| Interacting Gene | Interactions | Organisms | |
|---|---|---|---|
| 1. | ADRB2 | 642 | 10 |
| 2. | ADRB1 | 545 | 10 |
| 3. | TNF | 481 | 6 |
| 4. | MAPK1 | 330 | 10 |
| 5. | MAPK3 | 320 | 10 |
| 6. | NPPA | 263 | 5 |
| 7. | CASP3 | 246 | 9 |
| 8. | IL6 | 230 | 5 |
| 9. | CYP2E1 | 201 | 7 |
| 10. | ADRB3 | 167 | 5 |
| 11. | CAT | 162 | 7 |
| 12. | PTGS2 | 157 | 5 |
| 13. | IL1B | 144 | 4 |
| 14. | HMOX1 | 133 | 4 |
| 15. | NOS2 | 131 | 4 |
| 16. | RELA | 123 | 4 |
| 17. | CYP2D6 | 114 | 6 |
| 18. | FOS | 114 | 3 |
| 19. | BCL2 | 109 | 3 |
| 20. | MMP9 | 109 | 6 |
| 21. | PPARA | 108 | 4 |
| 22. | AGT | 104 | 5 |
| 23. | REN | 100 | 4 |
| 24. | ADRA1A | 99 | 5 |
| 25. | SOD2 | 91 | 6 |
| 26. | NFE2L2 | 81 | 4 |
| 27. | TGFB1 | 79 | 5 |
| 28. | ALDH2 | 78 | 3 |
| 29. | EDN1 | 78 | 6 |
| 30. | CNR1 | 77 | 5 |
| 31. | BAX | 76 | 3 |
| 32. | JUN | 73 | 3 |
| 33. | EGFR | 71 | 3 |
| 34. | MMP2 | 70 | 4 |
| 35. | CXCL8 | 69 | 2 |
| 36. | SOD1 | 69 | 8 |
| 37. | AKT1 | 68 | 3 |
| 38. | MPO | 65 | 3 |
| 39. | NPPB | 64 | 5 |
| 40. | SREBF1 | 63 | 3 |
| 41. | PPARGC1A | 61 | 4 |
| 42. | NOS3 | 60 | 6 |
| 43. | PPARG | 60 | 3 |
| 44. | VEGFA | 60 | 5 |
| 45. | NFKB1 | 59 | 3 |
| 46. | MYH7 | 58 | 3 |
| 47. | CASP9 | 56 | 4 |
| 48. | ACTA2 | 55 | 4 |
| 49. | ADRA1B | 55 | 6 |
| 50. | COL1A1 | 55 | 5 |