Estrenes - Diseases

These diseases are associated with Estrenes or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

Disease categories [Show chart]

1–50 of 14,816 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Estradiol	Mammary Neoplasms, Animal	M	113 genes: ACSL1 \| ACTG1 \| ADCY5 \| ALCAM \| ANXA1 \| ANXA2 \| AQP1 \| ATPIF1 \| BASP1 \| BRCA1 \| CAPZB \| CASK \| CCND1 \| CDC42 \| CDH1 \| CDK4 \| CDS1 \| CNN3 \| COL5A1 \| COMT \| COX1 \| CSN2 \| CSN3 \| DES \| DUSP6 \| EEF1A1 \| EFEMP1 \| EGFR \| EIF5A \| ENO1 \| EPCAM \| EPHX1 \| ERBB2 \| ESR1 \| ESR2 \| EZR \| FABP4 \| FN1 \| G0S2 \| GATA3 \| GATM \| GGT1 \| GSS \| H3F3B \| HBA1 \| HNRNPA1 \| HRAS \| ID3 \| ID4 \| IL6ST \| INS1 \| INSIG1 \| KITLG \| KNG1 \| KRT5 \| KRT71 \| LGALS7 \| LIN7A \| LPL \| LSR \| MGP \| MIF \| MIR10B \| PADI4 \| PDGFA \| PGR \| PHB \| PIK3R1 \| PKM \| PLK2 \| PPARA \| PRDX2 \| PRL \| PRLR \| PSME1 \| PTBP1 \| PTGER1 \| PTN \| RAN \| RASA1 \| RASSF1 \| RB1 \| RBP1 \| RBP4 \| RPL6 \| RPS14 \| S100A6 \| S100A8 \| S1PR1 \| SCARB1 \| SCD \| SELENOP \| SGK1 \| SLC12A2 \| SLC25A10 \| SOX9 \| SRSF2 \| STAT3 \| STAT5A \| STMN1 \| TF \| THRSP \| TKT \| TLE4 \| TP53I3 \| TPM3 \| TSC22D1 \| TUBB2B \| UBE2I \| VAMP8 \| WAP \| XDH \| YWHAZ	125.91	27
2.	Estrone	Prostatic Neoplasms	M	30 genes: AKR1C3 \| AKT1 \| ALAD \| AR \| COMT \| CXCL12 \| CYP17A1 \| CYP19A1 \| CYP1A1 \| CYP1B1 \| CYP3A4 \| EGFR \| ESR1 \| ESR2 \| FOXC1 \| HSD17B1 \| ICAM1 \| ID3 \| IL6 \| JAK2 \| MAPK3 \| NCOA1 \| NCOA3 \| OLFM1 \| PDZK1 \| SHBG \| SLC12A2 \| SULT1A1 \| SULT1E1 \| SULT2A1	66.61	58
3.	estradiol 3-benzoate	Breast Neoplasms	M	25 genes: ABCB1B \| ABCC1 \| ABCG2 \| ACTA2 \| AR \| BAX \| BCL2 \| CASP8 \| CAT \| CYP17A1 \| CYP19A1 \| CYP1B1 \| EGFR \| ESR1 \| ESR2 \| FGFR2 \| FOS \| GPX1 \| IGF1 \| IGF1R \| OCLN \| PARP1 \| PGR \| RAF1 \| TP53	53.15	59
4.	Estradiol	Cell Transformation, Neoplastic	M	92 genes: ACTG1 \| AKR1C1 \| AKR1C2 \| AKR1C3 \| BCL2 \| BRCA1 \| CAT \| CCND1 \| CD34 \| CDH1 \| CLDN1 \| CTNND2 \| CXCL8 \| CXCR4 \| EBF1 \| EDN1 \| EGF \| ENO2 \| EPAS1 \| ESR1 \| FN1 \| FOS \| HRAS \| IGBP1 \| IGF1R \| IL6 \| IL7R \| IRS1 \| JUN \| KRAS \| KRT14 \| KRT15 \| KRT19 \| KRT5 \| LGALS3 \| LOXL2 \| MAPK8 \| MDM2 \| MIR1275 \| MIR146A \| MIR15B \| MIR185 \| MIR1915 \| MIR200B \| MIR21 \| MIR320A \| MIR34B \| MIR34C \| MIR638 \| MIR92B \| MIR99B \| MIRLET7C \| MITF \| MMP14 \| MMP9 \| MUC1 \| MYC \| MYCN \| NCF1 \| NFKB1 \| NOS2 \| NOTCH1 \| NRG1 \| NSD2 \| OCLN \| PDCD4 \| PHGDH \| PIM1 \| PTK2 \| RAC1 \| RELA \| SATB2 \| SLC16A1 \| SLC2A1 \| SLC40A1 \| SNAI1 \| SOD1 \| SOD2 \| SP1 \| STAT3 \| TFRC \| TGFB1 \| TLX1 \| TNFAIP3 \| TP53 \| TP63 \| TRP53 \| TSC22D1 \| VIM \| WNT5A \| ZEB1 \| ZEB2	50.06	63
5.	Mifepristone	Inflammation	M	41 genes: ADIPOQ \| AHR \| AKT1 \| BDNF \| CCL2 \| CCL3 \| COL2A1 \| CXCL2 \| CXCL8 \| CYP2B1 \| CYP2B2 \| CYP3A23/3A1 \| EGR1 \| F2R \| HMOX1 \| ICAM1 \| IFNG \| IL10 \| IL17A \| IL1A \| IL1B \| IL6 \| MIF \| MMP2 \| MMP9 \| NOS2 \| OXT \| PARP1 \| PPARA \| PPARG \| PTGER4 \| PTGS2 \| SCGB1A1 \| STAT3 \| TGFA \| TGFB1 \| TNF \| TNFRSF11B \| TREX1 \| VEGFA \| ZFP36	43.53	65
6.	Estradiol	Ovarian Neoplasms	M	72 genes: AKT1 \| ANXA3 \| AQP3 \| AREG \| ARL11 \| ATF3 \| ATP7B \| BIRC5 \| BRCA1 \| BRCA2 \| BRIP1 \| CAV1 \| CCND2 \| CCNE1 \| CDH1 \| CDKN1B \| CTNNB1 \| CXCL8 \| CYP1B1 \| DLC1 \| EDNRA \| EGFR \| EPCAM \| ERBB2 \| EREG \| FASN \| FGF1 \| FOLR1 \| GADD45A \| HOXD9 \| IL6 \| IL6ST \| ITGA8 \| KRAS \| MAPK1 \| MAPK3 \| MET \| MKI67 \| MLH1 \| MSH2 \| MTOR \| MUC16 \| MYC \| NME2 \| NR5A1 \| PIK3CA \| PLEKHF1 \| PTEN \| RAD51C \| RBL2 \| SELENBP1 \| SKAP1 \| SKP2 \| SLC2A1 \| SLC5A5 \| SMARCA4 \| SOD1 \| SOD2 \| SPARC \| STAT3 \| SULF1 \| TERT \| TIPARP \| TLR4 \| TNFSF10 \| TP63 \| TUBB3 \| TYMS \| WNT7A \| XIAP \| YAP1 \| ZEB1	40.00	68
7.	Mifepristone	Infertility, Female	M	15 genes: ADIPOR2 \| AR \| CEBPA \| CEBPB \| CTGF \| CYP17A1 \| ESR1 \| ESR2 \| FSHB \| LEPR \| LHB \| MAPK1 \| MAPK3 \| NR1I2 \| PRL	33.54	9
8.	Estradiol	Endometrial Neoplasms	M	40 genes: ABCC9 \| AKR1B10 \| AKR1C1 \| AKR1C3 \| BIRC5 \| CCL2 \| CDH1 \| CDKN1C \| CXCL8 \| CYP11A1 \| DCN \| EP300 \| ESR1 \| ESR2 \| EZH2 \| FGFR2 \| HOXA10 \| HOXA11 \| HSD17B2 \| IGF1R \| MAP3K4 \| MLH3 \| MSH6 \| MYC \| NFE2L2 \| NRIP1 \| PAWR \| PGR \| PTEN \| RNF43 \| SEMA3B \| SEMA3F \| SOCS3 \| SRD5A2 \| STAR \| TNFSF10 \| TRP53 \| TSPYL2 \| VEGFA \| ZEB1	27.17	36
9.	estradiol 3-benzoate	Cocaine-Related Disorders	M	12 genes: BDNF \| DRD2 \| ESR2 \| FOS \| GABBR1 \| GRIN1 \| HTR2A \| MAPK1 \| MAPK3 \| PRL \| SLC6A3 \| SLC6A4	25.39	33
10.	Estrone	Adenocarcinoma	M	11 genes: CYP19A1 \| EGFR \| ESR1 \| ESR2 \| ID3 \| NCOA3 \| NR1I2 \| PGR \| PRL \| SELENBP1 \| TNF	23.76	19
11.	fulvestrant	Infertility, Male	M	13 genes: AHR \| AR \| BAX \| BCL2 \| CYP17A1 \| CYP1A1 \| ESR1 \| FSHB \| GNRH1 \| NOS3 \| SOD2 \| TP53 \| TSC22D3	22.28	16
12.	2-hydroxyestradiol	Breast Neoplasms	M	9 genes: AR \| CCND1 \| COMT \| CYP1A1 \| CYP1B1 \| CYP3A4 \| ESR1 \| ESR2 \| PTGS2	21.12	37
13.	Estradiol	Precancerous Conditions	M	63 genes: ACTC1 \| ACY1 \| AKT1 \| ALDH2 \| ALDH4A1 \| ARG1 \| ATP5B \| BCAT2 \| C9ORF3 \| CAT \| CCND1 \| CDH1 \| CDKN2A \| CEBPA \| CFL1 \| CHN2 \| CISH \| CPS1 \| DDX54 \| EFNB2 \| EGF \| EIF4EBP1 \| EXOSC2 \| FOXM1 \| FTH1 \| GJB1 \| GSTO1 \| GSTP1 \| HADH \| HRAS \| IFT88 \| IGF2 \| IGFBP1 \| IL6 \| IRS1 \| KRT8 \| MAGED4 \| MAP2K7 \| MAPK8 \| MAPK9 \| MDM2 \| MGMT \| MIR196B \| MIR200B \| MIR26B \| MIR92B \| MIR99B \| MPO \| NR1I3 \| PBLD \| PHB \| PIM1 \| PTGS2 \| SIRPA \| SIX3 \| SOD2 \| STAT3 \| STAT5A \| TPM4 \| TRIO \| TRP53 \| VEGFA \| ZBTB8OS	20.91	29
14.	Estriol	Hypertension	M	16 genes: AGTR1 \| ALB \| AR \| CYP1A1 \| FOS \| IGF1 \| IL6 \| JUN \| NOS2 \| NOS3 \| RELA \| SLC12A2 \| TGFB1 \| TNF \| VCAM1 \| VDR	20.25	26
15.	Estradiol	Edema	M	23 genes: AHR2 \| CALCA \| CASP3 \| CASP8 \| CASP9 \| CAT \| COL2A1 \| CXCL8 \| CYP1A \| GSR \| IL11 \| IL6 \| INS \| KNG1 \| MAP2K6 \| OXT \| POMC \| PTGS2 \| PTHLH \| SLC9A1 \| SLC9A2 \| TAC1 \| TNF	19.79	19
16.	2-hydroxyestradiol	Adenocarcinoma	M	6 genes: CCND1 \| CKB \| ESR1 \| ESR2 \| MYC \| PTGS2	18.25	8
17.	Estradiol	Prenatal Exposure Delayed Effects	M	9 genes: ADORA1 \| ATM \| CTGF \| FGF2 \| FOSB \| MAOA \| MYOD1 \| OGG1 \| PON1	16.74	15
18.	Estradiol	Arrhythmias, Cardiac	M	14 genes: ACE \| AGT \| AVP \| CNNM2 \| EDN1 \| ESR2 \| GJA1 \| KNG1 \| OPRK1 \| OPRL1 \| PPP1R1A \| PTGS2 \| SGO1 \| TRH	16.54	17
19.	Estradiol	Ovarian Cysts	M	18 genes: AGTR2 \| ANG \| C1QB \| CACNB3 \| CDH3 \| CFD \| COL11A1 \| CYP17A1 \| GABRA1 \| IHH \| MFAP2 \| NFKB1 \| NR2F1 \| PTGER4 \| PTGS1 \| SFRP4 \| TMOD1 \| UOX	15.68	2
20.	Estradiol	Pruritus	M	3 genes: ABCB11 \| F2RL1 \| TAC1	15.37	4
21.	estradiol-17 beta-glucuronide	Cholestasis	M	5 genes: ABCB11 \| ABCC2 \| ABCC3 \| SLCO1A1 \| SLCO1A4	14.78	25
22.	Estrone	Hypogonadism	M	4 genes: CYP17A1 \| CYP19A1 \| LEPR \| PRL	14.18	5
23.	estradiol valerate	Pituitary Neoplasms	M	3 genes: GH1 \| IGF1 \| PRL	13.62	10
24.	Estradiol	Cholestasis	M	70 genes: ABCB11 \| ABCC2 \| ABCC3 \| AGT \| ALDH8A1 \| BCAT1 \| BEX4 \| BTG3 \| C4ORF19 \| CADPS2 \| CAT \| CCL7 \| CXCL2 \| CXCL8 \| CYP1A2 \| CYP2B10 \| CYP7A1 \| CYP7B1 \| CYP8B1 \| DGAT2 \| DNAJB9 \| DNAJC12 \| EGR1 \| FGA \| GTPBP2 \| HACL1 \| HAO2 \| HFE2 \| HOGA1 \| ICAM1 \| ID4 \| IGF1 \| IL6 \| MAPK13 \| MAPK14 \| MBOAT1 \| MIR185 \| MIR24-1 \| MIR27B \| MIR411 \| MIR99A \| NFE2L2 \| NFXL1 \| NOS2 \| NPL \| NQO1 \| NR1H2 \| NR1H4 \| POMC \| PON1 \| RDX \| REEP5 \| RELA \| SERPINA1 \| SERPINA5 \| SERPINE1 \| SLC23A1 \| SLC23A2 \| SLC30A10 \| SLC51B \| SLCO1A1 \| SNAI1 \| SORL1 \| SRP72 \| TLR2 \| TNF \| UBA5 \| VCAM1 \| VIL1 \| WIPI1	13.09	25
25.	Estradiol	Abnormalities, Drug-Induced	M	5 genes: AHR2 \| CAT \| EPHX1 \| RHOA \| WNT11	13.03	6
26.	estrone sulfate	Breast Neoplasms	M	6 genes: ABCG2 \| EGF \| IL6 \| PDGFA \| PTGS1 \| SLCO1B1	12.38	11
27.	Estradiol	Prostatic Intraepithelial Neoplasia	M	11 genes: AR \| CDH1 \| CDKN1B \| DNMT1 \| ESR1 \| ESR2 \| GSTP1 \| MT2A \| PIM1 \| PTEN \| TOP2B	11.93	8
28.	Estradiol	Weight Loss	M	18 genes: ADIPOQ \| ADORA2A \| COL2A1 \| CRH \| EPO \| IL10 \| IL4 \| INS \| LEP \| LIF \| LTF \| MAPT \| MT1 \| NPY \| OXT \| POMC \| SOD1 \| TSC22D3	11.89	19
29.	Estradiol	Lupus Erythematosus, Systemic	M	30 genes: ANXA3 \| BLK \| C1QA \| CAT \| CFB \| CLU \| CRP \| CSK \| ETS1 \| FCGR2B \| HLA-DRB1 \| IFIH1 \| IL10 \| IL12B \| IL4 \| IL6 \| ITGAM \| NCF1 \| PRL \| PTGS2 \| PTPN22 \| PXK \| RASGRP1 \| SH2B3 \| STAT4 \| TERT \| TNFAIP3 \| TNIP1 \| TREX1 \| UHRF1BP1	11.78	27
30.	Estradiol	Skin Diseases	M	43 genes: AKAP9 \| CCL20 \| CCL3L3 \| CD44 \| CD83 \| CXCL2 \| CXCL3 \| ERCC2 \| FGFR2 \| GADD45B \| GJB3 \| GSTM1 \| GSTO1 \| HSPA1B \| ID2 \| IER3 \| IL1A \| IL1B \| IL1R1 \| IL1RN \| IL6 \| INPP5A \| NDUFB8 \| NR4A2 \| OGG1 \| PDE4B \| PELI1 \| PFKFB3 \| PIAS1 \| PRSS8 \| PTEN \| PTGS2 \| PTX3 \| RGS1 \| SCD1 \| SFPQ \| SKIL \| SOD2 \| SOX18 \| TNF \| TNFAIP6 \| TNIK \| ZFAND6	10.40	14
31.	nandrolone decanoate	Myocardial Infarction	M	5 genes: ACE \| CASP3 \| ICAM1 \| MMP9 \| TNF	10.37	8
32.	Estradiol	Alcoholism	M	20 genes: ADH1B \| ADH1C \| ALDH2 \| CCKAR \| CHRNA3 \| CHRNA5 \| COMT \| CYP2E1 \| FSHB \| GABBR1 \| GABRG2 \| GGT1 \| HTR2A \| LHB \| NPY \| PDE4B \| SHBG \| SLC6A4 \| TACR1 \| TF	10.05	18
33.	Estradiol	Torsades de Pointes	M	1 gene: CYP3A4	10.05	2
34.	Estradiol	Hematuria	M	3 genes: F7 \| PLAU \| POMC	9.81	5
35.	nandrolone decanoate	Hypertrophy, Left Ventricular	M	3 genes: ACE \| AGTR2 \| COL3A1	9.69	5
36.	Estradiol	Hyperkinesis	M	24 genes: ADCY1 \| ADORA2A \| BCHE \| CALCA \| CCK \| CRHR1 \| DRD1 \| DRD2 \| DRD3 \| FOS \| GABBR1 \| GRIA1 \| GRIA2 \| HTR2A \| HTR2C \| IL2 \| NGF \| NPPC \| NPY \| NTRK2 \| NTS \| OXT \| SLC6A3 \| TH	9.66	31
37.	estradiol 3-benzoate	Hyperkinesis	M	6 genes: DRD2 \| FOS \| GABBR1 \| HTR2A \| SLC6A3 \| TH	9.53	10
38.	Estradiol	Disease Models, Animal	M	44 genes: ABCB4 \| ABCC6 \| AIF1 \| AKT1 \| ALB \| APP \| ATP7B \| CALCA \| CAR2 \| CLDN11 \| DMD \| ERBB2 \| ESR1 \| F7 \| FAS \| FOS \| GFAP \| GRIN1 \| HBB \| HBEGF \| IFNG \| IL1B \| KRAS \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| MAPT \| MMP9 \| OVAL \| PIM1 \| PKD1 \| RHOA \| S100A10 \| S100B \| SERPINE1 \| SOD1 \| STAT3 \| TIMP1 \| TNF \| TRP53 \| TTPA \| VIM \| WNT11	9.51	47
39.	Estradiol	Fatty Liver	M	58 genes: APOB \| ATP7B \| ATPIF1 \| BIRC3 \| CAT \| CEBPB \| CNDP2 \| COL3A1 \| CXCL8 \| CYCS \| CYP19A1 \| CYP2E1 \| CYP7B1 \| F2 \| F2R \| FOXA1 \| GPD1L \| GPT \| GPX1 \| GPX4 \| GULO \| HADHB \| INS \| LDLR \| LEP \| LEPR \| MAT1A \| MIR10B \| MIR134 \| MIR139 \| MIR150 \| MIR197 \| MIR503 \| MIR542 \| MTTP \| MYC \| NR1I2 \| NREP \| PLIN2 \| PNPLA3 \| POMC \| PON1 \| PPARA \| PTEN \| PTMA \| SCD1 \| SERPINA6 \| SERPINE1 \| SIRT1 \| SLC2A2 \| SOD1 \| SOD2 \| SREBF1 \| STS \| TF \| TLR4 \| TNF \| XBP1	9.38	45
40.	Estrone	Kidney Neoplasms	M	4 genes: ABCB1 \| CYP1A1 \| MAPK1 \| MAPK3	8.75	4
41.	2-hydroxyestradiol	Cell Transformation, Neoplastic	M	3 genes: CCND1 \| ESR1 \| MYC	7.90	5
42.	Estradiol	Cocaine-Related Disorders	M	67 genes: AGO2 \| ARC \| BCHE \| BDNF \| CALM1 \| CALM2 \| CAMK2A \| CAMK4 \| CARTPT \| CCKBR \| CCSER1 \| CES1 \| CNR1 \| COMT \| CREB1 \| CRH \| CRHBP \| CRHR1 \| CRHR2 \| DRD1 \| DRD2 \| DRD3 \| EGR1 \| ESR2 \| FDFT1 \| FGF2 \| FOS \| FOSB \| GABBR1 \| GABRG2 \| GAD1 \| GAD2 \| GDNF \| GPSM1 \| GRIA1 \| GRIA2 \| GRIN1 \| GRM5 \| HDAC4 \| HDAC5 \| HOMER1 \| HOMER2 \| HTR1A \| HTR1B \| HTR2A \| ILK \| JUND \| MANEA \| MAPK1 \| MAPK3 \| MECP2 \| MIR369 \| MIR380 \| NGF \| NPY \| NR3C1 \| NTRK2 \| OPRK1 \| POMC \| PRL \| RPS6KA5 \| SCARB1 \| SLC1A2 \| SLC6A3 \| SLC6A4 \| TENM3 \| TYK2	7.39	114
43.	nandrolone decanoate	Fibrosis	M	3 genes: AGTR1A \| COL3A1 \| TNF	7.38	5
44.	Estradiol	Mood Disorders	M	1 gene: SLC6A4	6.90	2
45.	Estradiol	Bone Marrow Diseases	M	1 gene: NQO2	6.83	2
46.	Estradiol	Urinary Retention	M	1 gene: EDN1	6.61	4
47.	Estradiol	Anorexia	M	11 genes: CCK \| CRH \| CRHR1 \| CRHR2 \| IL1B \| IL1RN \| IL2 \| NPY \| TNF \| TNFRSF10A \| TNFRSF1A	6.47	12
48.	Estradiol	Cardiomyopathy, Hypertrophic	M	16 genes: FASN \| GAA \| HEY2 \| HSPB1 \| HSPD1 \| INS \| MYC \| MYH6 \| MYL2 \| NME1 \| POMC \| RAF1 \| RASSF1 \| SLC9A1 \| TNNT2 \| TP53	6.39	17
49.	nandrolone decanoate	Inflammation	M	4 genes: APOA1 \| ICAM1 \| MMP9 \| TNF	6.27	19
50.	Estradiol	Liver Diseases	M	53 genes: ACTA2 \| AFP \| AHR \| ALAD \| ALOX5AP \| ALPL \| AMACR \| ASAH2 \| ATP7B \| BCL2L1 \| CCK \| CCL2 \| CCR2 \| CD3D \| CD86 \| COL3A1 \| CRISPLD2 \| CSF3 \| CYP1A2 \| CYP7B1 \| DDAH1 \| ENO3 \| GGT1 \| GNG8 \| GPT \| HMOX1 \| HSPA1A \| IL11 \| IL1R2 \| ITGB6 \| JUP \| LAT \| MMP9 \| NFKB1 \| NOS2 \| NQO1 \| NR1H4 \| NRP1 \| RAC1 \| SC5D \| SERPINA1 \| SLCO1A1 \| SOCS1 \| SOCS3 \| SOD1 \| SRSF5 \| SULT1E1 \| TGM1 \| TIMP3 \| TM4SF4 \| TNF \| TXN \| TYROBP	6.12	40

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