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Chemical Leflunomide

Name Leflunomide
CAS Type 1 Name 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-
Equivalent Terms Arava | HWA486 | HWA 486 | HWA-486 | N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide | SU101
CAS Registry Number 75706-12-6
Definition An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
Structure Leflunomide
Top Interacting
Genes
MeSH® ID D000077339
External Links
ChEBI
75706-12-6
ChemIDplus®
75706-12-6
DrugBank
DB01097
Household Products Database
75706-12-6
HSDB®
75706-12-6
PubChem
D000077339
TOXLINE®
Query

Top ↑ Ancestors

Chemicals ← Heterocyclic Compounds Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Heterocyclic Compounds, 1-Ring Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Azoles Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Isoxazoles Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Leflunomide Has associated genes Has associated diseases Has associated phenotype references

Top ↑ Descendants

None.