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Chemical polychlorodibenzo-4-dioxin

These diseases are associated with polychlorodibenzo-4-dioxin. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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1–50 of 248 results.
  Disease Direct Evidence Enrichment Analysis Inference Network Inference Score References
1. Hypertension M
4 genes: AHR | CYP1A1 | HMOX1 | TP53 		8.35 8
2. Heart Defects, Congenital M   1 gene: AHR 3.53 2
3. Diabetes Mellitus M     1
4. Hypertriglyceridemia M     1
5. Hypoalphalipoproteinemias M     1
6. Metabolic Syndrome X M     1
7. Prostatic Neoplasms  
10 genes: AHR | COMT | CYP11B2 | CYP1A1 | CYP1B1 | DNMT1 | ESR1 | HMOX1 | HSD3B2 | TP53 		31.99 16
8. Breast Neoplasms  
9 genes: AHR | COMT | CYP1A1 | CYP1B1 | CYP2B1 | DNMT1 | ESR1 | HMOX1 | TP53 		26.15 30
9. Lung Neoplasms  
6 genes: CYP1A2 | CYP1B1 | ESR1 | FGF9 | HMOX1 | TP53 		18.28 12
10. Pulmonary Disease, Chronic Obstructive  
4 genes: CYP1A1 | CYP1A2 | HMOX1 | TP53 		17.71 4
11. Infertility, Male  
4 genes: AHR | CYP1A1 | ESR1 | TP53 		15.70 5
12. Lung Injury  
4 genes: AHR | CYP1A1 | CYP1A2 | HMOX1 		15.55 4
13. Dermatitis, Contact  
4 genes: AHR | CYP1A1 | CYP1B1 | HMOX1 		15.08 1
14. Carcinoma, Hepatocellular  
5 genes: COMT | CYP1A1 | ESR1 | HSD3B2 | TP53 		14.74 9
15. Musculoskeletal Pain  
2 genes: COMT | ESR1 		13.85 1
16. Cardiomegaly  
4 genes: AHR | CYP1A1 | CYP1B1 | HMOX1 		13.43 3
17. Adenocarcinoma  
4 genes: DNMT1 | ESR1 | FGF9 | TP53 		12.99 7
18. Hyperoxia  
2 genes: AHR | CYP1A1 		12.61 2
19. Growth Disorders  
3 genes: AHR | CYP1A2 | HMOX1 		12.14 2
20. Adrenal Hyperplasia, Congenital  
2 genes: CYP21A2 | HSD3B2 		11.68 3
21. Stomach Neoplasms  
4 genes: AHR | DNMT1 | HMOX1 | TP53 		11.48 7
22. Liver Neoplasms  
4 genes: AHR | ESR1 | HMOX1 | TP53 		11.28 5
23. Precursor Cell Lymphoblastic Leukemia-Lymphoma  
3 genes: CYP1A2 | CYP1B1 | TP53 		11.26 2
Has associated exposure references.
24. Prostatic Intraepithelial Neoplasia  
2 genes: DNMT1 | ESR1 		10.27 2
25. Pancreatic Neoplasms  
3 genes: AHR | CYP2B1 | TP53 		10.14 11
26. Carotid Artery Diseases  
2 genes: HMOX1 | TP53 		10.09 2
27. Carcinoma, Squamous Cell  
3 genes: CYP1A2 | CYP1B1 | TP53 		10.03 4
28. Diabetes Mellitus, Experimental  
3 genes: CYP1A1 | HMOX1 | TP53 		9.78 6
29. Splenic Diseases  
2 genes: AHR | CYP1A2 		9.76 1
30. Obesity  
3 genes: AHR | ESR1 | HMOX1 		9.31 5
31. Carcinoma  
3 genes: DNMT1 | ESR1 | TP53 		9.23 5
Has associated exposure references.
32. Neoplasm Invasiveness  
3 genes: AHR | ESR1 | HMOX1 		8.79 4
33. Colorectal Neoplasms  
3 genes: CYP1A2 | CYP1B1 | TP53 		8.74 11
34. Liver Diseases  
3 genes: AHR | CYP1A2 | HMOX1 		8.72 6
35. Hepatomegaly  
3 genes: CYP1A1 | CYP1A2 | CYP2B1 		8.61 2
36. Birth Weight  
2 genes: AHR | CYP1A1 		8.54 1
37. Neoplasm Metastasis  
3 genes: AHR | ESR1 | TP53 		8.47 3
38. Splenomegaly  
2 genes: AHR | CYP1A2 		7.92 2
39. Infertility, Female  
2 genes: ESR1 | TP53 		7.84 2
40. Mouth Neoplasms  
2 genes: CYP1B1 | TP53 		7.73 2
41. Mesothelioma, Malignant  
2 genes: FGF9 | TP53 		7.62 2
42. Arthritis, Experimental  
2 genes: AHR | DNMT1 		7.37 2
43. Atrophy  
2 genes: AHR | CYP1A2 		7.22 2
44. Glioma  
2 genes: CYP2B1 | TP53 		7.13 5
45. Congenital adrenal hyperplasia due to 21 hydroxylase deficiency     1 gene: CYP21A2 6.99 1
46. Ischemia  
2 genes: HMOX1 | TP53 		6.89 3
47. Coronary Artery Disease  
2 genes: ESR1 | HMOX1 		6.88 3
48. Carcinoma, Non-Small-Cell Lung  
2 genes: FGF9 | TP53 		6.85 4
Has associated exposure references.
49. Multiple Synostoses Syndrome 3     1 gene: FGF9 6.84 1
50. Adenoma  
2 genes: CYP1B1 | TP53 		6.83 2
1–50 of 248 results.
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