1. |
12-(3-adamantan-1-ylureido)dodecanoic acid
|
negative regulation of vasoconstriction
|
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
|
12-(3-adamantan-1-ylureido)dodecanoic acid promotes the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased negative regulation of vasoconstriction] |
1: Mus musculus |
Aorta |
|
1 |
2. |
12-(3-adamantan-1-ylureido)dodecanoic acid
|
leukocyte migration involved in inflammatory response
|
Bleomycin
|
12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased leukocyte migration involved in inflammatory response] |
1: Mus musculus |
Lung | Neutrophils |
|
1 |
3. |
12-(3-adamantan-1-ylureido)dodecanoic acid
|
leukocyte migration involved in inflammatory response
|
Bleomycin
|
12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased leukocyte migration involved in inflammatory response] |
1: Mus musculus |
Lung | Lymphocytes |
|
1 |
4. |
12-(3-adamantan-1-ylureido)dodecanoic acid
|
leukocyte migration involved in inflammatory response
|
Bleomycin
|
12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased leukocyte migration involved in inflammatory response] |
1: Mus musculus |
Lung | Macrophages |
|
1 |
5. |
12-(3-adamantan-1-ylureido)dodecanoic acid
|
cell proliferation
|
|
12-(3-adamantan-1-ylureido)dodecanoic acid results in decreased cell proliferation |
1: Homo sapiens |
Bronchi | Epithelial Cells | Cell Line |
4 genes: BAX | SPHK2 | TGFB1 | TP63
|
1 |
6. |
12-(3-adamantan-1-ylureido)dodecanoic acid
|
cell proliferation
|
|
12-(3-adamantan-1-ylureido)dodecanoic acid results in decreased cell proliferation |
1: Homo sapiens |
Lung | Fibroblasts | Cell Line |
4 genes: BAX | SPHK2 | TGFB1 | TP63
|
1 |
7. |
12-(3-adamantan-1-ylureido)dodecanoic acid
|
lactate dehydrogenase activity
|
|
12-(3-adamantan-1-ylureido)dodecanoic acid results in decreased lactate dehydrogenase activity |
1: Homo sapiens |
Bronchi | Epithelial Cells | Cell Line |
|
1 |
8. |
12-(3-adamantan-1-ylureido)dodecanoic acid
|
lactate dehydrogenase activity
|
|
12-(3-adamantan-1-ylureido)dodecanoic acid results in decreased lactate dehydrogenase activity |
1: Homo sapiens |
Lung | Fibroblasts | Cell Line |
|
1 |
9. |
2-aminoadamantane
|
response to antineoplastic agent
|
|
2-aminoadamantane analog results in increased response to antineoplastic agent |
1: Homo sapiens |
HCT116 Cells |
|
1 |
10. |
2-aminoadamantane
|
response to antineoplastic agent
|
Topotecan
|
[2-aminoadamantane analog results in increased response to antineoplastic agent] which results in increased susceptibility to Topotecan |
1: Homo sapiens |
HCT116 Cells |
|
1 |
11. |
2-aminoadamantane
|
response to antineoplastic agent
|
|
2-aminoadamantane analog results in increased response to antineoplastic agent |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
12. |
2-aminoadamantane
|
response to antineoplastic agent
|
Topotecan
|
[2-aminoadamantane analog results in increased response to antineoplastic agent] which results in increased susceptibility to Topotecan |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
13. |
3-(2-(3-(1-adamantyl)-4-hydroxyphenyl)-5-pyrimidinyl)-2-propenoic acid
|
cell proliferation
|
|
3-(2-(3-(1-adamantyl)-4-hydroxyphenyl)-5-pyrimidinyl)-2-propenoic acid results in decreased cell proliferation |
1: Mus musculus |
Breast | Cell Line, Tumor |
1 gene: BAD
|
1 |
14. |
3-(2-(3-(1-adamantyl)-4-hydroxyphenyl)-5-pyrimidinyl)-2-propenoic acid
|
cell proliferation
|
|
3-(2-(3-(1-adamantyl)-4-hydroxyphenyl)-5-pyrimidinyl)-2-propenoic acid results in decreased cell proliferation |
1: Homo sapiens |
Blood | Cell Line, Tumor |
1 gene: BAD
|
1 |
15. |
3-(2-(3-(1-adamantyl)-4-hydroxyphenyl)-5-pyrimidinyl)-2-propenoic acid
|
apoptotic process
|
|
3-(2-(3-(1-adamantyl)-4-hydroxyphenyl)-5-pyrimidinyl)-2-propenoic acid results in increased apoptotic process |
1: Homo sapiens |
Blood | Cell Line, Tumor |
6 genes: BAD | BIRC3 | CASP3 | NFKBIA | PARP1 | XIAP
|
1 |
16. |
Amantadine
|
regulation of blood pressure
|
|
Amantadine results in decreased regulation of blood pressure |
|
Vagus Nerve |
|
1 |
17. |
Amantadine
|
cell death
|
|
Amantadine results in decreased cell death |
|
Neurons | Cells, Cultured |
|
1 |
18. |
Amantadine
|
locomotion
|
|
Amantadine results in increased locomotion |
1: Homo sapiens |
Heel | Toes |
|
1 |
19. |
Amantadine
|
locomotion
|
|
Amantadine results in increased locomotion |
1: Homo sapiens |
Leg |
|
1 |
20. |
Amantadine
|
negative regulation of NMDA glutamate receptor activity
|
|
Amantadine results in increased negative regulation of NMDA glutamate receptor activity |
|
|
|
1 |
21. |
Amantadine
|
negative regulation of locomotion involved in locomotory behavior
|
|
Amantadine results in increased negative regulation of locomotion involved in locomotory behavior |
1: Mus musculus |
|
|
1 |
22. |
Amantadine
|
locomotory exploration behavior
|
|
Amantadine results in decreased locomotory exploration behavior |
1: Mus musculus |
|
|
1 |
23. |
Memantine
|
cell death
|
|
Memantine results in decreased cell death |
1: Rattus norvegicus |
Retinal Ganglion Cells |
|
1 |
24. |
Memantine
|
astrocyte activation
|
Streptozocin
|
Memantine inhibits the reaction [Streptozocin results in increased astrocyte activation] |
1: Rattus norvegicus |
Cerebral Cortex |
2 genes: APP | TNF
|
1 |
25. |
Memantine
|
positive regulation of reactive oxygen species biosynthetic process
|
Streptozocin
|
Memantine inhibits the reaction [Streptozocin results in increased positive regulation of reactive oxygen species biosynthetic process] |
1: Rattus norvegicus |
Neocortex | Synaptosomes |
|
1 |
26. |
Memantine
|
positive regulation of cytosolic calcium ion concentration
|
Streptozocin
|
Memantine inhibits the reaction [Streptozocin results in increased positive regulation of cytosolic calcium ion concentration] |
1: Rattus norvegicus |
Neocortex | Synaptosomes |
1 gene: DLG4
|
1 |
27. |
Memantine
|
positive regulation of reactive oxygen species biosynthetic process
|
Streptozocin
|
Memantine inhibits the reaction [Streptozocin results in increased positive regulation of reactive oxygen species biosynthetic process] |
1: Rattus norvegicus |
Hippocampus | Synaptosomes |
|
1 |
28. |
Memantine
|
positive regulation of cytosolic calcium ion concentration
|
Streptozocin
|
Memantine inhibits the reaction [Streptozocin results in increased positive regulation of cytosolic calcium ion concentration] |
1: Rattus norvegicus |
Hippocampus | Synaptosomes |
1 gene: DLG4
|
1 |
29. |
Memantine
|
positive regulation of succinate dehydrogenase activity
|
Streptozocin
|
Memantine inhibits the reaction [Streptozocin results in decreased positive regulation of succinate dehydrogenase activity] |
1: Rattus norvegicus |
Neocortex | Synaptosomes | Mitochondria |
|
1 |
30. |
Memantine
|
positive regulation of succinate dehydrogenase activity
|
Streptozocin
|
Memantine inhibits the reaction [Streptozocin results in decreased positive regulation of succinate dehydrogenase activity] |
1: Rattus norvegicus |
Hippocampus | Synaptosomes | Mitochondria |
|
1 |
31. |
Memantine
|
positive regulation of apoptotic process
|
Streptozocin
|
Memantine inhibits the reaction [Streptozocin results in increased positive regulation of apoptotic process] |
1: Rattus norvegicus |
Neocortex |
3 genes: CASP3 | CREB1 | TNF
|
1 |
32. |
Memantine
|
positive regulation of apoptotic process
|
Streptozocin
|
Memantine inhibits the reaction [Streptozocin results in increased positive regulation of apoptotic process] |
1: Rattus norvegicus |
Hippocampus |
3 genes: CASP3 | CREB1 | TNF
|
1 |
33. |
Memantine
|
regulation of resting membrane potential
|
Paraoxon
|
Memantine inhibits the reaction [Paraoxon affects regulation of resting membrane potential] |
1: Mus musculus |
Hippocampus |
|
1 |
34. |
Memantine
|
regulation of neuronal action potential
|
Paraoxon
|
Memantine inhibits the reaction [Paraoxon affects regulation of neuronal action potential] |
1: Mus musculus |
Hippocampus |
|
1 |
35. |
Memantine
|
excitatory postsynaptic potential
|
Paraoxon
|
Memantine inhibits the reaction [Paraoxon affects excitatory postsynaptic potential] |
1: Mus musculus |
Hippocampus | Pyramidal Cells |
|
1 |
36. |
Memantine
|
excitatory postsynaptic potential
|
methylatropine
| Paraoxon
|
[Memantine co-treated with methylatropine] inhibits the reaction [Paraoxon affects excitatory postsynaptic potential] |
1: Mus musculus |
Hippocampus | Pyramidal Cells |
|
1 |
37. |
Memantine
|
regulation of neuronal action potential
|
methylatropine
| Paraoxon
|
[Memantine co-treated with methylatropine] inhibits the reaction [Paraoxon affects regulation of neuronal action potential] |
1: Mus musculus |
Hippocampus |
|
1 |
38. |
Memantine
|
head development
|
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate
|
Memantine inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased head development] |
1: Danio rerio |
Head |
|
1 |
39. |
Memantine
|
positive regulation of neuron death
|
Pilocarpine
|
Memantine inhibits the reaction [Pilocarpine results in increased positive regulation of neuron death] |
1: Rattus norvegicus |
CA1 Region, Hippocampal |
1 gene: ITGAM
|
1 |
40. |
Memantine
|
positive regulation of neuron death
|
Pilocarpine
|
Memantine inhibits the reaction [Pilocarpine results in increased positive regulation of neuron death] |
1: Rattus norvegicus |
Amygdala |
1 gene: ITGAM
|
1 |
41. |
Memantine
|
positive regulation of neuron death
|
Pilocarpine
|
Memantine inhibits the reaction [Pilocarpine results in increased positive regulation of neuron death] |
1: Rattus norvegicus |
Thalamus |
1 gene: ITGAM
|
1 |
42. |
Memantine
|
memory
|
Ethanol
|
Memantine inhibits the reaction [Ethanol results in decreased memory] |
1: Mus musculus |
|
2 genes: APP | CREB1
|
1 |
43. |
Memantine
|
apoptotic process
|
Ethanol
|
Memantine inhibits the reaction [Ethanol results in increased apoptotic process] |
1: Mus musculus |
Hippocampus | Dentate Gyrus |
6 genes: APP | CASP3 | CASP7 | MAPK1 | MAPK3 | TNF
|
1 |
44. |
Memantine
|
cell growth
|
perfluorohexanesulfonic acid
|
Memantine inhibits the reaction [perfluorohexanesulfonic acid results in decreased cell growth] |
1: Rattus norvegicus |
Cerebellum | Neurons | Cells, Cultured |
|
1 |
45. |
Memantine
|
cell growth
|
perfluorooctane sulfonic acid
|
Memantine inhibits the reaction [perfluorooctane sulfonic acid results in decreased cell growth] |
1: Rattus norvegicus |
Cerebellum | Neurons | Cells, Cultured |
|
1 |
46. |
Memantine
|
cell growth
|
perfluorooctanoic acid
|
Memantine promotes the reaction [perfluorooctanoic acid results in decreased cell growth] |
1: Rattus norvegicus |
Cerebellum | Neurons | Cells, Cultured |
|
1 |
47. |
Memantine
|
cell growth
|
perfluorodecanoic acid
|
Memantine inhibits the reaction [perfluorodecanoic acid results in decreased cell growth] |
1: Rattus norvegicus |
Cerebellum | Neurons | Cells, Cultured |
|
1 |
48. |
N-(1-adamantyl)-1-pentylindazole-3-carboxamide
|
drug metabolic process
|
NAD
|
[NAD results in increased drug metabolic process] which results in increased oxidation of N-(1-adamantyl)-1-pentylindazole-3-carboxamide metabolite |
1: Homo sapiens |
Liver | Cytosol |
|
1 |
49. |
NSC 680410
|
response to oxidative stress
|
|
NSC 680410 results in increased response to oxidative stress |
1: Mus musculus |
Bone Marrow | Cell Line |
5 genes: ABL1 | AIFM1 | AKT1 | CYCS | MAP2K1
|
1 |
50. |
NSC 680410
|
response to oxidative stress
|
Bortezomib
|
Bortezomib promotes the reaction [NSC 680410 results in increased response to oxidative stress] |
1: Mus musculus |
Bone Marrow | Cell Line |
5 genes: ABL1 | AIFM1 | AKT1 | CYCS | MAP2K1
|
1 |