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Chemical Histocompatibility Antigens Class II

Name Histocompatibility Antigens Class II
Equivalent Terms Antigen, Class II | Antigen, IA | Antigen, I-A | Antigens, Class II | Antigens, Ia | Antigens, Ia-Like | Antigens, Immune-Associated | Antigens, Immune Response | Antigens, Immune-Response-Associated | Class II Antigen | Class II Antigens | Class II Histocompatibility Antigens | Class II Major Histocompatibility Antigens | I A Antigen | I-A Antigen | I-A-Antigen | IA Antigen | Ia Antigens | Ia Like Antigens | Ia-Like Antigens | Immune Associated Antigens | Immune-Associated Antigens | Immune Response Antigens | Immune Response Associated Antigens | Immune-Response-Associated Antigens
Definition Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D000949
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Top ↑ Ancestors

1. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Antigens Has associated genes Has associated diseases Has associated exposure references Antigens, Surface Has associated genes Has associated diseases Histocompatibility Antigens Histocompatibility Antigens Class II
2. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Antigens Has associated genes Has associated diseases Has associated exposure references Isoantigens Histocompatibility Antigens Histocompatibility Antigens Class II

Top ↑ Descendants

Histocompatibility Antigens Class II
  antigen Boston 1
  antigen H2-Ma
  antigen RhLA-DR
  BoDr-betaII antigen
  BoLA-DQA antigen
  BoLA-DQB antigen
  BoLA-DRB3 antigen
  BoLA-DYA protein, Bos indicus
  CDw78 antigen
  cysteine-tethered MOG-35-55 recombinant I-Ab
  DYB antigen
  H-2A(b) antigen, mouse
  H2-DMb1 protein, mouse
  H2-DMb2 protein, mouse
  H-2M antigen, mouse
  H2-M antigens
  H-2O antigen
View node H-2 Antigens
View node HLA-D Antigens
  HLA TB23 antigen
  I-A(b) antigen, mouse
  I-Ad antigen
  I-A g7 antigen
  I-Ak antigen
  Ia-like antigens, avian
  I-E-antigen
  I-J-antigen
  invariant chain
  Mamu-DQA1 protein, Macaca mulatta
  NFKBIL1 protein, human
  swine leukocyte antigen