Illuminating how chemicals affect human health.
Comparative Toxicogenomics Database

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	Chemical	Phenotype	Co-Mentioned Terms	Interaction	Organisms	Anatomy	Inference Network	References
1.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	cell death	1-Methyl-4-phenylpyridinium	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cell death]	1: Rattus norvegicus	PC12 Cells		2
2.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	anoikis		1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in increased anoikis	1: Homo sapiens	Lung | Cell Line, Tumor		1
3.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	cell death	benzyloxycarbonylleucyl-leucyl-leucine aldehyde | linsidomine	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [linsidomine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cell death]]	1: Rattus norvegicus	PC12 Cells		1
4.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	vasodilation	Mexiletine | Nitroprusside	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Mexiletine promotes the reaction [Nitroprusside results in increased vasodilation]]	1: Rattus norvegicus	Aorta		1
5.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	apoptotic process	Benzo(a)pyrene	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole promotes the reaction [Benzo(a)pyrene results in increased apoptotic process]	1: Rattus norvegicus	Liver | Epithelial Cells | Cell Line	3 genes: BCL2 | DDIT3 | TNFSF10	1
6.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	regulation of mitochondrial membrane potential	Benzo(a)pyrene	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Benzo(a)pyrene affects regulation of mitochondrial membrane potential]	1: Rattus norvegicus	Liver | Epithelial Cells | Cell Line	1 gene: BCL2	1
7.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	positive regulation of mitochondrial membrane permeability	spermine nitric oxide complex	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [spermine nitric oxide complex results in increased positive regulation of mitochondrial membrane permeability]	1: Rattus norvegicus	Myocytes, Cardiac | Cells, Cultured		1
8.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	positive regulation of mitochondrial depolarization	spermine nitric oxide complex	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [spermine nitric oxide complex results in increased positive regulation of mitochondrial depolarization]	1: Rattus norvegicus	Myocytes, Cardiac | Cells, Cultured		1
9.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	reactive nitrogen species metabolic process	Nitric Oxide	[1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole binds to Nitric Oxide] which results in increased reactive nitrogen species metabolic process				1
10.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	cell death	sibutramine	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole promotes the reaction [sibutramine results in increased cell death]	1: Homo sapiens	Aorta | Endothelial Cells		1
11.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	protein modification process	Paraquat	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Paraquat results in increased protein modification process]	1: Homo sapiens	Neurons | Cell Line, Tumor		1
12.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide	cell proliferation	Cadmium	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Cadmium results in increased cell proliferation]	1: Homo sapiens	MCF-7 Cells	6 genes: CD70 | CDK1 | FGF1 | IGF1 | NRG1 | PCNA	1
13.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide	regulation of nucleus size		2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide affects regulation of nucleus size	1: Homo sapiens	Skin | Cell Line, Tumor		1
14.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	MCL1 | Sorafenib	MCL1 protein inhibits the reaction [[Sorafenib co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] results in increased apoptotic process]	1: Homo sapiens	B-Lymphocytes | Cell Line, Tumor	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
15.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	Sorafenib	[Sorafenib co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] results in increased apoptotic process	1: Homo sapiens	B-Lymphocytes | Cell Line, Tumor	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
16.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	BCL2	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide promotes the reaction [BCL2 mutant form results in increased apoptotic process]		Bone Marrow | Cell Line, Tumor	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
17.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide promotes the reaction [ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate results in increased apoptotic process]		Bone Marrow | Cell Line, Tumor	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
18.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	BCL2 | ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [BCL2 inhibits the reaction [ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate results in increased apoptotic process]]		Bone Marrow | Cell Line, Tumor	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
19.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell proliferation	ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide promotes the reaction [ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate results in decreased cell proliferation]		Bone Marrow | Cell Line, Tumor	6 genes: CTNNB1 | EGFR | MAP2K1 | MKI67 | RAF1 | STAT3	1
20.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell proliferation		2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in decreased cell proliferation	1: Homo sapiens	Schwann Cells | Cell Line, Tumor	6 genes: CTNNB1 | EGFR | MAP2K1 | MKI67 | RAF1 | STAT3	1
21.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell proliferation		2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in decreased cell proliferation	1: Homo sapiens	Neurons | Cell Line, Tumor	6 genes: CTNNB1 | EGFR | MAP2K1 | MKI67 | RAF1 | STAT3	1
22.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process		2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in increased apoptotic process	1: Homo sapiens	Neurons | Cell Line, Tumor	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
23.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process		2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in increased apoptotic process	1: Homo sapiens	Schwann Cells | Cell Line, Tumor	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
24.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell cycle		2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in decreased cell cycle	1: Homo sapiens	Schwann Cells | Cell Line, Tumor	6 genes: AHR | DDIT3 | MAPK1 | MAPK3 | MKI67 | RPS6KB1	1
25.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell cycle		2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in decreased cell cycle	1: Homo sapiens	Neurons | Cell Line, Tumor	6 genes: AHR | DDIT3 | MAPK1 | MAPK3 | MKI67 | RPS6KB1	1
26.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process		2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in increased apoptotic process	1: Homo sapiens	Schwann Cells | Cells, Cultured	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
27.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	Arsenic Trioxide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide promotes the reaction [Arsenic Trioxide results in increased apoptotic process]	1: Homo sapiens	Bone Marrow	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
28.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	Arsenic Trioxide | TP53AIP1	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide promotes the reaction [Arsenic Trioxide results in increased apoptotic process]] which results in increased expression of TP53AIP1	1: Homo sapiens	Bone Marrow	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
29.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	Arsenic Trioxide	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with Arsenic Trioxide] results in increased apoptotic process	1: Homo sapiens	Bone Marrow	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
30.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	Arsenic Trioxide | TP53AIP1	[[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with Arsenic Trioxide] results in increased apoptotic process] which results in increased expression of TP53AIP1	1: Homo sapiens	Bone Marrow	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
31.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	Arsenic Trioxide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide promotes the reaction [Arsenic Trioxide results in increased apoptotic process]	1: Homo sapiens	K562 Cells	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
32.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	Arsenic Trioxide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide promotes the reaction [Arsenic Trioxide results in increased apoptotic process]	1: Homo sapiens	Granulocyte Precursor Cells | Cell Line, Tumor	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
33.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell death		2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in increased cell death	1: Homo sapiens	Breast | Cell Line, Tumor		1
34.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell death	7-hydroxystaurosporine	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide promotes the reaction [7-hydroxystaurosporine results in increased cell death]	1: Homo sapiens	Breast | Cell Line, Tumor		1
35.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell death	7-hydroxystaurosporine	7-hydroxystaurosporine promotes the reaction [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in increased cell death]	1: Homo sapiens	Breast | Cell Line, Tumor		1
36.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell proliferation	7-hydroxystaurosporine	[7-hydroxystaurosporine co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] results in decreased cell proliferation	1: Homo sapiens	Cells	6 genes: CTNNB1 | EGFR | MAP2K1 | MKI67 | RAF1 | STAT3	1
37.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell death	7-hydroxystaurosporine	[7-hydroxystaurosporine co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] results in increased cell death	1: Homo sapiens	Cells		1
38.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	Lovastatin	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide promotes the reaction [Lovastatin results in increased apoptotic process]	1: Rattus norvegicus	Brain | Cells, Cultured	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
39.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	apoptotic process	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased apoptotic process	1: Rattus norvegicus	Brain | Cells, Cultured	12 genes: AHR | AIFM1 | CASP3 | CASP9 | DDIT3 | MAPK1 | MAPK3 | MCL1 | RAF1 | RPS6KB1 | TP53AIP1 | TP73	1
40.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	positive regulation of ERK1 and ERK2 cascade	Plant Extracts	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Plant Extracts affects positive regulation of ERK1 and ERK2 cascade]	1: Homo sapiens	Hep G2 Cells	5 genes: EGF | EGFR | IL6 | MAP2K1 | MAPK3	1
41.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	positive regulation of G1/S transition of mitotic cell cycle	Quercetin	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Quercetin results in decreased positive regulation of G1/S transition of mitotic cell cycle]	1: Homo sapiens	Myeloid Progenitor Cells | Cell Line, Tumor		1
42.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	cell death	nefazodone	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [nefazodone results in increased cell death]	1: Homo sapiens	Hep G2 Cells		1
43.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	positive regulation of ERK1 and ERK2 cascade	cypermethrin	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [cypermethrin results in increased positive regulation of ERK1 and ERK2 cascade]	1: Mus musculus	Gonadotrophs | Cell Line	5 genes: EGF | EGFR | IL6 | MAP2K1 | MAPK3	1
44.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	ATP biosynthetic process	Leflunomide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide promotes the reaction [Leflunomide results in decreased ATP biosynthetic process]	1: Homo sapiens	Hep G2 Cells		1
45.	2-(2-fluorobenzamido)benzoate ethyl ester	positive regulation of superoxide anion generation	N-Formylmethionine Leucyl-Phenylalanine	2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased positive regulation of superoxide anion generation]	1: Homo sapiens	Neutrophils | Cells, Cultured	1 gene: ITGAM	1
46.	2-(2-fluorobenzamido)benzoate ethyl ester	activation of protein kinase B activity	N-Formylmethionine Leucyl-Phenylalanine	2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activation of protein kinase B activity]	1: Homo sapiens	Neutrophils | Cells, Cultured		1
47.	2-(2-fluorobenzamido)benzoate ethyl ester	positive regulation of reactive oxygen species biosynthetic process	N-Formylmethionine Leucyl-Phenylalanine	2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased positive regulation of reactive oxygen species biosynthetic process]	1: Homo sapiens	Neutrophils | Cells, Cultured		1
48.	2-(2-fluorobenzamido)benzoate ethyl ester	positive regulation of cyclic-nucleotide phosphodiesterase activity		2-(2-fluorobenzamido)benzoate ethyl ester results in decreased positive regulation of cyclic-nucleotide phosphodiesterase activity	1: Homo sapiens	Neutrophils | Cells, Cultured		1
49.	2-(2-fluorobenzamido)benzoate ethyl ester	positive regulation of cyclic-nucleotide phosphodiesterase activity	Cyclic AMP	[2-(2-fluorobenzamido)benzoate ethyl ester results in decreased positive regulation of cyclic-nucleotide phosphodiesterase activity] which results in increased abundance of Cyclic AMP	1: Homo sapiens	Neutrophils | Cells, Cultured		1
50.	2-(2-fluorobenzamido)benzoate ethyl ester	activation of protein kinase A activity	N-Formylmethionine Leucyl-Phenylalanine	[N-Formylmethionine Leucyl-Phenylalanine co-treated with 2-(2-fluorobenzamido)benzoate ethyl ester] results in increased activation of protein kinase A activity	1: Homo sapiens	Neutrophils | Cells, Cultured		1

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