Pregnadienes - Diseases

These diseases are associated with Pregnadienes or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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1–50 of 11,179 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Dexamethasone	Myocardial Ischemia	M	97 genes: ACTB \| ADIPOQ \| ADRB1 \| ADRB2 \| AGT \| ALDOA \| AREG \| ARNTL \| BHLHE40 \| CCL2 \| CCL3 \| CCL4 \| CCND1 \| CCND2 \| CD36 \| CD38 \| CDH2 \| CEBPD \| CES3 \| CIRBP \| CX3CL1 \| CXCL10 \| CXCL2 \| DCN \| DLAT \| DUSP1 \| EDN1 \| EGR2 \| ELN \| F3 \| FABP5 \| FGF2 \| GAS5 \| GBP2 \| GCH1 \| GCLC \| GDF15 \| GHR \| GK \| GSTM2 \| GSTP1 \| HADHA \| HGF \| HIVEP2 \| HK2 \| HMGB1 \| HMGCS2 \| HMOX1 \| HSPA1A \| HSPA2 \| ICAM1 \| ID1 \| ID3 \| IFNGR1 \| IGF1 \| IGFBP3 \| IL1A \| IL1B \| IL6 \| IL6ST \| IRF1 \| JAK2 \| JUNB \| KDR \| KLF4 \| MAP3K8 \| MAPK14 \| NFKBIA \| NOS3 \| NPPA \| NR4A1 \| PDHA1 \| PDK4 \| PEBP1 \| PFKFB3 \| PLA2G2A \| POMC \| PPAT \| PPM1B \| PPP2CA \| PRDX6 \| RGCC \| RXRG \| SELE \| SOD2 \| SPARC \| STAT5A \| SULT1A1 \| TFRC \| TLE4 \| TNF \| TUBA1A \| TXNRD1 \| VCAM1 \| VEGFA \| ZEB1 \| ZFP36	108.19	19
2.	Dexamethasone	Cardiomegaly	M	46 genes: ADRA1B \| ADRA2C \| AGT \| AGTR1A \| AHR \| AKT1 \| ATP2A2 \| CAV1 \| CCND2 \| CYP1A1 \| CYP1B1 \| CYP2C11 \| CYP2E1 \| CYP4A3 \| EDN1 \| FGF2 \| FHL2 \| GAS6 \| GSK3B \| HDAC2 \| HIF1A \| HMOX1 \| IGF1 \| IL18 \| IL1B \| LIF \| MT2A \| NOS3 \| NPPA \| NPPB \| NPR1 \| PLD1 \| POMC \| PPARA \| PPARD \| PRKCA \| PRKCB \| RBCK1 \| REN \| SLC2A4 \| SOD2 \| SRC \| STAT3 \| TNF \| TRIM63 \| UCP2	35.74	71
3.	Dexamethasone	Insulin Resistance	M	41 genes: ACACB \| ADIPOQ \| ADRB2 \| AHR \| AR \| C3 \| CASP1 \| CD36 \| CPE \| EGFR \| GH1 \| GNAS \| GPX3 \| HMOX1 \| HSD11B1 \| IGFBP2 \| INS \| INS1 \| INSR \| IRS1 \| IRS2 \| LEP \| LIPC \| NOS3 \| NR4A1 \| NR4A3 \| PIK3R1 \| PLTP \| PPARA \| PPARG \| PTEN \| PTPN1 \| RETN \| SCD1 \| SELENOP \| SIRT1 \| SLC2A4 \| SOD2 \| SREBF1 \| TNF \| TRIB3	32.72	54
4.	Dexamethasone	Craniofacial Abnormalities	M	38 genes: ACTB \| ANXA1 \| ATP6AP2 \| BMPR1A \| BNC2 \| COL11A1 \| COL2A1 \| CTNNB1 \| DLX5 \| EDN1 \| EDNRA \| EGFR \| EP300 \| ETS2 \| FGFR2 \| FZD4 \| GABRB3 \| GPC6 \| MASP1 \| MMP13 \| MMP2 \| MSX2 \| NOTCH1 \| PDGFRA \| PTEN \| RCAN1 \| RUNX2 \| RYK \| SATB2 \| SETBP1 \| SLC35D1 \| SMAD3 \| SOX9 \| TGFB2 \| TGFBR2 \| THRB \| TRP53 \| TRPS1	28.45	55
5.	Dexamethasone	Fatty Liver	M	45 genes: APOB \| BIRC3 \| CAR3 \| CAT \| CEBPB \| COL3A1 \| CXCL8 \| CYCS \| CYP19A1 \| CYP2E1 \| F2 \| F2R \| FGF21 \| GPD1L \| GPT \| GPX1 \| HADHB \| INS \| LDLR \| LEP \| MIR150 \| MIR17 \| MYC \| NR1H3 \| NR1I2 \| NREP \| PLIN2 \| POMC \| PON1 \| PPARA \| PPARD \| PTEN \| PTMA \| SCD1 \| SERPINA6 \| SERPINE1 \| SIRT1 \| SLC22A8 \| SOD1 \| SOD2 \| SREBF1 \| TF \| TLR4 \| TNF \| UCP2	25.10	44
6.	Dexamethasone	Myocardial Infarction	M	50 genes: ACE \| ACTA2 \| ADORA3 \| AGT \| APOE \| BAX \| BCL2 \| BCL2L1 \| CASP3 \| CAT \| CKB \| CKM \| CREB1 \| DDIT3 \| EPO \| ESR1 \| F2 \| F7 \| GCLC \| GSK3B \| HMGB1 \| HP \| HSD11B2 \| ICAM1 \| IL10 \| IL1B \| IL1RN \| IL6 \| LDHA \| MMP2 \| MMP9 \| MYH7 \| NOS2 \| NOS3 \| NPPA \| NR3C2 \| PAPPA \| PLAT \| PLAU \| PPARGC1A \| REN \| SOD1 \| SOD2 \| TGFB1 \| THBD \| TIMP2 \| TNF \| TNFRSF12A \| TNFSF4 \| TRP53	19.99	86
7.	Prednisolone	Carcinoma, Hepatocellular	M	18 genes: ABCB1 \| AR \| CCL3 \| CXCL8 \| CYR61 \| GJB1 \| IL6 \| KMT2A \| MET \| MMP9 \| MPO \| PCK1 \| PTGS2 \| SOD2 \| STAT4 \| TFPI2 \| TGFB1 \| TNF	18.89	26
8.	Dexamethasone	Disease Models, Animal	M	31 genes: ABCB4 \| ABCC6 \| AKT1 \| ALB \| APP \| CALCA \| CLDN11 \| CLN6 \| ESR1 \| F7 \| FAS \| FOS \| GFAP \| HBEGF \| IFNG \| IL1B \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| MMP9 \| OVAL \| PIM1 \| SERPINE1 \| SOD1 \| STAT3 \| TIMP1 \| TNF \| TRP53 \| VIM \| WNT11	17.75	34
9.	Dexamethasone	Dermatitis, Atopic	M	19 genes: CCL11 \| CCL17 \| CCL24 \| CCL5 \| CCR3 \| CXCL10 \| IFNG \| IL10 \| IL13 \| IL1B \| IL33 \| IL4 \| IL5 \| IL6 \| MAPK8 \| PPARA \| S100A8 \| SELE \| TSLP	16.03	10
10.	Prednisolone	Adenocarcinoma	M	13 genes: CTGF \| CXCL8 \| EFEMP1 \| ID3 \| IL1B \| KMT2A \| KRT8 \| MET \| PTGS2 \| SOD2 \| TGFB1 \| TNF \| VEGFA	15.71	15
11.	Dexamethasone	Nerve Degeneration	M	42 genes: ADRA1B \| APOE \| APP \| BAK1 \| BAX \| BCL2 \| BDNF \| CASP3 \| CD4 \| CDH2 \| CNR1 \| CP \| CTNNB1 \| DDC \| DDIT4 \| EPO \| ETS2 \| F2 \| FGF2 \| GRN \| IFNG \| IGF1 \| IGF2 \| LEP \| MAPK1 \| MAPK3 \| MT1 \| MT2 \| NGF \| NOS1 \| OTC \| PLAT \| PPARG \| SELENOP \| SIRT1 \| SLC18A2 \| SOD1 \| SOD2 \| TGFA \| TH \| TNF \| XDH	15.53	58
12.	Triamcinolone Acetonide	Carcinoma, Hepatocellular	M	7 genes: BID \| CASP8 \| IL6 \| PTGS2 \| TGFB1 \| TNF \| VCAM1	15.13	14
13.	Dexamethasone	Liver Diseases	M	37 genes: ACTA2 \| AHR \| ALOX5AP \| ALPL \| ASAH2 \| BCL2L1 \| CCL2 \| CD3D \| COL3A1 \| CSF3 \| CYP1A2 \| DDAH1 \| GABRR2 \| GPT \| GRK5 \| HMOX1 \| HPGDS \| HSPA1A \| IL11 \| IL1R2 \| LAT \| MMP9 \| NFKB1 \| NOS2 \| NQO1 \| NR1H4 \| OBP3 \| RAC1 \| RT1-DOA \| SERPINA1 \| SLCO1A1 \| SOCS1 \| SOD1 \| SULT1E1 \| TIMP3 \| TNF \| TYROBP	14.98	31
14.	Dexamethasone	Osteoporosis	M	21 genes: CA2 \| COL1A1 \| COL1A2 \| CYP19A1 \| CYP24A1 \| FGB \| GPX1 \| GSN \| IL6 \| IL6R \| LTF \| MGLL \| PDLIM4 \| POMC \| PTH \| REN \| SOD2 \| TGFB1 \| TNFRSF11B \| TNFSF11 \| VDR	14.78	23
15.	Dexamethasone	Sepsis	M	20 genes: ADM \| ANGPT1 \| CASP3 \| CSF3 \| HMGB1 \| IFNG \| IL10 \| LBP \| MAPK1 \| MAPK3 \| MIF \| MMP9 \| MT1 \| MT2 \| NOS2 \| NOS3 \| TGFB1 \| TGFBI \| TLR4 \| TNF	14.69	18
16.	Prednisolone	Obesity	M	12 genes: ACSL1 \| HSD11B1 \| IL6 \| MMP9 \| PCK1 \| POMC \| PTGS2 \| SOD2 \| STS \| TF \| TNF \| VLDLR	14.50	16
17.	alclometasone dipropionate	Dermatitis, Allergic Contact	M	4 genes: IFNG \| IL2 \| IL4 \| IL5	14.28	5
18.	Methylprednisolone	Hypertension	M	20 genes: AR \| BCL2 \| CAT \| COL1A1 \| CTGF \| CXCL2 \| EDN1 \| GPX1 \| HMOX1 \| HSD11B1 \| IL1B \| IL6 \| NOS2 \| PTGS2 \| RELA \| REN \| SOD2 \| TGFB1 \| TNF \| VWF	13.57	64
19.	Methylprednisolone	Hepatitis, Autoimmune	M	5 genes: CXCL1 \| IL4 \| IL5 \| IL6 \| TGFB1	13.34	2
20.	Dexamethasone	Headache	M	2 genes: CSF3 \| IL6	13.21	6
21.	Methylprednisolone	Myocardial Infarction	M	13 genes: BAX \| BCL2 \| CASP3 \| CAT \| ESR1 \| IL1B \| IL1RN \| IL6 \| NOS2 \| REN \| SOD2 \| TGFB1 \| TNF	12.81	18
22.	Methylprednisolone	Pneumonia	M	9 genes: CCL20 \| CXCL1 \| HMOX1 \| IL1B \| IL4 \| IL6 \| SIRT1 \| TGFB1 \| TNF	12.15	4
23.	Dexamethasone	Skin Diseases	M	25 genes: CCL20 \| CCL4 \| CD83 \| CXCL2 \| CXCL3 \| FGFR2 \| GADD45B \| GJB3 \| GSTM1 \| HSPA1B \| ID2 \| IER3 \| IL1A \| IL1B \| IL1R1 \| IL1RN \| IL6 \| N4BP2L2 \| PFKFB3 \| PTEN \| PTGS2 \| SCD1 \| SOD2 \| TNF \| TNFAIP6	12.11	9
24.	Dexamethasone	Hyperalgesia	M	44 genes: ADM \| AGT \| ALOX5 \| AVP \| BDKRB1 \| CACNA2D1 \| CALCA \| CCKBR \| CCL2 \| CNR1 \| CSK \| CXCL8 \| EDN1 \| FOS \| GDNF \| GFAP \| GRIN2B \| HMGB1 \| HTR2A \| IGF1 \| IL10 \| IL1A \| IL1B \| IL1RN \| IL6 \| INSR \| KNG1 \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| MMP3 \| NGF \| NOS1 \| NOS2 \| PDYN \| PTGS1 \| PTGS2 \| PTHLH \| SPARC \| TAC1 \| THBD \| TNF \| TNFRSF11B	11.30	62
25.	Betamethasone	Hypertension	M	9 genes: ACE \| ACE2 \| AGTR2 \| AR \| CCL2 \| HSD11B2 \| LHB \| NR3C1 \| PTGS2	10.88	23
26.	Triamcinolone Acetonide	Skin Diseases	M	4 genes: IL1B \| IL6 \| PTGS2 \| TNF	10.05	4
27.	Prednisolone	Hypertension	M	19 genes: ALB \| AR \| CCL2 \| COL1A1 \| CTGF \| CXCL2 \| HSD11B1 \| HSD11B2 \| IGF1 \| IL1B \| IL6 \| LTF \| MMP9 \| NR3C1 \| POMC \| PTGS2 \| SOD2 \| TGFB1 \| TNF	9.96	103
28.	Prednisolone	Cardiomyopathies	M	10 genes: ADORA2A \| IL1B \| IL4 \| IL6 \| POMC \| PTGS2 \| SOD2 \| TLR2 \| TNF \| TRIM63	9.91	10
29.	Cyproterone Acetate	Carcinoma, Hepatocellular	M	6 genes: APOA1 \| AR \| CCR1 \| CRP \| EGF \| MYC	9.80	10
30.	Dexamethasone	Hypercholesterolemia	M	18 genes: ABCA1 \| APOB \| APOE \| CES1 \| COL3A1 \| CYP7A1 \| EDN1 \| HMGCR \| ICAM1 \| LDLR \| LEP \| LPL \| MYLK \| NCF1 \| NR4A3 \| PON1 \| SELE \| VCAM1	9.75	21
31.	Dexamethasone	Muscular Atrophy	M	11 genes: AKT1 \| CITED2 \| CTNNB1 \| FBXO32 \| GH1 \| GSK3B \| IGF1 \| MT1 \| SOD1 \| TNF \| TRIM63	9.34	24
32.	Dexamethasone	Nervous System Diseases	M	31 genes: ABCB1 \| ABCC2 \| ABCG2 \| ACHE \| ADRB2 \| ATF3 \| BDNF \| CASP3 \| CASP9 \| CSF3 \| CYP2C8 \| CYP2C9 \| FOS \| FOXG1 \| GFAP \| GUSB \| ID3 \| NGF \| NOS1 \| NOTCH1 \| PENK \| PTGS2 \| SCN8A \| SELENOP \| SERPINE1 \| SLC10A2 \| SLC18A2 \| SLC2A1 \| SOD1 \| TNF \| TRP53	9.16	32
33.	Triamcinolone Acetonide	Dermatitis, Allergic Contact	M	4 genes: CASP8 \| IL4 \| IL5 \| TNF	9.12	7
34.	Dexamethasone	Hyperinsulinism	M	11 genes: COL3A1 \| FBN1 \| GCG \| GPX1 \| HMOX1 \| INS \| INSR \| IRS1 \| LEP \| NOS3 \| TSC22D3	9.07	18
35.	Triamcinolone Acetonide	Drug Hypersensitivity	M	4 genes: IL4 \| LTC4S \| OVAL \| TNF	9.04	6
36.	Prednisolone	Urinary Bladder Neoplasms	M	9 genes: CXCL8 \| IGF1 \| IL2 \| KMT2A \| MPO \| PTGS2 \| RHOA \| SOD2 \| TNF	8.67	19
37.	Prednisone	Pneumonia	M	7 genes: CCL11 \| IFNG \| IL13 \| IL4 \| POMC \| TGFB1 \| TNF	8.49	3
38.	Prednisolone	Sepsis	M	6 genes: CXCR2 \| IFNG \| IL10 \| MMP9 \| TGFB1 \| TNF	8.49	8
39.	Prednisolone	Osteoporosis	M	6 genes: COL1A1 \| IL6 \| LTF \| POMC \| SOD2 \| TGFB1	8.07	14
40.	Beclomethasone	Hypertension, Essential	M	3 genes: CYP3A5 \| NOS2 \| SELE	7.94	2
41.	Dexamethasone	Emphysema	M	7 genes: APOE \| FBLN5 \| NFE2L2 \| NOS2 \| PPP2R5A \| SERPINA1 \| TP53	7.84	8
42.	Methylprednisolone	Muscular Atrophy	M	4 genes: AKT1 \| FBXO32 \| TNF \| TRIM63	7.81	7
43.	Dexamethasone	Thrombosis	M	22 genes: AGT \| CD2 \| CYP2C19 \| CYP3A5 \| EPO \| F2 \| F3 \| GAS6 \| HGF \| HMOX1 \| KLF4 \| MERTK \| PF4 \| PLAT \| PLAU \| PTGER3 \| PTGS2 \| SERPINE1 \| SIRT1 \| THBD \| TNF \| TYRO3	7.35	39
44.	Methylprednisolone	Sepsis	M	5 genes: CASP3 \| MAPK1 \| NOS2 \| TGFB1 \| TNF	7.28	7
45.	Dexamethasone	Hallucinations	M	1 gene: HOMER1	7.20	2
46.	Danazol	Carcinoma, Hepatocellular	M	5 genes: AR \| CXCL8 \| ESR1 \| IL6 \| TNF	7.09	11
47.	Dydrogesterone	Drug-Induced Liver Injury	M	4 genes: IFNG \| IL4 \| IL6 \| TNF	7.09	12
48.	MOPP protocol	Infertility, Male	M	2 genes: FSHB \| LHB	6.93	4
49.	Methylprednisolone	Retinal Diseases	M	4 genes: HMOX1 \| NOS2 \| SIRT1 \| TNF	6.88	4
50.	Dexamethasone	Peripheral Nervous System Diseases	M	24 genes: ABCA1 \| ABCB1 \| ABCC1 \| ATF3 \| CASP9 \| CSF3 \| GFAP \| GJB3 \| GSTP1 \| ICAM1 \| IGF1 \| IGF1R \| IL6 \| JUN \| MBL2 \| MKI67 \| MMP3 \| NGF \| NPY \| PMP22 \| PPARD \| RHOBTB2 \| SOD2 \| UCHL1	6.73	26

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