1. |
10-hydroxycamptothecin
|
apoptotic process
|
|
10-hydroxycamptothecin results in increased apoptotic process |
1: Homo sapiens |
Ovary | Cell Line, Tumor |
4 genes: BCL2 | BCL2L1 | CASP3 | DDIT3
|
1 |
2. |
10-hydroxycamptothecin
|
mitotic cell cycle arrest
|
|
10-hydroxycamptothecin results in increased mitotic cell cycle arrest |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
3. |
10-hydroxycamptothecin
|
apoptotic process
|
|
10-hydroxycamptothecin results in increased apoptotic process |
1: Homo sapiens |
Lung | Cell Line, Tumor |
4 genes: BCL2 | BCL2L1 | CASP3 | DDIT3
|
1 |
4. |
10-hydroxycamptothecin
|
apoptotic process
|
|
10-hydroxycamptothecin analog results in increased apoptotic process |
1: Homo sapiens |
Lung | Cell Line, Tumor |
4 genes: BCL2 | BCL2L1 | CASP3 | DDIT3
|
1 |
5. |
10-hydroxycamptothecin
|
cell proliferation
|
|
10-hydroxycamptothecin results in decreased cell proliferation |
1: Homo sapiens |
Ovary | Cell Line, Tumor |
2 genes: BCL2 | BCL2L1
|
1 |
6. |
10-hydroxycamptothecin
|
mitotic cell cycle arrest
|
|
10-hydroxycamptothecin analog results in increased mitotic cell cycle arrest |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
7. |
10-hydroxycamptothecin
|
apoptotic DNA fragmentation
|
|
10-hydroxycamptothecin results in increased apoptotic DNA fragmentation |
1: Homo sapiens |
Ovary | Cell Line, Tumor |
1 gene: CASP3
|
1 |
8. |
10-hydroxycamptothecin
|
cell proliferation
|
|
10-hydroxycamptothecin results in decreased cell proliferation |
1: Homo sapiens |
Lung | Cell Line, Tumor |
2 genes: BCL2 | BCL2L1
|
1 |
9. |
10-hydroxycamptothecin
|
cell proliferation
|
roscovitine
|
roscovitine promotes the reaction [10-hydroxycamptothecin analog affects cell proliferation] |
1: Homo sapiens |
Lung | Cell Line, Tumor |
2 genes: BCL2 | BCL2L1
|
1 |
10. |
10-hydroxycamptothecin
|
apoptotic process
|
Fluorouracil
| Leucovorin
|
[10-hydroxycamptothecin co-treated with Fluorouracil co-treated with Leucovorin] results in increased apoptotic process |
1: Homo sapiens |
Intestine, Large | Cells |
4 genes: BCL2 | BCL2L1 | CASP3 | DDIT3
|
1 |
11. |
10-hydroxycamptothecin
|
cell proliferation
|
olomoucine
|
olomoucine promotes the reaction [10-hydroxycamptothecin analog affects cell proliferation] |
1: Homo sapiens |
Lung | Cell Line, Tumor |
2 genes: BCL2 | BCL2L1
|
1 |
12. |
10-hydroxycamptothecin
|
cell proliferation
|
|
10-hydroxycamptothecin analog affects cell proliferation |
1: Homo sapiens |
Lung | Cell Line, Tumor |
2 genes: BCL2 | BCL2L1
|
1 |
13. |
7-ethyl-10-hydroxycamptothecin glucuronide
|
drug metabolic process
|
Paclitaxel
|
[Paclitaxel results in increased drug metabolic process] which results in increased abundance of 7-ethyl-10-hydroxycamptothecin glucuronide |
1: Mus musculus |
Hepatocytes | Cells, Cultured |
|
1 |
14. |
7-ethyl-10-hydroxycamptothecin glucuronide
|
drug metabolic process
|
Paclitaxel
| TLR4
|
TLR4 protein mutant form inhibits the reaction [[Paclitaxel results in increased drug metabolic process] which results in increased abundance of 7-ethyl-10-hydroxycamptothecin glucuronide] |
1: Mus musculus |
Hepatocytes | Cells, Cultured |
|
1 |
15. |
7-ethyl-14-aminocamptothecin
|
cell proliferation
|
|
7-ethyl-14-aminocamptothecin results in decreased cell proliferation |
1: Homo sapiens |
HT29 Cells |
|
1 |
16. |
7-ethyl-14-aminocamptothecin
|
cell proliferation
|
|
7-ethyl-14-aminocamptothecin results in decreased cell proliferation |
1: Homo sapiens |
Prostate | Cell Line, Tumor |
|
1 |
17. |
7-ethyl-14-aminocamptothecin
|
cell proliferation
|
|
7-ethyl-14-aminocamptothecin results in decreased cell proliferation |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
18. |
9-aminocamptothecin
|
apoptotic process
|
|
9-aminocamptothecin results in increased apoptotic process |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
19. |
9-aminocamptothecin
|
cell proliferation
|
olomoucine
|
olomoucine promotes the reaction [9-aminocamptothecin results in decreased cell proliferation] |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
20. |
9-aminocamptothecin
|
mitotic cell cycle arrest
|
|
9-aminocamptothecin results in increased mitotic cell cycle arrest |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
21. |
9-aminocamptothecin
|
cell proliferation
|
|
9-aminocamptothecin results in decreased cell proliferation |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
22. |
9-aminocamptothecin
|
cell proliferation
|
roscovitine
|
roscovitine promotes the reaction [9-aminocamptothecin results in decreased cell proliferation] |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
23. |
9-methoxycamptothecin
|
positive regulation of extrinsic apoptotic signaling pathway
|
|
9-methoxycamptothecin affects positive regulation of extrinsic apoptotic signaling pathway |
1: Homo sapiens |
Cell Line, Tumor |
2 genes: CASP8 | FAS
|
1 |
24. |
9-methoxycamptothecin
|
positive regulation of reactive oxygen species metabolic process
|
|
9-methoxycamptothecin affects positive regulation of reactive oxygen species metabolic process |
1: Homo sapiens |
HeLa Cells |
2 genes: CDKN1A | TP53
|
1 |
25. |
9-methoxycamptothecin
|
positive regulation of tumor necrosis factor biosynthetic process
|
|
9-methoxycamptothecin affects positive regulation of tumor necrosis factor biosynthetic process |
1: Homo sapiens |
Ovary | Tumor Cells, Cultured |
|
1 |
26. |
9-methoxycamptothecin
|
cellular response to toxic substance
|
|
9-methoxycamptothecin affects cellular response to toxic substance |
1: Homo sapiens |
HeLa Cells |
|
1 |
27. |
9-methoxycamptothecin
|
positive regulation of apoptotic process
|
CASP8
|
[9-methoxycamptothecin results in increased activity of CASP8 protein] which affects positive regulation of apoptotic process |
1: Homo sapiens |
Ovary | Tumor Cells, Cultured |
12 genes: BAD | BAX | BCL2L1 | CASP3 | CASP8 | CASP9 | FAS | FASLG | JUN | PTGS2 | TNF | TP53
|
1 |
28. |
9-methoxycamptothecin
|
mitotic cell cycle arrest
|
|
9-methoxycamptothecin affects mitotic cell cycle arrest |
1: Homo sapiens |
Ovary | Tumor Cells, Cultured |
3 genes: CDKN1A | CDKN1B | TP53
|
1 |
29. |
9-methoxycamptothecin
|
regulation of tumor necrosis factor-mediated signaling pathway
|
|
9-methoxycamptothecin affects regulation of tumor necrosis factor-mediated signaling pathway |
1: Homo sapiens |
Cell Line, Tumor |
2 genes: CASP8 | TNF
|
1 |
30. |
9-methoxycamptothecin
|
response to oxidative stress
|
|
9-methoxycamptothecin affects response to oxidative stress |
1: Homo sapiens |
Cell Line, Tumor |
4 genes: BCL2 | BCL2L1 | PTGS2 | TP53
|
1 |
31. |
9-methoxycamptothecin
|
mitotic cell cycle arrest
|
|
9-methoxycamptothecin affects mitotic cell cycle arrest |
1: Homo sapiens |
HeLa Cells |
3 genes: CDKN1A | CDKN1B | TP53
|
1 |
32. |
9-methoxycamptothecin
|
positive regulation of apoptotic process
|
|
9-methoxycamptothecin affects positive regulation of apoptotic process |
1: Homo sapiens |
Ovary | Tumor Cells, Cultured |
12 genes: BAD | BAX | BCL2L1 | CASP3 | CASP8 | CASP9 | FAS | FASLG | JUN | PTGS2 | TNF | TP53
|
1 |
33. |
9-methoxycamptothecin
|
positive regulation of Fas signaling pathway
|
|
9-methoxycamptothecin affects positive regulation of Fas signaling pathway |
1: Homo sapiens |
Ovary | Tumor Cells, Cultured |
|
1 |
34. |
9-methoxycamptothecin
|
positive regulation of Fas signaling pathway
|
|
9-methoxycamptothecin affects positive regulation of Fas signaling pathway |
1: Homo sapiens |
HeLa Cells |
|
1 |
35. |
9-methoxycamptothecin
|
cellular response to toxic substance
|
|
9-methoxycamptothecin affects cellular response to toxic substance |
1: Homo sapiens |
Ovary | Cell Line, Tumor |
|
1 |
36. |
9-methoxycamptothecin
|
positive regulation of apoptotic process
|
|
9-methoxycamptothecin affects positive regulation of apoptotic process |
1: Homo sapiens |
HeLa Cells |
12 genes: BAD | BAX | BCL2L1 | CASP3 | CASP8 | CASP9 | FAS | FASLG | JUN | PTGS2 | TNF | TP53
|
1 |
37. |
9-methoxycamptothecin
|
positive regulation of FasL biosynthetic process
|
|
9-methoxycamptothecin affects positive regulation of FasL biosynthetic process |
1: Homo sapiens |
HeLa Cells |
|
1 |
38. |
9-methoxycamptothecin
|
positive regulation of reactive oxygen species metabolic process
|
|
9-methoxycamptothecin affects positive regulation of reactive oxygen species metabolic process |
1: Homo sapiens |
Ovary | Cell Line, Tumor |
2 genes: CDKN1A | TP53
|
1 |
39. |
9-methoxycamptothecin
|
positive regulation of FasL biosynthetic process
|
|
9-methoxycamptothecin affects positive regulation of FasL biosynthetic process |
1: Homo sapiens |
Ovary | Tumor Cells, Cultured |
|
1 |
40. |
9-methoxycamptothecin
|
positive regulation of apoptotic process
|
CASP9
|
[9-methoxycamptothecin results in increased activity of CASP9 protein] which affects positive regulation of apoptotic process |
1: Homo sapiens |
Ovary | Tumor Cells, Cultured |
12 genes: BAD | BAX | BCL2L1 | CASP3 | CASP8 | CASP9 | FAS | FASLG | JUN | PTGS2 | TNF | TP53
|
1 |
41. |
9-methoxycamptothecin
|
positive regulation of apoptotic process
|
CASP3
|
[9-methoxycamptothecin results in increased activity of CASP3 protein] which affects positive regulation of apoptotic process |
1: Homo sapiens |
Ovary | Tumor Cells, Cultured |
12 genes: BAD | BAX | BCL2L1 | CASP3 | CASP8 | CASP9 | FAS | FASLG | JUN | PTGS2 | TNF | TP53
|
1 |
42. |
9-methoxycamptothecin
|
positive regulation of intrinsic apoptotic signaling pathway
|
|
9-methoxycamptothecin affects positive regulation of intrinsic apoptotic signaling pathway |
1: Homo sapiens |
Cell Line, Tumor |
5 genes: BAD | BAX | BCL2 | BCL2L1 | TP53
|
1 |
43. |
9-methoxycamptothecin
|
positive regulation of apoptotic process
|
CASP3
|
[9-methoxycamptothecin results in increased activity of CASP3 protein] which affects positive regulation of apoptotic process |
1: Homo sapiens |
HeLa Cells |
12 genes: BAD | BAX | BCL2L1 | CASP3 | CASP8 | CASP9 | FAS | FASLG | JUN | PTGS2 | TNF | TP53
|
1 |
44. |
9-methoxycamptothecin
|
positive regulation of tumor necrosis factor biosynthetic process
|
|
9-methoxycamptothecin affects positive regulation of tumor necrosis factor biosynthetic process |
1: Homo sapiens |
HeLa Cells |
|
1 |
45. |
Camptothecin
|
autophagy
|
bafilomycin A
|
bafilomycin A inhibits the reaction [Camptothecin results in increased autophagy] |
1: Homo sapiens |
MCF-7 Cells |
6 genes: ATG5 | CTSB | EI24 | SQSTM1 | TP53 | TRP53
|
1 |
46. |
Camptothecin
|
apoptotic DNA fragmentation
|
Dexamethasone
|
Dexamethasone inhibits the reaction [Camptothecin results in increased apoptotic DNA fragmentation] |
1: Rattus norvegicus |
Neuroglia | Cell Line, Tumor |
1 gene: CASP3
|
1 |
47. |
Camptothecin
|
positive regulation of apoptotic DNA fragmentation
|
|
Camptothecin results in increased positive regulation of apoptotic DNA fragmentation |
1: Rattus norvegicus |
PC12 Cells |
1 gene: BAX
|
1 |
48. |
Camptothecin
|
positive regulation of apoptotic DNA fragmentation
|
|
Camptothecin results in increased positive regulation of apoptotic DNA fragmentation |
1: Homo sapiens |
Trophoblasts | Cell Line, Tumor |
1 gene: BAX
|
1 |
49. |
Camptothecin
|
apoptotic process
|
Dexamethasone
| STAT5A
|
STAT5A affects the reaction [Dexamethasone inhibits the reaction [Camptothecin results in increased apoptotic process]] |
1: Rattus norvegicus |
Neuroglia | Cell Line, Tumor |
46 genes: AIFM3 | AKT1 | ATG5 | ATM | BAX | BBC3 | BCL2 | BCL2L1 | BID | BIRC5 | BRCA1 | CASP10 | CASP2 | CASP3 | CASP7 | CASP8 | CASP9 | CFLAR | CHEK1 | CHEK2 | CLPTM1L | CYCS | E2F1 | EI24 | EP300 | FAS | GADD45A | GADD45G | IL1B | LGALS1 | MAP3K5 | MAP3K7 | MAPK1 | MAPK3 | MAPT | PARP1 | PLK3 | PPP2CA | PPP2R1A | RB1 | SIRT1 | SQSTM1 | TNFSF9 | TP53 | TRP53 | XIAP
|
1 |
50. |
Camptothecin
|
cell proliferation
|
C646 compound
|
C646 compound promotes the reaction [Camptothecin results in decreased cell proliferation] |
1: Homo sapiens |
Bone and Bones | Cell Line, Tumor |
14 genes: AKT1 | AR | BAX | BCL2 | BCL2L1 | BRCA2 | CREBBP | ERCC1 | MRE11 | PRKDC | TNFSF9 | TOP1 | TP53 | VEGFA
|
1 |