1. |
Apamin
|
vasodilation
|
INS
|
Apamin inhibits the reaction [INS protein results in increased vasodilation] |
|
Mesenteric Arteries |
|
1 |
2. |
Bee Venoms
|
glutathione biosynthetic process
|
propionic acid
|
Bee Venoms inhibits the reaction [propionic acid results in decreased glutathione biosynthetic process] |
1: Rattus norvegicus |
Brain |
|
1 |
3. |
Bee Venoms
|
DNA damage response, detection of DNA damage
|
propionic acid
|
Bee Venoms inhibits the reaction [propionic acid results in increased DNA damage response, detection of DNA damage] |
1: Rattus norvegicus |
Brain |
|
1 |
4. |
Bee Venoms
|
lipid catabolic process
|
propionic acid
|
Bee Venoms inhibits the reaction [propionic acid results in increased lipid catabolic process] |
1: Rattus norvegicus |
Brain |
|
1 |
5. |
Bee Venoms
|
cell death
|
propionic acid
|
Bee Venoms inhibits the reaction [propionic acid results in increased cell death] |
1: Rattus norvegicus |
Brain | Neurons |
|
1 |
6. |
Bee Venoms
|
superoxide dismutase activity
|
propionic acid
|
Bee Venoms inhibits the reaction [propionic acid results in decreased superoxide dismutase activity] |
1: Rattus norvegicus |
Brain |
|
1 |
7. |
Bee Venoms
|
protein oxidation
|
propionic acid
|
Bee Venoms inhibits the reaction [propionic acid results in increased protein oxidation] |
1: Rattus norvegicus |
Brain |
|
1 |
8. |
Bee Venoms
|
cell death
|
Bleomycin
|
Bee Venoms promotes the reaction [Bleomycin results in increased cell death] |
1: Rattus norvegicus |
Lymphocytes |
|
1 |
9. |
Bee Venoms
|
positive regulation of apoptotic DNA fragmentation
|
Bleomycin
|
Bee Venoms inhibits the reaction [Bleomycin results in increased positive regulation of apoptotic DNA fragmentation] |
1: Rattus norvegicus |
Lymphocytes |
1 gene: BAX
|
1 |
10. |
black widow spider venom
|
positive regulation of neuromuscular synaptic transmission
|
|
black widow spider venom results in decreased positive regulation of neuromuscular synaptic transmission |
1: Mus musculus |
Diaphragm | Neuromuscular Junction |
|
1 |
11. |
black widow spider venom
|
positive regulation of voltage-gated calcium channel activity
|
|
black widow spider venom results in decreased positive regulation of voltage-gated calcium channel activity |
1: Rattus norvegicus |
Ganglia, Spinal | Neurons | Cells, Cultured |
|
1 |
12. |
black widow spider venom
|
positive regulation of voltage-gated potassium channel activity
|
|
black widow spider venom results in decreased positive regulation of voltage-gated potassium channel activity |
1: Rattus norvegicus |
Ganglia, Spinal | Neurons | Cells, Cultured |
|
1 |
13. |
black widow spider venom
|
positive regulation of sodium ion transmembrane transport
|
|
black widow spider venom results in decreased positive regulation of sodium ion transmembrane transport |
1: Rattus norvegicus |
Ganglia, Spinal | Neurons | Cells, Cultured |
|
1 |
14. |
Charybdotoxin
|
vasodilation
|
INS
|
Charybdotoxin inhibits the reaction [INS protein results in increased vasodilation] |
|
Mesenteric Arteries |
|
1 |
15. |
Charybdotoxin
|
vasoconstriction
|
Nitric Oxide
| Phenylephrine
|
Charybdotoxin inhibits the reaction [Nitric Oxide inhibits the reaction [Phenylephrine results in increased vasoconstriction]] |
1: Rattus norvegicus |
Mesenteric Arteries |
|
1 |
16. |
Charybdotoxin
|
vasoconstriction
|
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one
| Nitric Oxide
| Phenylephrine
|
[Charybdotoxin co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] inhibits the reaction [Nitric Oxide inhibits the reaction [Phenylephrine results in increased vasoconstriction]] |
1: Rattus norvegicus |
Mesenteric Arteries |
|
1 |
17. |
Charybdotoxin
|
regulation of membrane potential
|
Nitric Oxide
| Phenylephrine
|
Charybdotoxin inhibits the reaction [Nitric Oxide inhibits the reaction [Phenylephrine results in increased regulation of membrane potential]] |
1: Rattus norvegicus |
Mesenteric Arteries | Muscle, Smooth, Vascular |
|
1 |
18. |
Charybdotoxin
|
regulation of membrane potential
|
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one
| Nitric Oxide
| Phenylephrine
|
[Charybdotoxin co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] inhibits the reaction [Nitric Oxide inhibits the reaction [Phenylephrine results in increased regulation of membrane potential]] |
1: Rattus norvegicus |
Mesenteric Arteries | Muscle, Smooth, Vascular |
|
1 |
19. |
Charybdotoxin
|
regulation of membrane potential
|
linsidomine
| Phenylephrine
|
Charybdotoxin inhibits the reaction [linsidomine inhibits the reaction [Phenylephrine results in increased regulation of membrane potential]] |
1: Rattus norvegicus |
Mesenteric Arteries | Muscle, Smooth, Vascular |
|
1 |
20. |
Charybdotoxin
|
vasoconstriction
|
linsidomine
| Phenylephrine
|
Charybdotoxin inhibits the reaction [linsidomine inhibits the reaction [Phenylephrine results in increased vasoconstriction]] |
1: Rattus norvegicus |
Mesenteric Arteries |
|
1 |
21. |
Charybdotoxin
|
vasoconstriction
|
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one
| linsidomine
| Phenylephrine
|
[Charybdotoxin co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] inhibits the reaction [linsidomine inhibits the reaction [Phenylephrine results in increased vasoconstriction]] |
1: Rattus norvegicus |
Mesenteric Arteries |
|
1 |
22. |
Charybdotoxin
|
vein smooth muscle contraction
|
Resveratrol
|
Charybdotoxin inhibits the reaction [Resveratrol results in decreased vein smooth muscle contraction] |
1: Rattus norvegicus |
Portal Vein |
|
1 |
23. |
Charybdotoxin
|
positive regulation of vasoconstriction
|
Acetylcholine
|
Charybdotoxin inhibits the reaction [Acetylcholine results in increased positive regulation of vasoconstriction] |
1: Rattus norvegicus |
Umbilical Veins |
|
1 |
24. |
Charybdotoxin
|
phospholipid scrambling
|
Calcimycin
|
Charybdotoxin inhibits the reaction [Calcimycin results in increased phospholipid scrambling] |
1: Homo sapiens |
Erythrocytes |
|
1 |
25. |
Charybdotoxin
|
phospholipid scrambling
|
lysophosphatidic acid
|
Charybdotoxin inhibits the reaction [lysophosphatidic acid results in increased phospholipid scrambling] |
1: Homo sapiens |
Erythrocytes |
|
1 |
26. |
Charybdotoxin
|
phospholipid scrambling
|
Tetradecanoylphorbol Acetate
|
Charybdotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phospholipid scrambling] |
1: Homo sapiens |
Erythrocytes |
|
1 |
27. |
Charybdotoxin
|
calcium ion homeostasis
|
lysophosphatidic acid
|
Charybdotoxin affects the reaction [lysophosphatidic acid affects calcium ion homeostasis] |
1: Homo sapiens |
Erythrocytes |
|
1 |
28. |
makatoxin I
|
behavioral response to chemical pain
|
|
makatoxin I results in increased behavioral response to chemical pain |
1: Rattus norvegicus |
|
|
1 |
29. |
makatoxin I
|
positive regulation of mechanosensory behavior
|
|
makatoxin I results in increased positive regulation of mechanosensory behavior |
1: Rattus norvegicus |
|
|
1 |
30. |
makatoxin I
|
thermosensory behavior
|
|
makatoxin I results in increased thermosensory behavior |
1: Rattus norvegicus |
|
|
1 |
31. |
makatoxin I
|
behavioral response to chemical pain
|
NPPB
|
NPPB protein inhibits the reaction [makatoxin I results in increased behavioral response to chemical pain] |
1: Rattus norvegicus |
|
|
1 |
32. |
makatoxin I
|
positive regulation of mechanosensory behavior
|
NPPB
|
NPPB protein inhibits the reaction [makatoxin I results in increased positive regulation of mechanosensory behavior] |
1: Rattus norvegicus |
|
|
1 |
33. |
makatoxin I
|
thermosensory behavior
|
NPPB
|
NPPB protein inhibits the reaction [makatoxin I results in increased thermosensory behavior] |
1: Rattus norvegicus |
|
|
1 |
34. |
margatoxin
|
positive regulation of potassium ion transmembrane transporter activity
|
Methamphetamine
|
margatoxin inhibits the reaction [Methamphetamine results in increased positive regulation of potassium ion transmembrane transporter activity] |
1: Rattus norvegicus |
Microglia |
|
1 |
35. |
margatoxin
|
positive regulation of apoptotic process
|
Methamphetamine
|
margatoxin inhibits the reaction [Methamphetamine results in increased positive regulation of apoptotic process] |
1: Rattus norvegicus |
Microglia |
2 genes: IL6 | TNF
|
1 |
36. |
mastoparan
|
positive regulation of mast cell degranulation
|
|
mastoparan results in increased positive regulation of mast cell degranulation |
1: Rattus norvegicus |
Peritoneum | Mast Cells |
|
1 |
37. |
Melitten
|
cell proliferation
|
|
Melitten results in decreased cell proliferation |
1: Homo sapiens |
Osteoblasts | Cell Line, Tumor |
14 genes: AKT1 | BAX | BCL2 | CDK4 | EGFR | FGF2 | HTR1A | IL18 | RAC1 | SHH | STAT3 | TGFA | TGFB1 | VEGFA
|
1 |
38. |
Melitten
|
cell death
|
|
Melitten results in increased cell death |
1: Rattus norvegicus |
Hippocampus | Neurons |
1 gene: P2RX7
|
1 |
39. |
Melitten
|
cellular response to stress
|
sodium arsenite
|
Melitten promotes the reaction [sodium arsenite affects cellular response to stress] |
1: Mus musculus |
Connective Tissue Cells | Cell Line |
|
1 |
40. |
Melitten
|
cellular response to sodium arsenite
|
sodium arsenite
|
Melitten promotes the reaction [sodium arsenite affects cellular response to sodium arsenite] |
1: Mus musculus |
Connective Tissue Cells | Cell Line |
|
1 |
41. |
Melitten
|
activation of phospholipase A2 activity
|
|
Melitten affects activation of phospholipase A2 activity |
|
|
1 gene: PLA2G1B
|
1 |
42. |
Melitten
|
positive regulation of cell proliferation
|
|
Melitten results in decreased positive regulation of cell proliferation |
1: Homo sapiens |
Hepatocytes | Cell Line, Tumor |
34 genes: ADAM10 | ADAM17 | AKT1 | BCL2 | CCND1 | CDK4 | CHRNA7 | EGFR | FGF2 | FN1 | GLI1 | HTR1A | IKBKB | IL18 | IL1B | IL4 | IL6 | IL6R | JAK2 | JUN | KDR | MAPK1 | MECP2 | PDGFRB | PLA2G1B | PLA2G4A | PTGS2 | RELA | SHH | STAT3 | TGFA | TGFB1 | TNF | VEGFA
|
1 |
43. |
Melitten
|
mitotic cell cycle arrest
|
|
Melitten results in increased mitotic cell cycle arrest |
1: Homo sapiens |
Hepatocytes | Cell Line, Tumor |
|
1 |
44. |
Melitten
|
positive regulation of intestinal epithelial structure maintenance
|
|
Melitten results in decreased positive regulation of intestinal epithelial structure maintenance |
1: Homo sapiens |
Caco-2 Cells |
|
1 |
45. |
omega-agatoxin-Aa4b
|
excitatory postsynaptic potential
|
Baclofen
|
omega-agatoxin-Aa4b inhibits the reaction [Baclofen results in decreased excitatory postsynaptic potential] |
1: Rattus norvegicus |
Suprachiasmatic Nucleus | Neurons |
|
1 |
46. |
omega-agatoxin-Aa4b
|
excitatory postsynaptic potential
|
Levetiracetam
|
omega-agatoxin-Aa4b inhibits the reaction [Levetiracetam affects excitatory postsynaptic potential] |
1: Rattus norvegicus |
Brain |
|
1 |
47. |
omega-agatoxin-Aa4b
|
apoptotic process
|
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
| Phencyclidine
|
omega-agatoxin-Aa4b inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased apoptotic process]] |
1: Rattus norvegicus |
Brain |
1 gene: CASP3
|
1 |
48. |
omega-Agatoxin IVA
|
positive regulation of cytosolic calcium ion concentration
|
Acetylcholine
|
omega-Agatoxin IVA inhibits the reaction [Acetylcholine results in increased positive regulation of cytosolic calcium ion concentration] |
1: Bos taurus |
Adrenal Medulla | Chromaffin Cells | Cells, Cultured |
1 gene: CACNA1A
|
1 |
49. |
omega-Agatoxin IVA
|
positive regulation of catecholamine secretion
|
Acetylcholine
|
omega-Agatoxin IVA inhibits the reaction [Acetylcholine results in increased positive regulation of catecholamine secretion] |
1: Bos taurus |
Adrenal Medulla | Chromaffin Cells | Cells, Cultured |
|
1 |
50. |
omega-Agatoxin IVA
|
positive regulation of cytosolic calcium ion concentration
|
Potassium Chloride
|
omega-Agatoxin IVA inhibits the reaction [Potassium Chloride results in increased positive regulation of cytosolic calcium ion concentration] |
1: Bos taurus |
Adrenal Medulla | Chromaffin Cells | Cells, Cultured |
1 gene: CACNA1A
|
1 |