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Chemical Dactinomycin

Name Dactinomycin
CAS Type 1 Name Actinomycin D
Equivalent Terms Ac-De | Actinomycin | Actinomycin D | Cosmegen | Cosmegen Lyovac | Lemery Brand of Dactinomycin | Lyovac-Cosmegen | Lyovac, Cosmegen | Meractinomycin | Merck Brand of Dactinomycin | Merck Frosst Brand of Dactinomycin | Merck Sharp & Dohme Brand of Dactinomycin | MSD Brand of Dactinomycin
CAS Registry Number 50-76-0
Definition A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Structure Dactinomycin
Top Interacting
Genes
MeSH® ID D003609
External Links

Top ↑ Ancestors

1. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 3-Ring Has associated genes Has associated diseases Has associated exposure references Dactinomycin Has associated genes Has associated diseases
2. ChemicalsPolycyclic Compounds Has associated genes Has associated diseases Has associated exposure references Macrocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Peptides, Cyclic Has associated genes Has associated diseases Has associated exposure references Dactinomycin Has associated genes Has associated diseases
3. ChemicalsAmino Acids, Peptides, and Proteins Has associated genes Has associated diseases Has associated exposure references Peptides Has associated genes Has associated diseases Has associated exposure references Peptides, Cyclic Has associated genes Has associated diseases Has associated exposure references Dactinomycin Has associated genes Has associated diseases

Top ↑ Descendants

Dactinomycin Has associated genes Has associated diseases
  1,1'-bis(L-alpha,beta-diaminopropionic acid)actinomycin D
  7-(2,3-epoxypropoxy)actinomycin D
  7-aminoactinomycin D
  7-azidoactinomycin D
  8-fluoro-actinomycin D
  ABV-ADV protocol
  AcFuCy protocol
  actinomine
  actinomycin C2
  actinomycin C3
  actinomycin D1
  actinomycin D2
  actinomycin D-dATGCAT complex
  actinomycin D lactam
  actinomycin D, valyl(2,2')-N-methylleucyl(5,5')-
  actinomycin G
  actinomycinic acid
  actinomycin K
  actinomycin S3
  actinomycin VII
  actinomycin X
  actinomycin X2
  aurantin
  azetomycins
  BAP protocol 2
  BCD protocol Has associated diseases
  bis-actinomycin D
  BOP-CISCA-POMB-ACE regimen Has associated diseases
  cactinomycin
  CHAMOCA regimen
  CHAMOMA protocol
  chounghwamycin A
  DD1 protocol
  desaminoactinomycin C
  dimethyl actinocynil bis(L-threonate)
  EMA-CO protocol
  EMACO protocol
  FDV protocol
  gluconimycin
  IVA protocol Has associated diseases
  Kengshenmycin
  levoristatin
  MAC combination
  MAC III protocol
  MAE protocol
  MDC protocol
  MEA regimen
  methylated actinomycin D
  MOFK protocol
  MOMK protocol
  N-(4-nitrobenzyloxycarbonyl)actinomycin D
  N8-actinomycin D
  PEA-M regimen
  PEA regimen
  POMB-ACE-PAV regimen
  POMB-ACE protocol
  POMB-ACE regimen
  Rosen's T-10 protocol Has associated diseases
  SIOP protocol
  T10 A protocol
  T-6 protocol
  T7 protocol
  VAB-6 regimen Has associated diseases
  VAB-III protocol
  VAB II protocol
  VAB-IV protocol
  VAB protocol
  VACAD protocol
  VACA protocol Has associated diseases
  VAC protocol Has associated diseases
  VAD regimen 2
  VAIA protocol