Pyridinium Compounds - Diseases

These diseases are associated with Pyridinium Compounds or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

Disease categories [Show chart]

1–50 of 5,396 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Paraquat	Pulmonary Fibrosis	M	38 genes: ADIPOQ \| CAT \| CCL2 \| CCL3 \| CEBPB \| CMA1 \| COL3A1 \| CSF2 \| CSF3 \| CTGF \| CXCL2 \| CXCL8 \| EDN1 \| ELN \| FGF1 \| FGF2 \| FN1 \| HGF \| HMGB1 \| HMOX1 \| IGF1 \| IL13 \| IL1B \| IL4 \| IL6 \| MECP2 \| MMP2 \| MMP9 \| MT2 \| NFE2L2 \| PDGFA \| PDGFB \| SOD3 \| SPP1 \| TGFA \| TGFB1 \| TIMP1 \| TNF	44.17	57
2.	1-Methyl-4-phenylpyridinium	Parkinson Disease	M	38 genes: ATP13A2 \| BDNF \| CP \| CYP2E1 \| DDC \| DDIT4 \| DRD2 \| GDNF \| GFAP \| GPX1 \| GSTM1 \| HMOX1 \| HSPA9 \| IGF1R \| IGF2R \| IL6 \| INS \| INSR \| KCNJ4 \| LRRK2 \| MAOA \| MAOB \| MAP3K5 \| MAPT \| MTA1 \| NGF \| NQO1 \| PARK2 \| PARK7 \| PINK1 \| PRKN \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TNF \| VPS35	40.92	77
3.	Paraquat	Parkinson Disease	M	44 genes: ABCB1 \| AIF1 \| ATP13A2 \| ATPSYNBETA \| BDNF \| BST1 \| CYP2E1 \| DDC \| DDIT4 \| DRD2 \| EDN1 \| GAK \| GDNF \| GFAP \| GPX1 \| GSTA4 \| GSTM1 \| GSTP1 \| HGF \| HMOX1 \| HSPA1A \| HSPA9 \| IGF1R \| IGF2 \| IGF2R \| IL6 \| LRRK2 \| MAG \| MAP3K5 \| MAPT \| NOS1 \| NQO1 \| PARK2 \| PARK7 \| PINK1 \| PRKN \| RPL14 \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TNF \| UP	40.47	90
4.	Paraquat	Nerve Degeneration	M	52 genes: ADORA1 \| APP \| ATP13A2 \| BAK1 \| BAX \| BCL2 \| BDNF \| CASP3 \| CD44 \| CDH1 \| CDK5R1 \| CHRNA7 \| CHRNB2 \| CTNNB1 \| CTR1C \| DDC \| DDIT4 \| EIF2S1 \| EPO \| ETS2 \| F2 \| FGF2 \| IFNG \| IGF1 \| IGF2 \| KCNJ6 \| LEP \| LRRK2 \| MAPK1 \| MAPK3 \| MPZ \| MT1 \| MT2 \| NGFR \| NOS1 \| OTC \| PINK1 \| PPARG \| PRKN \| PSEN1 \| SIRT1 \| SKN-1 \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TGFA \| TH \| TNF \| TSC2 \| XDH	32.13	72
5.	1-Methyl-4-phenylpyridinium	Nerve Degeneration	M	38 genes: ADORA1 \| APOE \| ATP13A2 \| ATXN3 \| BAX \| BCL2 \| BDNF \| CASP3 \| CDH2 \| CNTF \| CP \| DDC \| DDIT4 \| EIF2S1 \| EPOR \| FGF2 \| GHRL \| GRIN2D \| IGF1 \| KCNJ4 \| KCNJ6 \| LRRK2 \| MAPK1 \| MAPK3 \| NGF \| NGFR \| OTX2 \| PINK1 \| PPARG \| PRKN \| SIRT1 \| SLC18A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TH \| TNF	24.28	47
6.	Paraquat	Disease Models, Animal	M	33 genes: AIF1 \| AKT1 \| ALB \| APP \| CAR2 \| DMD \| ERBB2 \| FAS \| FOS \| GFAP \| GRIN1 \| HBB \| IFNG \| IL1B \| KL \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| MAPT \| MMP9 \| PARK2 \| PSEN1 \| S100B \| SERPINE1 \| SNCA \| SOD1 \| STAT3 \| TIMP1 \| TNF \| TRP53 \| TTPA \| VIM	24.25	38
7.	Paraquat	Inflammation	M	64 genes: ADIPOQ \| AGT \| AHR \| AKT1 \| ASIC1 \| BDNF \| CASP1 \| CCL2 \| CCL3 \| CHRNB2 \| COL2A1 \| CSF2 \| CXCL2 \| CXCL8 \| CYP3A2 \| EDN1 \| EFNB1 \| EGR1 \| EIF4EBP1 \| EPO \| FGF2 \| GALNS \| GATA3 \| HMGB1 \| HMOX1 \| ICAM1 \| IFNG \| IL10 \| IL13 \| IL1A \| IL1B \| IL6 \| LCN2 \| LEP \| MIF \| MMP2 \| MMP9 \| MPO \| MYD88 \| NLRP3 \| NOS2 \| PARP1 \| PPARA \| PPARG \| PROCR \| PTGS2 \| SCGB1A1 \| SELENOS \| SOD1 \| STAT3 \| TFRC \| TGFA \| TGFB1 \| TIMP1 \| TLR2 \| TLR4 \| TLR9 \| TNF \| TNFAIP3 \| TNFRSF11B \| TRPA1 \| TSC2 \| VEGFA \| ZFP36	23.19	95
8.	Paraquat	Kidney Failure, Chronic	M	23 genes: ACE \| ADIPOQ \| ADIPOR1 \| ALB \| CAT \| CCL2 \| CD68 \| CPT1A \| EPO \| HAMP \| HMOX1 \| IGF1 \| IL6 \| NCF1 \| NFKB1 \| NOX4 \| PPARA \| PTGS1 \| PTGS2 \| RELA \| SERPINE1 \| TGFB1 \| TNF	19.89	12
9.	Paraquat	Respiratory Distress Syndrome, Adult	M	18 genes: ACO2 \| ALAD \| ALB \| CCL2 \| CYB5A \| EDN1 \| GABRB1 \| LCN2 \| MIRLET7D \| MT2A \| MT3 \| PRDX6 \| RAMP2 \| S100A9 \| SERPINH1 \| SOD2 \| THBD \| TIMP1	15.89	5
10.	Diquat	Drug-Induced Liver Injury	M	17 genes: BAX \| BDH1 \| CAT \| GADD45A \| GCLC \| GOT1 \| GPT \| GSR \| GSTM1 \| GSTM2 \| HMOX1 \| IFNG \| IL6 \| MAP1LC3B \| NFE2L2 \| SOD1 \| SOD2	14.38	26
11.	1-Methyl-4-phenylpyridinium	Disease Models, Animal	M	21 genes: AKT1 \| ESR1 \| FOS \| GFAP \| IL1B \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| MAPT \| MMP9 \| PARK2 \| PIM1 \| PKD1 \| RHOA \| SNCA \| SOD1 \| STAT3 \| TNF \| TRP53 \| VIM	13.97	20
12.	Paraquat	Parkinsonian Disorders	M	22 genes: ALDH1A1 \| ALDH1A2 \| ATP13A2 \| DDC \| DJ-1BETA \| DOP1R2 \| DRD2 \| GDNF \| GSR \| HTRA2 \| LRRK2 \| MAPT \| PARK7 \| PARP1 \| PDYN \| PINK1 \| PRKCD \| PRKN \| PRL \| SLC18A2 \| SNCA \| TH	13.57	42
13.	Paraquat	Acute Lung Injury	M	16 genes: ACVR1 \| ASCL1 \| CAT \| CXCL2 \| EDN1 \| FAS \| FASLG \| ICAM1 \| MT1 \| MT2 \| NFE2L2 \| PPARG \| TGFB1 \| TNFAIP6 \| TXN \| VIP	12.98	35
14.	1-Methyl-4-phenylpyridinium	Neurodegenerative Diseases	M	15 genes: FTH1 \| FTL1 \| GDNF \| GSTM1 \| GSTM2 \| HMOX1 \| IL6 \| MAPT \| NGF \| NGFR \| SIRT1 \| SNCA \| SOD2 \| SPTAN1 \| VIM	12.92	17
15.	Paraquat	Asthma	M	26 genes: ALDH2 \| ARG1 \| ARG2 \| BCL2 \| CAT \| CCL2 \| EDN1 \| GSTM1 \| GSTP1 \| HMOX1 \| ICAM1 \| IL13 \| IL1B \| IL4 \| MMP9 \| NOS2 \| NQO1 \| PARP1 \| PLAU \| SOD1 \| TGFB1 \| TIMP3 \| TNC \| TNF \| TRPA1 \| VEGFA	12.83	34
16.	Paraquat	Fibrosis	M	24 genes: ADCY5 \| AGT \| AKT1 \| ALB \| ATM \| CCND2 \| COL1A1 \| COL3A1 \| CSF3 \| FECH \| GPX4 \| HMOX1 \| IL1B \| IL4 \| LEPR \| MIR21 \| PDGFB \| PTGS2 \| SIRT1 \| SOD2 \| STAT3 \| TGFB1 \| TLR4 \| TNF	11.64	30
17.	Paraquat	Hypersensitivity	M	20 genes: ALB \| CASP1 \| CCL19 \| CCL2 \| CCL20 \| CCL3 \| CXCL1 \| CYP1A1 \| IFNG \| IL13 \| IL18 \| IL1B \| IL4 \| IL6 \| MAP2K6 \| MTHFR \| SPP1 \| TGFB1 \| TNF \| TNFRSF1A	11.42	11
18.	Paraquat	Pneumonia	M	22 genes: AHR \| CASP1 \| CCL19 \| CCL2 \| CCL20 \| CSF2 \| CXCL1 \| HMOX1 \| IFNG \| IL13 \| IL18 \| IL1B \| IL4 \| IL6 \| MYD88 \| PARP1 \| SIRT1 \| SPP1 \| TGFB1 \| TLR4 \| TNF \| TNFRSF1A	10.79	8
19.	Paraquat	Tremor	M	2 genes: ACHE \| ADORA2A	9.19	3
20.	1-Methyl-4-phenylpyridinium	Parkinsonian Disorders	M	15 genes: ATP13A2 \| DDC \| DRD2 \| GDNF \| LRRK2 \| MAPT \| NGF \| PARK7 \| PARP1 \| PINK1 \| PRKCD \| PRKN \| SLC18A2 \| SNCA \| TH	9.17	36
21.	Paraquat	Drug-Induced Liver Injury	M	75 genes: ABCB1 \| ABCB1A \| ABCB1B \| ABCC1 \| ABCC2 \| ADIPOQ \| AHR \| AIFM1 \| ALB \| ANXA2 \| ARG1 \| ATG5 \| BAX \| CAR3 \| CAT \| CCL2 \| CLU \| COL3A1 \| CSF3 \| CTNNB1 \| CXCL1 \| CXCL10 \| CYP2E1 \| EDEM1 \| ENO1 \| FADS2 \| GADD45A \| GCLC \| GOT1 \| GPT \| GSR \| GSTM1 \| GSTM2 \| GSTM3 \| GSTP1 \| GSTT1 \| GSTT1B \| HAVCR1 \| HBA-A1 \| HMGB1 \| HMOX1 \| HPX \| IFNG \| IGF1 \| IL18 \| IL1A \| IL1B \| IL4 \| IL6 \| ITPR1 \| LCN2 \| LGALS3 \| MAP1LC3B \| MAP3K5 \| MIR10A \| MIR34C \| MMP2 \| MTHFR \| NFE2L2 \| NOX4 \| NR1I2 \| NR1I3 \| PDK4 \| PPARA \| PTGS2 \| RBP1 \| SESN2 \| SLPI \| SOD1 \| SOD2 \| SOD3 \| SPP1 \| TNF \| TTR \| VIM	8.99	72
22.	Paraquat	Diarrhea	M	2 genes: CSF3 \| IL1A	8.94	3
23.	Pyridostigmine Bromide	Disease Models, Animal	M	3 genes: AIF1 \| ALB \| GFAP	8.61	6
24.	Paraquat	Infertility, Male	M	15 genes: ACE \| AHR \| ALDH2 \| BAX \| BCL2 \| CFTR \| CYP1A1 \| ENO1 \| GPX4 \| MDM2 \| MTHFR \| NOS3 \| SOD2 \| TP53 \| TSC22D3	8.46	16
25.	Paraquat	Nervous System Diseases	M	26 genes: ABCB1 \| ABCC2 \| ABCG2 \| ACHE \| ASCL1 \| ATF3 \| BDNF \| CASP3 \| CASP9 \| CSF3 \| FOS \| GFAP \| MTHFR \| NEUROD1 \| NOS1 \| NOTCH1 \| PENK \| PTGS2 \| SERPINE1 \| SLC18A2 \| SLC2A1 \| SLC6A3 \| SOD1 \| TNF \| TRP53 \| TTPA	7.72	23
26.	Paraquat	Acute Kidney Injury	M	37 genes: ALB \| AMN \| BAX \| CD44 \| CLU \| EDN1 \| EGFR \| EPO \| FSTL1 \| G6PD \| GSK3B \| GSTM2 \| GSTP1 \| HAVCR1 \| HMOX1 \| HSPA1A \| IGF1 \| IGFBP1 \| IL10 \| IL20 \| IL6 \| LCN2 \| MPO \| MTHFR \| NFE2L2 \| NOS2 \| NOS3 \| NQO1 \| PPARG \| SIRT1 \| SLC11A1 \| SPP1 \| TGFB1 \| TNF \| TP53 \| UOX \| VEGFA	7.28	44
27.	Diquat	Infertility, Male	M	4 genes: BAX \| BCL2 \| GPX4 \| SOD2	7.26	5
28.	1-methyl-4-phenyl-2,3-dihydropyridinium	Nerve Degeneration	M	3 genes: GRN \| SOD2 \| TH	7.12	3
29.	Paraquat	Lung Injury	M	14 genes: AHR \| CCL2 \| CCL3 \| CYP1A1 \| CYP1A2 \| HMOX1 \| IL6 \| MT2 \| SIRT1 \| TGFA \| TLR4 \| TNC \| TNF \| TNFRSF1A	6.99	23
30.	Paraquat	Gliosis	M	7 genes: BDNF \| FGF2 \| GFAP \| MAPK1 \| MAPK3 \| TNFRSF21 \| TNR	6.67	7
31.	Paraquat	Retinal Degeneration	M	6 genes: BCL2 \| CCL2 \| CX3CR1 \| GDNF \| RHO \| SOD1	5.63	7
32.	Pyridostigmine Bromide	Learning Disorders	M	2 genes: ACHE \| SYP	5.54	3
33.	Paraquat	Kidney Diseases	M	41 genes: ABCB1A \| ACE \| ACTA2 \| AGT \| AGTR1 \| ALAD \| ALB \| ANXA1 \| CASP1 \| CDKN1A \| CLU \| CSF3 \| CTSD \| EDN1 \| EPO \| FGF2 \| GSTP1 \| HAVCR1 \| IGF1 \| KL \| LCN2 \| LEPR \| MIR21 \| MPO \| MTHFR \| NFE2L2 \| NOS2 \| NQO1 \| NR4A1 \| PARP1 \| PPARA \| PTGS2 \| PYCARD \| SLC12A3 \| SLC22A2 \| SLC47A1 \| SOD2 \| SPARC \| SPP1 \| TGFB1 \| WNK1	5.53	59
34.	Diquat	Lung Injury	M	3 genes: HMOX1 \| IL6 \| MT2	5.16	4
35.	Pyridostigmine Bromide	Memory Disorders	M	2 genes: ACHE \| SYP	5.03	3
36.	Paraquat	Drug-Related Side Effects and Adverse Reactions	M	33 genes: ABCB1 \| ABCB1A \| ABCC1 \| ABCC12 \| ABCC2 \| ABCC4 \| ABCG2 \| ACHE \| ADORA1 \| ADORA2A \| ALB \| BCHE \| CLU \| CSF2 \| CSF3 \| CYP1A2 \| CYP2E1 \| HAVCR1 \| HMGB1 \| HMOX1 \| HSPB6 \| IGF1 \| IGFBP1 \| IL3 \| MTHFR \| NFE2L2 \| PPARA \| PTGS2 \| SPP1 \| THBD \| TLR2 \| TRP53 \| TXN1	4.75	40
37.	Paraquat	Hemorrhage	M	4 genes: F2 \| FOS \| NQO1 \| PLAU	4.49	15
38.	1-Methyl-4-phenylpyridinium	Hypokinesia	M	1 gene: OPRL1	4.35	2
39.	Paraquat	Hypertension, Pulmonary	M	11 genes: ACE \| ARG2 \| CCL2 \| CXCL8 \| EDN1 \| HIF1A \| NOS3 \| SLC31A1 \| SOD2 \| TGFA \| TNF	4.33	14
40.	Pyridostigmine Bromide	Gliosis	M	1 gene: GFAP	4.29	2
41.	Diquat	Fetal Growth Retardation	M	2 genes: IGF1R \| SOD1	4.16	3
42.	Paraquat	Infertility	M	3 genes: KL \| LEPR \| PTGER2	3.78	4
43.	Paraquat	Edema	M	14 genes: AMN \| CASP3 \| CASP8 \| CASP9 \| CAT \| COL2A1 \| CXCL8 \| CYP1A \| GSR \| IL6 \| MAP2K6 \| PTGS2 \| TNF \| VIP	3.65	12
44.	Paraquat	Muscle Weakness	M	3 genes: CSF2 \| CSF3 \| DMD	3.47	3
45.	Paraquat	Cardiotoxicity	M	2 genes: BCHE \| MIR208A	3.36	3
46.	Pyridostigmine Bromide	Cognition Disorders	M	1 gene: BCHE	3.31	3
47.	Paraquat	Death	M	1 gene: BCHE	3.24	2
48.	1-Methyl-4-phenylpyridinium	MPTP Poisoning	M	1 gene: INS	3.17	1
49.	Diquat	Kidney Diseases	M	5 genes: MPO \| NFE2L2 \| NQO1 \| PARP1 \| SOD2	3.13	8
50.	Paraquat	Poisoning	M	9 genes: ABCB1 \| ACHE \| ALB \| BCHE \| CSF3 \| EPO \| GSK3B \| SLC22A2 \| XIRP1	3.07	15

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