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Chemical Camptothecin

Name Camptothecin
CAS Type 1 Name 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
Equivalent Term Camptothecine
CAS Registry Number 7689-03-4
Definition An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Structure Camptothecin
Top Interacting
Genes
MeSH® ID D002166
External Links

Top ↑ Ancestors

ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Alkaloids Has associated genes Has associated diseases Has associated exposure references Camptothecin Has associated genes Has associated diseases

Top ↑ Descendants

Camptothecin Has associated genes Has associated diseases
  10,11-methylenedioxy-14-azacamptothecin
  10,11-methylenedioxy-20-camptothecin
  10,11-methylenedioxycamptothecin
  10-(2-pyrazolylethoxy)camptothecin Has associated genes Has associated diseases
  10-amino-7-ethylcamptothecin
  10-aminocamptothecin
  10-bromoacetamidomethylcamptothecin
  10-hydroxycamptothecin Has associated genes Has associated diseases
  10-methoxy-9-nitrocamptothecin
  10-methoxycamptothecin
  10-O-(1-beta-D-glycosyl)camptothecin
  11-hydroxycamptothecin
  12-nitrocamptothecin
  14-azacamptothecin
  16a-thiocamptothecin
  18-hydroxycamptothecin
  20-fluorocamptothecin
  20-glycinate-10,11-methylenedioxycamptothecin
  20-glycinate-7-chloromethyl-10,11-methylenedioxycamptothecin
  20-O-glucopyranosyl camptothecin
  20-O-(Nalpha-(4-(3-O-methylfucopyranosyloxy)phenylaminothiocarbonyl)histidylvalyl)camptothecin
  (20S)-10-(3-aminopropyloxy)-7-ethylcamptothecin
  20(S)-sulfonylamidine camptothecin
  2,3-dihydro-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1H,12H-benzo(de)pyrano(3',4'-6,7)indolizino(1,2-b)quinoline-10,13(9H,15H)-dione
  4-deshydroxy-4-(N-methyl-(2-(((5-methoxy-1,2-dimethyl-4,7-dioxoindol-3-yl)methoxycarbonyl)(methyl)amino)ethyl)carbamoylmethyl)camptothecin
  4-deshydroxy-4-(N-methyl-(2-(((5-nitrofur-2-yl)methoxycarbonyl)(methyl)amino)ethyl)carbamoylmethyl)camptothecin
  5-aminocamptothecin
  5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino(3',4'-6,7)indolizino(1,2-b)quinoline-3,15-dione
  7-((3-piperidyl)-1-propynyl)camptothecin
  7-butyl-10-amino-camptothecin
  7-butyl-10-amino-camptothecin-beta-alanine-lysine
  7-chloromethyl-10,11-methylenedioxycamptothecin
  7-cyanocamptothecin
  7-cyclohexylfluorocamptothecin
  7-ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecine
  7-ethyl-10-hydroxy-20-deoxyaminocamptothecin
  7-ethyl-10-hydroxycamptothecin acetic acid
  7-ethyl-10-hydroxycamptothecin beta-glucuronide
  7-ethyl-10-hydroxycamptothecin glucuronide
  7-ethyl-10-methoxy-20-deoxyaminocamptothecin
  7-ethyl-14-aminocamptothecin
  7-ethylcamptothecin
  7-methyl-10,11-ethylenedioxy-20-camptothecin
  7-methyl-10-bromoacetamidomethylcamptothecin
  7-methyl-9-((2-(2-methylpiperidin-1-yl)acetyl)amino)homocamptothecin
  7-tert-butoxyiminomethylcamptothecin
  7-tert-butyldimethylsilyl-10-hydroxycamptothecin
  7-tert-butyldimethylsilyl-10-hydroxyhomocamptothecin
  7-thiomethyl-camptothecin
  9,16-diethyl-2,3-dihydro-9-hydroxy-12H-1,4-oxazino(3,2-f)pyrano(3',4'-6,7)indolizino(1,2-b)quinoline-10,13(9H,15H)-dione
  9-aminocamptothecin
  9-aminocamptothecin glucuronide
  9-aminocamptothecin lactone
  9-(benzoylamino)-7-methylhomocamptothecin
  9-methoxycamptothecin Has associated genes Has associated diseases
  belotecan Has associated diseases
  BMS 286309
  BMS 422461
  BN 80927
  camptothecin-20-glycinate ester
  camptothecin-20(s)-O-(N-(3'alpha,12alpha-dihydroxy-24'-carbonyl-5'beta-cholan))-lysine
  camptothecin, C20-propionate ester
  camptothecin copper(II) complex
  capecitabine-irinotecan combination
  CH 0793076
  chimmitecan
  cositecan
  CPT-10-B
  CPT417
  DE-310 cpd
  DHA-HCPT conjugate
  diflomotecan
  DRF-1042
  DS-8201a
  DTS-108
  exatecan
  EZN-2208
  FOLFOXIRI protocol
  GI 149893
  glycyl-DX-8951
  homocamptothecin Has associated genes Has associated diseases
  hydroxycamptothecinum Has associated genes Has associated diseases
  IDN5174
  IFL protocol Has associated diseases
  irinotecan Has associated genes Has associated diseases
  irinotecan sucrosofate
  IROX protocol
  isocamptothecin A
  isocamptothecin B
  IT-101
  JF-10-81
  lurtotecan
  maleimidohexyl-arginyl-arginyl-alanyl-leucyl-alanyl-leucyl-alanyl-camptothecin
  monomethoxypolyethylene glycol-carbonyl-glycyl-leucyl-phenylalanyl-glycyl-10-amino-7-ethylcamptothecin
  MXN-004
  namitecan
  NSC 100880 Has associated diseases
  NSC606985 Has associated genes Has associated diseases
  O-acetylcamptothecin
  ONCOFID-S Has associated diseases
  pegamotecan
  poly(ethylene glycol)-camptothecin conjugate
  polyglutamate camptothecin
  pumiloside
  RPR 121056 Has associated genes Has associated diseases
  rubitecan Has associated genes Has associated diseases
  S 38809
  sacituzumab govitecan
  simmitecan
  SN38-Glu
  ST 1481 Has associated genes Has associated diseases
  ST 1698
  ST 1976
  STA-12-8666
  TLC 388
View node Topotecan Has associated genes Has associated diseases
  XMT 1001
  ZBH-1205