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Chemical Botulinum Toxins

Name Botulinum Toxins
Equivalent Terms Botulin | Botulinum Toxin | Clostridium botulinum Toxins | Toxin, Botulinum | Toxins, Botulinum | Toxins, Clostridium botulinum
Definition Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Top Interacting
Genes
MeSH® ID D001905
External Links

Top ↑ Ancestors

ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Toxins, Biological Has associated genes Has associated diseases Has associated exposure references Bacterial Toxins Has associated genes Has associated diseases Has associated exposure references Botulinum Toxins Has associated genes Has associated diseases

Top ↑ Descendants

Botulinum Toxins Has associated genes Has associated diseases
View node Botulinum Toxins, Type A Has associated genes Has associated diseases
  botulinum toxin type C Has associated genes Has associated diseases
  botulinum toxin type D Has associated genes Has associated diseases
  botulinum toxin type E Has associated genes Has associated diseases
  botulinum toxin type F Has associated genes
  botulinum toxin type G Has associated genes
  Clostridium botulinum LL toxin
  Clostridium botulinum L toxin
  Clostridium botulinum M toxin
  CNBTX-A
  exoenzyme C3, Clostridium botulinum Has associated genes Has associated diseases
  hemagglutinin 33 protein, Clostridium botulinum
  NTNH protein, Clostridium botulinum
  SXN101959