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Chemical Cardiac Glycosides

Name Cardiac Glycosides
Equivalent Terms Cardiotonic Steroids | Glycosides, Cardiac | Steroids, Cardiotonic
Definition Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Top Interacting
Genes
MeSH® ID D002301
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Top ↑ Ancestors

1. ChemicalsPolycyclic Compounds Has associated genes Has associated diseases Has associated exposure references Fused-Ring Compounds Has associated genes Has associated diseases Has associated exposure references Steroids Has associated genes Has associated diseases Has associated exposure references Cardanolides Has associated genes Has associated diseases Cardiac Glycosides Has associated genes Has associated diseases
2. ChemicalsCarbohydrates Has associated genes Has associated diseases Has associated exposure references Glycosides Has associated genes Has associated diseases Has associated exposure references Cardiac Glycosides Has associated genes Has associated diseases

Top ↑ Descendants

Cardiac Glycosides Has associated genes Has associated diseases
  24-azido-3-((2,6-dideoxy-beta-hexapyranosyl)oxy)-14-hydroxy-21-norchol-20(22)-en-23-one
  2'-epi-2'-O-acetylthevetin B Has associated genes Has associated diseases
  3beta-O-(alpha-L-rhamnopyranosyl)-14beta-hydroperoxy-5beta-hydroxy-19-oxo-17beta-card-20(22)-enolide
  7,8-epoxysinogenin 3-methylglycosides
  acetyltanghinin
  acetylthevetin B
  bovoside
View node Bufanolides Has associated genes Has associated diseases
  calotropagenin
View node Cardenolides Has associated genes Has associated diseases
  cardiodigin
  Cd 412
  codeine, cardiac glycosides drug combination
  Cor-Vel liquid
  cryptosin
  cuspidoside
  deglucohyrcanoside
View node Digitalis Glycosides Has associated genes Has associated diseases
  digitoxigenin 3-O-(O-glucopyranosyl-(1-4)-2-O-acetyldigitalopyranoside)
  erysimin G
  ghalakinoside
  GHSC-73
  hydroxydihydrobovolide
  hyrcanoside
  maquiroside A
  Miroton
  oleandrigenin-beta-D-glucosyl (1-4)-beta-D-digitalose
  periplocymarin
  periplogenin 3-O-(O-glucopyranosyl-(1-4)-O-glucopyranosyl-(1-4)-cymaropyranoside)
  proceraside A
View node Proscillaridin Has associated genes Has associated diseases
  rohdealine
  scillaren
  strebloside-
View node Strophanthins Has associated genes Has associated diseases
  strospeside
  tanghinin
  thevetoside
  toxicarioside A
  toxicarioside F
  toxicarioside G
  toxicarioside H
  TXA9 compound
  Venocuran