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Chemical Amiloride

Name Amiloride
CAS Type 1 Name Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
Equivalent Terms Alphapharm Brand of Amiloride Hydrochloride | Amidal | Amiduret Trom | Amiloberag | Amiloride Hydrochloride | Amiloride Hydrochloride, Anhydrous | Amrad Brand of Amiloride Hydrochloride | Anhydrous Amiloride Hydrochloride | Berolina Brand of Amiloride Hydrochloride | Cahill May Roberts Brand of Amiloride Hydrochloride | Douglas Brand of Amiloride Hydrochloride | Hydrochloride, Amiloride | Hydrochloride, Anhydrous Amiloride | Kaluril | Merck Brand of Amiloride Hydrochloride | Merck Sharp & Dohme Brand of Amiloride Hydrochloride | Midamor | Midoride | Modamide | Trom, Amiduret | Trommsdorff Brand of Amiloride Hydrochloride
CAS Registry Number 2609-46-3
Definition A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Structure Amiloride
Top Interacting
Genes
MeSH® ID D000584
External Links

Top ↑ Ancestors

ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 1-Ring Has associated genes Has associated diseases Has associated exposure references Pyrazines Has associated genes Has associated diseases Amiloride Has associated genes Has associated diseases

Top ↑ Descendants

Amiloride Has associated genes Has associated diseases
  2',4'-dichlorobenzamil amiloride Has associated genes Has associated diseases
  2',4'-dimethylbenzamil
  2-chlorobenzylamiloride
  2'-methoxy-5'-nitrobenzamil
  3',4'-dichlorobenzamil
  3,5-diamino-6-fluoro-2-pyrazinoylguanidine
  3,5-diamino-N-(aminoiminomethyl)-6-bromopyrazine-N-methylcarboxamide
  4-(((((3,5-diamino-6-chloropyrazinyl)carbonyl)amino)iminomethyl)amino)-2,2,6,6-tetramethyl-1-piperidinyloxy
  5,6-dichloroamiloride
  5-benzylglycinyl amiloride
  5-diethylamiloride
  5-dimethylamiloride Has associated genes Has associated diseases
  5-(ethylpropyl)amiloride
  5H-amiloride
  5-(N-2'-(4''-azidosalicylamidino)ethyl-N'-isopropyl)amiloride
  5-(N-2'-aminoethyl-N'-isopropyl)amiloride-N-(4''-azidosalicylamide)
  5-N-(3-aminophenyl)amiloride
  5-(N-4-chlorobenzyl)-N-(2',4'-dimethyl)benzamil
  5-(N-butyl-N-methyl)amiloride
  5-(N-ethyl-(2'-methoxy-5'-nitrobenzyl))amiloride
  5-(N-methyl-N-(guanidinocarbonylmethyl))guanidine amiloride
  5-(N-methyl-N-isobutyl)amiloride Has associated genes Has associated diseases
  5-(N-methyl-N-propyl)amiloride
  5-(N,N-hexamethylene)amiloride Has associated genes Has associated diseases
  5-(N-propyl-N-butyl)-2',4'-dichlorobenzamil amiloride
  5-(N-tert-butyl)amiloride
  6-bromoamiloride
  6-bromobenzamil
  6-chloro-3,5-diaminopyrazine-3-carboxamide Has associated genes Has associated diseases
  6-iodoamiloride
  alpha',2'-benzobenzamil
  amiloride, bumetanide drug combination
  amiloride caproate
  amiloride, hydrochlorothiazide drug combination Has associated diseases
  benzamil Has associated genes Has associated diseases
  Esmalorid
  ethylisopropylamiloride Has associated genes Has associated diseases
  frumil Has associated diseases
  kalten
  Lometazid
  methylisopropylamiloride
  moducrin
  N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-(4-(2,3-dihydroxypropoxy)phenyl)butylguanidine
  N(5)-piperazine-amiloride
  N(5)-piperidine-amiloride
  NVP-QBE170
  phenylamil Has associated genes Has associated diseases
  photoamiloride-1
  uranidil A