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Chemical Clozapine

Name Clozapine
CAS Type 1 Name 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
Equivalent Terms Clozaril | Leponex
CAS Registry Number 5786-21-0
Definition A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Structure Clozapine
Top Interacting
Genes
MeSH® ID D003024
External Links

Top ↑ Ancestors

ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Heterocyclic Compounds, Fused-Ring Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Heterocyclic Compounds, 3-Ring Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Dibenzazepines Has associated genes Has associated diseases Has associated phenotype references Clozapine Has associated genes Has associated diseases Has associated phenotype references

Top ↑ Descendants

Clozapine Has associated genes Has associated diseases Has associated phenotype references
  11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
  2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Has associated genes Has associated diseases
  batelapine
  CGS 19649A
  CGS 22996
  clozapine N-glucuronide
  clozapine N-oxide Has associated genes Has associated diseases
  demethylclozapine
  dibenzo(c,e)azepine
  iozapine
  JL 13 compound
  JL 18
  norclozapine Has associated genes Has associated diseases
  N-piperonylclozapine
  seleptin