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Chemical Anesthetics, Local

Name Anesthetics, Local
Equivalent Terms Anesthetics, Conduction Blocking | Anesthetics, Conduction-Blocking | Anesthetics, Topical | Conduction Blocking Anesthetics | Conduction-Blocking Anesthetics | Local Anesthetics
Definition Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Curation Status No gene interactions have been curated for this chemical yet.
MeSH® ID D000779
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1. ChemicalsChemical Actions and Uses Has associated genes Has associated diseases Has associated exposure references Pharmacologic Actions Has associated genes Has associated diseases Has associated exposure references Physiological Effects of Drugs Has associated genes Has associated diseases Has associated exposure references Central Nervous System Depressants Has associated genes Has associated diseases Anesthetics Has associated genes Has associated diseases Anesthetics, Local Has associated diseases
2. ChemicalsChemical Actions and Uses Has associated genes Has associated diseases Has associated exposure references Pharmacologic Actions Has associated genes Has associated diseases Has associated exposure references Physiological Effects of Drugs Has associated genes Has associated diseases Has associated exposure references Peripheral Nervous System Agents Has associated genes Has associated diseases Sensory System Agents Has associated genes Has associated diseases Anesthetics, Local Has associated diseases
3. ChemicalsChemical Actions and Uses Has associated genes Has associated diseases Has associated exposure references Pharmacologic Actions Has associated genes Has associated diseases Has associated exposure references Therapeutic Uses Has associated genes Has associated diseases Has associated exposure references Central Nervous System Agents Has associated genes Has associated diseases Central Nervous System Depressants Has associated genes Has associated diseases Anesthetics Has associated genes Has associated diseases Anesthetics, Local Has associated diseases

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None.