMOX1 \| IGF1 \| IL1B \| IL1RN \| IL6 \| ITGA5 \| ITGB1 \| ITPK1 \| KRT19 \| KRT7 \| LDHB \| LOXL2 \| MALAT1 \| MAPK1 \| MAPK3 \| MET \| MIR200B \| MIR200C \| MMP1 \| MMP14 \| MMP2 \| MMP3 \| MMP9 \| MT2A \| MT3 \| MYD88 \| NME1 \| NRG1 \| NUAK1 \| PDCD4 \| PKM \| PLAU \| PLAUR \| RECK \| RELA \| RNF207 \| RPSA \| S100A4 \| SNAI1 \| SNAI2 \| SOD2 \| SORL1 \| SOX11 \| SP1 \| TF \| TGFB1 \| TIMP1 \| TKT \| TLR4 \| TMEM139 \| TNF \| TXN \| ZBTB16 \| ZFP36	68.14	75
14.	Cadmium	Neoplasm Invasiveness	M	70 genes: AHR \| AKR1B10 \| ALDOA \| ALOX5 \| AMBP \| ANGPTL4 \| ANXA1 \| ANXA2 \| CALR \| CAT \| CCL2 \| CDH1 \| CDKN2A \| CFL1 \| CHI3L1 \| CTNNB1 \| CTSD \| CXCL12 \| CXCR4 \| CYP2E1 \| EEF2 \| EGF \| EGFR \| ENO1 \| EPO \| ESR1 \| FN1 \| FTH1 \| FTL \| HGF \| HIF1A \| HMOX1 \| IGF1 \| IL1B \| IL1RN \| IL6 \| ITGA5 \| ITGB1 \| KRT19 \| KRT7 \| MAPK1 \| MAPK3 \| MET \| MMP1 \| MMP2 \| MMP9 \| MT2A \| MT3 \| NCAM1 \| NRG1 \| PAX6 \| PKM \| PLAU \| PLAUR \| PRDX2 \| PTEN \| PTK2 \| RELA \| S1PR2 \| SHBG \| SLC39A10 \| SOD2 \| SP1 \| TF \| TGFB1 \| TIMP3 \| TLR4 \| TNF \| TXN \| ZFP36	66.42	71
15.	Isoproterenol	Neoplasm Invasiveness	M	49 genes: ACTB \| AHR \| ANXA1 \| CALR \| CAT \| CCL2 \| CTSB \| CTSD \| CYP2E1 \| DMD \| EDNRB \| EGFR \| ENO1 \| EPS8 \| FGF16 \| FN1 \| HIF1A \| HMOX1 \| HPSE \| HRAS \| IGF1 \| IL1B \| IL1RN \| IL6 \| ITGB1 \| LDHB \| MAPK1 \| MAPK3 \| MMP1 \| MMP14 \| MMP2 \| MMP3 \| MMP9 \| MYD88 \| PKM \| PLAU \| PTEN \| RELA \| RNF207 \| S100A4 \| SET \| SOD2 \| SP1 \| TGFB1 \| TIMP1 \| TIMP3 \| TLR4 \| TNF \| ZBTB16	65.86	52
16.	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	Cell Transformation, Neoplastic	M	29 genes: AKR1C1 \| AKR1C2 \| BCL2 \| BRCA1 \| CCND1 \| CXCL8 \| CYP2A13 \| FN1 \| FOS \| IL6 \| JUN \| KRAS \| KRT15 \| LGALS3 \| MAPK8 \| MDM2 \| MMP9 \| MYC \| NFKB1 \| NRG1 \| PDCD4 \| PHGDH \| POR \| RELA \| TNFAIP3 \| TP53 \| TRP53 \| TSC22D1 \| VIM	64.44	26
17.	Tetradecanoylphorbol Acetate	Neoplasm Invasiveness	M	94 genes: ACTB \| ADAMTS1 \| AHR \| AKR1B10 \| ALOX5 \| ANGPTL4 \| ANXA1 \| ANXA2 \| BSG \| CALR \| CAT \| CCL2 \| CCL5 \| CD82 \| CDH1 \| CDKN2A \| CHI3L1 \| CSTB \| CTNNB1 \| CTSB \| CTSD \| CTSS \| CXCL12 \| CXCR4 \| CYP2E1 \| DEK \| EDNRB \| EGF \| EGFR \| EPS8 \| ESR1 \| FGF16 \| FN1 \| FOXP1 \| FTH1 \| FTL \| HGF \| HIF1A \| HMOX1 \| HPSE \| HRAS \| IGF1 \| IL1B \| IL1RN \| IL6 \| ITGA5 \| ITGB1 \| KRT19 \| MAPK1 \| MAPK3 \| MMP1 \| MMP14 \| MMP2 \| MMP3 \| MMP9 \| MT2A \| MYD88 \| MYLK \| NRG1 \| NUAK1 \| PDCD4 \| PKM \| PLAU \| PLAUR \| PRDX2 \| PTEN \| PTK2 \| RELA \| RPS6KA3 \| S100A4 \| S1PR2 \| SET \| SLC39A10 \| SLC6A12 \| SMPD1 \| SNAI1 \| SOD2 \| SORL1 \| SP1 \| SRC \| SUMO1 \| TGFB1 \| TGIF1 \| TIMP1 \| TIMP3 \| TKT \| TLN1 \| TLR4 \| TNF \| TXN \| UBQLN1 \| ZEB1 \| ZEB2 \| ZFP36	63.46	95
18.	nickel chloride	Neoplasm Invasiveness	M	51 genes: ACO1 \| ACTB \| AHR \| ALDOA \| ANGPTL4 \| ANXA2 \| CAT \| CCL2 \| CCL5 \| CDH1 \| CDKN2A \| CHI3L1 \| CSTB \| CXCL12 \| EEF2 \| EGF \| EGFR \| EPOR \| ESR1 \| FN1 \| FTL \| HIF1A \| HMOX1 \| IGF1 \| IL1B \| IL6 \| LOXL2 \| MAPK1 \| MAPK3 \| MMP2 \| MMP9 \| MT2A \| MYD88 \| NCAM1 \| NRG1 \| PKM \| PRDX2 \| PTEN \| PTK2 \| RECK \| RELA \| SHBG \| SLC39A10 \| SNAI1 \| SNAI2 \| SOD2 \| TGFB1 \| TIMP3 \| TLR4 \| TNF \| TXN	62.98	60
19.	Hyaluronic Acid	Neoplasm Metastasis	M	27 genes: ABCB1 \| ANXA1 \| ANXA4 \| CAT \| CD44 \| CFL1 \| EEF2 \| EGF \| EGFR \| ERP29 \| EZR \| HSP90AA1 \| IL6 \| MAPK1 \| MAPK3 \| MMP1 \| MMP2 \| MMP9 \| NME1 \| PLAU \| PLAUR \| PPIA \| SNAI2 \| TLR4 \| TNF \| VEGFA \| VIM	62.43	31
20.	arsenic trioxide	Cell Transformation, Neoplastic	M	71 genes: ACTG1 \| AKR1C1 \| AKR1C2 \| AKR1C3 \| BCL2 \| BRCA1 \| CAT \| CCL18 \| CCND1 \| CD34 \| CDH1 \| CLDN1 \| CXCL8 \| CXCR4 \| EDN1 \| EGF \| EIF3I \| ESR1 \| FN1 \| FOS \| HRAS \| IGF1R \| IL6 \| IRS1 \| JUN \| KCNH2 \| KRT14 \| KRT19 \| LGALS3 \| MAPK8 \| MDM2 \| MIR143 \| MIR146A \| MIR15B \| MIR191 \| MIR21 \| MIR29A \| MIR34C \| MMP14 \| MMP9 \| MYC \| MYCN \| MYD88 \| NCF1 \| NFKB1 \| NOS2 \| NOTCH1 \| NRG1 \| NSD2 \| PDCD4 \| PHGDH \| PIM1 \| RAC1 \| RELA \| SATB2 \| SLC2A1 \| SLC40A1 \| SNAI1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TFRC \| TGFB1 \| TNFAIP3 \| TP53 \| TP63 \| TRP53 \| TSC22D1 \| VIM \| ZEB1	62.35	55
21.	Reactive Oxygen Species	Cell Transformation, Neoplastic	M	30 genes: AKR1C1 \| AKR1C2 \| BCL2 \| BRCA1 \| CAT \| CCND1 \| CDH1 \| EDN1 \| FN1 \| FOS \| HRAS \| IL6 \| JUN \| KCNH2 \| KRAS \| LGALS3 \| MAPK8 \| MMP9 \| MYC \| NCF1 \| NOS2 \| PTK2 \| RAC1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TGFB1 \| TP53 \| TRP53	61.90	32
22.	chromium hexavalent ion	Neoplasm Metastasis	M	31 genes: ANXA1 \| CAT \| CDH1 \| CXCR4 \| EEF2 \| EGFR \| ERBB2 \| ESR1 \| GPX2 \| IL2 \| IL6 \| MAPK1 \| MAPK3 \| MAPK9 \| MLH1 \| MMP9 \| MYC \| PMS2 \| PTGS2 \| RB1 \| SNAI1 \| SNAI2 \| SOD2 \| SP1 \| STAT3 \| TNF \| TP53 \| TRP53 \| TWIST1 \| VEGFA \| VIM	60.64	38
23.	Lipopolysaccharides	Cell Transformation, Neoplastic	M	59 genes: BCL2 \| CAT \| CCL18 \| CCND1 \| CDH1 \| CLDN1 \| CXCL8 \| CXCR4 \| CYP2A13 \| EDN1 \| EGF \| ESR1 \| FN1 \| FOS \| HMGN1 \| HRAS \| IL6 \| IL7R \| IRS1 \| JUN \| KRAS \| LGALS3 \| MAPK8 \| MDM2 \| MIR106A \| MIR146A \| MIR205 \| MIR221 \| MITF \| MMP14 \| MMP9 \| MUC1 \| MYC \| MYD88 \| NCF1 \| NFKB1 \| NOS2 \| NOTCH1 \| OCLN \| PARG \| PHGDH \| PIM1 \| POR \| PTK2 \| RAC1 \| RELA \| SLC2A1 \| SLC40A1 \| SNAI1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TFRC \| TGFB1 \| TNFAIP3 \| TP53 \| TRP53 \| VIM	59.08	52
24.	cinnamic aldehyde	Cell Transformation, Neoplastic	M	26 genes: AKR1C1 \| AKR1C2 \| BCL2 \| CAT \| CXCL8 \| CXCR4 \| EPAS1 \| FN1 \| FOS \| IL6 \| IL7R \| JUN \| MAPK8 \| MDM2 \| MYC \| MYD88 \| NCF1 \| NFKB1 \| NOS2 \| POR \| RAC1 \| RELA \| SLC2A1 \| SOD2 \| TGFB1 \| TP53	58.86	27
25.	alpha-naphthoflavone	Neoplasm Invasiveness	M	23 genes: AHR \| CAT \| CCL2 \| CTSD \| EGFR \| ENO1 \| ESR1 \| IL1B \| IL1RN \| IL6 \| MAPK1 \| MAPK3 \| MMP1 \| MMP2 \| MMP3 \| MMP9 \| PKM \| PTK2 \| RELA \| SOD2 \| SRC \| TGFB1 \| TNF	58.58	37
26.	Nicotine	Neoplasm Metastasis	M	50 genes: ACE \| AGTR2 \| ALOX5 \| ANXA1 \| CAT \| CD44 \| CDH1 \| CLIC1 \| CXCR4 \| DHFR \| EEF2 \| EGFR \| EML4 \| EPO \| EZR \| HSP90AA1 \| IGF1 \| IL2 \| IL6 \| ITGB1 \| MALAT1 \| MAPK1 \| MAPK3 \| MAPK9 \| MED28 \| MMP1 \| MMP2 \| MMP9 \| MYC \| PLAU \| PLAUR \| PROX1 \| PTEN \| PTGS2 \| RB1 \| SLC39A6 \| SNAI1 \| SNAI2 \| SOD2 \| SP1 \| SPP1 \| STAT3 \| TFPI2 \| TGFB1 \| TNF \| TP53 \| TRP53 \| TWIST1 \| VEGFA \| VIM	58.40	54
27.	Diethylnitrosamine	Neoplasm Metastasis	M	79 genes: ABCB1 \| ABCC4 \| ACE \| AHR \| ALDOA \| ALOX5 \| ANGPTL4 \| ANXA1 \| AXL \| CAT \| CAV1 \| CD44 \| CDH1 \| CDH2 \| CFL1 \| CXCL12 \| DAPK1 \| DHFR \| DPYD \| EGF \| EGFR \| ENPP2 \| EPOR \| ERCC4 \| ERP29 \| ETV4 \| EZR \| FLT1 \| FTL \| GDF15 \| GJB1 \| GPX2 \| HGF \| HSP90AA1 \| HSPA1A \| IGF1 \| IL2 \| IL6 \| ITGB1 \| KRAS \| LCN2 \| LGALS3 \| LY96 \| MALAT1 \| MAPK1 \| MAPK3 \| MAPK9 \| MET \| MLH1 \| MMP2 \| MMP9 \| MTHFR \| MYC \| NDRG1 \| NME1 \| OGN \| PLAU \| PPIA \| PRNP \| PTEN \| PTGS2 \| RB1 \| RECK \| S100A4 \| SERPINB5 \| SLC39A4 \| SOD2 \| SPP1 \| STAT3 \| TGFB1 \| TGFBR2 \| TNF \| TNFSF10 \| TP53 \| TPM4 \| TRP53 \| UCHL3 \| VEGFA \| VIM	57.55	85
28.	arsenite	Cell Transformation, Neoplastic	M	51 genes: BCL2 \| CAT \| CCND1 \| CD34 \| CDH1 \| CXCL8 \| CXCR4 \| EBF1 \| EDN1 \| EGF \| ENO2 \| ESR1 \| FN1 \| FOS \| IL6 \| IL7R \| IRS1 \| JUN \| KRAS \| KRT14 \| KRT15 \| KRT19 \| KRT5 \| LIN28B \| MAPK8 \| MDM2 \| MIR21 \| MIR29A \| MIRLET7C \| MMP9 \| MYC \| MYCN \| MYD88 \| NFKB1 \| NOS2 \| NOTCH1 \| NRG1 \| PDCD4 \| RAC1 \| RELA \| SLC2A1 \| SOD1 \| SOD2 \| STAT3 \| TGFB1 \| TP53 \| TP63 \| TRP53 \| TSC22D1 \| VIM \| WNT5A	57.37	46
29.	lysophosphatidic acid	Neoplasm Invasiveness	M	17 genes: ALOX5 \| BCAR1 \| CXCL12 \| EGFR \| EPO \| HIF1A \| IL1B \| IL6 \| MAPK1 \| MAPK3 \| MMP9 \| MYLK \| PLAU \| PTK2 \| RHOA \| TIMP1 \| TNF	55.74	28
30.	Cadmium Chloride	Neoplasm Invasiveness	M	97 genes: ACO1 \| ACTB \| ADAMTS1 \| AHR \| ALDOA \| ALOX5 \| AMBP \| ANGPTL4 \| ANXA1 \| ANXA2 \| AXL \| CALR \| CALU \| CAT \| CCL2 \| CCL5 \| CDH1 \| CDKN2A \| CFL1 \| CHI3L1 \| CSTB \| CTNNB1 \| CTSB \| CTSD \| CTSS \| CXCL12 \| CXCR4 \| CYP2E1 \| DEK \| EGF \| EGFR \| ENO1 \| EPO \| EPS8 \| ESR1 \| FN1 \| FTH1 \| HGF \| HIF1A \| HMOX1 \| HPSE \| HRAS \| ID4 \| IGF1 \| IL1B \| IL1RN \| IL6 \| ITGA5 \| ITGB1 \| KRT19 \| LDHB \| MALAT1 \| MAPK1 \| MAPK3 \| MET \| MMP1 \| MMP14 \| MMP2 \| MMP9 \| MT2A \| MT3 \| MYD88 \| MYLK \| NCAM1 \| NME1 \| NRG1 \| NUAK1 \| PAX6 \| PDCD4 \| PKM \| PLAU \| PRDX2 \| PTEN \| RELA \| RHOA \| RPS6KA3 \| RPSA \| SET \| SLC39A10 \| SMPD1 \| SNAI1 \| SOD2 \| SP1 \| SRC \| SUMO1 \| TF \| TGFB1 \| TIMP1 \| TIMP3 \| TKT \| TLN1 \| TLR4 \| TNF \| TWIST1 \| TXN \| ZBTB16 \| ZFP36	54.72	84
31.	Asbestos, Crocidolite	Neoplasm Invasiveness	M	46 genes: AHR \| CAT \| CCL2 \| CDH1 \| CDKN2A \| CHI3L1 \| CTNNB1 \| CTSB \| EGF \| EGFR \| EPS8 \| FN1 \| HIF1A \| HMOX1 \| HRAS \| IGF1 \| IL1B \| IL1RN \| IL6 \| ITGB1 \| MAPK1 \| MAPK3 \| MET \| MMP1 \| MMP2 \| MMP3 \| MMP9 \| MT2A \| MYLK \| NRG1 \| PLAU \| PLAUR \| PTEN \| RELA \| RHOA \| S1PR2 \| SOD2 \| SP1 \| SRC \| TGFB1 \| TGIF1 \| TIMP1 \| TKT \| TNF \| TXN \| ZFP36	54.43	61
32.	Hexachlorobenzene	Neoplasm Invasiveness	M	24 genes: AHR \| ANXA1 \| CAT \| CDH1 \| CDKN2A \| CXCR4 \| CYP2E1 \| EGFR \| ESR1 \| FN1 \| GLYCAM1 \| HMOX1 \| IL1B \| IL6 \| MAPK1 \| MAPK3 \| MMP2 \| MMP9 \| PRDX2 \| SOD2 \| SRC \| TF \| TGFB1 \| TIMP1	54.35	40
33.	hydroquinone	Neoplasm Invasiveness	M	24 genes: AHR \| CAT \| CCL2 \| CCL5 \| CXCL12 \| CYP2E1 \| FN1 \| FTH1 \| HMOX1 \| HRAS \| IL1B \| IL6 \| ITGB1 \| MAPK1 \| MAPK3 \| MMP14 \| MMP2 \| MMP3 \| MMP9 \| RELA \| SOD2 \| TLR4 \| TNF \| TXN	54.01	38
34.	monomethylarsonic acid	Cell Transformation, Neoplastic	M	17 genes: CAT \| CCND1 \| CDH1 \| ESR1 \| FOS \| IGF1R \| JUN \| MDM2 \| MYC \| NFKB1 \| RELA \| SLC2A1 \| SOD1 \| SOD2 \| STAT3 \| TGFB1 \| TP53	53.11	19
35.	Y 27632	Neoplasm Invasiveness	M	19 genes: CDH1 \| CFL1 \| CTSB \| CXCL12 \| EGF \| FN1 \| HIF1A \| IL1B \| IL6 \| ITGB1 \| MAPK1 \| MAPK3 \| MMP2 \| MMP9 \| RELA \| RHOA \| RPS6KA3 \| TGFB1 \| TNF	53.09	37
36.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	Neoplasm Metastasis	M	34 genes: AHR \| ALDOA \| ALOX5 \| ANGPTL4 \| ANXA1 \| CAT \| CDH1 \| EGF \| EGFR \| ERBB2 \| ERCC1 \| ESR1 \| EZR \| GPX2 \| HSP90AA1 \| IL2 \| IL6 \| LCN2 \| MAPK1 \| MAPK3 \| MIR638 \| MLH1 \| MMP2 \| MMP9 \| MYC \| OSM \| PTEN \| PTGS2 \| RB1 \| SERPINB5 \| SOD2 \| SP1 \| TNF \| TP53	51.20	39
37.	Cadmium	Cell Transformation, Neoplastic	M	56 genes: AKR1C1 \| AKR1C2 \| AKR1C3 \| BCL2 \| BRCA1 \| CAT \| CCND1 \| CDH1 \| CXCL8 \| CXCR4 \| EDN1 \| EGF \| EIF3I \| ENO2 \| ESR1 \| FN1 \| FOS \| IGF1R \| IL6 \| IL7R \| IRS1 \| JUN \| KRAS \| KRT14 \| KRT19 \| KRT5 \| MAPK8 \| MDM2 \| MIR1275 \| MIR146A \| MIR15B \| MIR21 \| MMP9 \| MUC1 \| MYC \| NCF1 \| NOS2 \| NRG1 \| OCLN \| PTK2 \| RAC1 \| RELA \| SLC16A1 \| SLC2A1 \| SLC40A1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TFRC \| TGFB1 \| TNFAIP3 \| TP53 \| TP63 \| TRP53 \| VIM	50.32	48
38.	Estradiol	Cell Transformation, Neoplastic	M	92 genes: ACTG1 \| AKR1C1 \| AKR1C2 \| AKR1C3 \| BCL2 \| BRCA1 \| CAT \| CCND1 \| CD34 \| CDH1 \| CLDN1 \| CTNND2 \| CXCL8 \| CXCR4 \| EBF1 \| EDN1 \| EGF \| ENO2 \| EPAS1 \| ESR1 \| FN1 \| FOS \| HRAS \| IGBP1 \| IGF1R \| IL6 \| IL7R \| IRS1 \| JUN \| KRAS \| KRT14 \| KRT15 \| KRT19 \| KRT5 \| LGALS3 \| LOXL2 \| MAPK8 \| MDM2 \| MIR1275 \| MIR146A \| MIR15B \| MIR185 \| MIR1915 \| MIR200B \| MIR21 \| MIR320A \| MIR34B \| MIR34C \| MIR638 \| MIR92B \| MIR99B \| MIRLET7C \| MITF \| MMP14 \| MMP9 \| MUC1 \| MYC \| MYCN \| NCF1 \| NFKB1 \| NOS2 \| NOTCH1 \| NRG1 \| NSD2 \| OCLN \| PDCD4 \| PHGDH \| PIM1 \| PTK2 \| RAC1 \| RELA \| SATB2 \| SLC16A1 \| SLC2A1 \| SLC40A1 \| SNAI1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TFRC \| TGFB1 \| TLX1 \| TNFAIP3 \| TP53 \| TP63 \| TRP53 \| TSC22D1 \| VIM \| WNT5A \| ZEB1 \| ZEB2	50.30	63
39.	monomethylarsonous acid	Cell Transformation, Neoplastic	M	32 genes: AKR1C1 \| AKR1C2 \| BCL2 \| CAT \| CCND1 \| CDH1 \| CTNND2 \| CXCL8 \| CXCR4 \| EBF1 \| FOS \| IGF1R \| IL6 \| IL7R \| IRS1 \| JUN \| MMP9 \| MYC \| NFKB1 \| NRG1 \| PDCD4 \| PIM1 \| RAC1 \| RELA \| SNAI1 \| SOD1 \| SOD2 \| STAT3 \| TGFB1 \| TNFAIP3 \| TP53 \| WNT5A	49.54	40
40.	Ethanol	Neoplasm Invasiveness	M	66 genes: ACTB \| AHR \| ALDOA \| ALOX5 \| ANXA1 \| BSG \| CALR \| CAT \| CCL2 \| CFL1 \| CHRNA7 \| CTNNB1 \| CTSB \| CTSD \| CTSS \| CYP2E1 \| EDNRB \| EEF2 \| EGFR \| ENO1 \| ESR1 \| FN1 \| FOXP1 \| FTL \| HGF \| HIF1A \| HMOX1 \| IGF1 \| IL1B \| IL1RN \| IL6 \| ITGA5 \| LOXL2 \| MALAT1 \| MAPK1 \| MAPK3 \| MET \| MMP2 \| MMP3 \| MMP9 \| MT2A \| MT3 \| MYD88 \| MYLK \| NME1 \| PLAU \| PRDX2 \| RELA \| RHOA \| RPSA \| S100A4 \| SET \| SMPD1 \| SOD2 \| SP1 \| SRC \| TF \| TGFB1 \| TGIF1 \| TIMP1 \| TKT \| TLR4 \| TMEM139 \| TNF \| TXN \| ZBTB16	49.12	61
41.	Iron	Neoplasm Invasiveness	M	30 genes: ACO1 \| ANXA1 \| ANXA2 \| CALR \| CAT \| CCL2 \| CCL5 \| CHI3L1 \| EPO \| FTH1 \| FTL \| HIF1A \| HMOX1 \| HRAS \| IGF1 \| IL1B \| IL6 \| IREB2 \| MAPK1 \| MAPK3 \| MMP1 \| MT2A \| SOD2 \| SP1 \| SRC \| TF \| TGFB1 \| TGIF1 \| TNF \| ZFP36	48.92	33
42.	nickel chloride	Cell Transformation, Neoplastic	M	41 genes: APC \| BCL2 \| CAT \| CCL18 \| CCND1 \| CDH1 \| CXCL8 \| EGF \| ENO2 \| ESR1 \| FN1 \| FOS \| IL6 \| JUN \| LOXL2 \| MAPK8 \| MDM2 \| MIR21 \| MMP9 \| MYC \| MYCN \| MYD88 \| NFKB1 \| NOS2 \| NOTCH1 \| NRG1 \| PHGDH \| POR \| PTK2 \| RELA \| SLC2A1 \| SLC40A1 \| SNAI1 \| SOD1 \| SOD2 \| TFRC \| TGFB1 \| TNFAIP3 \| TP53 \| TP63 \| TRP53	48.74	40
43.	Asbestos, Crocidolite	Cell Transformation, Neoplastic	M	40 genes: AKR1C2 \| BCL2 \| BRCA1 \| CAT \| CCND1 \| CDH1 \| CLDN1 \| CXCL8 \| EBF1 \| EDN1 \| EGF \| EPAS1 \| FN1 \| FOS \| HRAS \| IGF1R \| IL6 \| IL7R \| JUN \| MAPK8 \| MITF \| MMP9 \| MYC \| NFKB1 \| NOS2 \| NOTCH1 \| NRG1 \| RELA \| SLC40A1 \| SOD1 \| SOD2 \| SP1 \| TFRC \| TGFB1 \| TNFAIP3 \| TP53 \| TP63 \| TRP53 \| TSC22D1 \| VIM	48.32	40
44.	Cacodylic Acid	Cell Transformation, Neoplastic	M	23 genes: BCL2 \| CAT \| CCND1 \| CDH1 \| CTNND2 \| ESR1 \| FOS \| IGF1R \| JUN \| LGALS3 \| MAPK8 \| MDM2 \| MMP14 \| MMP9 \| MYC \| NFKB1 \| NOTCH1 \| NRG1 \| RELA \| SOD1 \| STAT3 \| TGFB1 \| TP53	48.09	24
45.	perfluorooctanoic acid	Neoplasm Invasiveness	M	53 genes: ACO1 \| ACTB \| AHR \| AKR1B10 \| ALDOA \| AMBP \| ANGPTL4 \| ANXA1 \| BCAR1 \| CALR \| CALU \| CAT \| CCL2 \| CD82 \| CDH1 \| CDKN2A \| CFL1 \| CSTB \| CTNNB1 \| CTSD \| CTSS \| CYP2E1 \| EEF2 \| EGF \| EGFR \| ENO1 \| ESR1 \| FN1 \| FTH1 \| HGF \| HMOX1 \| IGF1 \| IL1B \| IL6 \| IREB2 \| MAPK1 \| MAPK3 \| MMP2 \| MMP9 \| MT3 \| NRG1 \| PAX6 \| PLAUR \| PTEN \| RELA \| RNF207 \| RPSA \| SORL1 \| TIMP3 \| TLN1 \| TNF \| UBQLN1 \| ZEB2	47.96	54
46.	monomethylarsonous acid	Neoplasm Metastasis	M	35 genes: AHR \| CAT \| CD44 \| CDH1 \| CXCR4 \| EGFR \| ERBB2 \| GDF15 \| GPX2 \| HPSE \| HSP90AA1 \| HSPA1A \| IL2 \| IL6 \| LCN2 \| MAPK1 \| MAPK3 \| MMP2 \| MMP9 \| MYC \| MYLK \| PLAU \| PTGS2 \| RAC1 \| RB1 \| SERPINB5 \| SLC7A11 \| SNAI1 \| SOD2 \| STAT3 \| TGFB1 \| TGFBR2 \| TLR4 \| TNF \| TP53	47.72	47
47.	Azoxymethane	Cell Transformation, Neoplastic	M	17 genes: APC \| BCL2 \| CCND1 \| CDH1 \| HRAS \| IGF1R \| IL6 \| KRAS \| MMP9 \| MYC \| NFKB1 \| NOS2 \| RELA \| STAT3 \| TGFB1 \| TP53 \| TRP53	47.21	27
48.	3,4,5,3',4'-pentachlorobiphenyl	Neoplasm Metastasis	M	45 genes: ACKR3 \| AGTR1 \| AHR \| ANXA4 \| AXL \| CAT \| CAV1 \| CDH1 \| CDH2 \| CSF3 \| CXCL12 \| CYP19A1 \| DMD \| EGF \| EIF1AX \| ENPP2 \| ESR1 \| FGF13 \| FLT1 \| FTL \| GDF15 \| HGF \| IGF1 \| IL18 \| IL6 \| LCN2 \| LGALS3 \| MAPK1 \| MAPK3 \| MET \| MMP2 \| MMP9 \| PDE5A \| PRNP \| PTGS2 \| SLC7A11 \| SNAI1 \| SOD2 \| SPP1 \| STAT3 \| TLR4 \| TNF \| TP53 \| VEGFA \| VIM	45.42	52
49.	Asbestos, Serpentine	Cell Transformation, Neoplastic	M	26 genes: BCL2 \| CCND1 \| CDH1 \| CXCL8 \| CXCR4 \| FN1 \| HRAS \| IL6 \| IL7R \| JUN \| KRT19 \| MAPK8 \| MMP14 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| NRG1 \| RAC1 \| RELA \| SNAI1 \| SOD2 \| TGFB1 \| TNFAIP3 \| TP53 \| VIM	44.29	29
50.	Methylnitrosourea	Cell Transformation, Neoplastic	M	24 genes: APC \| BCL2 \| CCND1 \| CDH1 \| ESR1 \| FOS \| HRAS \| IGF1R \| IRS1 \| JUN \| KRAS \| LGALS3 \| MAPK8 \| MYC \| NOS2 \| PARG \| RELA \| SNAI1 \| SOD2 \| TP53 \| TRP53 \| VIM \| WNT5A \| ZEB1	43.72	34

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