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Chemical Clozapine

Name Clozapine
CAS Type 1 Name 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
Equivalent Terms Clozaril | Leponex
CAS Registry Number 5786-21-0
Definition A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Structure Clozapine
Top Interacting
Genes
MeSH® ID D003024
External Links

Top ↑ Ancestors

ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 3-Ring Has associated genes Has associated diseases Has associated exposure references Dibenzazepines Has associated genes Has associated diseases Clozapine Has associated genes Has associated diseases

Top ↑ Descendants

Clozapine Has associated genes Has associated diseases
  11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
  2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Has associated genes Has associated diseases
  batelapine
  CGS 19649A
  CGS 22996
  clozapine N-glucuronide
  clozapine N-oxide Has associated genes Has associated diseases
  demethylclozapine
  dibenzo(c,e)azepine
  iozapine
  JL 13 compound
  JL 18
  norclozapine Has associated genes Has associated diseases
  N-piperonylclozapine
  seleptin