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Chemical Cholera Toxin

Name Cholera Toxin
Equivalent Terms Cholera Enterotoxin CT | Cholera Exotoxin | Choleragen | Choleragenoid | Cholera Toxin A Subunit | Cholera Toxin B Subunit | Cholera Toxin Protomer A | Cholera Toxin Protomer B | CT, Cholera Enterotoxin | Enterotoxin CT, Cholera | Exotoxin, Cholera | Procholeragenoid | Toxin, Cholera
CAS Registry Number 9012-63-9
Definition An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Top Interacting
Genes
MeSH® ID D002772
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Top ↑ Ancestors

1. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Toxins, Biological Has associated genes Has associated diseases Has associated exposure references Bacterial Toxins Has associated genes Has associated diseases Has associated exposure references Cholera Toxin Has associated genes Has associated diseases
2. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Toxins, Biological Has associated genes Has associated diseases Has associated exposure references Enterotoxins Has associated genes Has associated diseases Cholera Toxin Has associated genes Has associated diseases

Top ↑ Descendants

Cholera Toxin Has associated genes Has associated diseases
  Ace toxin
  cholera holotoxin, His(29)-
  cholera toxin B-immunodominant peptide conjugate (234-246)
  cholera toxin B-insulin conjugate
  cholera toxin B-saporin conjugate
  cholera toxin, B subunit (50-64)
  cholera toxin B subunit (50-75)
  cholera toxin, B subunit-horseradish peroxidase
  cholera toxoid
  CTA1-DD protein, recombinant
  CTA1R7K-COL-DD
  E coli O18 O-specific polysaccharide-cholera toxin
  EpsD protein, Vibrio cholerae
  human chorionic gonadotropin-cholera toxoid conjugate
  hybrid toxin, diphtheria-cholera
  N-acetyl-cholera toxin (50-64)-3-amide
  SNC-rCTB vaccine
  zonula occludens toxin, Vibrio cholerae
  zonulin